Acvr2a-specific antibody and method of use thereof

ABSTRACT

The present disclosure provides antibodies that specifically bind to and block signaling by ACVR2A, i.e., ACVR2A but not ACVR2B, as well as methods for using the same. The antibodies may be used for the treatment of a number of conditions associated with muscle atrophy, as well as other conditions.

CROSS-REFERENCING

This application claims the benefit of U.S. provisional application Ser. No. 62/477,911, filed on Mar. 28, 2017, which application is incorporated herein in its entirety.

BACKGROUND

The activin receptor, type II A (ACVR2A) is a high affinity receptor for the activin proteins as well as other members of the TGF-beta superfamily. ACVR2A is generally thought to transduce signals that lead to the phosphorylation of one or more SMAD transcription factors, particularly SMADs 1, 2, 3 and 5. ACVR2A has been implicated in the regulation of a wide range of biological processes, including bone formation, muscle formation, red blood cell formation, tumor growth, immune function and the production of reproductive hormones.

There is a need for reagents, e.g., antibodies, that specifically bind to ACVR2A and inhibit ACVR2A signaling.

SUMMARY OF THE INVENTION

The present disclosure provides antibodies that specifically bind to and block signaling by ACVR2A, i.e., ACVR2A but not ACVR2B. The antibodies are useful in various treatment, diagnostic, and monitoring applications. In some embodiments, an antibody may comprise: (a) a variable domain comprising: i. heavy chain CDR1, CDR2 and CDR3 regions that are identical the heavy chain CDR1, CDR2 and CDR3 regions of an antibody selected from any of Tables 2A-2F; and ii. light chain CDR1, CDR2 and CDR3 regions that are identical the light chain CDR1, CDR2 and CDR3 regions of the antibody selected from any of Tables 2A-2F; or (b) a variant of said variable domain of (a) that is otherwise identical to said antibody variable domain except for up to 15 amino acid substitutions in said CDR regions.

In some embodiments, an antibody may comprise: (a) a heavy chain variable domain comprising a heavy chain framework, a CDR1 region, a CDR2 region, and a CDR3 region of sequence ARSATWHDTXLD (SEQ ID NO:6538) or a variant of ARSATWHDTXLD (SEQ ID NO:6538) that comprises up to three amino acid substitutions, and (b) a light chain variable domain comprising a light chain framework, a CDR1 region, a CDR2 region, and a CDR3 region.

Definitions

The terms “antibodies” and “immunoglobulin” include antibodies or immunoglobulins of any isotype, fragments of antibodies which retain specific binding to antigen, including, but not limited to, Fab, Fv, scFv, and Fd fragments, chimeric antibodies, humanized antibodies, single-chain antibodies, and fusion proteins comprising an antigen-binding portion of an antibody and a non-antibody protein. The antibodies may be detectably labeled, e.g., with a radioisotope, an enzyme which generates a detectable product, a fluorescent protein, and the like. The antibodies may be further conjugated to other moieties, such as members of specific binding pairs, e.g., biotin (member of biotin-avidin specific binding pair), and the like. The antibodies may also be bound to a solid support, including, but not limited to, polystyrene plates or beads, and the like. Also encompassed by the term are Fab′, Fv, F(ab′)₂, and or other antibody fragments that retain specific binding to antigen, and monoclonal antibodies. An antibody may be monovalent or bivalent.

“Antibody fragments” comprise a portion of an intact antibody, for example, the antigen binding or variable region of the intact antibody. Examples of antibody fragments include Fab, Fab′, F(ab′)₂, and Fv fragments; diabodies; linear antibodies (Zapata et al., Protein Eng. 8(10): 1057-1062 (1995)); single-chain antibody molecules; and multispecific antibodies formed from antibody fragments. Papain digestion of antibodies produces two identical antigen-binding fragments, called “Fab” fragments, each with a single antigen-binding site, and a residual “Fc” fragment, a designation reflecting the ability to crystallize readily. Pepsin treatment yields an F(ab′)₂ fragment that has two antigen combining sites and is still capable of cross-linking antigen.

“Fv” is the minimum antibody fragment which contains a complete antigen-recognition and -binding site. This region consists of a dimer of one heavy- and one light-chain variable domain in tight, non-covalent association. It is in this configuration that the three CDRS of each variable domain interact to define an antigen-binding site on the surface of the V_(H)-V_(L) dimer. Collectively, the six CDRs confer antigen-binding specificity to the antibody. However, even a single variable domain (or half of an Fv comprising only three CDRs specific for an antigen) has the ability to recognize and bind antigen, although at a lower affinity than the entire binding site.

The “Fab” fragment also contains the constant domain of the light chain and the first constant domain (CH₁) of the heavy chain. Fab fragments differ from Fab′ fragments by the addition of a few residues at the carboxyl terminus of the heavy chain CH₁ domain including one or more cysteines from the antibody hinge region. Fab′-SH is the designation herein for Fab′ in which the cysteine residue(s) of the constant domains bear a free thiol group. F(ab′)₂ antibody fragments originally were produced as pairs of Fab′ fragments which have hinge cysteines between them. Other chemical couplings of antibody fragments are also known.

The “light chains” of antibodies (immunoglobulins) from any vertebrate species can be assigned to one of two clearly distinct types, called kappa and lambda, based on the amino acid sequences of their constant domains. Depending on the amino acid sequence of the constant domain of their heavy chains, immunoglobulins can be assigned to different classes. There are five major classes of immunoglobulins: IgA, IgD, IgE, IgG, and IgM, and several of these may be further divided into subclasses (isotypes), e.g., IgG1, IgG2, IgG3, IgG4, IgA, and IgA2.

“Single-chain Fv” or “sFv” antibody fragments comprise the V_(H) and V_(L) domains of antibody, wherein these domains are present in a single polypeptide chain. In some embodiments, the Fv polypeptide further comprises a polypeptide linker between the V_(H) and V_(L) domains, which enables the sFv to form the desired structure for antigen binding. For a review of sFv, see Pluckthun in The Pharmacology of Monoclonal Antibodies, vol. 113, Rosenburg and Moore eds., Springer-Verlag, New York, pp. 269-315 (1994).

The term “diabodies” refers to small antibody fragments with two antigen-binding sites, which fragments comprise a heavy-chain variable domain (V_(H)) connected to a light-chain variable domain (V_(L)) in the same polypeptide chain (V_(H)—V_(L)). By using a linker that is too short to allow pairing between the two domains on the same chain, the domains are forced to pair with the complementary domains of another chain and create two antigen-binding sites. Diabodies are described more fully in, for example, EP 404,097; WO 93/11161; and Hollinger et al., Proc. Natl. Acad. Sci. USA, 90:6444-6448 (1993).

As used herein, the term “affinity” refers to the equilibrium constant for the reversible binding of two agents and is expressed as a dissociation constant (Kd). Affinity can be at least 1-fold greater, at least 2-fold greater, at least 3-fold greater, at least 4-fold greater, at least 5-fold greater, at least 6-fold greater, at least 7-fold greater, at least 8-fold greater, at least 9-fold greater, at least 10-fold greater, at least 20-fold greater, at least 30-fold greater, at least 40-fold greater, at least 50-fold greater, at least 60-fold greater, at least 70-fold greater, at least 80-fold greater, at least 90-fold greater, at least 100-fold greater, or at least 1000-fold greater, or more, than the affinity of an antibody for unrelated amino acid sequences. Affinity of an antibody to a target protein can be, for example, from about 100 nanomolar (nM) to about 0.1 nM, from about 100 nM to about 1 picomolar (pM), or from about 100 nM to about 1 femtomolar (fM) or more. As used herein, the term “avidity” refers to the resistance of a complex of two or more agents to dissociation after dilution. The terms “immunoreactive” and “preferentially binds” are used interchangeably herein with respect to antibodies and/or antigen-binding fragments.

The term “binding” refers to a direct association between two molecules, due to, for example, covalent, electrostatic, hydrophobic, and ionic and/or hydrogen-bond interactions, including interactions such as salt bridges and water bridges. An ACVR2A-specific antibody antibodies binds specifically to an epitope within a ACVR2A polypeptide. Non-specific binding would refer to binding with an affinity of less than about 10⁻⁷ M, e.g., binding with an affinity of 10⁻⁶ M, 10⁻⁵ M, 10⁻⁴ M, etc.

As used herein, the term “CDR” or “complementarity determining region” is intended to mean the non-contiguous antigen combining sites found within the variable region of both heavy and light chain polypeptides. CDRs have been described by Kabat et al., J. Biol. Chem. 252:6609-6616 (1977); Kabat et al., U.S. Dept. of Health and Human Services, “Sequences of proteins of immunological interest” (1991); by Chothia et al., J. Mol. Biol. 196:901-917 (1987); and MacCallum et al., J. Mol. Biol. 262:732-745 (1996), where the definitions include overlapping or subsets of amino acid residues when compared against each other. Nevertheless, application of either definition to refer to a CDR of an antibody or grafted antibodies or variants thereof is intended to be within the scope of the term as defined and used herein. The amino acid residues which encompass the CDRs as defined by each of the above cited references are set forth below in Table 1 as a comparison.

TABLE 1 CDR Definitions Kabat¹ Chothia² MacCallum³ V_(H) CDR1 31-35 26-32 30-35 V_(H) CDR2 50-65 53-55 47-58 V_(H) CDR3  95-102  96-101  93-101 V_(L) CDR1 24-34 26-32 30-36 V_(L) CDR2 50-56 50-52 46-55 V_(L) CDR3 89-97 91-96 89-96 ¹Residue numbering follows the nomenclature of Kabat et al., supra ²Residue numbering follows the nomenclature of Chothia et al., supra ³Residue numbering follows the nomenclature of MacCallum et al., supra

As used herein, the term “framework” when used in reference to an antibody variable region is intended to mean all amino acid residues outside the CDR regions within the variable region of an antibody. A variable region framework is generally a discontinuous amino acid sequence between about 100-120 amino acids in length but is intended to reference only those amino acids outside of the CDRs. As used herein, the term “framework region” is intended to mean each domain of the framework that is separated by the CDRs.

An “isolated” antibody is one that has been identified and separated and/or recovered from a component of its natural environment. Contaminant components of its natural environment are materials that would interfere with diagnostic or therapeutic uses for the antibody, and may include enzymes, hormones, and other proteinaceous or nonproteinaceous solutes. In some embodiments, the antibody will be purified (1) to greater than 90%, greater than 95%, or greater than 98%, by weight of antibody as determined by the Lowry method, for example, more than 99% by weight, (2) to a degree sufficient to obtain at least 15 residues of N-terminal or internal amino acid sequence by use of a spinning cup sequenator, or (3) to homogeneity by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) under reducing or nonreducing conditions using Coomassie blue or silver stain. Isolated antibody includes the antibody in situ within recombinant cells since at least one component of the antibody's natural environment will not be present. In some instances, isolated antibody will be prepared by at least one purification step.

As used herein, the terms “treatment,” “treating,” and the like, refer to obtaining a desired pharmacologic and/or physiologic effect. The effect may be prophylactic in terms of completely or partially preventing a disease or symptom thereof and/or may be therapeutic in terms of a partial or complete cure for a disease and/or adverse effect attributable to the disease. “Treatment,” as used herein, covers any treatment of a disease in a mammal, particularly in a human, and includes: (a) preventing the disease from occurring in a subject which may be predisposed to the disease but has not yet been diagnosed as having it; (b) inhibiting the disease, i.e., arresting its development; and (c) relieving the disease, i.e., causing regression of the disease.

The terms “individual,” “subject,” “host,” and “patient,” used interchangeably herein, refer to a mammal, including, but not limited to, murines (rats, mice), non-human primates, humans, canines, felines, ungulates (e.g., equines, bovines, ovines, porcines, caprines), etc.

A “therapeutically effective amount” or “efficacious amount” refers to the amount of an ACVR2A-specific antibody that, when administered to a mammal or other subject for treating a disease, is sufficient to effect such treatment for the disease. The “therapeutically effective amount” will vary depending on the ACVR2A-specific antibody, the disease and its severity and the age, weight, etc., of the subject to be treated.

A “biological sample” encompasses a variety of sample types obtained from an individual and can be used in a diagnostic or monitoring assay. The definition encompasses blood and other liquid samples of biological origin, solid tissue samples such as a biopsy specimen or tissue cultures or cells derived therefrom and the progeny thereof. The definition also includes samples that have been manipulated in any way after their procurement, such as by treatment with reagents, solubilization, or enrichment for certain components, such as polynucleotides. The term “biological sample” encompasses a clinical sample, and also includes cells in culture, cell supernatants, cell lysates, serum, plasma, biological fluid, and tissue samples.

The present disclosure may make use of consensus sequences. If an amino acid sequence is indicated as being “of sequence Y”, where Y is a consensus sequence, the amino acid sequence falls within the consensus sequence. In a consensus sequence, the amino acid “X” can be any amino acid.

Before the present invention is further described, it is to be understood that this invention is not limited to particular embodiments described, as such may, of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting, since the scope of the present invention will be limited only by the appended claims.

Where a range of values is provided, it is understood that each intervening value, to the tenth of the unit of the lower limit unless the context clearly dictates otherwise, between the upper and lower limit of that range and any other stated or intervening value in that stated range, is encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included in the smaller ranges, and are also encompassed within the invention, subject to any specifically excluded limit in the stated range. Where the stated range includes one or both of the limits, ranges excluding either or both of those included limits are also included in the invention.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can also be used in the practice or testing of the present invention, the preferred methods and materials are now described. All publications mentioned herein are incorporated herein by reference to disclose and describe the methods and/or materials in connection with which the publications are cited.

It must be noted that as used herein and in the appended claims, the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to “an antibody” includes a plurality of such antibodies and reference to “the ACVR2A-specific antibody” includes reference to one or more ACVR2A-specific antibodies and equivalents thereof known to those skilled in the art, and so forth. It is further noted that the claims may be drafted to exclude any optional element. As such, this statement is intended to serve as antecedent basis for use of such exclusive terminology as “solely,” “only” and the like in connection with the recitation of claim elements, or use of a “negative” limitation.

The publications discussed herein are provided solely for their disclosure prior to the filing date of the present application. Nothing herein is to be construed as an admission that the present invention is not entitled to antedate such publication by virtue of prior invention. Further, the dates of publication provided may be different from the actual publication dates which may need to be independently confirmed.

DETAILED DESCRIPTION

The present disclosure provides antibodies that specifically bind to and block signaling by ACVR2A, i.e., ACVR2A but not ACVR2B. In some embodiments, the antibody may comprise (a) a variable domain comprising: i. heavy chain CDR1, CDR2 and CDR3 regions that are identical the heavy chain CDR1, CDR2 and CDR3 regions of an antibody selected from any of Tables 2A-2F; and ii. light chain CDR1, CDR2 and CDR3 regions that are identical the light chain CDR1, CDR2 and CDR3 regions of the antibody selected from any of Tables 2A-2F; or (b) a variant of the variable domain of (a) that is otherwise identical to the antibody variable domain of (a) except for up to 15 amino acid substitutions in the CDR regions, e.g., up to 15, up to 14, up to 13, up to 12, up to 11, up to 10, up to 9, up to 8, up to 7, up to 6, up to 5, up to 4, up to 3, up to 2 amino acid substitutions in the CDR regions.

In some embodiments, the antibody may comprise: a heavy chain variable domain comprising: a heavy chain framework, a CDR1 region, a CDR2 region, and a CDR3 region of sequence AxxAxWHDTxLD; and a light chain variable domain comprising: a light chain framework, a CDR1 region, a CDR2 region, and a CDR3 region. For example, in some embodiments, the heavy chain variable domain of the antibody may comprise a CDR3 region of sequence ARSATWHDTxLD (SEQ ID NO: 6538) (e.g., ARAANWHDTA/HLD (SEQ ID NO: 6539)), ARAATWHDTxLD (SEQ ID NO: 6540) (e.g., ARAATWHDTH/ALD (SEQ ID NO: 6541)), ARGANWHDTxLD (SEQ ID NO: 6542) (e.g., ARGANWHDTA/HLD (SEQ ID NO: 6543)), ARGATWHDTxLD (SEQ ID NO: 6544) (e.g., ARGATWHDTH/ALD (SEQ ID NO: 6545)), ARSANWHDTxLD (SEQ ID NO: 6546) (e.g., AR/KSANWHDTA/HLD (SEQ ID NO: 6547)) or ARSATWHDTxLD (SEQ ID NO: 6548) (e.g., ARSATWHDTH/ALD (SEQ ID NO: 6549)).

As will be shown below, there is considerable diversity in the heavy chain CDR1, heavy chain CDR2, light chain CDR1, light chain CDR2 and light chain CDR3 regions in the present antibodies. Therefore, consistent with Barrios et al (Mol. Recognit. 2004 17: 332-8) and Bowers et al (J. Biol. Chem. 2013 288: 7688-96) the heavy chain CDR3 is believed primarily responsible for antigen binding in the present antibody.

In some embodiments, the antibody may comprise a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of D/SS/DYG/SMH/N (SEQ ID NO: 6550), ii. a CDR2 region that has a sequence of WVA/SS/G/NINYNG/SGYT/KS/G (SEQ ID NO: 6551), and iii. a CDR3 region that has a sequence of ARAANWHDTA/HLD (SEQ ID NO: 6552); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of XXYL/VNWY (SEQ ID NO: 6553) (e.g., L/V/I/SS/T/RYL/VNWY (SEQ ID NO: 6554)), ii. a CDR2 region that has a sequence of LV/LIYXXXS/NR/LX (SEQ ID NO: 6555)(e.g., LV/LIYA/Y/VA/V/TT/S/NS/NR/LA/H/Q/P (SEQ ID NO: 6556)), and iii. a CDR3 region that has a sequence of QQ/HSY/DXXPL (SEQ ID NO: 6557) (e.g., QQ/HSY/DD/E/S/NL/N/S/TPL (SEQ ID NO: 6558)).

In some embodiments, the antibody may comprise a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of D/SS/DYG/SMH/N (SEQ ID NO: 6550), ii. a CDR2 region that has a sequence of WVA/SS/G/NINYNG/SGYT/KS/G (SEQ ID NO: 6551), and iii. a CDR3 region that has a sequence of ARAATWHDTH/ALD (SEQ ID NO: 6559); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of XS/TYL/VNWY (SEQ ID NO: 6560) (e.g., L/V/I/SS/TYL/VNWY (SEQ ID NO: 6561)), ii. a CDR2 region that has a sequence of LL/VIYA/YXXS/NR/LX (SEQ ID NO: 6562)(e.g., LL/VIYA/YA/T/VT/S/NS/NR/LA/P/Q (SEQ ID NO: 6563)), and iii. a CDR3 region that has a sequence of QQSY/D/NXXPL (SEQ ID NO: 6564) (e.g., QQSY/D/ND/E/S/NL/S/T/NPL (SEQ ID NO: 6565)).

In some embodiments, the antibody may comprise a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of S/DS/DYS/GMN/H (SEQ ID NO: 6566), ii. a CDR2 region that has a sequence of WVS/AG/S/NINYNG/SGYT/KS/G (SEQ ID NO: 6567), and iii. a CDR3 region that has a sequence of ARGANWHDTA/HLD (SEQ ID NO: 6543); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of XS/TYL/VNWY (SEQ ID NO: 6568) (e.g., L/V/S/IS/TYL/VNWY (SEQ ID NO: 6569)), ii. a CDR2 region that has a sequence of LL/VIYAXT/SSR/LX (SEQ ID NO: 6570) (e.g., LL/VIYAA/V/TT/SSR/LA/H/Q (SEQ ID NO: 6571)), and iii. a CDR3 region that has a sequence of QQSY/DXXPL (SEQ ID NO: 6572) (e.g., QQSY/DD/E/S/NS/T/N/LPL (SEQ ID NO: 6573)).

In some embodiments, the antibody may comprise a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of S/DS/DYS/GMN/H (SEQ ID NO: 6574), ii. a CDR2 region that has a sequence of WVA/SG/N/SINYNG/SGYT/KS/G (SEQ ID NO: 6575), and iii. a CDR3 region that has a sequence of ARGATWHDTH/ALD (SEQ ID NO: 6544); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of XS/TYL/VNWY (SEQ ID NO: 6568) (e.g., L/I/V/SS/TYL/VNWY (SEQ ID NO: 6576)), ii. a CDR2 region that has a sequence of LL/VIYAXT/SSR/LX (SEQ ID NO: 6570) (e.g., LL/VIYAA/V/TT/SSR/LA/H/Q (SEQ ID NO: 6571)), and iii. a CDR3 region that has a sequence of QQSY/DXXPL (SEQ ID NO: 6572) (e.g., QQSY/DD/E/S/NT/S/N/LPL (SEQ ID NO: 6577)).

In some embodiments, the antibody may comprise a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of S/DS/DYG/SMN/H (SEQ ID NO: 6578), ii. a CDR2 region that has a sequence of WVS/AG/N/SINYNG/SGYT/KS/G (SEQ ID NO: 6579), and iii. a CDR3 region that has a sequence of AR/KSANWHDTA/HLD (SEQ ID NO: 6580); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of XS/TYL/VNWY (SEQ ID NO: 6568) (e.g., L/V/I/SS/TYL/VNWY (SEQ ID NO: 6561)), ii. a CDR2 region that has a sequence of LL/VIYA/YXT/SS/NR/LX (SEQ ID NO: 6581) (e.g., LL/VIYA/YA/V/TT/SS/NR/LA/H/Q (SEQ ID NO: 6582)), and iii. a CDR3 region that has a sequence of QQSY/DXXPL (SEQ ID NO: 6572) (e.g., QQSY/DD/E/N/S S/T/L/NPL (SEQ ID NO: 6583)).

In some embodiments, the antibody may comprise a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of D/SS/DYS/GMN/H (SEQ ID NO: 6584), ii. a CDR2 region that has a sequence of WVA/SG/N/SINYNG/SGYT/KS/G (SEQ ID NO: 6585), and iii. a CDR3 region that has a sequence of ARSATWHDTH/ALD (SEQ ID NO: 6586); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of XXYL/VNWY (SEQ ID NO: 6587) (e.g., L/V/I/SS/T/RYL/VNWY (SEQ ID NO: 6588)), ii. a CDR2 region that has a sequence of LL/VIYA/YXT/SS/NR/LX (SEQ ID NO: 6589) (e.g., LL/VIYA/YA/V/TT/SS/NR/LA/H/Q (SEQ ID NO: 6590)), and iii. a CDR3 region that has a sequence of QQSY/DXXPL (SEQ ID NO: 6572) (e.g., QQSY/DD/E/S/NL/N/T/SPL (SEQ ID NO: 6591)).

In some embodiments the antibody may comprise: a heavy chain variable domain comprising an amino acid sequence that is at least 80% identical to (e.g., at least 90%, at least 95%, at least 98%, at least 99%, or 100% identical to) the amino acid sequence of the heavy chain variable domain of an antibody selected from any of Tables 2A-2F; and a light chain variable domain comprising an amino acid sequence that is at least 80% identical to (e.g., at least 90%, at least 95%, at least 98%, at least 99%, or 100% identical to) the light chain variable domain of the antibody selected from any of Tables 2A-2F.

Tables 2A-2F provides the amino acid sequences of the heavy and light variable domains of some examples of the present antibody.

TABLE 2A Group I Antibody Sequences Ab VH sequence VL sequence 365_B04 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK GMHWVRQAPGKGLEWVASINYNSGYTSYADSV PGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSDESPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 58) NO: 1) 365_B10 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSILRYLNWYQQK SMHWVRQAPGKGLEWVASINYNSGYKGYADSV PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSDNLPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 59) NO: 2) 365_C03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQK GMHWVRQAPGKGLEWVAGINYNSGYKGYADSV PGKAPKLVIYATTSLASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 60) NO: 3) 365_C06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSISTYVNWYQQK GMHWVRQAPGKGLEWVSGINYNGGYTSYADSV PGKAPKLLIYAVTSLASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 61) NO: 4) 365_D04 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQK GMHWVRQAPGKGLEWVAGINYNGGYKSYADSV PGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 62) NO: 5) 365_E04 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK GMHWVRQAPGKGLEWVASINYNGGYKSYADSV PGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 63) NO: 6) 365_F11 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQK SMNWVRQAPGKGLEWVSGINYNSGYKGYADSV PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 64) NO: 7) 365_G07 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQK GMHWVRQAPGKGLEWVSSINYNGGYTSYADSV PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 65) NO: 8) 365_H08 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQK GMHWVRQAPGKGLEWVASINYNGGYKSYADSV PGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 66) NO: 9) 366_A02 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQK GMNWVRQAPGKGLEWVASINYNSGYKGYADSV PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 67) NO: 10) 366_A04 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK GMNWVRQAPGKGLEWVAGINYNGGYTSYADSV PGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSDDSPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 68) NO: 11) 366_D01 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQK GMHWVRQAPGKGLEWVSSINYNGGYTGYADSV PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 69) NO: 12) 366 D03 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK GMHWVRQAPGKGLEWVSSINYNGGYTGYADSV PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 70) NO: 13) 366_F10 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQK SMNWVRQAPGKGLEWVAGINYNGGYTGYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 71) NO: 14) 366_G06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQK GMHWVRQAPGKGLEWVASINYNGGYTGYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 72) NO: 15) 367_B09 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK GMHWVRQAPGKGLEWVASINYNGGYTSYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 73) NO: 16) 367_B11 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQK SMHWVRQAPGKGLEWVANINYNSGYTSYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 74) NO: 17) 367_C09 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK GMHWVRQAPGKGLEWVASINYNGGYTSYADSV PGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 75) NO: 18) 367_D11 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQK GMHWVRQAPGKGLEWVSNINYNGGYKSYADSV PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 76) NO: 19) 367_F06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSISSYVNWYQQK GMNWVRQAPGKGLEWVSSINYNSGYTSYADSV PGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 77) NO: 20) 367_H01 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK GMNWVRQAPGKGLEWVSGINYNGGYKSYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 78) NO: 21) 368_A02 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQK GMNWVRQAPGKGLEWVAGINYNGGYKSYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 79) NO: 22) 368_A06 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK SMHWVRQAPGKGLEWVAGINYNSGYKGYADSV PGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 80) NO: 23) 368_A12 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK SMHWVRQAPGKGLEWVSSINYNSGYKGYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 81) NO: 24) 368_B03 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK GMNWVRQAPGKGLEWVSGINYNGGYTSYADSV PGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQHSYENPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 82) NO: 25) 368_B08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQK GMNWVRQAPGKGLEWVSSINYNGGYTSYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 83) NO: 26) 368_B10 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK GMHWVRQAPGKGLEWVASINYNGGYTSYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSDELPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 84) NO: 27) 368_B11 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQK GMHWVRQAPGKGLEWVSGINYNGGYKSYADSV PGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 85) NO: 28) 368_C09 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQK SMHWVRQAPGKGLEWVSNINYNGGYTGYADSV PGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 86) NO: 29) 368 D09 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQK GMHWVRQAPGKGLEWVAGINYNSGYKSYADSV PGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 87) NO: 30) 368_F02 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQK GMNWVRQAPGKGLEWVASINYNSGYTSYADSV PGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYSLPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 88) NO: 31) 368_F10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQK GMNWVRQAPGKGLEWVAGINYNSGYTSYADSV PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 89) NO: 32) 369_B03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQK GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV PGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 90) NO: 33) 369_G10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQK GMHWVRQAPGKGLEWVASINYNGGYTSYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 91) NO: 34) 369_H03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQK SMHWVRQAPGKGLEWVASINYNSGYKSYADSV PGKAPKLLIYATTSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 92) NO: 35) 370_B01 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK GMHWVRQAPGKGLEWVSGINYNGGYKSYADSV PGKAPKLLIYVASSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYSLPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 93) NO: 36) 370_D06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQK GMNWVRQAPGKGLEWVASINYNGGYTSYADSV PGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 94) NO: 37) 370_G04 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK GMHWVRQAPGKGLEWVSGINYNGGYTGYADSV PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 95) NO: 38) 370_H08 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK GMHWVRQAPGKGLEWVASINYNGGYTSYADSV PGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYSLPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 96) NO: 39) 371_A04 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK GMNWVRQAPGKGLEWVSSINYNSGYTGYADSV PGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 97) NO: 40) 371_A09 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVNWYQQK GMNWVRQAPGKGLEWVSGINYNGGYKSYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 98) NO: 41) 371_D07 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK GMNWVRQAPGKGLEWVANINYNGGYKGYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 99) NO: 42) 371_D12 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQK GMNWVRQAPGKGLEWVSGINYNGGYKSYADSV PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 100) NO: 43) 371_H02 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQK SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV PGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 101) NO: 44) 372_A09 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQK GMNWVRQAPGKGLEWVSGINYNGGYTSYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 102) NO: 45) 372_B11 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQK SMHWVRQAPGKGLEWVAGINYNSGYTSYADSV PGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 103) NO: 46) 372_E02 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQK GMNWVRQAPGKGLEWVASINYNGGYTSYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 104) NO: 47) 373_E11 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQK GMHWVRQAPGKGLEWVASINYNGGYTSYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 105) NO: 48) 373_H02 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQK GMHWVRQAPGKGLEWVAGINYNSGYTSYADSV PGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYXNPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 106) NO: 49) 374_B02 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQK SMHWVRQAPGKGLEWVAGINYNSGYTSYADSV PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 107) NO: 50) 374_F03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQK GMNWVRQAPGKGLEWVASINYNGGYTSYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 108) NO: 51) 375_A04 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK GMNWVRQAPGKGLEWVAGINYNGGYKSYADSV PGKAPKLVIYYVNNLPSGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 109) NO: 52) 375_A11 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQK GMHWVRQAPGKGLEWVSSINYNSGYKSYADSV PGKAPKLLIYYVTNLASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 110) NO: 53) 375_C10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSISTYLNWYQQK GMHWVRQAPGKGLEWVASINYNGGYTSYADSV PGKAPKLVIYAASSLQSGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 111) NO: 54) 375_F12 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK GMHWVRQAPGKGLEWVASINYNGGYTSYADSV PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSDELPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 112) NO: 55) 375_H01 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK SMNWVRQAPGKGLEWVAGINYNSGYTSYADSV PGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYSNPLTFGGGTKVEIK (SEQ ID ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID NO: 113) NO: 56) 376_G02 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSISRYLNWYQQK GMNWVRQAPGKGLEWVSGINYNGGYTSYADSV PGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTISSL KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC QPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ID ARAANWHDTALDYWGQGTLVTVSS (SEQ ID NO: 114) NO: 57)

Table 3A provides the amino acid sequences of the CDRs of the antibodies shown in Table 2A.

TABLE 3A CDR sequences for Group I antibodies Ab HCDR1 HCDR2 HCDR3 LCDR1 LCDR2 LCDR3 365_B04 SSYGMH WVASINYNSGYTS ARAANWHDTALD LTYLNWY LLIYAATSRH QQSDESPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 172) 229) NO: NO: 343) NO: 400) 115) 286) 365_B10 DDYSMH WVASINYNSGYKG ARAANWHDTALD LRYLNWY LLIYAATSRA QQSDNLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 173) 230) NO: NO: 344) NO: 401) 116) 287) 365_C03 SSYGMH WVAGINYNSGYKG ARAANWHDTHLD LTYVNWY LVIYATTSLA QQSYNTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 174) 231) NO: NO: 345) NO: 402) 117) 288) 365_C06 SDYGMH WVSGINYNGGYTS ARAANWHDTALD STYVNWY LLIYAVTSLA QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 175) 232) NO: NO: 346) NO: 403) 118) 289) 365_D04 SDYGMH WVAGINYNGGYKS ARAANWHDTALD SSYLNWY LVIYAVTSRA QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 176) 233) NO: NO: 347) NO: 404) 119) 290) 365_E04 DSYGMH WVASINYNGGYKS ARAANWHDTALD LSYVNWY LLIYAATSLA QQSYELPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 177) 234) NO: NO: 348) NO: 405) 120) 291) 365_F11 DSYSMN WVSGINYNSGYKG ARAANWHDTHLD ISYVNWY LLIYAATSRA QQSYNTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 178) 235) NO: NO: 349) NO: 406) 121) 292) 365_G07 DSYGMH WVSSINYNGGYTS ARAANWHDTALD VSYLNWY LLIYAATSRA QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 179) 236) NO: NO: 350) NO: 407) 122) 293) 365_H08 SSYGMH WVASINYNGGYKS ARAANWHDTALD SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 180) 237) NO: NO: 351) NO: 408) 123) 294) 366_A02 DSYGMN WVASINYNSGYKG ARAANWHDTHLD VSYVNWY LLIYAATSRA QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 181) 238) NO: NO: 352) NO: 409) 124) 295) 366_A04 SSYGMN WVAGINYNGGYTS ARAANWHDTALD LTYLNWY LVIYAATSLA QQSDDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 182) 239) NO: NO: 353) NO: 410) 125) 296) 366_D01 SSYGMH WVSSINYNGGYTG ARAANWHDTHLD LTYVNWY LLIYAATSRA QQSYENPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 183) 240) NO: NO: 354) NO: 411) 126) 297) 366_D03 DSYGMH WVSSINYNGGYTG ARAANWHDTHLD LSYVNWY LLIYAATSRA QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 184) 241) NO: NO: 355) NO: 412) 127) 298) 366_F10 DSYSMN WVAGINYNGGYTG ARAANWHDTHLD VSYLNWY LVIYAATSRA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 185) 242) NO: NO: 356) NO: 413) 128) 299) 366_G06 SSYGMH WVASINYNGGYTG ARAANWHDTHLD VSYVNWY LVIYAATSRA QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 186) 243) NO: NO: 357) NO: 414) 129) 300) 367_B09 DSYGMH WVASINYNGGYTS ARAANWHDTALD LSYVNWY LVIYAATSRA QQSYENPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 187) 244) NO: NO: 358) NO: 415) 130) 301) 367_B11 SDYSMH WVANINYNSGYTS ARAANWHDTALD LSYLNWY LVIYAATSRA QQSYSTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 188) 245) NO: NO: 359) NO: 416) 131) 302) 367_C09 DSYGMH WVASINYNGGYTS ARAANWHDTHLD LVIYAATSRH LSYVNWY QQSYNTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 189) 246) NO: NO: 360) NO: 417) 132) 303) 367_D11 DSYGMH WVSNINYNGGYKS ARAANWHDTALD ISYLNWY LLIYAATSRA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 190) 247) NO: NO: 361) NO: 418) 133) 304) 367_F06 SSYGMN WVSSINYNSGYTS ARAANWHDTALD SSYVNWY LLIYAVTSRA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 191) 248) NO: NO: 362) NO: 419) 134) 305) 367_H01 DSYGMN WVSGINYNGGYKS ARAANWHDTALD LTYLNWY LVIYAATSRA QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 192) 249) NO: NO: 363) NO: 420) 135) 306) 368_A02 DSYGMN WVAGINYNGGYKS ARAANWHDTHLD ISYVNWY LVIYAATSRA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 193) 250) NO: NO: 364) NO: 421) 136) 307) 368_A06 DSYSMH WVAGINYNSGYKG ARAANWHDTHLD LSYVNWY LLIYAATSRH QQSYNSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 194) 251) NO: NO: 365) NO: 422) 137) 308) 368_Al2 DSYSMH WVSSINYNSGYKG ARAANWHDTALD LTYLNWY LVIYAATSRA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 195) 252) NO: NO: 366) NO: 423) 138) 309) 368_B03 DDYGMN WVSGINYNGGYTS ARAANWHDTALD LTYLNWY LVIYAATSLA QHSYENPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 196) 253) NO: NO: 367) NO: 424) 139) 310) 368_B08 DSYGMN WVSSINYNGGYTS ARAANWHDTHLD LTYVNWY LVIYAATSRA QQSYENPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 197) 254) NO: NO: 368) NO: 425) 140) 311) 368_B10 DSYGMH WVASINYNGGYTS ARAANWHDTALD LTYLNWY LVIYAATSRA QQSDELPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 198) 255) NO: NO: 369) NO: 426) 141) 312) 368_B11 DSYGMH WVSGINYNGGYKS ARAANWHDTHLD LSYLNWY LLIYAASSLQ QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 199) 256) NO: NO: 370) NO: 427) 142) 313) 368_C09 SSYSMH WVSNINYNGGYTG ARAANWHDTHLD LTYVNWY LLIYAATSLA QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 200) 257) NO: NO: 371) NO: 428) 143) 314) 368_D09 DSYGMH WVAGINYNSGYKS ARAANWHDTHLD VSYVNWY LLIYAATSLA QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 201) 258) NO: NO: 372) NO: 429) 144) 315) 368_F02 SSYGMN WVASINYNSGYTS ARAANWHDTHLD LSYLNWY LLIYAASSLQ QQSYSLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 202) 259) NO: NO: 373) NO: 430) 145) 316) 368_F10 SSYGMN WVAGINYNSGYTS ARAANWHDTHLD VSYVNWY LLIYAATSRA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 203) 260) NO: NO: 374) NO: 431) 146) 317) 369_B03 SSYGMH WVAGINYNGGYTS ARAANWHDTALD LTYVNWY LVIYAATSLA QQSYELPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 204) 261) NO: NO: 375) NO: 432) 147) 318) 369_G10 SSYGMH WVASINYNGGYTS ARAANWHDTALD LSYLNWY LVIYAATSRA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 205) 262) NO: NO: 376) NO: 433) 148) 319) 369_H03 SSYSMH WVASINYNSGYKS ARAANWHDTALD VSYLNWY LLIYATTSRA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 206) 263) NO: NO: 377) NO: 434) 149) 320) 370_B01 DDYGMH WVSGINYNGGYKS ARAANWHDTALD LSYVNWY LLIYVASSRA QQSYSLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 207) 264) NO: NO: 378) NO: 435) 150) 321) 370_D06 SSYGMN WVASINYNGGYTS ARAANWHDTHLD ISYLNWY LVIYAATSLA QQSYSSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 208) 265) NO: NO: 379) NO: 436) 151) 322) 370_G04 SSYGMH WVSGINYNGGYTG ARAANWHDTALD LSYVNWY LLIYAATSRA QQSYSTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 209) 266) NO: NO: 380) NO: 437) 152) 323) 370_H08 SSYGMH WVASINYNGGYTS ARAANWHDTHLD LSYVNWY LLIYAATSRH QQSYSLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 210) 267) NO: NO: 381) NO: 438) 153) 324) 371_A04 D SYGMN WVSSINYNSGYTG ARAANWHDTALD LTYLNWY LLIYAVTSRA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 211) 268) NO: NO: 382) NO: 439) 154) 325) 371_A09 SSYGMN WVSGINYNGGYKS ARAANWHDTALD VTYVNWY LVIYAATSRA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 212) 269) NO: NO: 383) NO: 440) 155) 326) 371_D07 DDYGMN WVANINYNGGYKG ARAANWHDTHLD LTYLNWY LVIYAATSRA QQSYELPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 213) 270) NO: NO: 384) NO: 441) 156) 327) 371_D12 DSYGMN WVSGINYNGGYKS ARAANWHDTALD LSYLNWY LLIYAATSRA QQSYELPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 214) 271) NO: NO: 385) NO: 442) 157) 328) 371_H02 DDYSMN WVSGINYNGGYKS ARAANWHDTHLD ISYLNWY LVIYAATSLA QQSYENPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 215) 272) NO: NO: 386) NO: 443) 158) 329) 372_A09 DSYGMN WVSGINYNGGYTS ARAANWHDTALD LSYLNWY LVIYAATSRA QQSYNSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 216) 273) NO: NO: 387) NO: 444) 159) 330) 372_B11 SSYSMH WVAGINYNSGYTS ARAANWHDTHLD LTYVNWY LVIYAATSLA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 217) 274) NO: NO: 388) NO: 445) 160) 331) 372_E02 SSYGMN WVASINYNGGYTS ARAANWHDTALD ISYVNWY LVIYAATSRA QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 218) 275) NO: NO: 389) NO: 446) 161) 332) 373_E11 DSYGMH WVASINYNGGYTS ARAANWHDTALD VSYLNWY LVIYAATSRA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 219) 276) NO: NO: 390) NO: 447) 162) 333) 373_H02 SSYGMH WVAGINYNSGYTS ARAANWHDTALD VSYVNWY LLIYAATSRH QQSYXNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO:  220) 277) NO: NO: 391) NO: 448) 163) 334) 374_B02 DSYSMH WVAGINYNSGYTS ARAANWHDTHLD ISYLNWY LLIYAATSRA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 221) 278) NO: NO: 392) NO: 449) 164) 335) 374_F03 SSYGMN WVASINYNGGYTS ARAANWHDTHLD ISYVNWY LVIYAATSRA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 222) 279) NO: NO: 393) NO: 450) 165) 336) 375_A04 DSYGMN WVAGINYNGGYKS ARAANWHDTALD LTYLNWY LVIYYVNNLP QQSYNSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 223) 280) NO: NO: 394) NO: 451) 166) 337) 375_A11 SDYGMH WVSSINYNSGYKS ARAANWHDTALD VSYLNWY LLIYYVTNLA QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 224) 281) NO: NO: 395) NO: 452) 167) 338) 375_C10 SSYGMH WVASINYNGGYTS ARAANWHDTALD STYLNWY LVIYAASSLQ QQSYSTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 225) 282) NO: NO: 396) NO: 453) 168) 339) 375_F12 DSYGMH WVASINYNGGYTS ARAANWHDTALD LTYLNWY LVIYAATSRA QQSDELPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 226) 283) NO: NO: 397) NO: 454) 169) 340) 375_H01 SDYSMN WVAGINYNSGYTS ARAANWHDTHLD LTYLNWY LLIYAATSRH QQSYSNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 227) 284) NO: NO: 398) NO: 455) 170) 341) 376_G02 SDYGMN WVSGINYNGGYTS ARAANWHDTALD SRYLNWY LVIYAATSLA QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 228) 285) NO: NO: 399) NO: 456) 171) 342)

The consensus sequences for each of these CDRs shown in FIG. 3A are as follows:

HCDR1: (SEQ ID NO: 6550) D/SS/DYG/SMH/N HCDR2: (SEQ ID NO: 6551) WVA/SS/G/NINYNG/SGYT/KS/G HCDR3: (SEQ ID NO: 6552) ARAANWHDTA/HLD LCDR1: (SEQ ID NO: 6554) L/V/I/SS/T/RYL/VNWY LCDR2: (SEQ ID NO: 6592) LV/LIYA/Y/VA/V/TT/S/NS/NR/LA/H/Q/P LCDR3 (SEQ ID NO: 6593) QQ/HSY/DD/E/S/NL/N/S/TPL

TABLE 2B Group II Antibody Sequences Ab VH sequence VL sequence 365_A05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ GMHWVRQAPGKGLEWVSSINYNGGYTSYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 528) NO: 457) 365_B08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ GMNWVRQAPGKGLEWVSNINYNSGYKGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 529) NO: 458) 365_B12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSISTYVNWYQQ GMHWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYAVTSLHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 530) NO: 459) 365_D03 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ SMHWVRQAPGKGLEWVASINYNGGYKSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 531) NO: 460) 365_D08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIITYVNWYQQ SMHWVRQAPGKGLEWVSSINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 532) NO: 461) 365_E06 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMNWVRQAPGKGLEWVSGINYNGGYTGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 533) NO: 462) 365_F10 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVNWYQQ GMHWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 534) NO: 463) 365_G06 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDSTPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 535) NO: 464) 365_G08 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ GMHWVRQAPGKGLEWVASINYNGGYTSYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 536) NO: 465) 366_B09 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMHWVRQAPGKGLEWVSSINYNSGYKSYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 537) NO: 466) 366_C05 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ GMHWVRQAPGKGLEWVSSINYNGGYTGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 538) NO: 467) 366_E07 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDNSPLTFGGGTKVEIK (SEQ ARAATWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 539) NO: 468) 366_G02 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMHWVRQAPGKGLEWVSSINYNGGYTSYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDDNPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 540) NO: 469) 366_H01 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMHWVRQAPGKGLEWVANINYNGGYTSYADSV KPGKAPKLVIYATTSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 541) NO: 470) 367_C06 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMHWVRQAPGKGLEWVASINYNGGYKSYADSV KPGKAPKLVIYAATSLHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 542) NO: 471) 367_C12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMHWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYATTSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 543) NO: 472) 367_E08 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMNWVRQAPGKGLEWVASINYNGGYTSYADSV KPGKAPKLLIYATTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 544) NO: 473) 367_E10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMHWVRQAPGKGLEWVSSINYNGGYTGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 545) NO: 474) 367_F08 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMHWVRQAPGKGLEWVSSINYNSGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSNELPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 546) NO: 475) 367_F10 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMNWVRQAPGKGLEWVSGINYNSGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 547) NO: 476) 367_G03 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ SMHWVRQAPGKGLEWVANINYNGGYTSYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 548) NO: 477) 367_G11 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMHWVRQAPGKGLEWVASINYNGGYTSYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDDSPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 549) NO: 478) 367_H08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ GMNWVRQAPGKGLEWVSSINYNGGYTSYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNLPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 550) NO: 479) 368_B04 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ GMHWVRQAPGKGLEWVSSINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 551) NO: 480) 368_B12 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ GMHWVRQAPGKGLEWVSGINYNSGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 552) NO: 481) 368_C04 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMHWVRQAPGKGLEWVSNINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 553) NO: 482) 368_C07 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ GMHWVRQAPGKGLEWVAGINYNSGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 554) NO: 483) 368_C12 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMHWVRQAPGKGLEWVASINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDSNPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 555) NO: 484) 368_D03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSIITYVNWYQQ SMHWVRQAPGKGLEWVASINYNGGYTSYADSV KPGKAPKLLIYATTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 556) NO: 485) 368_D06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMNWVRQAPGKGLEWVSNINYNGGYTGYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 557) NO: 486) 368 D07 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ GMHWVRQAPGKGLEWVASINYNGGYTGYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 558) NO: 487) 368_E05 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMHWVRQAPGKGLEWVSSINYNGGYKSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 559) NO: 488) 368_E08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMHWVRQAPGKGLEWVANINYNSGYTGYADSV KPGKAPKLVIYAATSLHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 560) NO: 489) 368_G11 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMHWVRQAPGKGLEWVSGINYNSGYKSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDNTPLTFGGGTKVEIK (SEQ ARAATWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 561) NO: 490) 368_H03 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ SMHWVRQAPGKGLEWVASINYNGGYTGYADSV KPGKAPKLVIYAVTSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSNPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 562) NO: 491) 369_A04 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ GMHWVRQAPGKGLEWVASINYNGGYKSYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 563) NO: 492) 369_A12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMHWVRQAPGKGLEWVASINYNSGYTGYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 564) NO: 493) 369_B07 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ GMHWVRQAPGKGLEWVANINYNGGYKSYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 565) NO: 494) 369_B08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMHWVRQAPGKGLEWVSSINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 566) NO: 495) 369_C06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ SMHWVRQAPGKGLEWVSSINYNGGYKSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 567) NO: 496) 369_C09 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ GMHWVRQAPGKGLEWVSSINYNGGYTGYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 568) NO: 497) 369_C11 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMHWVRQAPGKGLEWVAGINYNGGYTGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 569) NO: 498) 369_E03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 570) NO: 499) 370_B06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 571) NO: 500) 370_B07 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ GMHWVRQAPGKGLEWVANINYNSGYKSYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 572) NO: 501) 370_E12 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 573) NO: 502) 370_H05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMHWVRQAPGKGLEWVSNINYNGGYTSYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDSLPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 574) NO: 503) 371_A05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMHWVRQAPGKGLEWVSNINYNGGYKSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDNLPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 575) NO: 504) 371_B02 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ GMNWVRQAPGKGLEWVSNINYNGGYTSYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNNPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 576) NO: 505) 371_B11 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMHWVRQAPGKGLEWVASINYNSGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 577) NO: 506) 371_C02 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ GMHWVRQAPGKGLEWVAGINYNSGYTGYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 578) NO: 507) 371_D05 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMHWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 579) NO: 508) 371_F07 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDSNPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 580) NO: 509) 371_G07 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSLPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 581) NO: 510) 372_D07 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 582) NO: 511) 373_B01 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMHWVRQAPGKGLEWVSGINYNGGYKSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 583) NO: 512) 373_D11 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 584) NO: 513) 373_G06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMHWVRQAPGKGLEWVASINYNSGYTGYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNLPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 585) NO: 514) 374_A10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMHWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 586) NO: 515) 374_A12 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMHWVRQAPGKGLEWVSSINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDSNPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 587) NO: 516) 374_B01 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMHWVRQAPGKGLEWVAGINYNSGYTSYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 588) NO: 517) 374_B07 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ GMHWVRQAPGKGLEWVSSINYNGGYKSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 589) NO: 518) 374_H02 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMHWVRQAPGKGLEWVASINYNGGYTSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 590) NO: 519) 375_C03 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ SMHWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 591) NO: 520) 375_C05 EVQLLESGGGLVQPGGSLRLSCAASGFTFXSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMNWVRQAPGKGLEWVASINYNGGYKGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 592) NO: 521) 375_D02 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVSNINYNGGYTSYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 593) NO: 522) 375_G08 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSISSYVNWYQQ GMHWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 594) NO: 523) 375_H04 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMHWVRQAPGKGLEWVAGINYNSGYTGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSNPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 595) NO: 524) 376_D08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMNWVRQAPGKGLEWVANINYNSGYKSYADSV KPGKAPKLVIYYANNRPSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSNPLTFGGGTKVEIK (SEQ ARAATWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 596) NO: 525) 376_F09 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ SMHWVRQAPGKGLEWVSSINYNGGYKSYADSV KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 597) NO: 526) 376_H12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSIITYLNWYQQ GMHWVRQAPGKGLEWVASINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 598) NO: 527)

Table 3B provides the amino acid sequences of the CDRs of the antibodies shown in Table 2B.

TABLE 3B CDR sequences for Group II antibodies Ab HCDR1 HCDR2 HCDR3 LCDR1 LCDR2 LCDR3 365_A05 SSYGMH WVSSINYNGGYTS ARAATWHDTHLD SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID  (SEQ ID NO: 670) (SEQ ID NO: 742) (SEQ ID NO: 813) (SEQ ID NO: 884) (SEQ ID NO: 955) NO: 599) 365_B08 DSYGMN WVSNINYNSGYKG ARAATWHDTHLD VTYLNWY LLIYAATSRA QQSYSSPL (SEQ ID  (SEQ ID NO: 671) (SEQ ID NO: 743) (SEQ ID NO: 814) (SEQ ID NO: 885) (SEQ ID NO: 956) NO: 600) 365_B12 SDYGMH WVSGINYNGGYTS ARAATWHDTHLD STYVNWY LLIYAVTSLH QQSYDNPL (SEQ ID  (SEQ ID NO: 672) (SEQ ID NO: 744) (SEQ ID NO: 815) (SEQ ID NO: 886) (SEQ ID NO: 957) NO: 601) 365_D03 DDYSMH WVASINYNGGYKS ARAATWHDTHLD VSYLNWY LVIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 673) (SEQ ID NO: 745) (SEQ ID NO: 816) (SEQ ID NO: 887) (SEQ ID NO: 958) NO: 602) 365_D08 DSYSMH WVSSINYNGGYTS ARAATWHDTHLD ITYVNWY LLIYAATSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 674) (SEQ ID NO: 746) (SEQ ID NO: 817) (SEQ ID NO: 888) (SEQ ID NO: 959) NO: 603) 365_E06 DSYGMN WVSGINYNGGYTG ARAATWHDTHLD LTYLNWY LVIYAATSRA QQSYNTPL (SEQ ID  (SEQ ID NO: 675) (SEQ ID NO: 747) (SEQ ID NO: 818) (SEQ ID NO: 889) (SEQ ID NO: 960) NO: 604) 365_F10 DDYGMH WVSGINYNGGYTS ARAATWHDTHLD VTYVNWY LLIYAATSRA QQSYELPL (SEQ ID  (SEQ ID NO: 676) (SEQ ID NO: 748) (SEQ ID NO: 819) (SEQ ID NO: 890) (SEQ ID NO: 961) NO: 605) 365_G06 DSYGMH WVAGINYNGGYTS ARAATWHDTHLD LSYLNWY LLIYAATSLA QQSDSTPL (SEQ ID  (SEQ ID NO: 677) (SEQ ID NO: 749) (SEQ ID NO: 820) (SEQ ID NO: 891) (SEQ ID NO: 962) NO: 606) 365_G08 SSYGMH WVASINYNGGYTS ARAATWHDTHLD SSYLNWY LLIYAASSLQ QQSYETPL (SEQ ID  (SEQ ID NO: 678) (SEQ ID NO: 750) (SEQ ID NO: 821) (SEQ ID NO: 892) (SEQ ID NO: 963) NO: 607) 366_B09 SDYGMH WVSSINYNSGYKS ARAATWHDTHLD LTYLNWY LVIYAATSRH QQSYDSPL (SEQ ID  (SEQ ID NO: 679) (SEQ ID NO: 751) (SEQ ID NO: 822) (SEQ ID NO: 893) (SEQ ID NO: 964) NO: 608) 366_C05 DDYGMH WVSSINYNGGYTG ARAATWHDTHLD ISYLNWY LVIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 680) (SEQ ID NO: 752) (SEQ ID NO: 823) (SEQ ID NO: 894) (SEQ ID NO: 965) NO: 609) 366_E07 DSYGMH WVAGINYNGGYTS ARAATWHDTALD LTYLNWY LVIYAATSRH QQSDNSPL (SEQ ID  (SEQ ID NO: 681) (SEQ ID NO: 753) (SEQ ID NO: 824) (SEQ ID NO: 895) (SEQ ID NO: 966) NO: 610) 366_G02 DSYGMH WVSSINYNGGYTS ARAATWHDTHLD LTYLNWY LLIYAATSRH QQSDDNPL (SEQ ID  (SEQ ID NO: 682) (SEQ ID NO: 754) (SEQ ID NO: 825) (SEQ ID NO: 896) (SEQ ID NO: 967) NO: 611) 366_H01 DDYSMH WVANINYNGGYTS ARAATWHDTHLD LTYLNWY LVIYATTSRH QQSYESPL (SEQ ID  (SEQ ID NO: 683) (SEQ ID NO: 755) (SEQ ID NO: 826) (SEQ ID NO: 897) (SEQ ID NO: 968) NO: 612) 367_C06 DSYSMH WVASINYNGGYKS ARAATWHDTHLD LTYLNWY LVIYAATSLH QQSYDTPL (SEQ ID  (SEQ ID NO: 684) (SEQ ID NO: 756) (SEQ ID NO: 827) (SEQ ID NO: 898) (SEQ ID NO: 969) NO: 613) 367_C12 SSYGMH WVSGINYNGGYTS ARAATWHDTHLD LSYVNWY LLIYATTSRH QQSYESPL (SEQ ID  (SEQ ID NO: 685) (SEQ ID NO: 757) (SEQ ID NO: 828) (SEQ ID NO: 899) (SEQ ID NO: 970) NO: 614) 367_E08 SDYGMN WVASINYNGGYTS ARAATWHDTHLD LSYLNWY LLIYATTSRA QQSYDNPL (SEQ ID  (SEQ ID NO: 686) (SEQ ID NO: 758) (SEQ ID NO: 829) (SEQ ID NO: 900) (SEQ ID NO: 971) NO: 615) 367_E10 SSYGMH WVSSINYNGGYTG ARAATWHDTHLD LSYVNWY LLIYAATSRA QQSYELPL (SEQ ID  (SEQ ID NO: 687) (SEQ ID NO: 759) (SEQ ID NO: 830) (SEQ ID NO: 901) (SEQ ID NO: 972) NO: 616) 367_F08 SSYGMH WVSSINYNSGYTS ARAATWHDTHLD LSYVNWY LVIYAATSRA QQSNELPL (SEQ ID  (SEQ ID NO: 688) (SEQ ID NO: 760) (SEQ ID NO: 831) (SEQ ID NO: 902) (SEQ ID NO: 973) NO: 617) 367_F10 DSYGMN WVSGINYNSGYTS ARAATWHDTHLD LTYLNWY LLIYAATSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 689) (SEQ ID NO: 761) (SEQ ID NO: 832) (SEQ ID NO: 903) (SEQ ID NO: 974) NO: 618) 367_G03 DSYSMH WVANINYNGGYTS ARAATWHDTHLD VSYVNWY LVIYAATSRH QQSYDLPL (SEQ ID  (SEQ ID NO: 690) (SEQ ID NO: 762) (SEQ ID NO: 833) (SEQ ID NO: 904) (SEQ ID NO: 975) NO: 619) 367_G11 SSYGMH WVASINYNGGYTS ARAATWHDTHLD LTYLNWY LLIYAATSRH QQSDDSPL (SEQ ID  (SEQ ID NO: 691) (SEQ ID NO: 763) (SEQ ID NO: 834) (SEQ ID NO: 905) (SEQ ID NO: 976) NO: 620) 367_H08 DSYGMN WVSSINYNGGYTS ARAATWHDTHLD LTYVNWY LLIYAATSRH QQSYNLPL (SEQ ID  (SEQ ID NO: 692) (SEQ ID NO: 764) (SEQ ID NO: 835) (SEQ ID NO: 906) (SEQ ID NO: 977) NO: 621) 368_B04 DSYGMH WVSSINYNGGYTS ARAATWHDTHLD VSYLNWY LVIYAATSRA QQSYENPL (SEQ ID  (SEQ ID NO: 693) (SEQ ID NO: 765) (SEQ ID NO: 836) (SEQ ID NO: 907) (SEQ ID NO: 978) NO: 622) 368_B12 DSYGMH WVSGINYNSGYTS ARAATWHDTHLD VSYVNWY LLIYAATSRA QQSYDLPL (SEQ ID  (SEQ ID NO: 694) (SEQ ID NO: 766) (SEQ ID NO: 837) (SEQ ID NO: 908) (SEQ ID NO: 979) NO: 623) 368_C04 DSYGMH WVSNINYNGGYTS ARAATWHDTHLD LSYVNWY LLIYAATSRA QQSYSTPL (SEQ ID  (SEQ ID NO: 695) (SEQ ID NO: 767) (SEQ ID NO: 838) (SEQ ID NO: 909) (SEQ ID NO: 980) NO: 624) 368_C07 SSYGMH WVAGINYNSGYTS ARAATWHDTHLD VSYVNWY LVIYAATSRA QQSYENPL (SEQ ID  (SEQ ID NO: 696) (SEQ ID NO: 768) (SEQ ID NO: 839) (SEQ ID NO: 910) (SEQ ID NO: 981) NO: 625) 368_C12 DSYGMH WVASINYNGGYTS ARAATWHDTHLD LTYLNWY LLIYAATSRA QQSDSNPL (SEQ ID  (SEQ ID NO: 697) (SEQ ID NO: 769) (SEQ ID NO: 840) (SEQ ID NO: 911) (SEQ ID NO: 982) NO: 626) 368_D03 SDYSMH WVASINYNGGYTS ARAATWHDTHLD ITYVNWY LLIYATTSRA QQSYDLPL (SEQ ID  (SEQ ID NO: 698) (SEQ ID NO: 770) (SEQ ID NO: 841) (SEQ ID NO: 912) (SEQ ID NO: 983) NO: 627) 368_D06 SSYGMN WVSNINYNGGYTG ARAATWHDTHLD LSYVNWY LVIYAATSRH QQSYENPL (SEQ ID  (SEQ ID NO: 699) (SEQ ID NO: 771) (SEQ ID NO: 842) (SEQ ID NO: 913) (SEQ ID NO: 984) NO: 628) 368_D07 DSYGMH WVASINYNGGYTG ARAATWHDTHLD SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID  (SEQ ID NO: 700) (SEQ ID NO: 772) (SEQ ID NO: 843) (SEQ ID NO: 914) (SEQ ID NO: 985) NO: 629) 368_E05 DSYSMH WVSSINYNGGYKS ARAATWHDTHLD LSYLNWY LVIYAATSRA QQSYSSPL (SEQ ID  (SEQ ID NO: 701) (SEQ ID NO: 773) (SEQ ID NO: 844) (SEQ ID NO: 915) (SEQ ID NO: 986) NO: 630) 368_E08 DSYGMH WVANINYNSGYTG ARAATWHDTHLD LSYVNWY LVIYAATSLH QQSYETPL (SEQ ID  (SEQ ID NO: 702) (SEQ ID NO: 774) (SEQ ID NO: 845) (SEQ ID NO: 916) (SEQ ID NO: 987) NO: 631) 368_G11 DSYGMH WVSGINYNSGYKS ARAATWHDTALD LTYLNWY LLIYAATSRA QQSDNTPL (SEQ ID  (SEQ ID NO: 703) (SEQ ID NO: 775) (SEQ ID NO: 846) (SEQ ID NO: 917) (SEQ ID NO: 988) NO: 632) 368_H03 DDYSMH WVASINYNGGYTG ARAATWHDTHLD LSYVNWY LVIYAVTSRH QQSYSNPL (SEQ ID  (SEQ ID NO: 704) (SEQ ID NO: 776) (SEQ ID NO: 847) (SEQ ID NO: 918) (SEQ ID NO: 989) NO: 633) 369_A04 DSYGMH WVASINYNGGYKS ARAATWHDTHLD VSYVNWY LVIYAATSLA QQSYDLPL (SEQ ID  (SEQ ID NO: 705) (SEQ ID NO: 777) (SEQ ID NO: 848) (SEQ ID NO: 919) (SEQ ID NO: 990) NO: 634) 369_A12 SSYSMH WVASINYNSGYTG ARAATWHDTHLD LTYLNWY LLIYAATSRH QQSYDLPL (SEQ ID  (SEQ ID NO: 706) (SEQ ID NO: 778) (SEQ ID NO: 849) (SEQ ID NO: 920) (SEQ ID NO: 991) NO: 635) 369_B07 DSYGMH WVANINYNGGYKS ARAATWHDTHLD VSYVNWY LVIYAATSLA QQSYDLPL (SEQ ID  (SEQ ID NO: 707) (SEQ ID NO: 779) (SEQ ID NO: 850) (SEQ ID NO: 921) (SEQ ID NO: 992) NO: 636) 369_B08 DSYGMH WVSSINYNGGYTS ARAATWHDTHLD LSYVNWY LLIYAATSRA QQSYESPL (SEQ ID  (SEQ ID NO: 708) (SEQ ID NO: 780) (SEQ ID NO: 851) (SEQ ID NO: 922) (SEQ ID NO: 993) NO: 637) 369_C06 SSYSMH WVSSINYNGGYKS ARAATWHDTHLD LSYVNWY LLIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 709) (SEQ ID NO: 781) (SEQ ID NO: 852) (SEQ ID NO: 923) (SEQ ID NO: 994) NO: 638) 369_C09 SSYGMH WVSSINYNGGYTG ARAATWHDTHLD VSYLNWY LVIYAATSRH QQSYDLPL (SEQ ID  (SEQ ID NO: 710) (SEQ ID NO: 782) (SEQ ID NO: 853) (SEQ ID NO: 924) (SEQ ID NO: 995) NO: 639) 369_C11 SDYGMH WVAGINYNGGYTG ARAATWHDTHLD LSYLNWY LVIYAATSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 711) (SEQ ID NO: 783) (SEQ ID NO: 854) (SEQ ID NO: 925) (SEQ ID NO: 996) NO: 640) 369_E03 SSYGMH WVAGINYNGGYTS ARAATWHDTHLD LSYVNWY LLIYAATSLA QQSYENPL (SEQ ID  (SEQ ID NO: 712) (SEQ ID NO: 784) (SEQ ID NO: 855) (SEQ ID NO: 926) (SEQ ID NO: 997) NO: 641) 370_B06 SSYGMH WVAGINYNGGYTS ARAATWHDTHLD VSYVNWY LVIYAATSRA QQSYETPL (SEQ ID  (SEQ ID NO: 713) (SEQ ID NO: 785) (SEQ ID NO: 856) (SEQ ID NO: 927) (SEQ ID NO: 998) NO: 642) 370_B07 SSYGMH WVANINYNSGYKS ARAATWHDTHLD LTYVNWY LLIYAATSRH QQSYSSPL (SEQ ID  (SEQ ID NO: 714) (SEQ ID NO: 786) (SEQ ID NO: 857) (SEQ ID NO: 928) (SEQ ID NO: 999) NO: 643) 370_E12 DSYGMH WVAGINYNGGYTS ARAATWHDTHLD LSYVNWY LLIYAATSRA QQSYENPL (SEQ ID  (SEQ ID NO: 715) (SEQ ID NO: 787) (SEQ ID NO: 858) (SEQ ID NO: 929) (SEQ ID NO: 1000) NO: 644) 370_H05 SSYGMH WVSNINYNGGYTS ARAATWHDTHLD LSYLNWY LLIYAASSLQ QQSDSLPL (SEQ ID  (SEQ ID NO: 716) (SEQ ID NO: 788) (SEQ ID NO: 859) (SEQ ID NO: 930) (SEQ ID NO: 1001) NO: 645) 371_A05 SSYGMH WVSNINYNGGYKS ARAATWHDTHLD LTYLNWY LLIYAATSRA QQSDNLPL (SEQ ID  (SEQ ID NO: 717) (SEQ ID NO: 789) (SEQ ID NO: 860) (SEQ ID NO: 931) (SEQ ID NO: 1002) NO: 646) 371_B02 DSYGMN WVSNINYNGGYTS ARAATWHDTHLD LTYVNWY LVIYAATSLA QQSYNNPL (SEQ ID  (SEQ ID NO: 718) (SEQ ID NO: 790) (SEQ ID NO: 861) (SEQ ID NO: 932) (SEQ ID NO: 1003) NO: 647) 371_B11 SSYSMH WVASINYNSGYTS ARAATWHDTHLD LTYLNWY LLIYAATSRA QQSYELPL (SEQ ID  (SEQ ID NO: 719) (SEQ ID NO: 791) (SEQ ID NO: 862) (SEQ ID NO: 933) (SEQ ID NO: 1004) NO: 648) 371_C02 DSYGMH WVAGINYNSGYTG ARAATWHDTHLD LTYVNWY LLIYAASSLQ QQSYDTPL (SEQ ID  (SEQ ID NO: 720) (SEQ ID NO: 792) (SEQ ID NO: 863) (SEQ ID NO: 934) (SEQ ID NO: 1005) NO: 649) 371_D05 DDYGMH WVSGINYNGGYTS ARAATWHDTHLD LTYLNWY LLIYAASSLQ QQSYDSPL (SEQ ID  (SEQ ID NO: 721) (SEQ ID NO: 793) (SEQ ID NO: 864) (SEQ ID NO: 935) (SEQ ID NO: 1006) NO: 650) 371_F07 SSYGMH WVAGINYNGGYTS ARAATWHDTHLD LTYLNWY LLIYAATSLA QQSDSNPL (SEQ ID  (SEQ ID NO: 722) (SEQ ID NO: 794) (SEQ ID NO: 865) (SEQ ID NO: 936) (SEQ ID NO: 1007) NO: 651) 371_G07 SDYGMH WVAGINYNGGYTS ARAATWHDTHLD VSYVNWY LVIYAATSRA QQSYSLPL (SEQ ID  (SEQ ID NO: 723) (SEQ ID NO: 795) (SEQ ID NO: 866) (SEQ ID NO: 937) (SEQ ID NO: 1008) NO: 652) 372_D07 SSYGMN WVAGINYNGGYTS ARAATWHDTHLD LSYLNWY LLIYAATSRA QQSYESPL (SEQ ID  (SEQ ID NO: 724) (SEQ ID NO: 796) (SEQ ID NO: 867) (SEQ ID NO: 938) (SEQ ID NO: 1009) NO: 653) 373_B01 DSYGMH WVSGINYNGGYKS ARAATWHDTHLD LSYVNWY LVIYAATSRA QQSYDLPL (SEQ ID  (SEQ ID NO: 725) (SEQ ID NO: 797) (SEQ ID NO: 868) (SEQ ID NO: 939) (SEQ ID NO: 1010) NO: 654) 373_D11 SSYGMH WVAGINYNGGYTS ARAATWHDTHLD LTYVNWY LLIYAATSRA QQSYDNPL (SEQ ID  (SEQ ID NO: 726) (SEQ ID NO: 798) (SEQ ID NO: 869) (SEQ ID NO: 940) (SEQ ID NO: 1011) NO: 655) 373_G06 SSYGMH WVASINYNSGYTG ARAATWHDTHLD LSYVNWY LLIYAATSLA QQSYNLPL (SEQ ID  (SEQ ID NO: 727) (SEQ ID NO: 799) (SEQ ID NO: 870) (SEQ ID NO: 941) (SEQ ID NO: 1012) NO: 656) 374_A10 SSYGMH WVSGINYNGGYTS ARAATWHDTHLD LSYVNWY LLIYAATSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 728) (SEQ ID NO: 800) (SEQ ID NO: 871) (SEQ ID NO: 942) (SEQ ID NO: 1013) NO: 657) 374_A12 DSYGMH WVSSINYNGGYTS ARAATWHDTHLD LTYLNWY LLIYAATSRA QQSDSNPL (SEQ ID  (SEQ ID NO: 729) (SEQ ID NO: 801) (SEQ ID NO: 872) (SEQ ID NO: 943) (SEQ ID NO: 1014) NO: 658) 374_B01 DSYGMH WVAGINYNSGYTS ARAATWHDTHLD LSYLNWY LLIYAASSLQ QQSYDSPL (SEQ ID  (SEQ ID NO: 730) (SEQ ID NO: 802) (SEQ ID NO: 873) (SEQ ID NO: 944) (SEQ ID NO: 1015) NO: 659) 374_B07 SSYGMH WVSSINYNGGYKS ARAATWHDTHLD ISYLNWY LLIYAATSLA QQSYESPL (SEQ ID  (SEQ ID NO: 731) (SEQ ID NO: 803) (SEQ ID NO: 874) (SEQ ID NO: 945) (SEQ ID NO: 1016) NO: 660) 374_H02 SSYGMH WVASINYNGGYTS ARAATWHDTHLD LSYVNWY LLIYAATSLA QQSYDTPL (SEQ ID  (SEQ ID NO: 732) (SEQ ID NO: 804) (SEQ ID NO: 875) (SEQ ID NO: 946) (SEQ ID NO: 1017) NO: 661) 375_C03 DSYSMH WVSGINYNGGYTS ARAATWHDTHLD LSYVNWY LVIYAATSRA QQSYESPL (SEQ ID  (SEQ ID NO: 733) (SEQ ID NO: 805) (SEQ ID NO: 876) (SEQ ID NO: 947) (SEQ ID NO: 1018) NO: 662) 375_C05 XSYGMN WVASINYNGGYKG ARAATWHDTHLD LSYLNWY LLIYAATSRA QQSYELPL (SEQ ID  (SEQ ID NO: 734) (SEQ ID NO: 806) (SEQ ID NO: 877) (SEQ ID NO: 948) (SEQ ID NO: 1019) NO: 663) 375_D02 SSYSMN WVSNINYNGGYTS ARAATWHDTHLD LTYLNWY LLIYAASSLQ QQSYELPL (SEQ ID  (SEQ ID NO: 735) (SEQ ID NO: 807) (SEQ ID NO: 878) (SEQ ID NO: 949) (SEQ ID NO: 1020) NO: 664) 375_G08 SSYGMH WVSGINYNGGYTS ARAATWHDTHLD SSYVNWY LLIYAVTSRA QQSYSTPL (SEQ ID  (SEQ ID NO: 736) (SEQ ID NO: 808) (SEQ ID NO: 879) (SEQ ID NO: 950) (SEQ ID NO: 1021) NO: 665) 375_H04 SSYGMH WVAGINYNSGYTG ARAATWHDTHLD LSYLNWY LVIYAATSRA QQSYSNPL (SEQ ID  (SEQ ID NO: 737) (SEQ ID NO: 809) (SEQ ID NO: 880) (SEQ ID NO: 951) (SEQ ID NO: 1022) NO: 666) 376_D08 DSYGMN WVANINYNSGYKS ARAATWHDTALD LTYLNWY LVIYYANNRP QQSYSNPL (SEQ ID  (SEQ ID NO: 738) (SEQ ID NO: 810) (SEQ ID NO: 881) (SEQ ID NO: 952) (SEQ ID NO: 1023) NO: 667) 376_F09 DSYSMH WVSSINYNGGYKS ARAATWHDTHLD LTYVNWY LLIYAVTSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 739) (SEQ ID NO: 811) (SEQ ID NO: 882) (SEQ ID NO: 953) (SEQ ID NO: 1024) NO: 668) 376_H12 SDYGMH WVASINYNGGYTS ARAATWHDTHLD ITYLNWY LVIYAATSRA QQSYESPL (SEQ ID  (SEQ ID NO: 740) (SEQ ID NO: 812) (SEQ ID NO: 883) (SEQ ID NO: 954) (SEQ ID NO: 1025) NO: 669)

The consensus sequences for each of these CDRs shown in FIG. 3B are as follows:

HCDR1: (SEQ ID NO: 6550) D/SS/DYG/SMH/N HCDR2: (SEQ ID NO: 6551) WVA/SS/G/NINYNG/SGYT/KS/G HCDR3: (SEQ ID NO: 6559) ARAATWHDTH/ALD LCDR1: (SEQ ID NO: 6561) L/V/I/SS/TYL/VNWY LCDR2: (SEQ ID NO: 6563) LL/VIYA/YA/T/VT/S/NS/NR/LA/P/Q LCDR3: (SEQ ID NO: 6565) QQSY/D/ND/E/S/NL/S/T/NPL

TABLE 2C Group III Antibody Sequences Ab VH sequence VL sequence 365_C05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYKGYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1205) NO: 1026) 365_E10 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ SMNWVRQAPGKGLEWVSSINYNSGYKGYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1206) NO: 1027) 365_E12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMNWVRQAPGKGLEWVSNINYNGGYTGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1207) NO: 1028) 365_F02 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYKGYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1208) NO: 1029) 365_F03 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVSSINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1209) NO: 1030) 365_G03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ GMNWVRQAPGKGLEWVAGINYNSGYKGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1210) NO: 1031) 365_G04 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTGYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1211) NO: 1032) 365_G05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMNWVRQAPGKGLEWVSGINYNGGYKGYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1212) NO: 1033) 365_G09 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIITYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1213) NO: 1034) 365_H07 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSISTYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1214) NO: 1035) 366_A06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ SMNWVRQAPGKGLEWVASINYNGGYKSYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1215) NO: 1036) 366_A08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ SMNWVRQAPGKGLEWVSGINYNSGYKGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1216) NO: 1037) 366_B05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNSGYKSYADSV KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1217) NO: 1038) 366_B07 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ GMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYATTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1218) NO: 1039) 366_E01 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMNWVRQAPGKGLEWVSNINYNGGYKSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1219) NO: 1040) 366_E08 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ SMNWVRQAPGKGLEWVSNINYNGGYTSYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSNPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1220) NO: 1041) 366_F02 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMNWVRQAPGKGLEWVSGINYNSGYTGYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1221) NO: 1042) 366_G12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMHWVRQAPGKGLEWVSGINYNSGYKGYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1222) NO: 1043) 366_H04 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMNWVRQAPGKGLEWVSNINYNGGYKSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1223) NO: 1044) 367_A03 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ GMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYATTSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1224) NO: 1045) 367_A06 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMNWVRQAPGKGLEWVASINYNGGYKGYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1225) NO: 1046) 367_A08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1226) NO: 1047) 367_A10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIITYVNWYQQ GMNWVRQAPGKGLEWVAGINYNSGYTSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1227) NO: 1048) 367_A12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMNWVRQAPGKGLEWVSGINYNSGYTSYADSV KPGKAPKLLIYAATSLHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNNPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1228) NO: 1049) 367_B01 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSISSYVNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYKGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1229) NO: 1050) 367_B04 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNSGYKSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1230) NO: 1051) 367_B12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMHWVRQAPGKGLEWVASINYNGGYKSYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1231) NO: 1052) 367_C07 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ SMNWVRQAPGKGLEWVSSINYNSGYTGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNLPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1232) NO: 1053) 367_C10 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1233) NO: 1054) 367_D03 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIITYLNWYQQ SMNWVRQAPGKGLEWVSSINYNGGYTGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1234) NO: 1055) 367_D06 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSISTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1235) NO: 1056) 367_D08 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDDLPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1236) NO: 1057) 367_D12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ SMNWVRQAPGKGLEWVSSINYNGGYTGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1237) NO: 1058) 367_E05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1238) NO: 1059) 367_F01 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ SMNWVRQAPGKGLEWVSNINYNGGYKSYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1239) NO: 1060) 367_G01 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ GMNWVRQAPGKGLEWVASINYNSGYTGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1240) NO: 1061) 367_G04 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVAGINYNSGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1241) NO: 1062) 367_H02 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ GMNWVRQAPGKGLEWVSSINYNGGYTGYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1242) NO: 1063) 367_H03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIITYVNWYQQ GMNWVRQAPGKGLEWVAGINYNSGYTSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1243) NO: 1064) 368_A03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTGYADSV KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1244) NO: 1065) 368_A04 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYKSYADSV KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1245) NO: 1066) 368_B09 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMNWVRQAPGKGLEWVSNINYNGGYKGYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1246) NO: 1067) 368_C02 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSISTYVNWYQQ SMNWVRQAPGKGLEWVANINYNGGYKGYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1247) NO: 1068) 368_C08 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1248) NO: 1069) 368_E12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ GMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1249) NO: 1070) 368_F09 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMNWVRQAPGKGLEWVSGINYNSGYTSYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1250) NO: 1071) 368_H02 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ GMNWVRQAPGKGLEWVAGINYNSGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1251) NO: 1072) 368_H05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ SMNWVRQAPGKGLEWVANINYNGGYKSYADSV KPGKAPKLVIYATTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1252) NO: 1073) 369_A07 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYKGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1253) NO: 1074) 369_B05 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1254) NO: 1075) 369_C05 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSISSYVNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLVIYATTSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1255) NO: 1076) 369_D03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1256) NO: 1077) 369_D07 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ GMNWVRQAPGKGLEWVSGINYNGGYKSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1257) NO: 1078) 369_D09 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMNWVRQAPGKGLEWVSNINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1258) NO: 1079) 369_E06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ GMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1259) NO: 1080) 369_F08 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMHWVRQAPGKGLEWVSGINYNSGYTSYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1260) NO: 1081) 369_G08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVSSINYNGGYKGYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1261) NO: 1082) 370_A02 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ GMNWVRQAPGKGLEWVAGINYNGGYTGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1262) NO: 1083) 370_B03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVANINYNGGYTGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNNPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1263) NO: 1084) 370_B11 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNSGYTSYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQGYDLPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1264) NO: 1085) 370_B12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYKGYADSV KPGKAPKLVIYATTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1265) NO: 1086) 370_D01 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVSSINYNGGYTGYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1266) NO: 1087) 370_D05 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSIITYLNWYQQ SMNWVRQAPGKGLEWVSNINYNGGYKGYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1267) NO: 1088) 370_F03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMNWVRQAPGKGLEWVSSINYNSGYKSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1268) NO: 1089) 370_H02 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVSGINYNSGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1269) NO: 1090) 370_H07 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYKSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDSSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1270) NO: 1091) 371_A10 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYKGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1271) NO: 1092) 371_B03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMHWVRQAPGKGLEWVASINYNGGYTSYADSV KPGKAPKLLIYATTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1272) NO: 1093) 371_B04 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV KPGKAPKLVIYAVTSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1273) NO: 1094) 371_B09 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ SMNWVRQAPGKGLEWVAGINYNSGYTGYADSV KPGKAPKLVIYATTSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1274) NO: 1095) 371_B12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNSGYTSYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNNPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1275) NO: 1096) 371_C01 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ GMHWVRQAPGKGLEWVSSINYNGGYTGYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1276) NO: 1097) 371_C04 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMNWVRQAPGKGLEWVSGINYNSGYKGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1277) NO: 1098) 371_C05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMHWVRQAPGKGLEWVANINYNGGYTGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1278) NO: 1099) 371_C12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ SMNWVRQAPGKGLEWVAGINYNSGYKSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1279) NO: 1100) 371_D02 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYKSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1280) NO: 1101) 371_D04 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTGYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1281) NO: 1102) 371_E06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSISTYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYAVTSLHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1282) NO: 1103) 371_E07 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1283) NO: 1104) 371_E10 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSISTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1284) NO: 1105) 371_F10 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ GMNWVRQAPGKGLEWVSGINYNSGYTSYADSV KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1285) NO: 1106) 371_F11 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1286) NO: 1107) 371_G02 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMNWVRQAPGKGLEWVASINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1287) NO: 1108) 371_G04 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV KPGKAPKLLIYAATSLHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1288) NO: 1109) 371_G09 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVANINYNGGYTGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDSTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1289) NO: 1110) 371_G11 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMNWVRQAPGKGLEWVSNINYNSGYTSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1290) NO: 1111) 371_H04 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMNWVRQAPGKGLEWVSNINYNGGYTGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1291) NO: 1112) 371_H05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ GMNWVRQAPGKGLEWVSGINYNSGYKSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSLPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1292) NO: 1113) 371_H06 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ GMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1293) NO: 1114) 371_H08 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQ GMNWVRQAPGKGLEWVASINYNGGYKGYADSV KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1294) NO: 1115) 371_H10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSISTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNSGYKSYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1295) NO: 1116) 372_B02 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ SMNWVRQAPGKGLEWVSGINYNSGYTSYADSV KPGKAPKLLIYAVTSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1296) NO: 1117) 372_C06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1297) NO: 1118) 372_D03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ SMNWVRQAPGKGLEWVAGINYNSGYKSYADSV KPGKAPKLVIYAVTSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1298) NO: 1119) 372_E01 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYKGYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1299) NO: 1120) 372_G12 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTGYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1300) NO: 1121) 373_A01 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ GMNWVRQAPGKGLEWVSNINYNGGYTGYADSV KPGKAPKLVIYATTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNLPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1301) NO: 1122) 373_A03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVANINYNGGYTGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1302) NO: 1123) 373_A05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ SMNWVRQAPGKGLEWVSGINYNSGYKSYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1303) NO: 1124) 373_A09 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1304) NO: 1125) 373_A11 EVQLLESGGGLVQPGGSLRLSCAASGFTFSNY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMNWVRQAPGKGLEWVANINYNGGYTGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1305) NO: 1126) 373_A12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVSSINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1306) NO: 1127) 373_B05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ SMNWVRQAPGKGLEWVSNINYNGGYKSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSNPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1307) NO: 1128) 373_B07 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1308) NO: 1129) 373_C03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1309) NO: 1130) 373_C07 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNSGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1310) NO: 1131) 373_C10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1311) NO: 1132) 373_D03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1312) NO: 1133) 373_D12 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ SMNWVRQAPGKGLEWVSSINYNSGYKGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSLPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1313) NO: 1134) 373_E10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1314) NO: 1135) 373_F08 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1315) NO: 1136) 373_F11 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ GMHWVRQAPGKGLEWVSGINYNSGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNLPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1316) NO: 1137) 373_F12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSISTYLNWYQQ SMNWVRQAPGKGLEWVSNINYNGGYTGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1317) NO: 1138) 373_G08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVSNINYNGGYTSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1318) NO: 1139) 373_H03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNSGYKSYADSV KPGKAPKLLIYATTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1319) NO: 1140) 373_H07 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1320) NO: 1141) 373_H09 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIITYLNWYQQ GMNWVRQAPGKGLEWVASINYNSGYKSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDDSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1321) NO: 1142) 374_A06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVSSINYNSGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1322) NO: 1143) 374_A09 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ SMNWVRQAPGKGLEWVSSINYNGGYKGYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1323) NO: 1144) 374_B03 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1324) NO: 1145) 374_B05 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNSGYTSYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1325) NO: 1146) 374_B08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1326) NO: 1147) 374_B10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ SMNWVRQAPGKGLEWVSSINYNSGYTSYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1327) NO: 1148) 374_C01 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMNWVRQAPGKGLEWVSGINYNSGYKSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1328) NO: 1149) 374_C09 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ GMNWVRQAPGKGLEWVSSINYNGGYKGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1329) NO: 1150) 374_C12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYKSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDNSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1330) NO: 1151) 374_D03 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYKSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1331) NO: 1152) 374_D05 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVSGINYNSGYTGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1332) NO: 1153) 374_D06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1333) NO: 1154) 374_D07 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNSGYKSYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1334) NO: 1155) 374_D10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ GMHWVRQAPGKGLEWVASINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1335) NO: 1156) 374_E10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1336) NO: 1157) 374_E12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1337) NO: 1158) 374_F06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAATSLHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1338) NO: 1159) 374_F07 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVASINYNGGYTGYADSV KPGKAPKLVIYAVTSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1339) NO: 1160) 374_F08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1340) NO: 1161) 374_G03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDDTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1341) NO: 1162) 374_G08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1342) NO: 1163) 374_G09 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVRYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYKGYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1343) NO: 1164) 374_G10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ SMNWVRQAPGKGLEWVSSINYNSGYTSYADSV KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1344) NO: 1165) 374_G11 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1345) NO: 1166) 374_H01 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1346) NO: 1167) 374_H11 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAATSLHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSNPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1347) NO: 1168) 375_A01 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1348) NO: 1169) 375_A07 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVSSINYNSGYTGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1349) NO: 1170) 375_A08 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1350) NO: 1171) 375_A12 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNSGYKSYADSV KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1351) NO: 1172) 375_B12 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYKSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1352) NO: 1173) 375_C04 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1353) NO: 1174) 375_D01 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1354) NO: 1175) 375_D10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1355) NO: 1176) 375_E02 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1356) NO: 1177) 375_E03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVANINYNGGYTGYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1357) NO: 1178) 375_E05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1358) NO: 1179) 375_E06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1359) NO: 1180) 375_E10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1360) NO: 1181) 375_F02 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVASINYNSGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1361) NO: 1182) 375_F07 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVSNINYNGGYTGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1362) NO: 1183) 375_F08 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ GMNWVRQAPGKGLEWVSSINYNSGYKSYADSV KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1363) NO: 1184) 375_G04 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ GMNWVRQAPGKGLEWVASINYNSGYTGYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1364) NO: 1185) 375_G05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID No: 1365) NO: 1186) 375_H05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ SMNWVRQAPGKGLEWVSNINYNGGYTGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1366) NO: 1187) 375_H07 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1367) NO: 1188) 376_A03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ GMNWVRQAPGKGLEWVAGINYNGGYTGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1368) NO: 1189) 376_B03 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ SMNWVRQAPGKGLEWVAGINYNSGYKSYADSV KPGKAPKLVIYAVTSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1369) NO: 1190) 376_B10 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYKGYADSV KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1370) NO: 1191) 376_C04 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMNWVRQAPGKGLEWVSNINYNGGYTGYADSV KPGKAPKLLIYAVTSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1371) NO: 1192) 376_C08 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ SMNWVRQAPGKGLEWVAGINYNSGYTGYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1372) NO: 1193) 376_D07 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1373) NO: 1194) 376_E02 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYKGYADSV KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSDNTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1374) NO: 1195) 376_E11 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1375) NO: 1196) 376_F01 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYKSYADSV KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1376) NO: 1197) 376_F06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ GMNWVRQAPGKGLEWVSGINYNGGYTGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1377) NO: 1198) 376_G05 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1378) NO: 1199) 376_G06 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ GMNWVRQAPGKGLEWVAGINYNGGYTGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID ID NO: 1379) NO: 1200) 376_G10 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ GMNWVRQAPGKGLEWVAGINYNGGYTSYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1380) NO: 1201) 376_H01 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYKGYADSV KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1381) NO: 1202) 376_H04 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ SMNWVRQAPGKGLEWVAGINYNGGYKGYADSV KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1382) NO: 1203) 376_H11 EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY DIQMTQSPSSLSASVGDRVTITCRASQSISRYLNWYQQ SMNWVRQAPGKGLEWVSNINYNGGYTGYADSV KPGKAPKLLIYAVTSLASGVPSRFSGSGSGTDFTLTIS KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ ARGANWHDTALDYWGQGTLVTVSS (SEQ ID ID NO: 1383) NO: 1204)

Table 3C provides the amino acid sequences of the CDRs of the antibodies shown in Table 2C.

TABLE 3C CDR sequences for Group III antibodies Ab HCDR1 HCDR2 HCDR3 LCDR1 LCDR2 LCDR3 365_C05 SDYSMN WVSGINYNGGYKG ARGANWHDTHLD LTYLNWY LLIYAATSRH QQSYNSPL (SEQ ID  (SEQ ID NO: 5643) (SEQ ID NO: 5822) (SEQ ID NO: 6001) (SEQ ID NO: 6180) (SEQ ID NO: 6359) NO: 5464) 365_E10 DSYSMN WVSSINYNSGYKG ARGANWHDTHLD SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID  (SEQ ID NO: 5644) (SEQ ID NO: 5823) (SEQ ID NO: 6002) (SEQ ID NO: 6181) (SEQ ID NO: 6360) NO: 5465) 365_E12 SDYGMN WVSNINYNGGYTG ARGANWHDTALD LTYLNWY LLIYAATSRA QQSYETPL (SEQ ID  (SEQ ID NO: 5645) (SEQ ID NO: 5824) (SEQ ID NO: 6003) (SEQ ID NO: 6182) (SEQ ID NO: 6361) NO: 5466) 365_F02 SSYSMN WVSGINYNGGYKG ARGANWHDTHLD LTYVNWY LLIYAATSRH QQSYDTPL (SEQ ID  (SEQ ID NO: 5646) (SEQ ID NO: 5825) (SEQ ID NO: 6004) (SEQ ID NO: 6183) (SEQ ID NO: 6362) NO: 5467) 365_F03 DSYSMN WVSSINYNGGYTS ARGANWHDTHLD LSYLNWY LLIYAATSRA QQSYDNPL (SEQ ID  (SEQ ID NO: 5647) (SEQ ID NO: 5826) (SEQ ID NO: 6005) (SEQ ID NO: 6184) (SEQ ID NO: 6363) NO: 5468) 365_G03 SSYGMN WVAGINYNSGYKG ARGANWHDTHLD VSYLNWY LLIYAATSRA QQSYNTPL (SEQ ID  (SEQ ID NO: 5648) (SEQ ID NO: 5827) (SEQ ID NO: 6006) (SEQ ID NO: 6185) (SEQ ID NO: 6364) NO: 5469) 365_G04 DSYSMN WVAGINYNGGYTG ARGANWHDTHLD VSYVNWY LVIYAATSLA QQSYDTPL (SEQ ID  (SEQ ID NO: 5649) (SEQ ID NO: 5828) (SEQ ID NO: 6007) (SEQ ID NO: 6186) (SEQ ID NO: 6365) NO: 5470) 365_G05 SSYGMN WVSGINYNGGYKG ARGANWHDTALD LSYLNWY LVIYAATSLA QQSYENPL (SEQ ID  (SEQ ID NO: 5650) (SEQ ID NO: 5829) (SEQ ID NO: 6008) (SEQ ID NO: 6187) (SEQ ID NO: 6366) NO: 5471) 365_G09 SSYSMN WVSGINYNGGYKS ARGANWHDTHLD ITYLNWY LVIYAATSRA QQSYNSPL (SEQ ID  (SEQ ID NO: 5651) (SEQ ID NO: 5830) (SEQ ID NO: 6009) (SEQ ID NO: 6188) (SEQ ID NO: 6367) NO: 5472) 365_H07 DSYSMN WVSGINYNGGYTS ARGANWHDTHLD STYVNWY LLIYAATSRH QQSYENPL (SEQ ID  (SEQ ID NO: 5652) (SEQ ID NO: 5831) (SEQ ID NO: 6010) (SEQ ID NO: 6189) (SEQ ID NO: 6368) NO: 5473) 366_A06 SDYSMN WVASINYNGGYKS ARGANWHDTHLD SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID  (SEQ ID NO: 5653) (SEQ ID NO: 5832) (SEQ ID NO: 6011) (SEQ ID NO: 6190) (SEQ ID NO: 6369) NO: 5474) 366_A08 DDYSMN WVSGINYNSGYKG ARGANWHDTHLD VSYVNWY LVIYAATSRA QQSYNSPL (SEQ ID  (SEQ ID NO: 5654) (SEQ ID NO: 5833) (SEQ ID NO: 6012) (SEQ ID NO: 6191) (SEQ ID NO: 6370) NO: 5475) 366_B05 SDYSMN WVSGINYNSGYKS ARGANWHDTALD SSYLNWY LVIYAVTSRA QQSYELPL (SEQ ID  (SEQ ID NO: 5655) (SEQ ID NO: 5834) (SEQ ID NO: 6013) (SEQ ID NO: 6192) (SEQ ID NO: 6371) NO: 5476) 366_B07 SDYGMN WVSGINYNGGYTS ARGANWHDTHLD VSYLNWY LVIYATTSRA QQSYNSPL (SEQ ID  (SEQ ID NO: 5656) (SEQ ID NO: 5835) (SEQ ID NO: 6014) (SEQ ID NO: 6193) (SEQ ID NO: 6372) NO: 5477) 366_E01 DSYGMN WVSNINYNGGYKS ARGANWHDTHLD LTYLNWY LLIYAATSRA QQSYSSPL (SEQ ID  (SEQ ID NO: 5657) (SEQ ID NO: 5836) (SEQ ID NO: 6015) (SEQ ID NO: 6194) (SEQ ID NO: 6373) NO: 5478) 366_E08 SDYSMN WVSNINYNGGYTS ARGANWHDTHLD VTYLNWY LLIYAATSRH QQSYSNPL (SEQ ID  (SEQ ID NO: 5658) (SEQ ID NO: 5837) (SEQ ID NO: 6016) (SEQ ID NO: 6195) (SEQ ID NO: 6374) NO: 5479) 366_F02 SSYGMN WVSGINYNSGYTG ARGANWHDTHLD LTYLNWY LVIYAATSRH QQSYDNPL (SEQ ID  (SEQ ID NO: 5659) (SEQ ID NO: 5838) (SEQ ID NO: 6017) (SEQ ID NO: 6196) (SEQ ID NO: 6375) NO: 5480) 366_G12 SSYGMH WVSGINYNSGYKG ARGANWHDTHLD LSYLNWY LLIYAATSRH QQSYNTPL (SEQ ID  (SEQ ID NO: 5660) (SEQ ID NO: 5839) (SEQ ID NO: 6018) (SEQ ID NO: 6197) (SEQ ID NO: 6376) NO: 5481) 366_H04 DSYGMN WVSNINYNGGYKS ARGANWHDTHLD LTYLNWY LLIYAATSRA QQSYSSPL (SEQ ID  (SEQ ID NO: 5661) (SEQ ID NO: 5840) (SEQ ID NO: 6019) (SEQ ID NO: 6198) (SEQ ID NO: 6377) NO: 5482) 367_A03 DSYGMN WVAGINYNGGYTS ARGANWHDTALD LTYVNWY LLIYATTSRH QQSYDSPL (SEQ ID  (SEQ ID NO: 5662) (SEQ ID NO: 5841) (SEQ ID NO: 6020) (SEQ ID NO: 6199) (SEQ ID NO: 6378) NO: 5483) 367_A06 DSYGMN WVASINYNGGYKG ARGANWHDTHLD LSYVNWY LLIYAATSRH QQSYDTPL (SEQ ID  (SEQ ID NO: 5663) (SEQ ID NO: 5842) (SEQ ID NO: 6021) (SEQ ID NO: 6200) (SEQ ID NO: 6379) NO: 5484) 367_A08 DSYGMN WVAGINYNGGYTS ARGANWHDTHLD LTYLNWY LLIYAVTSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5664) (SEQ ID NO: 5843) (SEQ ID NO: 6022) (SEQ ID NO: 6201) (SEQ ID NO: 6380) NO: 5485) 367_A10 SSYGMN WVAGINYNSGYTS ARGANWHDTHLD ITYVNWY LLIYAATSLA QQSYDLPL (SEQ ID  (SEQ ID NO: 5665) (SEQ ID NO: 5844) (SEQ ID NO: 6023) (SEQ ID NO: 6202) (SEQ ID NO: 6381) NO: 5486) 367_A12 SSYGMN WVSGINYNSGYTS ARGANWHDTHLD LSYLNWY LLIYAATSLH QQSYNNPL (SEQ ID  (SEQ ID NO: 5666) (SEQ ID NO: 5845) (SEQ ID NO: 6024) (SEQ ID NO: 6203) (SEQ ID NO: 6382) NO: 5487) 367_B01 SSYSMN WVAGINYNGGYKG ARGANWHDTALD SSYVNWY LVIYAATSRA QQSYSTPL (SEQ ID  (SEQ ID NO: 5667) (SEQ ID NO: 5846) (SEQ ID NO: 6025) (SEQ ID NO: 6204) (SEQ ID NO: 6383) NO: 5488) 367_B04 DSYSMN WVSGINYNSGYKS ARGANWHDTHLD LSYLNWY LLIYAATSRA QQSYELPL (SEQ ID  (SEQ ID NO: 5668) (SEQ ID NO: 5847) (SEQ ID NO: 6026) (SEQ ID NO: 6205) (SEQ ID NO: 6384) NO: 5489) 367_B12 SSYGMH WVASINYNGGYKS ARGANWHDTHLD LSYVNWY LVIYAATSLA QQSYDTPL (SEQ ID  (SEQ ID NO: 5669) (SEQ ID NO: 5848) (SEQ ID NO: 6027) (SEQ ID NO: 6206) (SEQ ID NO: 6385) NO: 5490) 367_C07 SSYSMN WVSSINYNSGYTG ARGANWHDTHLD LTYVNWY LLIYAATSRA QQSYNLPL (SEQ ID  (SEQ ID NO: 5670) (SEQ ID NO: 5849) (SEQ ID NO: 6028) (SEQ ID NO: 6207) (SEQ ID NO: 6386) NO: 5491) 367_C10 DSYSMN WVSGINYNGGYTS ARGANWHDTALD VSYVNWY LLIYAVTSRA QQSYETPL (SEQ ID  (SEQ ID NO: 5671) (SEQ ID NO: 5850) (SEQ ID NO: 6029) (SEQ ID NO: 6208) (SEQ ID NO: 6387) NO: 5492) 367_D03 DSYSMN WVSSINYNGGYTG ARGANWHDTHLD ITYLNWY LLIYAATSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 5672) (SEQ ID NO: 5851) (SEQ ID NO: 6030) (SEQ ID NO: 6209) (SEQ ID NO: 6388) NO: 5493) 367_D06 DSYSMN WVAGINYNGGYTS ARGANWHDTHLD STYLNWY LVIYAATSLA QQSYNSPL (SEQ ID  (SEQ ID NO: 5673) (SEQ ID NO: 5852) (SEQ ID NO: 6031) (SEQ ID NO: 6210) (SEQ ID NO: 6389) NO: 5494) 367_D08 SDYSMN WVAGINYNGGYTS ARGANWHDTHLD LSYLNWY LVIYAATSRH QQSDDLPL (SEQ ID  (SEQ ID NO: 5674) (SEQ ID NO: 5853) (SEQ ID NO: 6032) (SEQ ID NO: 6211) (SEQ ID NO: 6390) NO: 5495) 367_D12 SSYSMN WVSSINYNGGYTG ARGANWHDTHLD VSYVNWY LVIYAATSRA QQSYESPL (SEQ ID  (SEQ ID NO: 5675) (SEQ ID NO: 5854) (SEQ ID NO: 6033) (SEQ ID NO: 6212) (SEQ ID NO: 6391) NO: 5496) 367_E05 SSYGMN WVAGINYNGGYTS ARGANWHDTHLD LSYLNWY LLIYAATSRH QQSYDSPL (SEQ ID  (SEQ ID NO: 5676) (SEQ ID NO: 5855) (SEQ ID NO: 6034) (SEQ ID NO: 6213) (SEQ ID NO: 6392) NO: 5497) 367_F01 DSYSMN WVSNINYNGGYKS ARGANWHDTHLD ISYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID  (SEQ ID NO: 5677) (SEQ ID NO: 5856) (SEQ ID NO: 6035) (SEQ ID NO: 6214) (SEQ ID NO: 6393) NO: 5498) 367_G01 DSYGMN WVASINYNSGYTG ARGANWHDTHLD SSYLNWY LVIYAATSRA QQSYDLPL (SEQ ID  (SEQ ID NO: 5678) (SEQ ID NO: 5857) (SEQ ID NO: 6036) (SEQ ID NO: 6215) (SEQ ID NO: 6394) NO: 5499) 367_G04 SSYSMN WVAGINYNSGYTS ARGANWHDTHLD LSYLNWY LVIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5679) (SEQ ID NO: 5858) (SEQ ID NO: 6037) (SEQ ID NO: 6216) (SEQ ID NO: 6395) NO: 5500) 367_H02 DSYGMN WVSSINYNGGYTG ARGANWHDTHLD SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID  (SEQ ID NO: 5680) (SEQ ID NO: 5859) (SEQ ID NO: 6038) (SEQ ID NO: 6217) (SEQ ID NO: 6396) NO: 5501) 367_H03 SSYGMN WVAGINYNSGYTS ARGANWHDTHLD ITYVNWY LLIYAATSLA QQSYDLPL (SEQ ID  (SEQ ID NO: 5681) (SEQ ID NO: 5860) (SEQ ID NO: 6039) (SEQ ID NO: 6218) (SEQ ID NO: 6397) NO: 5502) 368_A03 SSYSMN WVSGINYNGGYTG ARGANWHDTHLD ISYLNWY LLIYAVTSRA QQSYENPL (SEQ ID  (SEQ ID NO: 5682) (SEQ ID NO: 5861) (SEQ ID NO: 6040) (SEQ ID NO: 6219) (SEQ ID NO: 6398) NO: 5503) 368_A04 DDYSMN WVAGINYNGGYKS ARGANWHDTHLD LTYLNWY LVIYAVTSRA QQSYELPL (SEQ ID  (SEQ ID NO: 5683) (SEQ ID NO: 5862) (SEQ ID NO: 6041) (SEQ ID NO: 6220) (SEQ ID NO: 6399) NO: 5504) 368_B09 DSYGMN WVSNINYNGGYKG ARGANWHDTHLD LSYLNWY LLIYAATSRH QQSYDTPL (SEQ ID  (SEQ ID NO: 5684) (SEQ ID NO: 5863) (SEQ ID NO: 6042) (SEQ ID NO: 6221) (SEQ ID NO: 6400) NO: 5505) 368_C02 DDYSMN WVANINYNGGYKG ARGANWHDTHLD STYVNWY LLIYAATSLA QQSYSTPL (SEQ ID  (SEQ ID NO: 5685) (SEQ ID NO: 5864) (SEQ ID NO: 6043) (SEQ ID NO: 6222) (SEQ ID NO: 6401) NO: 5506) 368_C08 SDYSMN WVSGINYNGGYTS ARGANWHDTHLD LTYVNWY LLIYAASSLQ QQSYSTPL (SEQ ID  (SEQ ID NO: 5686) (SEQ ID NO: 5865) (SEQ ID NO: 6044) (SEQ ID NO: 6223) (SEQ ID NO: 6402) NO: 5507) 368_E12 SDYGMN WVAGINYNGGYTS ARGANWHDTHLD VSYVNWY LVIYAVTSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5687) (SEQ ID NO: 5866) (SEQ ID NO: 6045) (SEQ ID NO: 6224) (SEQ ID NO: 6403) NO: 5508) 368_F09 SSYGMN WVSGINYNSGYTS ARGANWHDTHLD LTYLNWY LLIYAASSLQ QQSYETPL (SEQ ID  (SEQ ID NO: 5688) (SEQ ID NO: 5867) (SEQ ID NO: 6046) (SEQ ID NO: 6225) (SEQ ID NO: 6404) NO: 5509) 368_H02 SSYGMN WVAGINYNSGYTS ARGANWHDTALD VTYLNWY LVIYAATSRA QQSYESPL (SEQ ID  (SEQ ID NO: 5689) (SEQ ID NO: 5868) (SEQ ID NO: 6047) (SEQ ID NO: 6226) (SEQ ID NO: 6405) NO: 5510) 368_H05 SSYSMN WVANINYNGGYKS ARGANWHDTHLD VSYVNWY LVIYATTSRA QQSYESPL (SEQ ID  (SEQ ID NO: 5690) (SEQ ID NO: 5869) (SEQ ID NO: 6048) (SEQ ID NO: 6227) (SEQ ID NO: 6406) NO: 5511) 369_A07 SSYSMN WVAGINYNGGYKG ARGANWHDTALD LSYLNWY LVIYAATSRA QQSYESPL (SEQ ID  (SEQ ID NO: 5691) (SEQ ID NO: 5870) (SEQ ID NO: 6049) (SEQ ID NO: 6228) (SEQ ID NO: 6407) NO: 5512) 369_B05 DSYSMN WVSGINYNGGYKS ARGANWHDTHLD ISYLNWY LLIYAATSLA QQSYDTPL (SEQ ID  (SEQ ID NO: 5692) (SEQ ID NO: 5871) (SEQ ID NO: 6050) (SEQ ID NO: 6229) (SEQ ID NO: 6408) NO: 5513) 369_C05 DSYSMN WVAGINYNGGYTS ARGANWHDTALD SSYVNWY LVIYATTSRH QQSYNSPL (SEQ ID  (SEQ ID NO: 5693) (SEQ ID NO: 5872) (SEQ ID NO: 6051) (SEQ ID NO: 6230) (SEQ ID NO: 6409) NO: 5514) 369_D03 SSYSMN WVSGINYNGGYTS ARGANWHDTHLD LTYLNWY LVIYAATSRA QQSYENPL (SEQ ID  (SEQ ID NO: 5694) (SEQ ID NO: 5873) (SEQ ID NO: 6052) (SEQ ID NO: 6231) (SEQ ID NO: 6410) NO: 5515) 369_D07 SSYGMN WVSGINYNGGYKS ARGANWHDTHLD VSYLNWY LVIYAATSRA QQSYDLPL (SEQ ID  (SEQ ID NO: 5695) (SEQ ID NO: 5874) (SEQ ID NO: 6053) (SEQ ID NO: 6232) (SEQ ID NO: 6411) NO: 5516) 369_D09 SDYGMN WVSNINYNGGYTS ARGANWHDTALD LTYLNWY LLIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5696) (SEQ ID NO: 5875) (SEQ ID NO: 6054) (SEQ ID NO: 6233) (SEQ ID NO: 6412) NO: 5517) 369_E06 SSYGMN WVSGINYNGGYTS ARGANWHDTALD ISYLNWY LVIYAATSRH QQSYDSPL (SEQ ID  (SEQ ID NO: 5697) (SEQ ID NO: 5876) (SEQ ID NO: 6055) (SEQ ID NO: 6234) (SEQ ID NO: 6413) NO: 5518) 369_F08 SDYGMH WVSGINYNSGYTS ARGANWHDTALD LSYLNWY LLIYAASSLQ QQSYDLPL (SEQ ID  (SEQ ID NO: 5698) (SEQ ID NO: 5877) (SEQ ID NO: 6056) (SEQ ID NO: 6235) (SEQ ID NO: 6414) NO: 5519) 369_G08 DSYSMN WVSSINYNGGYKG ARGANWHDTHLD LTYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID  (SEQ ID NO: 5699) (SEQ ID NO: 5878) (SEQ ID NO: 6057) (SEQ ID NO: 6236) (SEQ ID NO: 6415) NO: 5520) 370_A02 DSYGMN WVAGINYNGGYTG ARGANWHDTALD VTYLNWY LVIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5700) (SEQ ID NO: 5879) (SEQ ID NO: 6058) (SEQ ID NO: 6237) (SEQ ID NO: 6416) NO: 5521) 370_B03 SSYSMN WVANINYNGGYTG ARGANWHDTALD LSYLNWY LVIYAATSRA QQSYNNPL (SEQ ID  (SEQ ID NO: 5701) (SEQ ID NO: 5880) (SEQ ID NO: 6059) (SEQ ID NO: 6238) (SEQ ID NO: 6417) NO: 5522) 370_B11 DSYSMN WVSGINYNSGYTS ARGANWHDTHLD LSYLNWY LVIYAATSRH QQGYDLPL (SEQ ID  (SEQ ID NO: 5702) (SEQ ID NO: 5881) (SEQ ID NO: 6060) (SEQ ID NO: 6239) (SEQ ID NO: 6418) NO: 5523) 370_B12 SDYSMN WVSGINYNGGYKG ARGANWHDTALD LSYVNWY LVIYATTSRA QQSYETPL (SEQ ID  (SEQ ID NO: 5703) (SEQ ID NO: 5882) (SEQ ID NO: 6061) (SEQ ID NO: 6240) (SEQ ID NO: 6419) NO: 5524) 370_D01 SSYSMN WVSSINYNGGYTG ARGANWHDTALD LSYLNWY LLIYAATSRH QQSYNTPL (SEQ ID  (SEQ ID NO: 5704) (SEQ ID NO: 5883) (SEQ ID NO: 6062) (SEQ ID NO: 6241) (SEQ ID NO: 6420) NO: 5525) 370_D05 DDYSMN WVSNINYNGGYKG ARGANWHDTALD ITYLNWY LVIYAATSRH QQSYDTPL (SEQ ID  (SEQ ID NO: 5705) (SEQ ID NO: 5884) (SEQ ID NO: 6063) (SEQ ID NO: 6242) (SEQ ID NO: 6421) NO: 5526) 370_F03 SSYGMN WVSSINYNSGYKS ARGANWHDTALD LSYVNWY LLIYAATSRA QQSYENPL (SEQ ID  (SEQ ID NO: 5706) (SEQ ID NO: 5885) (SEQ ID NO: 6064) (SEQ ID NO: 6243) (SEQ ID NO: 6422) NO: 5527) 370_H02 DSYSMN WVSGINYNSGYTS ARGANWHDTHLD LTYLNWY LLIYAATSRA QQSYESPL (SEQ ID  (SEQ ID NO: 5707) (SEQ ID NO: 5886) (SEQ ID NO: 6065) (SEQ ID NO: 6244) (SEQ ID NO: 6423) NO: 5528) 370_H07 SSYSMN WVAGINYNGGYKS ARGANWHDTALD LSYLNWY LLIYAATSLA QQSDSSPL (SEQ ID  (SEQ ID NO: 5708) (SEQ ID NO: 5887) (SEQ ID NO: 6066) (SEQ ID NO: 6245) (SEQ ID NO: 6424) NO: 5529) 371_A10 DDYSMN WVSGINYNGGYKG ARGANWHDTALD VSYLNWY LVIYAATSRA QQSYENPL (SEQ ID  (SEQ ID NO: 5709) (SEQ ID NO: 5888) (SEQ ID NO: 6067) (SEQ ID NO: 6246) (SEQ ID NO: 6425) NO: 5530) 371_B03 SSYGMH WVASINYNGGYTS ARGANWHDTHLD LSYVNWY LLIYATTSRA QQSYDNPL (SEQ ID  (SEQ ID NO: 5710) (SEQ ID NO: 5889) (SEQ ID NO: 6068) (SEQ ID NO: 6247) (SEQ ID NO: 6426) NO: 5531) 371_B04 SSYSMN WVSGINYNGGYKS ARGANWHDTALD LSYLNWY LVIYAVTSRH QQSYDSPL (SEQ ID  (SEQ ID NO: 5711) (SEQ ID NO: 5890) (SEQ ID NO: 6069) (SEQ ID NO: 6248) (SEQ ID NO: 6427) NO: 5532) 371_B09 SSYSMN WVAGINYNSGYTG ARGANWHDTHLD LSYVNWY LVIYATTSLA QQSYDTPL (SEQ ID  (SEQ ID NO: 5712) (SEQ ID NO: 5891) (SEQ ID NO: 6070) (SEQ ID NO: 6249) (SEQ ID NO: 6428) NO: 5533) 371_B12 SDYSMN WVAGINYNSGYTS ARGANWHDTALD VTYLNWY LVIYAATSRH QQSYNNPL (SEQ ID  (SEQ ID NO: 5713) (SEQ ID NO: 5892) (SEQ ID NO: 6071) (SEQ ID NO: 6250) (SEQ ID NO: 6429) NO: 5534) 371_C01 SSYGMH WVSSINYNGGYTG ARGANWHDTHLD VSYLNWY LLIYAATSRH QQSYDNPL (SEQ ID  (SEQ ID NO: 5714) (SEQ ID NO: 5893) (SEQ ID NO: 6072) (SEQ ID NO: 6251) (SEQ ID NO: 6430) NO: 5535) 371_C04 DSYGMN WVSGINYNSGYKG ARGANWHDTALD LSYLNWY LLIYAATSRA QQSYSTPL (SEQ ID  (SEQ ID NO: 5715) (SEQ ID NO: 5894) (SEQ ID NO: 6073) (SEQ ID NO: 6252) (SEQ ID NO: 6431) NO: 5536) 371_C05 SDYGMH WVANINYNGGYTG ARGANWHDTALD LSYLNWY LLIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5716) (SEQ ID NO: 5895) (SEQ ID NO: 6074) (SEQ ID NO: 6253) (SEQ ID NO: 6432) NO: 5537) 371_C12 SSYSMN WVAGINYNSGYKS ARGANWHDTHLD VSYVNWY LLIYAATSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 5717) (SEQ ID NO: 5896) (SEQ ID NO: 6075) (SEQ ID NO: 6254) (SEQ ID NO: 6433) NO: 5538) 371_D02 DDYSMN WVAGINYNGGYKS ARGANWHDTALD VTYLNWY LLIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5718) (SEQ ID NO: 5897) (SEQ ID NO: 6076) (SEQ ID NO: 6255) (SEQ ID NO: 6434) NO: 5539) 371_D04 DDYSMN WVAGINYNGGYTG ARGANWHDTHLD VSYVNWY LLIYAATSLA QQSYENPL (SEQ ID  (SEQ ID NO: 5719) (SEQ ID NO: 5898) (SEQ ID NO: 6077) (SEQ ID NO: 6256) (SEQ ID NO: 6435) NO: 5540) 371_E06 SSYSMN WVSGINYNGGYTS ARGANWHDTALD STYLNWY LLIYAVTSLH QQSYESPL (SEQ ID  (SEQ ID NO: 5720) (SEQ ID NO: 5899) (SEQ ID NO: 6078) (SEQ ID NO: 6257) (SEQ ID NO: 6436) NO: 5541) 371_E07 DSYSMN WVAGINYNGGYTS ARGANWHDTALD ISYLNWY LLIYAATSLA QQSYESPL (SEQ ID  (SEQ ID NO: 5721) (SEQ ID NO: 5900) (SEQ ID NO: 6079) (SEQ ID NO: 6258) (SEQ ID NO: 6437) NO: 5542) 371_E10 DSYSMN WVAGINYNGGYTS ARGANWHDTALD STYLNWY LLIYAVTSRA QQSYNSPL (SEQ ID  (SEQ ID NO: 5722) (SEQ ID NO: 5901) (SEQ ID NO: 6080) (SEQ ID NO: 6259) (SEQ ID NO: 6438) NO: 5543) 371_F10 DSYGMN WVSGINYNSGYTS ARGANWHDTALD SSYLNWY LVIYAVTSRA QQSYESPL (SEQ ID  (SEQ ID NO: 5723) (SEQ ID NO: 5902) (SEQ ID NO: 6081) (SEQ ID NO: 6260) (SEQ ID NO: 6439) NO: 5544) 371_F11 SSYSMN WVSGINYNGGYTS ARGANWHDTALD ISYVNWY LLIYAVTSRA QQSYDLPL (SEQ ID  (SEQ ID NO: 5724) (SEQ ID NO: 5903) (SEQ ID NO: 6082) (SEQ ID NO: 6261) (SEQ ID NO: 6440) NO: 5545) 371_G02 DSYGMN WVASINYNGGYTS ARGANWHDTHLD LSYLNWY LLIYAATSRA QQSYDLPL (SEQ ID  (SEQ ID NO: 5725) (SEQ ID NO: 5904) (SEQ ID NO: 6083) (SEQ ID NO: 6262) (SEQ ID NO: 6441) NO: 5546) 371_G04 DSYSMN WVSGINYNGGYKS ARGANWHDTALD LSYLNWY LLIYAATSLH QQSYESPL (SEQ ID  (SEQ ID NO: 5726) (SEQ ID NO: 5905) (SEQ ID NO: 6084) (SEQ ID NO: 6263) (SEQ ID NO: 6442) NO: 5547) 371_G09 SSYSMN WVANINYNGGYTG ARGANWHDTALD LSYLNWY LVIYAATSRA QQSDSTPL (SEQ ID  (SEQ ID NO: 5727) (SEQ ID NO: 5906) (SEQ ID NO: 6085) (SEQ ID NO: 6264) (SEQ ID NO: 6443) NO: 5548) 371_G11 SSYGMN WVSNINYNSGYTS ARGANWHDTALD LSYVNWY LLIYAATSLA QQSYDSPL (SEQ ID  (SEQ ID NO: 5728) (SEQ ID NO: 5907) (SEQ ID NO: 6086) (SEQ ID NO: 6265) (SEQ ID NO: 6444) NO: 5549) 371_H04 SSYGMN WVSNINYNGGYTG ARGANWHDTALD LTYLNWY LLIYAATSRA QQSYNSPL (SEQ ID  (SEQ ID NO: 5729) (SEQ ID NO: 5908) (SEQ ID NO: 6087) (SEQ ID NO: 6266) (SEQ ID NO: 6445) NO: 5550) 371_H05 SSYGMN WVSGINYNSGYKS ARGANWHDTALD ISYLNWY LLIYAATSLA QQSYSLPL (SEQ ID  (SEQ ID NO: 5730) (SEQ ID NO: 5909) (SEQ ID NO: 6088) (SEQ ID NO: 6267) (SEQ ID NO: 6446) NO: 5551) 371_H06 DSYGMN WVSGINYNGGYTS ARGANWHDTALD SSYLNWY LVIYAVTSRA QQSYDLPL (SEQ ID  (SEQ ID NO: 5731) (SEQ ID NO: 5910) (SEQ ID NO: 6089) (SEQ ID NO: 6268) (SEQ ID NO: 6447) NO: 5552) 371_H08 SSYGMN WVASINYNGGYKG ARGANWHDTHLD ISYVNWY LVIYAVTSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 5732) (SEQ ID NO: 5911) (SEQ ID NO: 6090) (SEQ ID NO: 6269) (SEQ ID NO: 6448) NO: 5553) 371_H10 SSYSMN WVAGINYNSGYKS ARGANWHDTHLD STYLNWY LLIYAATSRH QQSYENPL (SEQ ID  (SEQ ID NO: 5733) (SEQ ID NO: 5912) (SEQ ID NO: 6091) (SEQ ID NO: 6270) (SEQ ID NO: 6449) NO: 5554) 372_B02 SSYSMN WVSGINYNSGYTS ARGANWHDTALD LSYVNWY LLIYAVTSLA QQSYETPL (SEQ ID  (SEQ ID NO: 5734) (SEQ ID NO: 5913) (SEQ ID NO: 6092) (SEQ ID NO: 6271) (SEQ ID NO: 6450) NO: 5555) 372_C06 SDYSMN WVSGINYNGGYTS ARGANWHDTALD VSYVNWY LLIYAATSRA QQSYSSPL (SEQ ID  (SEQ ID NO: 5735) (SEQ ID NO: 5914) (SEQ ID NO: 6093) (SEQ ID NO: 6272) (SEQ ID NO: 6451) NO: 5556) 372_D03 SSYSMN WVAGINYNSGYKS ARGANWHDTALD LSYVNWY LVIYAVTSRH QQSYDSPL (SEQ ID  (SEQ ID NO: 5736) (SEQ ID NO: 5915) (SEQ ID NO: 6094) (SEQ ID NO: 6273) (SEQ ID NO: 6452) NO: 5557) 372_E01 DDYSMN WVSGINYNGGYKG ARGANWHDTALD VSYLNWY LVIYAATSRH QQSYDSPL (SEQ ID  (SEQ ID NO: 5737) (SEQ ID NO: 5916) (SEQ ID NO: 6095) (SEQ ID NO: 6274) (SEQ ID NO: 6453) NO: 5558) 372_G12 DSYSMN WVAGINYNGGYTG ARGANWHDTHLD LTYLNWY LVIYAATSRH QQSYDSPL (SEQ ID  (SEQ ID NO: 5738) (SEQ ID NO: 5917) (SEQ ID NO: 6096) (SEQ ID NO: 6275) (SEQ ID NO: 6454) NO: 5559) 373_A01 SSYGMN WVSNINYNGGYTG ARGANWHDTHLD VTYLNWY LVIYATTSRA QQSYNLPL (SEQ ID  (SEQ ID NO: 5739) (SEQ ID NO: 5918) (SEQ ID NO: 6097) (SEQ ID NO: 6276) (SEQ ID NO: 6455) NO: 5560) 373_A03 SDYSMN WVANINYNGGYTG ARGANWHDTALD LSYLNWY LVIYAATSRA QQSYDNPL (SEQ ID  (SEQ ID NO: 5740) (SEQ ID NO: 5919) (SEQ ID NO: 6098) (SEQ ID NO: 6277) (SEQ ID NO: 6456) NO: 5561) 373_A05 SDYSMN WVSGINYNSGYKS ARGANWHDTHLD LSYVNWY LVIYAATSRH QQSYESPL (SEQ ID  (SEQ ID NO: 5741) (SEQ ID NO: 5920) (SEQ ID NO: 6099) (SEQ ID NO: 6278) (SEQ ID NO: 6457) NO: 5562) 373_A09 DSYSMN WVAGINYNGGYTS ARGANWHDTALD LTYLNWY LLIYAATSLA QQSYDTPL (SEQ ID  (SEQ ID NO: 5742) (SEQ ID NO: 5921) (SEQ ID NO: 6100) (SEQ ID NO: 6279) (SEQ ID NO: 6458) NO: 5563) 373_A11 SNYGMN WVANINYNGGYTG ARGANWHDTALD LTYLNWY LLIYAATSRA QQSYDLPL (SEQ ID  (SEQ ID NO: 5743) (SEQ ID NO: 5922) (SEQ ID NO: 6101) (SEQ ID NO: 6280) (SEQ ID NO: 6459) NO: 5564) 373_A12 SSYSMN WVSSINYNGGYTS ARGANWHDTALD LTYLNWY LVIYAATSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 5744) (SEQ ID NO: 5923) (SEQ ID NO: 6102) (SEQ ID NO: 6281) (SEQ ID NO: 6460) NO: 5565) 373_B05 SDYSMN WVSNINYNGGYKS ARGANWHDTALD VTYLNWY LVIYAATSRA QQSYSNPL (SEQ ID  (SEQ ID NO: 5745) (SEQ ID NO: 5924) (SEQ ID NO: 6103) (SEQ ID NO: 6282) (SEQ ID NO: 6461) NO: 5566) 373_B07 DSYSMN WVSGINYNGGYTS ARGANWHDTALD LTYVNWY LVIYAATSRA QQSYELPL (SEQ ID  (SEQ ID NO: 5746) (SEQ ID NO: 5925) (SEQ ID NO: 6104) (SEQ ID NO: 6283) (SEQ ID NO: 6462) NO: 5567) 373_C03 SSYSMN WVSGINYNGGYKS ARGANWHDTALD VTYLNWY LVIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5747) (SEQ ID NO: 5926) (SEQ ID NO: 6105) (SEQ ID NO: 6284) (SEQ ID NO: 6463) NO: 5568) 373_C07 DSYSMN WVAGINYNSGYTS ARGANWHDTHLD LTYLNWY LVIYAATSRA QQSYETPL (SEQ ID  (SEQ ID NO: 5748) (SEQ ID NO: 5927) (SEQ ID NO: 6106) (SEQ ID NO: 6285) (SEQ ID NO: 6464) NO: 5569) 373_C10 SSYSMN WVAGINYNGGYTS ARGANWHDTALD LTYVNWY LLIYAATSRA QQSYDNPL (SEQ ID  (SEQ ID NO: 5749) (SEQ ID NO: 5928) (SEQ ID NO: 6107) (SEQ ID NO: 6286) (SEQ ID NO: 6465) NO: 5570) 373_D03 SSYSMN WVSGINYNGGYTS ARGANWHDTALD VSYLNWY LLIYAATSLA QQSYDTPL (SEQ ID  (SEQ ID NO: 5750) (SEQ ID NO: 5929) (SEQ ID NO: 6108) (SEQ ID NO: 6287) (SEQ ID NO: 6466) NO: 5571) 373_D12 DSYSMN WVSSINYNSGYKG ARGANWHDTHLD LSYVNWY LLIYAATSRA QQSYSLPL (SEQ ID  (SEQ ID NO: 5751) (SEQ ID NO: 5930) (SEQ ID NO: 6109) (SEQ ID NO: 6288) (SEQ ID NO: 6467) NO: 5572) 373_E10 SDYSMN WVSGINYNGGYTS ARGANWHDTALD LTYVNWY LVIYAATSRH QQSYETPL (SEQ ID  (SEQ ID NO: 5752) (SEQ ID NO: 5931) (SEQ ID NO: 6110) (SEQ ID NO: 6289) (SEQ ID NO: 6468) NO: 5573) 373_F08 SSYSMN WVSGINYNGGYTS ARGANWHDTALD LTYLNWY LLIYAATSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 5753) (SEQ ID NO: 5932) (SEQ ID NO: 6111) (SEQ ID NO: 6290) (SEQ ID NO: 6469) NO: 5574) 373_F11 DSYGMH WVSGINYNSGYTS ARGANWHDTHLD VSYVNWY LLIYAATSRA QQSYNLPL (SEQ ID  (SEQ ID NO: 5754) (SEQ ID NO: 5933) (SEQ ID NO: 6112) (SEQ ID NO: 6291) (SEQ ID NO: 6470) NO: 5575) 373_F12 SSYSMN WVSNINYNGGYTG ARGANWHDTALD STYLNWY LVIYAATSRA QQSYETPL (SEQ ID  (SEQ ID NO: 5755) (SEQ ID NO: 5934) (SEQ ID NO: 6113) (SEQ ID NO: 6292) (SEQ ID NO: 6471) NO: 5576) 373_G08 DSYSMN WVSNINYNGGYTS ARGANWHDTALD LTYLNWY LLIYAATSLA QQSYDSPL (SEQ ID  (SEQ ID NO: 5756) (SEQ ID NO: 5935) (SEQ ID NO: 6114) (SEQ ID NO: 6293) (SEQ ID NO: 6472) NO: 5577) 373_H03 SSYSMN WVSGINYNSGYKS ARGANWHDTALD LSYLNWY LLIYATTSRA QQSYENPL (SEQ ID  (SEQ ID NO: 5757) (SEQ ID NO: 5936) (SEQ ID NO: 6115) (SEQ ID NO: 6294) (SEQ ID NO: 6473) NO: 5578) 373_H07 SSYSMN WVAGINYNGGYTS ARGANWHDTHLD VTYLNWY LLIYAASSLQ QQSYDSPL (SEQ ID  (SEQ ID NO: 5758) (SEQ ID NO: 5937) (SEQ ID NO: 6116) (SEQ ID NO: 6295) (SEQ ID NO: 6474) NO: 5579) 373_H09 SSYGMN WVASINYNSGYKS ARGANWHDTHLD ITYLNWY LVIYAATSRA QQSDDSPL (SEQ ID  (SEQ ID NO: 5759) (SEQ ID NO: 5938) (SEQ ID NO: 6117) (SEQ ID NO: 6296) (SEQ ID NO: 6475) NO: 5580) 374_A06 SSYSMN WVSSINYNSGYTS ARGANWHDTHLD LSYLNWY LVIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5760) (SEQ ID NO: 5939) (SEQ ID NO: 6118) (SEQ ID NO: 6297) (SEQ ID NO: 6476) NO: 5581) 374_A09 SSYSMN WVSSINYNGGYKG ARGANWHDTHLD LTYVNWY LLIYAATSLA QQSYDSPL (SEQ ID  (SEQ ID NO: 5761) (SEQ ID NO: 5940) (SEQ ID NO: 6119) (SEQ ID NO: 6298) (SEQ ID NO: 6477) NO: 5582) 374_B03 DSYSMN WVSGINYNGGYTS ARGANWHDTALD LTYLNWY LVIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5762) (SEQ ID NO: 5941) (SEQ ID NO: 6120) (SEQ ID NO: 6299) (SEQ ID NO: 6478) NO: 5583) 374_B05 DSYSMN WVSGINYNSGYTS ARGANWHDTALD VSYLNWY LLIYAATSRH QQSYESPL (SEQ ID  (SEQ ID NO: 5763) (SEQ ID NO: 5942) (SEQ ID NO: 6121) (SEQ ID NO: 6300) (SEQ ID NO: 6479) NO: 5584) 374_B08 DSYSMN WVAGINYNGGYTS ARGANWHDTALD VSYVNWY LLIYAATSRH QQSYELPL (SEQ ID  (SEQ ID NO: 5764) (SEQ ID NO: 5943) (SEQ ID NO: 6122) (SEQ ID NO: 6301) (SEQ ID NO: 6480) NO: 5585) 374_B10 SSYSMN WVSSINYNSGYTS ARGANWHDTHLD LTYVNWY LVIYAATSLA QQSYDTPL (SEQ ID  (SEQ ID NO: 5765) (SEQ ID NO: 5944) (SEQ ID NO: 6123) (SEQ ID NO: 6302) (SEQ ID NO: 6481) NO: 5586) 374_C01 DSYGMN WVSGINYNSGYKS ARGANWHDTALD LTYLNWY LLIYAATSRA QQSYETPL (SEQ ID  (SEQ ID NO: 5766) (SEQ ID NO: 5945) (SEQ ID NO: 6124) (SEQ ID NO: 6303) (SEQ ID NO: 6482) NO: 5587) 374_C09 DSYGMN WVSSINYNGGYKG ARGANWHDTHLD VSYLNWY LVIYAATSRA QQSYELPL (SEQ ID  (SEQ ID NO: 5767) (SEQ ID NO: 5946) (SEQ ID NO: 6125) (SEQ ID NO: 6304) (SEQ ID NO: 6483) NO: 5588) 374_C12 SSYSMN WVAGINYNGGYKS ARGANWHDTALD LTYLNWY LVIYAATSRA QQSDNSPL (SEQ ID  (SEQ ID NO: 5768) (SEQ ID NO: 5947) (SEQ ID NO: 6126) (SEQ ID NO: 6305) (SEQ ID NO: 6484) NO: 5589) 374_D03 DSYSMN WVAGINYNGGYKS ARGANWHDTHLD VTYLNWY LLIYAATSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 5769) (SEQ ID NO: 5948) (SEQ ID NO: 6127) (SEQ ID NO: 6306) (SEQ ID NO: 6485) NO: 5590) 374_D05 DSYSMN WVSGINYNSGYTG ARGANWHDTHLD LTYLNWY LLIYAATSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 5770) (SEQ ID NO: 5949) (SEQ ID NO: 6128) (SEQ ID NO: 6307) (SEQ ID NO: 6486) NO: 5591) 374_D06 SSYSMN WVSGINYNGGYTS ARGANWHDTALD LSYVNWY LVIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5771) (SEQ ID NO: 5950) (SEQ ID NO: 6129) (SEQ ID NO: 6308) (SEQ ID NO: 6487) NO: 5592) 374_D07 DSYSMN WVSGINYNSGYKS ARGANWHDTALD VSYLNWY LVIYAATSLA QQSYNSPL (SEQ ID  (SEQ ID NO: 5772) (SEQ ID NO: 5951) (SEQ ID NO: 6130) (SEQ ID NO: 6309) (SEQ ID NO: 6488) NO: 5593) 374_D10 SSYGMH WVASINYNGGYTS ARGANWHDTHLD LTYVNWY LLIYAATSRA QQSYDNPL (SEQ ID  (SEQ ID NO: 5773) (SEQ ID NO: 5952) (SEQ ID NO: 6131) (SEQ ID NO: 6310) (SEQ ID NO: 6489) NO: 5594) 374_E10 SSYSMN WVSGINYNGGYKS ARGANWHDTALD LSYLNWY LLIYAATSRH QQSYDSPL (SEQ ID  (SEQ ID NO: 5774) (SEQ ID NO: 5953) (SEQ ID NO: 6132) (SEQ ID NO: 6311) (SEQ ID NO: 6490) NO: 5595) 374_E12 SSYSMN WVSGINYNGGYKS ARGANWHDTALD LSYLNWY LVIYAATSRA QQSYDNPL (SEQ ID  (SEQ ID NO: 5775) (SEQ ID NO: 5954) (SEQ ID NO: 6133) (SEQ ID NO: 6312) (SEQ ID NO: 6491) NO: 5596) 374_F06 SSYSMN WVSGINYNGGYTS ARGANWHDTALD ISYVNWY LVIYAATSLH QQSYSTPL (SEQ ID  (SEQ ID NO: 5776) (SEQ ID NO: 5955) (SEQ ID NO: 6134) (SEQ ID NO: 6313) (SEQ ID NO: 6492) NO: 5597) 374_F07 DSYSMN WVASINYNGGYTG ARGANWHDTHLD LSYLNWY LVIYAVTSLA QQSYESPL (SEQ ID  (SEQ ID NO: 5777) (SEQ ID NO: 5956) (SEQ ID NO: 6135) (SEQ ID NO: 6314) (SEQ ID NO: 6493) NO: 5598) 374_F08 DSYSMN WVSGINYNGGYKS ARGANWHDTALD LTYVNWY LVIYAVTSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 5778) (SEQ ID NO: 5957) (SEQ ID NO: 6136) (SEQ ID NO: 6315) (SEQ ID NO: 6494) NO: 5599) 374_G03 SDYSMN WVSGINYNGGYTS ARGANWHDTALD SSYLNWY LVIYAATSRA QQSDDTPL (SEQ ID  (SEQ ID NO: 5779) (SEQ ID NO: 5958) (SEQ ID NO: 6137) (SEQ ID NO: 6316) (SEQ ID NO: 6495) NO: 5600) 374_G08 DSYSMN WVSGINYNGGYTS ARGANWHDTALD LTYVNWY LVIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5780) (SEQ ID NO: 5959) (SEQ ID NO: 6138) (SEQ ID NO: 6317) (SEQ ID NO: 6496) NO: 5601) 374_G09 SSYSMN WVAGINYNGGYKG ARGANWHDTHLD VRYLNWY LVIYAATSLA QQSYELPL (SEQ ID  (SEQ ID NO: 5781) (SEQ ID NO: 5960) (SEQ ID NO: 6139) (SEQ ID NO: 6318) (SEQ ID NO: 6497) NO: 5602) 374_G10 SSYSMN WVSSINYNSGYTS ARGANWHDTHLD VSYLNWY LVIYAVTSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5782) (SEQ ID NO: 5961) (SEQ ID NO: 6140) (SEQ ID NO: 6319) (SEQ ID NO: 6498) NO: 5603) 374_G11 SDYSMN WVSGINYNGGYTS ARGANWHDTALD ISYVNWY LVIYAATSLA QQSYDSPL (SEQ ID  (SEQ ID NO: 5783) (SEQ ID NO: 5962) (SEQ ID NO: 6141) (SEQ ID NO: 6320) (SEQ ID NO: 6499) NO: 5604) 374_H01 DSYSMN WVAGINYNGGYTS ARGANWHDTHLD LSYLNWY LVIYAATSLA QQSYENPL (SEQ ID  (SEQ ID NO: 5784) (SEQ ID NO: 5963) (SEQ ID NO: 6142) (SEQ ID NO: 6321) (SEQ ID NO: 6500) NO: 5605) 374_H11 SSYSMN WVSGINYNGGYTS ARGANWHDTALD ISYVNWY LVIYAATSLH QQSYSNPL (SEQ ID  (SEQ ID NO: 5785) (SEQ ID NO: 5964) (SEQ ID NO: 6143) (SEQ ID NO: 6322) (SEQ ID NO: 6501) NO: 5606) 375_A01 DSYSMN WVAGINYNGGYTS ARGANWHDTALD LSYLNWY LVIYAATSRA QQSYNTPL (SEQ ID  (SEQ ID NO: 5786) (SEQ ID NO: 5965) (SEQ ID NO: 6144) (SEQ ID NO: 6323) (SEQ ID NO: 6502) NO: 5607) 375_A07 DSYSMN WVSSINYNSGYTG ARGANWHDTHLD LTYLNWY LLIYAATSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 5787) (SEQ ID NO: 5966) (SEQ ID NO: 6145) (SEQ ID NO: 6324) (SEQ ID NO: 6503) NO: 5608) 375_A08 SSYSMN WVAGINYNGGYTG ARGANWHDTALD VTYLNWY LLIYAATSRA QQSYESPL (SEQ ID  (SEQ ID NO: 5788) (SEQ ID NO: 5967) (SEQ ID NO: 6146) (SEQ ID NO: 6325) (SEQ ID NO: 6504) NO: 5609) 375_A12 SSYSMN WVSGINYNSGYKS ARGANWHDTALD LSYLNWY LVIYAVTSRA QQSYETPL (SEQ ID  (SEQ ID NO: 5789) (SEQ ID NO: 5968) (SEQ ID NO: 6147) (SEQ ID NO: 6326) (SEQ ID NO: 6505) NO: 5610) 375_B12 DSYSMN WVAGINYNGGYKS ARGANWHDTALD VTYLNWY LLIYAATSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 5790) (SEQ ID NO: 5969) (SEQ ID NO: 6148) (SEQ ID NO: 6327) (SEQ ID NO: 6506) NO: 5611) 375_C04 SDYSMN WVAGINYNGGYTS ARGANWHDTALD LTYLNWY LVIYAATSRA QQSYESPL (SEQ ID  (SEQ ID NO: 5791) (SEQ ID NO: 5970) (SEQ ID NO: 6149) (SEQ ID NO: 6328) (SEQ ID NO: 6507) NO: 5612) 375_D01 SSYSMN WVSGINYNGGYTG ARGANWHDTALD LTYLNWY LVIYAATSRA QQSYETPL (SEQ ID  (SEQ ID NO: 5792) (SEQ ID NO: 5971) (SEQ ID NO: 6150) (SEQ ID NO: 6329) (SEQ ID NO: 6508) NO: 5613) 375_D10 SSYSMN WVAGINYNGGYTS ARGANWHDTALD LTYVNWY LLIYAATSRA QQSDDSPL (SEQ ID  (SEQ ID NO: 5793) (SEQ ID NO: 5972) (SEQ ID NO: 6151) (SEQ ID NO: 6330) (SEQ ID NO: 6509) NO: 5614) 375_E02 SDYSMN WVAGINYNGGYTS ARGANWHDTALD LTYLNWY LLIYAATSRA QQSYSSPL (SEQ ID  (SEQ ID NO: 5794) (SEQ ID NO: 5973) (SEQ ID NO: 6152) (SEQ ID NO: 6331) (SEQ ID NO: 6510) NO: 5615) 375_E03 SDYSMN WVANINYNGGYTG ARGANWHDTHLD LTYLNWY LVIYAATSLA QQSYDNPL (SEQ ID  (SEQ ID NO: 5795) (SEQ ID NO: 5974) (SEQ ID NO: 6153) (SEQ ID NO: 6332) (SEQ ID NO: 6511) NO: 5616) 375_E05 SSYSMN WVAGINYNGGYTS ARGANWHDTALD LSYLNWY LVIYAATSLA QQSYSSPL (SEQ ID  (SEQ ID NO: 5796) (SEQ ID NO: 5975) (SEQ ID NO: 6154) (SEQ ID NO: 6333) (SEQ ID NO: 6512) NO: 5617) 375_E06 SSYSMN WVSGINYNGGYKS ARGANWHDTALD LSYLNWY LVIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5797) (SEQ ID NO: 5976) (SEQ ID NO: 6155) (SEQ ID NO: 6334) (SEQ ID NO: 6513) NO: 5618) 375_E10 SSYSMN WVSGINYNGGYTS ARGANWHDTALD LSYLNWY LVIYAATSRA QQSYDNPL (SEQ ID  (SEQ ID NO: 5798) (SEQ ID NO: 5977) (SEQ ID NO: 6156) (SEQ ID NO: 6335) (SEQ ID NO: 6514) NO: 5619) 375_F02 SSYSMN WVASINYNSGYTS ARGANWHDTHLD LSYLNWY LLIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5799) (SEQ ID NO: 5978) (SEQ ID NO: 6157) (SEQ ID NO: 6336) (SEQ ID NO: 6515) NO: 5620) 375_F07 SDYSMN WVSNINYNGGYTG ARGANWHDTALD LSYLNWY LLIYAATSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5800) (SEQ ID NO: 5979) (SEQ ID NO: 6158) (SEQ ID NO: 6337) (SEQ ID NO: 6516) NO: 5621) 375_F08 SSYGMN WVSSINYNSGYKS ARGANWHDTHLD LSYLNWY LLIYAATSRH QQSYDNPL (SEQ ID  (SEQ ID NO: 5801) (SEQ ID NO: 5980) (SEQ ID NO: 6159) (SEQ ID NO: 6338) (SEQ ID NO: 6517) NO: 5622) 375_G04 SSYGMN WVASINYNSGYTG ARGANWHDTHLD VSYVNWY LLIYAATSLA QQSYDSPL (SEQ ID  (SEQ ID NO: 5802) (SEQ ID NO: 5981) (SEQ ID NO: 6160) (SEQ ID NO: 6339) (SEQ ID NO: 6518) NO: 5623) 375_G05 SSYSMN WVAGINYNGGYTS ARGANWHDTALD VSYLNWY LLIYAVTSRA QQSYDSPL (SEQ ID  (SEQ ID NO: 5803) (SEQ ID NO: 5982) (SEQ ID NO: 6161) (SEQ ID NO: 6340) (SEQ ID NO: 6519) NO: 5624) 375_H05 SSYSMN WVSNINYNGGYTG ARGANWHDTALD LSYVNWY LLIYAATSRA QQSYDTPL (SEQ ID  (SEQ ID NO: 5804) (SEQ ID NO: 5983) (SEQ ID NO: 6162) (SEQ ID NO: 6341) (SEQ ID NO: 6520) NO: 5625) 375_H07 SSYSMN WVAGINYNGGYTS ARGANWHDTALD LSYLNWY LLIYAATSLA QQSYSSPL (SEQ ID  (SEQ ID NO: 5805) (SEQ ID NO: 5984) (SEQ ID NO: 6163) (SEQ ID NO: 6342) (SEQ ID NO: 6521) NO: 5626) 376_A03 SSYGMN WVAGINYNGGYTG ARGANWHDTALD LTYLNWY LLIYAATSRA QQSYSTPL (SEQ ID  (SEQ ID NO: 5806) (SEQ ID NO: 5985) (SEQ ID NO: 6164) (SEQ ID NO: 6343) (SEQ ID NO: 6522) NO: 5627) 376_B03 SSYSMN WVAGINYNSGYKS ARGANWHDTALD LSYVNWY LVIYAVTSRH QQSYDSPL (SEQ ID  (SEQ ID NO: 5807) (SEQ ID NO: 5986) (SEQ ID NO: 6165) (SEQ ID NO: 6344) (SEQ ID NO: 6523) NO: 5628) 376_B10 SDYSMN WVAGINYNGGYKG ARGANWHDTALD LSYLNWY LVIYAATSLA QQSYSTPL (SEQ ID  (SEQ ID NO: 5808) (SEQ ID NO: 5987) (SEQ ID NO: 6166) (SEQ ID NO: 6345) (SEQ ID NO: 6524) NO: 5629) 376_C04 SSYGMN WVSNINYNGGYTG ARGANWHDTALD LSYVNWY LLIYAVTSRH QQSYDNPL (SEQ ID  (SEQ ID NO: 5809) (SEQ ID NO: 5988) (SEQ ID NO: 6167) (SEQ ID NO: 6346) (SEQ ID NO: 6525) NO: 5630) 376_C08 DSYSMN WVAGINYNSGYTG ARGANWHDTHLD LSYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID  (SEQ ID NO: 5810) (SEQ ID NO: 5989) (SEQ ID NO: 6168) (SEQ ID NO: 6347) (SEQ ID NO: 6526) NO: 5631) 376_D07 DSYSMN WVSGINYNGGYTS ARGANWHDTHLD SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID  (SEQ ID NO: 5811) (SEQ ID NO: 5990) (SEQ ID NO: 6169) (SEQ ID NO: 6348) (SEQ ID NO: 6527) NO: 5632) 376_E02 SSYSMN WVAGINYNGGYKG ARGANWHDTALD LSYVNWY LVIYAATSRH QQSDNTPL (SEQ ID  (SEQ ID NO: 5812) (SEQ ID NO: 5991) (SEQ ID NO: 6170) (SEQ ID NO: 6349) (SEQ ID NO: 6528) NO: 5633) 376_E11 SSYSMN WVSGINYNGGYTS ARGANWHDTALD LTYVNWY LVIYAATSRA QQSYELPL (SEQ ID  (SEQ ID NO: 5813) (SEQ ID NO: 5992) (SEQ ID NO: 6171) (SEQ ID NO: 6350) (SEQ ID NO: 6529) NO: 5634) 376_F01 SDYSMN WVAGINYNGGYKS ARGANWHDTALD SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID  (SEQ ID NO: 5814) (SEQ ID NO: 5993) (SEQ ID NO: 6172) (SEQ ID NO: 6351) (SEQ ID NO: 6530) NO: 5635) 376_F06 SSYGMN WVSGINYNGGYTG ARGANWHDTHLD LTYVNWY LVIYAATSRA QQSYETPL (SEQ ID  (SEQ ID NO: 5815) (SEQ ID NO: 5994) (SEQ ID NO: 6173) (SEQ ID NO: 6352) (SEQ ID NO: 6531) NO: 5636) 376_G05 SSYSMN WVAGINYNGGYTS ARGANWHDTALD ISYVNWY LVIYAATSRA QQSYESPL (SEQ ID  (SEQ ID NO: 5816) (SEQ ID NO: 5995) (SEQ ID NO: 6174) (SEQ ID NO: 6353) (SEQ ID NO: 6532) NO: 5637) 376_G06 SSYGMN WVAGINYNGGYTG ARGANWHDTHLD VSYVNWY LVIYAATSRA QQSYNSPL (SEQ ID  (SEQ ID NO: 5817) (SEQ ID NO: 5996) (SEQ ID NO: 6175) (SEQ ID NO: 6354) (SEQ ID NO: 6533) NO: 5638) 376_G10 DSYGMN WVAGINYNGGYTS ARGANWHDTALD LSYVNWY LLIYAATSRA QQSYESPL (SEQ ID  (SEQ ID NO: 5818) (SEQ ID NO: 5997) (SEQ ID NO: 6176) (SEQ ID NO: 6355) (SEQ ID NO: 6534) NO: 5639) 376_H01 SDYSMN WVAGINYNGGYKG ARGANWHDTALD LTYLNWY LLIYAATSRA QQSYSTPL (SEQ ID  (SEQ ID NO: 5819) (SEQ ID NO: 5998) (SEQ ID NO: 6177) (SEQ ID NO: 6356) (SEQ ID NO: 6535) NO: 5640) 376_H04 SSYSMN WVAGINYNGGYKG ARGANWHDTALD LTYVNWY LVIYAATSRA QQSYDLPL (SEQ ID  (SEQ ID NO: 5820) (SEQ ID NO: 5999) (SEQ ID NO: 6178) (SEQ ID NO: 6357) (SEQ ID NO: 6536) NO: 5641) 376_H11 DSYSMN WVSNINYNGGYTG ARGANWHDTALD SRYLNWY LLIYAVTSLA QQSYESPL (SEQ ID  (SEQ ID NO: 5821) (SEQ ID NO: 6000) (SEQ ID NO: 6179) (SEQ ID NO: 6358) (SEQ ID NO: 6537) NO: 5642)

The consensus sequences for each of these CDRs shown in FIG. 3C are as follows:

HCDR1: (SEQ ID NO: 6566) S/DS/DYS/GMN/H HCDR2: (SEQ ID NO: 6594) WVS/AG/S/NINYNG/SGYT/KS/G HCDR3: (SEQ ID NO: 6543) ARGANWHDTA/HLD LCDR1: (SEQ ID NO: 6569) L/V/S/IS/TYL/VNWY LCDR2: (SEQ ID NO:) LL/VIYAA/V/TT/SSR/LA/H/Q LCDR3: (SEQ ID NO: 6571) QQSY/DD/E/S/NS/T/N/LPL

TABLE 2D Group IV Antibody Sequences Ab VH sequence VL sequence 365_A08 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN SSYSMNWVRQAPGKGLEWVASINYNGGYK WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSDNTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1477) TVSS (SEQ ID NO: 1384) 365_A09 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN SSYGMHWVRQAPGKGLEWVASINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1478) TVSS (SEQ ID NO: 1385) 365_C02 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSISTYLN DSYSMNWVRQAPGKGLEWVSNINYNGGYK WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1479) TVSS (SEQ ID NO: 1386) 365_C04 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN DSYSMNWVRQAPGKGLEWVANINYNGGYK WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1480) TVSS (SEQ ID NO: 1387) 365_D02 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN SSYSMHWVRQAPGKGLEWVASINYNGGYT WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1481) TVSS (SEQ ID NO: 1388) 365_D07 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN SSYGMNWVRQAPGKGLEWVSSINYNSGYK WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1482) TVSS (SEQ ID NO: 1389) 365_D10 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSISTYLN SSYSMNWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1483) TVSS (SEQ ID NO: 1390) 365_E11 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN DDYSMNWVRQAPGKGLEWVSSINYNGGYK WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1484) TVSS (SEQ ID NO: 1391) 365_F05 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVN SSYGMNWVRQAPGKGLEWVASINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1485) TVSS (SEQ ID NO: 1392) 365_H05 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN SSYGMNWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1486) TVSS (SEQ ID NO: 1393) 366_D08 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN SSYGMHWVRQAPGKGLEWVSNINYNGGYK WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1487) TVSS (SEQ ID NO: 1394) 366_F08 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN SSYGMNWVRQAPGKGLEWVSSINYNGGYT WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1488) TVSS (SEQ ID NO: 1395) 366_G09 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN DDYSMNWVRQAPGKGLEWVASINYNSGYT WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1489) TVSS (SEQ ID NO: 1396) 367_A02 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN DSYGMNWVRQAPGKGLEWVSSINYNSGYK WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1490) TVSS (SEQ ID NO: 1397) 367_B06 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN SSYSMNWVRQAPGKGLEWVANINYNGGYT WYQQKPGKAPKLVIYAATSLHSGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1491) TVSS (SEQ ID NO: 1398) 367_C08 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN DSYSMHWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSDSNPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1492) TVSS (SEQ ID NO: 1399) 367_D05 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN SDYSMNWVRQAPGKGLEWVSSINYNGGYK WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1493) TVSS (SEQ ID NO: 1400) 367_D09 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN DSYGMNWVRQAPGKGLEWVASINYNGGYK WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1494) TVSS (SEQ ID NO: 1401) 367_E07 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN SDYSMNWVRQAPGKGLEWVSSINYNGGYK WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1495) TVSS (SEQ ID NO: 1402) 367_E12 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN SSYGMHWVRQAPGKGLEWVASINYNGGYT WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1496) TVSS (SEQ ID NO: 1403) 367_F09 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN DSYSMHWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSDSNPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1497) TVSS (SEQ ID NO: 1404) 367_H05 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN SSYGMHWVRQAPGKGLEWVASINYNSGYK WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1498) TVSS (SEQ ID NO: 1405) 367_H10 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN SSYGMNWVRQAPGKGLEWVASINYNGGYT WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1499) TVSS (SEQ ID NO: 1406) 368_B02 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN SSYGMNWVRQAPGKGLEWVSGINYNSGYK WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1500) TVSS (SEQ ID NO: 1407) 368_C11 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN SDYSMNWVRQAPGKGLEWVSSINYNSGYK WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1501) TVSS (SEQ ID NO: 1408) 368_D02 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSISTYLN DDYGMNWVRQAPGKGLEWVSNINYNGGYT WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1502) TVSS (SEQ ID NO: 1409) 368_D12 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN SSYGMNWVRQAPGKGLEWVSSINYNGGYT WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1503) TVSS (SEQ ID NO: 1410) 368_F06 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN DDYSMHWVRQAPGKGLEWVANINYNSGYT WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1504) TVSS (SEQ ID NO: 1411) 368_G03 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN SSYSMNWVRQAPGKGLEWVSGINYNSGYT WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTALDYWGQGTLV KVEIK (SEQ ID NO: 1505) TVSS (SEQ ID NO: 1412) 368_G10 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN SSYSMHWVRQAPGKGLEWVSSINYNGGYT WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1506) TVSS (SEQ ID NO: 1413) 368_H06 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN DSYGMHWVRQAPGKGLEWVANINYNGGYK WYQQKPGKAPKLLIYATTSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1507) TVSS (SEQ ID NO: 1414) 368_H11 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN DSYGMHWVRQAPGKGLEWVASINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSDDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1508) TVSS (SEQ ID NO: 1415) 369_A11 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN DSYGMNWVRQAPGKGLEWVANINYNGGYK WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1509) TVSS (SEQ ID NO: 1416) 369_C12 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SSYGMNWVRQAPGKGLEWVANINYNGGYK WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1510) TVSS (SEQ ID NO: 1417) 369_D08 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SDYSMNWVRQAPGKGLEWVASINYNGGYK WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1511) TVSS (SEQ ID NO: 1418) 369_E05 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SDYGMNWVRQAPGKGLEWVANINYNGGYK WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1512) TVSS (SEQ ID NO: 1419) 369_E08 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN SSYSMNWVRQAPGKGLEWVASINYNSGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1513) TVSS (SEQ ID NO: 1420) 369_F05 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN SSYSMNWVRQAPGKGLEWVSGINYNGGYK WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQGYDSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1514) TVSS (SEQ ID NO: 1421) 369_F09 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN SSYGMHWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1515) TVSS (SEQ ID NO: 1422) 369_G05 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN SSYSMNWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1516) TVSS (SEQ ID NO: 1423) 369_H02 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN DDYSMNWVRQAPGKGLEWVSNINYNGGYK WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1517) TVSS (SEQ ID NO: 1424) 369_H08 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN SSYSMNWVRQAPGKGLEWVAGINYNSGYK WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1518) TVSS (SEQ ID NO: 1425) 369_H12 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVN SSYSMNWVRQAPGKGLEWVAGINYNGGYK WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1519) TVSS (SEQ ID NO: 1426) 370_B08 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN SDYSMNWVRQAPGKGLEWVANINYNGGYT WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1520) TVSS (SEQ ID NO: 1427) 370_C06 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN SSYSMNWVRQAPGKGLEWVANINYNGGYK WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1521) TVSS (SEQ ID NO: 1428) 370_C07 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN SSYSMNWVRQAPGKGLEWVANINYNGGYK WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1522) TVSS (SEQ ID NO: 1429) 370_C10 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN DSYSMNWVRQAPGKGLEWVSNINYNSGYK WYQQKPGKAPKLLIYATTSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1523) TVSS (SEQ ID NO: 1430) 370_D03 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN SSYSMNWVRQAPGKGLEWVASINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1524) TVSS (SEQ ID NO: 1431) 370_D09 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN SDYSMNWVRQAPGKGLEWVSGINYNSGYT WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1525) TVSS (SEQ ID NO: 1432) 370_E04 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SSYSMNWVRQAPGKGLEWVANINYNGGYK WYQQKPGKAPKLLIYAVTSLHSGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1526) TVSS (SEQ ID NO: 1433) 370_E05 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSISTYLN SSYGMNWVRQAPGKGLEWVSNINYNGGYK WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1527) TVSS (SEQ ID NO: 1434) 370_F01 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN SSYGMNWVRQAPGKGLEWVSNINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1528) TVSS (SEQ ID NO: 1435) 370_F02 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN DSYGMNWVRQAPGKGLEWVANINYNGGYT WYQQKPGKAPKLLIYAVTSRHSGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1529) TVSS (SEQ ID NO: 1436) 370_F12 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN SDYSMNWVRQAPGKGLEWVANINYNGGYT WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1530) TVSS (SEQ ID NO: 1437) 370_G08 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SDYSMNWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1531) TVSS (SEQ ID NO: 1438) 370_H04 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN SSYSMNWVRQAPGKGLEWVSNINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1532) TVSS (SEQ ID NO: 1439) 370_H06 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN DDYSMNWVRQAPGKGLEWVANINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1533) TVSS (SEQ ID NO: 1440) 371_B01 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN DSYSMNWVRQAPGKGLEWVSNINYNSGYT WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1534) TVSS (SEQ ID NO: 1441) 371_C06 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN SSYSMNWVRQAPGKGLEWVSSINYNGGYT WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1535) TVSS (SEQ ID NO: 1442) 371_C07 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN DSYGMNWVRQAPGKGLEWVSNINYNGGYT WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTALDYWGQGTLV KVEIK (SEQ ID NO: 1536) TVSS (SEQ ID NO: 1443) 371_E05 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN SSYSMNWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1537) TVSS (SEQ ID NO: 1444) 371_E08 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN SSYSMNWVRQAPGKGLEWVSNINYNSGYK WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1538) TVSS (SEQ ID NO: 1445) 371_E09 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SDYSMNWVRQAPGKGLEWVSGINYNSGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1539) TVSS (SEQ ID NO: 1446) 371_E12 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN DSYSMNWVRQAPGKGLEWVSGINYNSGYK WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1540) TVSS (SEQ ID NO: 1447) 371_F03 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN SSYSMNWVRQAPGKGLEWVSGINYNGGYT WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1541) TVSS (SEQ ID NO: 1448) 371_F09 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SSYSMNWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1542) TVSS (SEQ ID NO: 1449) 371_G01 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SDYSMNWVRQAPGKGLEWVSNINYNGGYT WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1543) TVSS (SEQ ID NO: 1450) 371_H11 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SSYSMNWVRQAPGKGLEWVSGINYNGGYK WYQQKPGKAPKLLIYATTSRHSGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1544) TVSS (SEQ ID NO: 1451) 372_B09 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SSYSMNWVRQAPGKGLEWVSSINYNSGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1545) TVSS (SEQ ID NO: 1452) 372_E08 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN SDYSMNWVRQAPGKGLEWVSNINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1546) TVSS (SEQ ID NO: 1453) 372_F02 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SSYGMHWVRQAPGKGLEWVASINYNGGYT WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1547) TVSS (SEQ ID NO: 1454) 372_H11 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN SSYGMHWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1548) TVSS (SEQ ID NO: 1455) 373_A06 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN SSYSMNWVRQAPGKGLEWVSGINYNGGYK WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1549) TVSS (SEQ ID NO: 1456) 373_B09 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN DSYSMNWVRQAPGKGLEWVSGINYNGGYK WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1550) TVSS (SEQ ID NO: 1457) 373_D06 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN SSYSMNWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1551) TVSS (SEQ ID NO: 1458) 373_F07 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN SSYSMNWVRQAPGKGLEWVSGINYNSGYK WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1552) TVSS (SEQ ID NO: 1459) 373_G02 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN SSYSMNWVRQAPGKGLEWVSGINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1553) TVSS (SEQ ID NO: 1460) 374_A04 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SSYSMNWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1554) TVSS (SEQ ID NO: 1461) 374_A05 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIVRYLN SDYGMNWVRQAPGKGLEWVANINYNGGYK WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1555) TVSS (SEQ ID NO: 1462) 374_C10 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN SSYSMNWVRQAPGKGLEWVSSINYNGGYK WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1556) TVSS (SEQ ID NO: 1463) 374_D04 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN SSYSMNWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1557) TVSS (SEQ ID NO: 1464) 374_D09 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN DSYGMNWVRQAPGKGLEWVANINYNGGYK WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1558) TVSS (SEQ ID NO: 1465) 374_G05 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN SSYSMNWVRQAPGKGLEWVSNINYNSGYK WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1559) TVSS (SEQ ID NO: 1466) 374_H05 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN SSYSMNWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1560) TVSS (SEQ ID NO: 1467) 375_A03 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN DSYSMNWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1561) TVSS (SEQ ID NO: 1468) 375_B03 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SSYSMNWVRQAPGKGLEWVAGINYNGGYT WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1562) TVSS (SEQ ID NO: 1469) 375 C01 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN SSYGMNWVRQAPGKGLEWVSSINYNGGYK WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1563) TVSS (SEQ ID NO: 1470) 375_C11 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN SSYSMNWVRQAPGKGLEWVSSINYNGGYT WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1564) TVSS (SEQ ID NO: 1471) 375_F10 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SSYSMNWVRQAPGKGLEWVSGINYNGGYT WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1565) TVSS (SEQ ID NO: 1472) 375_H08 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SSYSMNWVRQAPGKGLEWVSGINYNGGYT WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1566) TVSS (SEQ ID NO: 1473) 376_A02 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN SSYSMNWVRQAPGKGLEWVAGINYNGGYK WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1567) TVSS (SEQ ID NO: 1474) 376_A05 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SSYSMNWVRQAPGKGLEWVAGINYNSGYK WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG GYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1568) TVSS (SEQ ID NO: 1475) 376_A07 EVQLLESGGGLVQPGGSLRLSCAASGFTF DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN SSYSMNWVRQAPGKGLEWVSGINYNGGYK WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG SYADSVKGRFTISRDNSKNTLYLQMNSLR TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT AEDTAVYYCARGATWHDTHLDYWGQGTLV KVEIK (SEQ ID NO: 1569) TVSS (SEQ ID NO: 1476)

Table 3D provides the amino acid sequences of the CDRs of the antibodies shown in Table 2D.

TABLE 3D CDR sequences for Group IV antibodies Ab HCDR1 HCDR2 HCDR3 LCDR1 LCDR2 LCDR3 365_A08 SSYSMN WVASINYNGGYKS ARGATWHDTHLD ITYLNWY LVIYAATSRA QQSDNTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1663) 1756) NO: NO: 1942) NO: 1570) 1849) 2035) 365_A09 SSYGMH WVASINYNGGYTS ARGATWHDTHLD LSYVNWY LLIYAATSRA QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1664) 1757) NO: NO: 1943) NO: 1571) 1850) 2036) 365_C02 DSYSMN WVSNINYNGGYKG ARGATWHDTHLD STYLNWY LVIYAATSRH QQSYENPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1665) 1758) NO: NO: 1944) NO: 1572) 1851) 2037) 365_C04 DSYSMN WVANINYNGGYKG ARGATWHDTHLD LTYLNWY LVIYAATSLA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1666) 1759) NO: NO: 1945) NO: 1573) 1852) 2038) 365_D02 SSYSMH WVASINYNGGYTS ARGATWHDTHLD VTYLNWY LLIYAATSLA QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1667) 1760) NO: NO: 1946) NO: 1574) 1853) 2039) 365_D07 SSYGMN WVSSINYNSGYKS ARGATWHDTHLD SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1668) 1761) NO: NO: 1947) NO: 1575) 1854) 2040) 365_D10 SSYSMN WVAGINYNGGYTG ARGATWHDTHLD STYLNWY LLIYAATSRA QQSYESPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1669) 1762) NO: NO: 1948) NO: 1576) 1855) 2041) 365_E11 DDYSMN WVSSINYNGGYKS ARGATWHDTHLD SSYLNWY LLIYAASSLQ QQSYNTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1670) 1763) NO: NO: 1949) NO: 1577) 1856) 2042) 365_F05 SSYGMN WVASINYNGGYTS ARGATWHDTHLD VTYVNWY LLIYAATSRA QQSYETPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1671) 1764) NO: NO: 1950) NO: 1578) 1857) 2043) 365_H05 SSYGMN WVAGINYNGGYTS ARGATWHDTHLD LTYVNWY LLIYAATSLH QQSYSTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1672) 1765) NO: NO: 1951) NO: 1579) 1858) 2044) 366_D08 SSYGMH WVSNINYNGGYKS ARGATWHDTHLD LSYVNWY LVIYAATSLA QQSYENPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1673) 1766) NO: NO: 1952) NO: 1580) 1859) 2045) 366_F08 SSYGMN WVSSINYNGGYTS ARGATWHDTHLD SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1674) 1767) NO: NO: 1953) NO: 1581) 1860) 2046) 366_G09 DDYSMN WVASINYNSGYTG ARGATWHDTHLD LSYVNWY LVIYAATSRA QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1675) 1768) NO: NO: 1954) NO: 1582) 1861) 2047) 367_A02 DSYGMN WVSSINYNSGYKG ARGATWHDTHLD ISYLNWY LLIYAVTSRA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1676) 1769) NO: NO: 1955) NO: 1583) 1862) 2048) 367_B06 SSYSMN WVANINYNGGYTG ARGATWHDTHLD ISYVNWY LVIYAATSLH QQSYNSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1677) 1770) NO: NO: 1956) NO: 1584) 1863) 2049) 367_C08 DSYSMH WVAGINYNGGYTS ARGATWHDTHLD LTYLNWY LLIYAATSLA QQSDSNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1678) 1771) NO: NO: 1957) NO: 1585) 1864) 2050) 367_D05 SDYSMN WVSSINYNGGYKS ARGATWHDTHLD ISYVNWY LVIYAATSLA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1679) 1772) NO: NO: 1958) NO: 1586) 1865) 2051) 367_D09 DSYGMN WVASINYNGGYKS ARGATWHDTHLD LTYLNWY LLIYAATSLA QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1680) 1773) NO: NO: 1959) NO: 1587) 1866) 2052) 367_E07 SDYSMN WVSSINYNGGYKG ARGATWHDTHLD LSYVNWY LVIYAATSRA QQSYENPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1681) 1774) NO: NO: 1960) NO: 1588) 1867) 2053) 367_E12 SSYGMH WVASINYNGGYTS ARGATWHDTHLD LTYVNWY LLIYAASSLQ QQSYNSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1682) 1775) NO: NO: 1961) NO: 1589) 1868) 2054) 367_F09 DSYSMH WVAGINYNGGYTS ARGATWHDTHLD LTYLNWY LLIYAATSLA QQSDSNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1683) 1776) NO: NO: 1962) NO: 1590) 1869) 2055) 367 H05 SSYGMH WVASINYNSGYKS ARGATWHDTHLD LSYVNWY LLIYAASSLQ QQSYSTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: NO: NO: 1870) NO: 1963) 2056) 1591) 1684) 1777) 367_H10 SSYGMN WVASINYNGGYTG ARGATWHDTHLD LSYVNWY LVIYAATSRA QQSYELPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1685) 1778) NO: NO: 1964) NO: 1592) 1871) 2057) 368_B02 SSYGMN WVSGINYNSGYKS ARGATWHDTHLD SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1686) 1779) NO: NO: 1965) NO: 1593) 1872) 2058) 368_C11 SDYSMN WVSSINYNSGYKS ARGATWHDTHLD ISYLNWY LLIYAATSRA QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1687) 1780) NO: NO: 1966) NO: 1594) 1873) 2059) 368_D02 DDYGMN WVSNINYNGGYTG ARGATWHDTHLD STYLNWY LVIYAATSRH QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1688) 1781) NO: NO: 1967) NO: 1595) 1874) 2060) 368_D12 SSYGMN WVSSINYNGGYTS ARGATWHDTHLD LSYVNWY LVIYAATSRA QQSYNNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1689) 1782) NO: NO: 1968) NO: 1596) 1875) 2061) 368_F06 DDYSMH WVANINYNSGYTG ARGATWHDTHLD LSYLNWY LVIYATTSRA QQSYENPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1690) 1783) NO: NO: 1969) NO: 1597) 1876) 2062) 368_G03 SSYSMN WVSGINYNSGYTS ARGATWHDTALD LSYLNWY LVIYAATSRA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1691) 1784) NO: NO: 1970) NO: 1598) 1877) 2063) 368_G10 SSYSMH WVSSINYNGGYTS ARGATWHDTHLD VSYVNWY LVIYAATSRA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1692) 1785) NO: NO: 1971) NO: 1599) 1878) 2064) 368_H06 DSYGMH WVANINYNGGYKS ARGATWHDTHLD LTYVNWY LLIYATTSRA QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1693) 1786) NO: NO: 1972) NO: 1600) 1879) 2065) 368_H11 DSYGMH WVASINYNGGYTS ARGATWHDTHLD LSYLNWY LLIYAATSRA QQSDDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1694) 1787) NO: NO: 1973) NO: 1601) 1880) 2066) 369_A11 DSYGMN WVANINYNGGYKG ARGATWHDTHLD ITYLNWY LVIYAATSRH QQSYESPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1695) 1788) NO: NO: 1974) NO: 1602) 1881) 2067) 369_C12 SSYGMN WVANINYNGGYKG ARGATWHDTHLD LTYLNWY LLIYAATSRH QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1696) 1789) NO: NO: 1975) NO: 1603) 1882) 2068) 369_D08 SDYSMN WVASINYNGGYKG ARGATWHDTHLD LTYLNWY LLIYAATSRA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1697) 1790) NO: NO: 1976) NO: 1604) 1883) 2069) 369_E05 SDYGMN WVANINYNGGYKS ARGATWHDTHLD LTYLNWY LLIYAATSLA QQSYETPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1698) 1791) NO: NO: 1977) NO: 1605) 1884) 2070) 369_E08 SSYSMN WVASINYNSGYTG ARGATWHDTHLD LTYVNWY LLIYAATSRA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1699) 1792) NO: NO: 1978) NO: 1606) 1885) 2071) 369_F05 SSYSMN WVSGINYNGGYKS ARGATWHDTHLD SSYLNWY LLIYAASSLQ QQGYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1700) 1793) NO: NO: 1979) NO: 1607) 1886) 2072) 369_F09 SSYGMH WVAGINYNGGYTS ARGATWHDTHLD LTYVNWY LLIYAATSRA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1701) 1794) NO: NO: 1980) NO: 1608) 1887) 2073) 369_G05 SSYSMN WVAGINYNGGYTS ARGATWHDTHLD VSYLNWY LLIYAATSRH QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1702) 1795) NO: NO: 1981) NO: 1609) 1888) 2074) 369_H02 DDYSMN WVSNINYNGGYKS ARGATWHDTHLD ISYLNWY LLIYAATSRA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1703) 1796) NO: NO: 1982) NO: 1610) 1889) 2075) 369_H08 SSYSMN WVAGINYNSGYKS ARGATWHDTHLD LSYVNWY LVIYAATSLA QQSYESPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1704) 1797) NO: NO: 1983) NO: 1611) 1890) 2076) 369_H12 SSYSMN WVAGINYNGGYKS ARGATWHDTHLD VTYVNWY LVIYAATSRA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1705) 1798) NO: NO: 1984) NO: 1612) 1891) 2077) 370_B08 SDYSMN WVANINYNGGYTG ARGATWHDTHLD LSYLNWY LLIYAASSLQ QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1706) 1799) NO: NO: 1985) NO: 1613) 1892) 2078) 370_C06 SSYSMN WVANINYNGGYKS ARGATWHDTHLD LTYVNWY LLIYAASSLQ QQSYSTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1707) 1800) NO: NO: 1986) NO: 1614) 1893) 2079) 370_C07 SSYSMN WVANINYNGGYKS ARGATWHDTHLD LSYLNWY LLIYAATSRH QQSYESPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1708) 1801) NO: NO: 1987) NO: 1615) 1894) 2080) 370_C10 DSYSMN WVSNINYNSGYKG ARGATWHDTHLD VSYVNWY LLIYATTSRA QQSYSSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1709) 1802) NO: NO: 1988) NO: 1616) 1895) 2081) 370_D03 SSYSMN WVASINYNGGYTS ARGATWHDTHLD ITYLNWY LLIYAATSRA QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1710) 1803) NO: NO: 1989) NO: 1617) 1896) 2082) 370_D09 SDYSMN WVSGINYNSGYTS ARGATWHDTHLD VTYLNWY LVIYAATSRA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1711) 1804) NO: NO: 1990) NO: 1618) 1897) 2083) 370_E04 SSYSMN WVANINYNGGYKG ARGATWHDTHLD LTYLNWY LLIYAVTSLH QQSYETPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1712) 1805) NO: NO: 1991) NO: 1619) 1898) 2084) 370_E05 SSYGMN WVSNINYNGGYKG ARGATWHDTHLD STYLNWY LVIYAVTSRA QQSYNSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1713) 1806) NO: NO: 1992) NO: 1620) 1899) 2085) 370_F01 SSYGMN WVSNINYNGGYTS ARGATWHDTHLD VSYLNWY LLIYAATSRA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1714) 1807) NO: NO: 1993) NO: 1621) 1900) 2086) 370_F02 DSYGMN WVANINYNGGYTG ARGATWHDTHLD LSYLNWY LLIYAVTSRH QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1715) 1808) NO: NO: 1994) NO: 1622) 1901) 2087) 370_F12 SDYSMN WVANINYNGGYTG ARGATWHDTHLD LSYLNWY LLIYAASSLQ QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1716) 1809) NO: NO: 1995) NO: 1623) 1902) 2088) 370_G08 SDYSMN WVAGINYNGGYTG ARGATWHDTHLD LTYLNWY LVIYAATSRA QQSYESPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1717) 1810) NO: NO: 1996) NO: 1624) 1903) 2089) 370_H04 SSYSMN WVSNINYNGGYTG ARGATWHDTHLD LSYVNWY LLIYAATSRA QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1718) 1811) NO: NO: 1997) NO: 1625) 1904) 2090) 370_H06 DDYSMN WVANINYNGGYTG ARGATWHDTHLD LTYLNWY LLIYAATSRA QQSYETPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1719) 1812) NO: NO: 1998) NO: 1626) 1905) 2091) 371_B01 DSYSMN WVSNINYNSGYTG ARGATWHDTHLD LSYVNWY LLIYAATSLA QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1720) 1813) NO: NO: 1999) NO: 1627) 1906) 2092) 371_C06 SSYSMN WVSSINYNGGYTS ARGATWHDTHLD SSYLNWY LLIYAVTSRA QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1721) 1814) NO: NO: 2000) NO: 1628) 1907) 2093) 371_C07 DSYGMN WVSNINYNGGYTG ARGATWHDTALD LSYLNWY LLIYAATSLA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1722) 1815) NO: NO: 2001) NO: 1629) 1908) 2094) 371_E05 SSYSMN WVAGINYNGGYTS ARGATWHDTHLD ISYLNWY LVIYAATSRA QQSYSSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1723) 1816) NO: NO: 2002) NO: 1630) 1909) 2095) 371_E08 SSYSMN WVSNINYNSGYKS ARGATWHDTHLD VSYVNWY LVIYAATSRH QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1724) 1817) NO: NO: 2003) NO: 1631) 1910) 2096) 371_E09 SDYSMN WVSGINYNSGYTS ARGATWHDTHLD LTYLNWY LLIYAATSRA QQSYNSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1725) 1818) NO: NO: 2004) NO: 1632) 1911) 2097) 371_E12 DSYSMN WVSGINYNSGYKS ARGATWHDTHLD LSYLNWY LLIYAATSLA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1726) 1819) NO: NO: 2005) NO: 1633) 1912) 2098) 371_F03 SSYSMN WVSGINYNGGYTS ARGATWHDTHLD ITYLNWY LLIYAATSLH QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1727) 1820) NO: NO: 2006) NO: 1634) 1913) 2099) 371_F09 SSYSMN WVAGINYNGGYTS ARGATWHDTHLD LTYLNWY LLIYAATSRA QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1728) 1821) NO: NO: 2007) NO: 1635) 1914) 2100) 371_G01 SDYSMN WVSNINYNGGYTS ARGATWHDTHLD LTYLNWY LLIYAATSLA QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1729) 1822) NO: NO: 2008) NO: 1636) 1915) 2101) 371_H11 SSYSMN WVSGINYNGGYKG ARGATWHDTHLD LTYLNWY LLIYATTSRH QQSYESPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1730) 1823) NO: NO: 2009) NO: 1637) 1916) 2102) 372_B09 SSYSMN WVSSINYNSGYTS ARGATWHDTHLD LTYLNWY LLIYAATSRA QQSYETPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1731) 1824) NO: NO: 2010) NO: 1638) 1917) 2103) 372_E08 SDYSMN WVSNINYNGGYTS ARGATWHDTHLD ITYLNWY LLIYAATSRA QQSYNLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1732) 1825) NO: NO: 2011) NO: 1639) 1918) 2104) 372_F02 SSYGMH WVASINYNGGYTS ARGATWHDTHLD LTYLNWY LVIYAATSRH QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1733) 1826) NO: NO: 2012) NO: 1640) 1919) 2105) 372_H11 SSYGMH WVAGINYNGGYTS ARGATWHDTHLD LSYVNWY LLIYAATSRA QQSYENPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1734) 1827) NO: NO: 2013) NO: 1641) 1920) 2106) 373_A06 SSYSMN WVSGINYNGGYKS ARGATWHDTHLD VTYLNWY LLIYAASSLQ QQSYSTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1735) 1828) NO: NO: 2014) NO: 1642) 1921) 2107) 373_B09 DSYSMN WVSGINYNGGYKS ARGATWHDTHLD LSYLNWY LVIYAATSLA QQSYETPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1736) 1829) NO: NO: 2015) NO: 1643) 1922) 2108) 373_D06 SSYSMN WVAGINYNGGYTS ARGATWHDTHLD VTYLNWY LLIYAATSRA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1737) 1830) NO: NO: 2016) NO: 1644) 1923) 2109) 373_F07 SSYSMN WVSGINYNSGYKS ARGATWHDTHLD LSYLNWY LLIYAATSLA QQSYETPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1738) 1831) NO: NO: 2017) NO: 1645) 1924) 2110) 373_G02 SSYSMN WVSGINYNGGYTS ARGATWHDTHLD ITYLNWY LLIYAATSRA QQSYSSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1739) 1832) NO: NO: 2018) NO: 1646) 1925) 2111) 374_A04 SSYSMN WVAGINYNGGYTS ARGATWHDTHLD LTYLNWY LVIYAATSRA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1740) 1833) NO: NO: 2019) NO: 1647) 1926) 2112) 374_A05 SDYGMN WVANINYNGGYKG ARGATWHDTHLD VRYLNWY LVIYAATSLA QQSYELPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1741) 1834) NO: NO: 2020) NO: 1648) 1927) 2113) 374_C10 SSYSMN WVSSINYNGGYKG ARGATWHDTHLD VTYLNWY LLIYAATSLA QQSYNTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1742) 1835) NO: NO: 2021) NO: 1649) 1928) 2114) 374_D04 SSYSMN WVAGINYNGGYTS ARGATWHDTHLD LSYLNWY LVIYAATSRH QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1743) 1836) NO: NO: 2022) NO: 1650) 1929) 2115) 374_D09 DSYGMN WVANINYNGGYKG ARGATWHDTHLD ISYVNWY LLIYAATSLA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1744) 1837) NO: NO: 2023) NO: 1651) 1930) 2116) 374_G05 SSYSMN WVSNINYNSGYKG ARGATWHDTHLD ISYLNWY LLIYAATSRA QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1745) 1838) NO: NO: 2024) NO: 1652) 1931) 2117) 374_H05 SSYSMN WVAGINYNGGYTS ARGATWHDTHLD LSYVNWY LVIYAATSRA QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1746) 1839) NO: NO: 2025) NO: 1653) 1932) 2118) 375_A03 DSYSMN WVAGINYNGGYTS ARGATWHDTHLD LTYLNWY LLIYAATSRH QQSYDNPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1747) 1840) NO: NO: 2026) NO: 1654) 1933) 2119) 375_B03 SSYSMN WVAGINYNGGYTS ARGATWHDTHLD LTYLNWY LLIYAATSRA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1748) 1841) NO: NO: 2027) NO: 1655) 1934) 2120) 375_C01 SSYGMN WVSSINYNGGYKG ARGATWHDTHLD SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1749) 1842) NO: NO: 2028) NO: 1656) 1935) 2121) 375_C11 SSYSMN WVSSINYNGGYTS ARGATWHDTHLD LSYVNWY LLIYAATSRH QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1750) 1843) NO: NO: 2029) NO: 1657) 1936) 2122) 375_F10 SSYSMN WVSGINYNGGYTG ARGATWHDTHLD LTYLNWY LVIYAATSRA QQSYDTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1751) 1844) NO: NO: 2030) NO: 1658) 1937) 2123) 375_H08 SSYSMN WVSGINYNGGYTS ARGATWHDTHLD LTYLNWY LLIYAATSLA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1752) 1845) NO: NO: 2031) NO: 1659) 1938) 2124) 376_A02 SSYSMN WVAGINYNGGYKS ARGATWHDTHLD LSYLNWY LLIYAATSRA QQSYDLPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1753) 1846) NO: NO: 2032) NO: 1660) 1939) 2125) 376_A05 SSYSMN WVAGINYNSGYKG ARGATWHDTHLD LTYLNWY LLIYAATSRA QQSYNTPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1754) 1847) NO: NO: 2033) NO: 1661) 1940) 2126) 376_A07 SSYSMN WVSGINYNGGYKS ARGATWHDTHLD LTYLNWY LLIYAATSRA QQSYDSPL (SEQ (SEQ ID NO: (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID ID NO: 1755) 1848) NO: NO: 2034) NO: 1662) 1941) 2127)

The consensus sequences for each of these CDRs shown in FIG. 3D are as follows:

HCDR1: (SEQ ID NO: 6574) S/DS/DYS/GMN/H HCDR2: (SEQ ID NO: 6575) WVA/SG/N/SINYNG/SGYT/KS/G HCDR3: (SEQ ID NO: 6595) ARGATWHDTH/ALD LCDR1: (SEQ ID NO: 6596) L/I/V/SS/TYL/VNWY LCDR2: (SEQ ID NO: 6571) LL/VIYAA/V/TT/SSR/LA/H/Q LCDR3: (SEQ ID NO: 6577) QQSY/DD/E/S/NT/S/N/LPL

TABLE 2E Group V Antibody Sequences Ab VH sequence VL sequence 365_A03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2376) GTLVTVSS (SEQ ID NO: 2128) 365_A11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDDYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2377) GTLVTVSS (SEQ ID NO: 2129) 365_A12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYGMHWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCAKSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2378) GTLVTVSS (SEQ ID NO: 2130) 365_B01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYVN FDSYGMHWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2379) GTLVTVSS (SEQ ID NO: 2131) 365_B06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYGMHWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYATTSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2380) GTLVTVSS (SEQ ID NO: 2132) 365_B07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYGMHWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2381) GTLVTVSS (SEQ ID NO: 2133) 365_B11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FSSYGMHWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYATTSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2382) GTLVTVSS (SEQ ID NO: 2134) 365_C01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FDSYGMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2383) GTLVTVSS (SEQ ID NO: 2135) 365_C10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYGMHWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2384) GTLVTVSS (SEQ ID NO: 2136) 365_C11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2385) GTLVTVSS (SEQ ID NO: 2137) 365_C12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSSYGMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAVTSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2386) GTLVTVSS (SEQ ID NO: 2138) 365_D09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMHWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2387) GTLVTVSS (SEQ ID NO: 2139) 365_D11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FDSYGMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2388) GTLVTVSS (SEQ ID NO: 2140) 365_D12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2389) GTLVTVSS (SEQ ID NO: 2141) 365_E01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FSDYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2390) GTLVTVSS (SEQ ID NO: 2142) 365_E05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSSYGMHWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2391) GTLVTVSS (SEQ ID NO: 2143) 365_E07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYGMHWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCAKSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2392) GTLVTVSS (SEQ ID NO: 2144) 365_E09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYGMHWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2393) GTLVTVSS (SEQ ID NO: 2145) 365_F01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2394) GTLVTVSS (SEQ ID NO: 2146) 365_F06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYGMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDNLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2395) GTLVTVSS (SEQ ID NO: 2147) 365_F12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSDYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2396) GTLVTVSS (SEQ ID NO: 2148) 365_G01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYGMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYATTSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2397) GTLVTVSS (SEQ ID NO: 2149) 365_G11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYVN FSSYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAVTSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2398) GTLVTVSS (SEQ ID NO: 2150) 365_H02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSDYGMNWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2399) GTLVTVSS (SEQ ID NO: 2151) 365_H03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDDYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSLHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2400) GTLVTVSS (SEQ ID NO: 2152) 365_H06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYVN FSSYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2401) GTLVTVSS (SEQ ID NO: 2153) 365_H10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVN FDSYGMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2402) GTLVTVSS (SEQ ID NO: 2154) 365_H11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2403) GTLVTVSS (SEQ ID NO: 2155) 365_H12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYVN FSSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2404) GTLVTVSS (SEQ ID NO: 2156) 366_A07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSSYGMHWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2405) GTLVTVSS (SEQ ID NO: 2157) 366_B08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2406) GTLVTVSS (SEQ ID NO: 2158) 366_B10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FSSYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2407) GTLVTVSS (SEQ ID NO: 2159) 366_B12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2408) GTLVTVSS (SEQ ID NO: 2160) 366_D04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYVN FSSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYATTSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2409) GTLVTVSS (SEQ ID NO: 2161) 366_E10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYGMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2410) GTLVTVSS (SEQ ID NO: 2162) 366_F04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSDYGMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYATTSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2411) GTLVTVSS (SEQ ID NO: 2163) 366_F05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDNTPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2412) GTLVTVSS (SEQ ID NO: 2164) 366_F07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN FSDYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2413) GTLVTVSS (SEQ ID NO: 2165) EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN 366_G04 FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2414) GTLVTVSS (SEQ ID NO: 2166) EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN 366_G05 FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2415) GTLVTVSS (SEQ ID NO: 2167) 366_H06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMNWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLLIYATTSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2416) GTLVTVSS (SEQ ID NO: 2168) 366_H07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FSSYGMHWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2417) GTLVTVSS (SEQ ID NO: 2169) 366_H08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSDYGMNWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2418) GTLVTVSS (SEQ ID NO: 2170) 366_H09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FDSYGMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2419) GTLVTVSS (SEQ ID NO: 2171) 367_A04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN FSSYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2420) GTLVTVSS (SEQ ID NO: 2172) 367_A05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSDYGMNWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2421) GTLVTVSS (SEQ ID NO: 2173) 367_B02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FDSYGMNWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2422) GTLVTVSS (SEQ ID NO: 2174) 367_B03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2423) GTLVTVSS (SEQ ID NO: 2175) 367_B07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FSDYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2424) GTLVTVSS (SEQ ID NO: 2176) 367_B08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSDYGMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2425) GTLVTVSS (SEQ ID NO: 2177) 367_C01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDDYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYATTSLHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2426) GTLVTVSS (SEQ ID NO: 2178) 367_C05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDDYGMNWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2427) GTLVTVSS (SEQ ID NO: 2179) 367_C11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2428) GTLVTVSS (SEQ ID NO: 2180) 367_D10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2429) GTLVTVSS (SEQ ID NO: 2181) 367_E01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYATTSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2430) GTLVTVSS (SEQ ID NO: 2182) 367_E04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSDYSMNWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2431) GTLVTVSS (SEQ ID NO: 2183) 367_E06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN FDSYSMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2432) GTLVTVSS (SEQ ID NO: 2184) 367_E09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSDYGMNWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2433) GTLVTVSS (SEQ ID NO: 2185) 367_E11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FDSYGMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2434) GTLVTVSS (SEQ ID NO: 2186) 367_F03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2435) GTLVTVSS (SEQ ID NO: 2187) 367_F07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FDSYGMHWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2436) GTLVTVSS (SEQ ID NO: 2188) 367_F11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2437) GTLVTVSS (SEQ ID NO: 2189) 367_G05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FSDYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2438) GTLVTVSS (SEQ ID NO: 2190) 367_G06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYATTSLHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2439) GTLVTVSS (SEQ ID NO: 2191) 367_G10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FDDYGMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2440) GTLVTVSS (SEQ ID NO: 2192) 367_H06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN FSSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2441) GTLVTVSS (SEQ ID NO: 2193) 367_H11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2442) GTLVTVSS (SEQ ID NO: 2194) 368_A01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FSSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2443) GTLVTVSS (SEQ ID NO: 2195) 368_A05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2444) GTLVTVSS (SEQ ID NO: 2196) 368_A07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSNELPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2445) GTLVTVSS (SEQ ID NO: 2197) 368_A09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2446) GTLVTVSS (SEQ ID NO: 2198) 368_B01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN FSSYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2447) GTLVTVSS (SEQ ID NO: 2199) 368_B06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FDSYGMHWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2448) GTLVTVSS (SEQ ID NO: 2200) 368_B07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FSDYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2449) GTLVTVSS (SEQ ID NO: 2201) 368_C05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDSNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2450) GTLVTVSS (SEQ ID NO: 2202) 368_D01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMHWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDSTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2451) GTLVTVSS (SEQ ID NO: 2203) 368_D04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISTYVN FSSYGMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAVTSRHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2452) GTLVTVSS (SEQ ID NO: 2204) 368_D05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2453) GTLVTVSS (SEQ ID NO: 2205) 368_D11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDDYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2454) GTLVTVSS (SEQ ID NO: 2206) 368_E01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLLIYAVTSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2455) GTLVTVSS (SEQ ID NO: 2207) 368_E02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2456) GTLVTVSS (SEQ ID NO: 2208) 368_E04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2457) GTLVTVSS (SEQ ID NO: 2209) 368_E06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSDYGMHWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYGATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2458) GTLVTVSS (SEQ ID NO: 2210) 368_E07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCAKSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2459) GTLVTVSS (SEQ ID NO: 2211) 368_F03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCAKSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2460) GTLVTVSS (SEQ ID NO: 2212) 368_F11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSDYGMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2461) GTLVTVSS (SEQ ID NO: 2213) 368_G01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSDYGMHWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2462) GTLVTVSS (SEQ ID NO: 2214) 368_G12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYVN FSSYGMNWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2463) GTLVTVSS (SEQ ID NO: 2215) 368_H04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCAKSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2464) GTLVTVSS (SEQ ID NO: 2216) 369_A02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2465) GTLVTVSS (SEQ ID NO: 2217) 369_A03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAVTSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQGYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2466) GTLVTVSS (SEQ ID NO: 2218) 369_B01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2467) GTLVTVSS (SEQ ID NO: 2219) 369_C02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2468) GTLVTVSS (SEQ ID NO: 2220) 369_C03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2469) GTLVTVSS (SEQ ID NO: 2221) 369_C04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYTTTSLHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2470) GTLVTVSS (SEQ ID NO: 2222) 369_D01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSDYGMNWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2471) GTLVTVSS (SEQ ID NO: 2223) 369_D02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSDYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2472) GTLVTVSS (SEQ ID NO: 2224) 369_D04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYGMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2473) GTLVTVSS (SEQ ID NO: 2225) 369_D12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2474) GTLVTVSS (SEQ ID NO: 2226) 369_E02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYATTSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2475) GTLVTVSS (SEQ ID NO: 2227) 369_E11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FSSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2476) GTLVTVSS (SEQ ID NO: 2228) 369_E12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FSSYGMHWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2477) GTLVTVSS (SEQ ID NO: 2229) 369_F01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYGMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2478) GTLVTVSS (SEQ ID NO: 2230) 369_F02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FSSYGMNWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2479) GTLVTVSS (SEQ ID NO: 2231) 369_F03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSDYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2480) GTLVTVSS (SEQ ID NO: 2232) 369_F06 EVQLLESGGGLVQPGGSLRLSCAASGFT FDDYSMNWVRQAPGKGLEWVAGINYNGG DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN YKGYADSVKGRFTISRDNSKNTLYLQMN WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG SLRAEDTAVYYCARSANWHDTALDYWGQ TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT GTLVTVSS (SEQ ID NO: 2233) KVEIK (SEQ ID NO: 2481) 369_F10 EVQLLESGGGLVQPGGSLRLSCAASGFT FDSYGMNWVRQAPGKGLEWVSNINYNSG DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN YKSYADSVKGRFTISRDNSKNTLYLQMN WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG SLRAEDTAVYYCARSANWHDTALDYWGQ TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT GTLVTVSS (SEQ ID NO: 2234) KVEIK (SEQ ID NO: 2482) 369_F11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FDSYGMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2483) GTLVTVSS (SEQ ID NO: 2235) 369_G01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2484) GTLVTVSS (SEQ ID NO: 2236) 369_G04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYATTSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2485) GTLVTVSS (SEQ ID NO: 2237) 369_G06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2486) GTLVTVSS (SEQ ID NO: 2238) 369_G11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2487) GTLVTVSS (SEQ ID NO: 2239) 369_G12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDNTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2488) GTLVTVSS (SEQ ID NO: 2240) 369_H05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSSYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2489) GTLVTVSS (SEQ ID NO: 2241) 369_H06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSSYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2490) GTLVTVSS (SEQ ID NO: 2242) 369_H09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDDYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAVTSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2491) GTLVTVSS (SEQ ID NO: 2243) 370_A01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISTYLN FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2492) GTLVTVSS (SEQ ID NO: 2244) 370_A03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2493) GTLVTVSS (SEQ ID NO: 2245) 370_A04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN FDSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2494) GTLVTVSS (SEQ ID NO: 2246) 370_A12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2495) GTLVTVSS (SEQ ID NO: 2247) 370_C01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2496) GTLVTVSS (SEQ ID NO: 2248) 370_C03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYYVTNRQSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2497) GTLVTVSS (SEQ ID NO: 2249) 370_C05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2498) GTLVTVSS (SEQ ID NO: 2250) 370_C08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISNYLN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2499) GTLVTVSS (SEQ ID NO: 2251) 370_C09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FDSYGMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2500) GTLVTVSS (SEQ ID NO: 2252) 370_D04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2501) GTLVTVSS (SEQ ID NO: 2253) 370_D11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FDSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2502) GTLVTVSS (SEQ ID NO: 2254) 370_E03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYGMNWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLVIYYASNRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2503) GTLVTVSS (SEQ ID NO: 2255) 370_E06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYATTSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2504) GTLVTVSS (SEQ ID NO: 2256) 370_E09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDDSSMHWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCAKSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2505) GTLVTVSS (SEQ ID NO: 2257) 370_F05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSSYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2506) GTLVTVSS (SEQ ID NO: 2258) 370_F07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2507) GTLVTVSS (SEQ ID NO: 2259) 370_F10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2508) GTLVTVSS (SEQ ID NO: 2260) 370_G02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FSDYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2509) GTLVTVSS (SEQ ID NO: 2261) 370_G03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2510) GTLVTVSS (SEQ ID NO: 2262) 370_G06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSDYGMHWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDNTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2511) GTLVTVSS (SEQ ID NO: 2263) 370_G09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2512) GTLVTVSS (SEQ ID NO: 2264) 370_G10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN FSDYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYVVNNRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2513) GTLVTVSS (SEQ ID NO: 2265) 370_G11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FSSYSMNWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2514) GTLVTVSS (SEQ ID NO: 2266) 370_H01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2515) GTLVTVSS (SEQ ID NO: 2267) 370_H09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSSYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2516) GTLVTVSS (SEQ ID NO: 2268) 371_A03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSDYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2517) GTLVTVSS (SEQ ID NO: 2269) 371_A06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2518) GTLVTVSS (SEQ ID NO: 2270) 371_A07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSDYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2519) GTLVTVSS (SEQ ID NO: 2271) 371_A08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMHWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2520) GTLVTVSS (SEQ ID NO: 2272) 371_A12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2521) GTLVTVSS (SEQ ID NO: 2273) 371_B06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2522) GTLVTVSS (SEQ ID NO: 2274) 371_B07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2523) GTLVTVSS (SEQ ID NO: 2275) 371_C03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2524) GTLVTVSS (SEQ ID NO: 2276) 371_D06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FDDYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2525) GTLVTVSS (SEQ ID NO: 2277) 371_D09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2526) GTLVTVSS (SEQ ID NO: 2278) 371_F01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2527) GTLVTVSS (SEQ ID NO: 2279) 371_F04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2528) GTLVTVSS (SEQ ID NO: 2280) 371_F06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FDSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2529) GTLVTVSS (SEQ ID NO: 2281) 371_F08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FDDYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2530) GTLVTVSS (SEQ ID NO: 2282) 371_G05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2531) GTLVTVSS (SEQ ID NO: 2283) 371_G10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYVN FSSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2532) GTLVTVSS (SEQ ID NO: 2284) 371_H09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2533) GTLVTVSS (SEQ ID NO: 2285) 372_A04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2534) GTLVTVSS (SEQ ID NO: 2286) 372_B04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2535) GTLVTVSS (SEQ ID NO: 2287) 372_C07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSDYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDNTPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2536) GTLVTVSS (SEQ ID NO: 2288) 372_D02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYGMHWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2537) GTLVTVSS (SEQ ID NO: 2289) 372_F03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2538) GTLVTVSS (SEQ ID NO: 2290) 372_F06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSDYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2539) GTLVTVSS (SEQ ID NO: 2291) 372_F08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSDYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2540) GTLVTVSS (SEQ ID NO: 2292) 372_F09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2541) GTLVTVSS (SEQ ID NO: 2293) 373_A02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYGMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYATTSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2542) GTLVTVSS (SEQ ID NO: 2294) 373_A08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2543) GTLVTVSS (SEQ ID NO: 2295) 373_A10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2544) GTLVTVSS (SEQ ID NO: 2296) 373_B04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYGMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2545) GTLVTVSS (SEQ ID NO: 2297) 373_B06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSDYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2546) GTLVTVSS (SEQ ID NO: 2298) 373_B10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2547) GTLVTVSS (SEQ ID NO: 2299) 373_B12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FDSYGMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2548) GTLVTVSS (SEQ ID NO: 2300) 373_C02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDDYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2549) GTLVTVSS (SEQ ID NO: 2301) 373_C04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FSSYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2550) GTLVTVSS (SEQ ID NO: 2302) 373_C06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2551) GTLVTVSS (SEQ ID NO: 2303) 373_C08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FSSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2552) GTLVTVSS (SEQ ID NO: 2304) 373_C11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2553) GTLVTVSS (SEQ ID NO: 2305) 373_D01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2554) GTLVTVSS (SEQ ID NO: 2306) 373_D04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2555) GTLVTVSS (SEQ ID NO: 2307) 373_D05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2556) GTLVTVSS (SEQ ID NO: 2308) 373_D08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2557) GTLVTVSS (SEQ ID NO: 2309) 373_D10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2558) GTLVTVSS (SEQ ID NO: 2310) 373_E01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSSYGMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2559) GTLVTVSS (SEQ ID NO: 2311) 373_B05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2560) GTLVTVSS (SEQ ID NO: 2312) 373_E07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2561) GTLVTVSS (SEQ ID NO: 2313) 373_E12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2562) GTLVTVSS (SEQ ID NO: 2314) 373_G10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSDYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2563) GTLVTVSS (SEQ ID NO: 2315) 373_G12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYATTSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2564) GTLVTVSS (SEQ ID NO: 2316) 373_H01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2565) GTLVTVSS (SEQ ID NO: 2317) 373_H05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSDYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2566) GTLVTVSS (SEQ ID NO: 2318) 374_A07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2567) GTLVTVSS (SEQ ID NO: 2319) 374_B04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FSSYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2568) GTLVTVSS (SEQ ID NO: 2320) 374_B06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2569) GTLVTVSS (SEQ ID NO: 2321) 374_B12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN FDSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2570) GTLVTVSS (SEQ ID NO: 2322) 374_C03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2571) GTLVTVSS (SEQ ID NO: 2323) 374_C06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDDYSMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2572) GTLVTVSS (SEQ ID NO: 2324) 374_D01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYVN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2573) GTLVTVSS (SEQ ID NO: 2325) 374_D08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2574) GTLVTVSS (SEQ ID NO: 2326) 374_E01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYVN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2575) GTLVTVSS (SEQ ID NO: 2327) 374_E02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2576) GTLVTVSS (SEQ ID NO: 2328) 374_E05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSFVN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2577) GTLVTVSS (SEQ ID NO: 2329) 374_E07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYVN FSDYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2578) GTLVTVSS (SEQ ID NO: 2330) 374_E08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2579) GTLVTVSS (SEQ ID NO: 2331) 374_E11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FSSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2580) GTLVTVSS (SEQ ID NO: 2332) 374_F01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2581) GTLVTVSS (SEQ ID NO: 2333) 374_F02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FDSYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2582) GTLVTVSS (SEQ ID NO: 2334) 374_F04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2583) GTLVTVSS (SEQ ID NO: 2335) 374_F10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2584) GTLVTVSS (SEQ ID NO: 2336) 374_F11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAVTSLASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2585) GTLVTVSS (SEQ ID NO: 2337) 374_G04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2586) GTLVTVSS (SEQ ID NO: 2338) 374_G06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMHWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2587) GTLVTVSS (SEQ ID NO: 2339) 374_G07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2588) GTLVTVSS (SEQ ID NO: 2340) 374_H03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2589) GTLVTVSS (SEQ ID NO: 2341) 374_H04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2590) GTLVTVSS (SEQ ID NO: 2342) 374_H06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2591) GTLVTVSS (SEQ ID NO: 2343) 374_H07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2592) GTLVTVSS (SEQ ID NO: 2344) 374_H09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLVIYAVTSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2593) GTLVTVSS (SEQ ID NO: 2345) 375_A05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2594) GTLVTVSS (SEQ ID NO: 2346) 375_C06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDDYGMHWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2595) GTLVTVSS (SEQ ID NO: 2347) 375_D04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDDSSMHWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCAKSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2596) GTLVTVSS (SEQ ID NO: 2348) 375_D05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FSSYSMNWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTHLDYWGQ KVEIK (SEQ ID NO: 2597) GTLVTVSS (SEQ ID NO: 2349) 375_D07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN FSSYGMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2598) GTLVTVSS (SEQ ID NO: 2350) 375_D08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN FSDYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2599) GTLVTVSS (SEQ ID NO: 2351) 375_D12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYGMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2600) GTLVTVSS (SEQ ID NO: 2352) 375_E01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2601) GTLVTVSS (SEQ ID NO: 2353) 375_E07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FSDYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYVVTNRESGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2602) GTLVTVSS (SEQ ID NO: 2354) 375_H12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYYVTNRQSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSIPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2603) GTLVTVSS (SEQ ID NO: 2355) 376_A04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FDSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2604) GTLVTVSS (SEQ ID NO: 2356) 376_A10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSDYGMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2605) GTLVTVSS (SEQ ID NO: 2357) 376_A12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2606) GTLVTVSS (SEQ ID NO: 2358) 376_B04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FDSYGMHWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2607) GTLVTVSS (SEQ ID NO: 2359) 376_B05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FSSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2608) GTLVTVSS (SEQ ID NO: 2360) 376_B09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2609) GTLVTVSS (SEQ ID NO: 2361) 376_B11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2610) GTLVTVSS (SEQ ID NO: 2362) 376_C01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2611) GTLVTVSS (SEQ ID NO: 2363) 376_C02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FDSYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2612) GTLVTVSS (SEQ ID NO: 2364) 376_C12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2613) GTLVTVSS (SEQ ID NO: 2365) 376_D05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2614) GTLVTVSS (SEQ ID NO: 2366) 376_D11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2615) GTLVTVSS (SEQ ID NO: 2367) 376_E03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2616) GTLVTVSS (SEQ ID NO: 2368) 376_E08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSDYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2617) GTLVTVSS (SEQ ID NO: 2369) 376_F03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYVN FDSYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYATTSLASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2618) GTLVTVSS (SEQ ID NO: 2370) 376_F04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN FDSYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2619) GTLVTVSS (SEQ ID NO: 2371) 376_G08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2620) GTLVTVSS (SEQ ID NO: 2372) 376_G09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISYYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2621) GTLVTVSS (SEQ ID NO: 2373) 376_H09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN FSDYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYYVSNLPSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2622) GTLVTVSS (SEQ ID NO: 2374) 376_H10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSANWHDTALDYWGQ KVEIK (SEQ ID NO: 2623) GTLVTVSS (SEQ ID NO: 2375)

Table 3E provides the amino acid sequences of the CDRs of the antibodies shown in Table 2E.

TABLE 3E CDR sequences for Group V antibodies Ab HCDR1 HCDR2 HCDR3 LCDR1 LCDR2 LCDR3 365_A03 SSYSMN WVAGINYNSGYKG ARSANWHDTALD LSYLNWY LVIYAVTSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2624) NO: 2872) NO: 3120) NO: 3368) NO: 3616) NO: 3864) 365_A11 DDYGMN WVSGINYNSGYTS ARSANWHDTALD LSYLNWY LVIYAATSLA QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2625) NO: 2873) NO: 3121) NO: 3369) NO: 3617) NO: 3865) 365_A12 SSYGMH WVAGINYNGGYTS AKSANWHDTHLD LTYVNWY LLIYAATSRH QQSYENPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2626) NO: 2874) NO: 3122) NO: 3370) NO: 3618) NO: 3866) 365_B01 DSYGMH WVASINYNSGYTS ARSANWHDTALD SSYVNWY LVIYAATSRA QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2627) NO: 2875) NO: 3123) NO: 3371) NO: 3619) NO: 3867) 365_B06 DSYGMH WVSNINYNGGYKS ARSANWHDTALD LTYVNWY LLIYATTSLA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2628) NO: 2876) NO: 3124) NO: 3372) NO: 3620) NO: 3868) 365_B07 SSYGMH WVASINYNSGYTS ARSANWHDTALD LTYLNWY LLIYAATSRA QQSYENPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2629) NO: 2877) NO: 3125) NO: 3373) NO: 3621) NO: 3869) 365_B11 SSYGMH WVAGINYNGGYTS ARSABWGDTALD ISYLNWY LVIYATTSRH QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2630) NO: 2878) NO: 3126) NO: 3374) NO: 3622) NO: 3870) 365_C01 DSYGMN WVSSINYNSGYKS ARSANWHDTHLD VSYLNWY LVIYAVTSRA QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2631) NO: 2879) NO: 3127) NO: 3375) NO: 3623) NO: 3871) 365_C10 SSYGMH WVASINYNGGYTS ARSANWHDTALD LSYVNWY LLIYAATSLA QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2632) NO: 2880) NO: 3128) NO: 3376) NO: 3624) NO: 3872) 365_C11 SSYSMN WVAGINYNGGYKS ARSANWHDTHLD ITYLNWY LVIYAVTSRA QQSYSLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2633) NO: 2881) NO: 3129) NO: 3377) NO: 3625) NO: 3873) 365_C12 SSYGMN WVAGINYNSGYKS ARSANWHDTALD VSYVNWY LVIYAVTSLA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2634) NO: 2882) NO: 3130) NO: 3378) NO: 2626) NO: 3874) 365_D09 SSYGMH WVSGINYNSGYTS ARSANWHDTALD LSYLNWY LLIYAATSRA QQSDESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2635) NO: 2883) NO: 3131) NO: 3379) NO: 3627) NO: 3875) 365_D11 DSYGMN WVSNINYNSGYTS ARSANWHDTALD VSYLNWY LVIYAATSRA QQSYSSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2636) NO: 2884) NO: 3132) NO: 3380) NO: 3628) NO: 3876) 365_D12 DSYGMN WVSNINYNGGYTG ARSANWHDTALD VTYLNWY LVIYAATSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2637) NO: 2885) NO: 3133) NO: 3381) NO: 3629) NO: 3877) 365_E01 SDYSMN WVSGINYNSGYKG ARSANWHDTALD ISYLNWY LLIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2638) NO: 2886) NO: 3134) NO: 3382) NO: 3630) NO: 3878) 365_E05 SSYGMH WVAGINYNGGYTS ARSANWHDTALD VSYVNWY LLIYAATSLA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2639) NO: 2887) NO: 3135) NO: 3383) NO: 3631) NO: 3879) 365_E07 DSYGMH WVSGINYNSGYTS AKSANWHDTHLD LSYLNWY LLIYAATSRA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2640) NO: 2888) NO: 3136) NO: 3384) NO: 3632) NO: 3880) 365_E09 SSYGMH WVASINYNSGYKS ARSANWHDTALD LTYVNWY LVIYAATSRA QQSDDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2641) NO: 2889) NO: 3137) NO: 3385) NO: 3633) NO: 3881) 365_F01 DSYSMN WVSGINYNSGYKG ARSANWHDTHLD VSYLNWY LVIYAATSLA QQSYELPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2642) NO: 2890) NO: 3138) NO: 3386) NO: 3634) NO: 3882) 365_F06 SSYGMN WVAGINYNSGYKS ARSANWHDTALD LSYVNWY LLIYAATSRA QQSDNLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2643) NO: 2891) NO: 3139) NO: 3387) NO: 3635) NO: 3883) 365_F12 SDYSMN WVSGINYNGGYTS ARSANWHDTHLD LTYVNWY LVIYAATSRH QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2644) NO: 2892) NO: 3140) NO: 3388) NO: 3636) NO: 3884) 365_G01 DSYGMN WVAGINYNSGYKS ARSANWHDTALD LTYVNWY LLIYATTSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2645) NO: 2893) NO: 3141) NO: 3389) NO: 3637) NO: 3885) 365_G11 SSYGMN WVANINYNGGYTG ARSANWHDTALD ITYVNWY LLIYAVTSRH QQSYNSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2646) NO: 2894) NO: 3142) NO: 3390) NO: 3638) NO: 3886) 365_H02 SDYGMN WVSSINYNGGYTG ARSANWHDTHLD LTYLNWY LLIYAATSRA QQSYENPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2647) NO: 2895) NO: 3143) NO: 3391) NO: 3639) NO: 3887) 365_H03 DDYGMN WVAGINYNGGYKS ARSANWHDTALD LSYVNWY LVIYAATSLH QQSYNNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2648) NO: 2896) NO: 3144) NO: 3392) NO: 3640) NO: 3888) 365_H06 SSYGMN WVSGINYNSGYTG ARSANWHDTALD SSYVNWY LLIYAATSRA QQSYSTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2649) NO: 2897) NO: 3145) NO: 3393) NO: 3641) NO: 3889) 365_H10 DSYGMN WVAGINYNSGYKS ARSANWHDTHLD VTYVNWY LVIYAATSLA QQSYNTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2650) NO: 2898) NO: 3146) NO: 3394) NO: 3642) NO: 3890) 365_H11 SSYSMN WVSGINYNSGYTG ARSANWHDTALD LTYLNWY LLIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2651) NO: 2899) NO: 3147) NO: 3395) NO: 3643) NO: 3891) 365_H12 SSYSMN WVSNINYNGGYKS ARSANWHDTHLD ITYVNWY LLIYAATSRA QQSYSTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2652) NO: 2900) NO: 3148) NO: 3396) NO: 3644) NO: 3892) 366_A07 SSYGMH WVASINYNGGYTG ARSANWHDTALD VSYVNWY LVIYAATSRH QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2653) NO: 2901) NO: 3149) NO: 3397) NO: 3645) NO: 3893) 366_B08 DSYGMN WVSNINYNGGYKG ARSANWHDTHLD VSYLNWY LLIYAATSRH QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2654) NO: 2902) NO: 3150) NO: 3398) NO: 3646) NO: 3894) 366_B10 SSYGMN WVSGINYNSGYTS ARSANWHDTALD ISYLNWY LLIYAATSRA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2655) NO: 2903) NO: 3151) NO: 3399) NO: 3647) NO: 3895) 366_B12 SSYSMN WVAGINYNSGYKG ARSANWHDTALD LTYVNWY LLIYAATSRA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2656) NO: 2904) NO: 3152) NO: 3400) NO: 3648) NO: 3896) 366_D04 SSYSMN WVSGINYNGGYTS ARSANWHDTALD SSYVNWY LLIYATTSRA QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2657) NO: 2905) NO: 3153) NO: 3401) NO: 3649) NO: 3897) 366_E10 DSYGMN WVSGINYNGGYKG ARSANWHDTHLD LSYVNWY LVIYAATSRH QQSYSLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2658) NO: 2906) NO: 3154) NO: 3402) NO: 3650) NO: 3898) 366_F04 SDYGMN WVSGINYNGGYTS ARSANWHDTALD LSYVNWY LVIYATTSRH QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2659) NO: 2907) NO: 3155) NO: 3403) NO: 3651) NO: 3899) 366_F05 SSYSMN WVANINYNSGYKS ARSANWHDTHLD LTYLNWY LLIYAATSRA QQSDNTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2660) NO: 2908) NO: 3156) NO: 3404) NO: 3652) NO: 3900) 366_F07 SDYSMN WVAGINYNSGYTS ARSANWHDTHLD ITYLNWY LLIYAATSRA QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2661) NO: 2909) NO: 3157) NO: 3405) NO: 3653) NO: 3901) 366_G04 SSYSMN WVSGINYNSGYTS ARSANWHDTALD ITYLNWY LLIYAATSRA QQSDDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2662) NO: 2910) NO: 3158) NO: 3406) NO: 3654) NO: 3902) 366_G05 DSYGMN WVSNINYNGGYTS ARSANWHDTALD ISYVNWY LVIYAATSRA QQSYENPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2663) NO: 2911) NO: 3159) NO: 3407) NO: 3655) NO: 3903) 366_H06 SSYGMN WVSSINYNGGYTG ARSANWHDTALD LSYLNWY LLIYATTSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2664) NO: 2912) NO: 3160) NO: 3408) NO: 3656) NO: 3904) 366_H07 SSYGMH WVSGINYNGGYTS ARSANWHDTALD ISYVNWY LVIYAVTSRA QQSYENPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2665) NO: 2913) NO: 3161) NO: 3409) NO: 3657) NO: 3905) 366_H08 SDYGMN WVASINYNSGYTS ARSANWHDTHLD LSYVNWY LLIYAATSRH QQSYNNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2666) NO: 2914) NO: 3162) NO: 3410) NO: 3658) NO: 3906) 366_H09 DSYGMN WVSNINYNSGYKG ARSANWHDTALD VSYVNWY LVIYATTSRA QQSYSSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2667) NO: 2915) NO: 3163) NO: 3411) NO: 3659) NO: 3907) 367_A04 SSYSMN WVSNINYNSGYKS ARSANWHDTALD ITYLNWY LLIYAATSRA QQSDDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2668) NO: 2916) NO: 3164) NO: 3412) NO: 3660) NO: 3908) 367_A05 SDYGMN WVSSINYNGGYKG ARSANWHDTALD LSYLNWY LVIYAVTSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2669) NO: 2917) NO: 3165) NO: 3413) NO: 3661) NO: 3909) 367_B02 DSYGMN WVSSINYNGGYTS ARSANWHDTALD VTYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2670) NO: 2918) NO: 3166) NO: 3414) NO: 3662) NO: 3910) 367_B03 SSYGMN WVAGINYNGGYKS ARSANWHDTALD LTYLNWY LLIYAATSLA QQSYNLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2671) NO: 2919) NO: 3167) NO: 3415) NO: 3663) NO: 3911) 367_B07 SDYSMN WVAGINYNSGYTG ARSANWHDTHLD ISYVNWY LLIYAATSLA QQSYNLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2672) NO: 2920) NO: 3168) NO: 3416) NO: 3664) NO: 3912) 367_B08 SDYGMN WVSGINYNGGYKG ARSANWHDTALD LTYLNWY LVIYAATSRA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2673) NO: 2921) NO: 3169) NO: 3417) NO: 3665) NO: 3913) 367_C01 DDYSMN WVSGINYNGGYKS ARSANWHDTHLD LTYLNWY LVIYATTSLH QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2674) NO: 2922) NO: 3170) NO: 3418) NO: 3666) NO: 3914) 367_C05 DDYGMN WVSSINYNGGYTG ARSANWHDTHLD LSYVNWY LVIYAATSRH QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2675) NO: 2923) NO: 3171) NO: 3419) NO: 3667) NO: 3915) 367_C11 DSYSMN WVSSINYNSGYTG ARSANWHDTHLD LSYLNWY LVIYAATSRH QQSYNTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2676) NO: 2924) NO: 3172) NO: 3420) NO: 3668) NO: 3916) 367_D10 DSYGMN WVSNINYNGGYTS ARSANWHDTALD ISYLNWY LVIYAATSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2677) NO: 2925) NO: 3173) NO: 3421) NO: 3669) NO: 3917) 367_E01 SSYGMN WVAGINYNGGYKS ARSANWHDTALD LSYVNWY LLIYTTSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2678) NO: 2926) NO: 3174) NO: 3422) NO: 3670) NO: 3918) 367_E04 SDYSMN WVSSINYNGGYKG ARSANWHDTHLD LSYLNWY LLIYAATSRA QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2679) NO: 2927) NO: 3175) NO: 3423) NO: 3671) NO: 3919) 367_E06 DSYSMN WVSSINYNSGYKG ARSANWHDTHLD SYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2680) NO: 2928) NO: 3176) NO: 3424) NO: 3672) NO: 3920) 367_E09 SDYGMN WVASINYNSGYKG ARSANWHDTALD LSYLNWY LVIYATTSRA QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2681) NO: 2929) NO: 3177) NO: 3425) NO: 3673) NO: 3921) 367_E11 DSYGMN WVSSINYNSGYKG ARSANWHDTHLD VSYVNWY LVIYAATSRH QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2682) NO: 2930) NO: 3178) NO: 3426) NO: 3674) NO: 3922) 367_F03 SSYSMN WVAGINYNSGYKS ARSANWHDTALD LSYVNWY LVIYAATSLA QQSDDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2683) NO: 2931) NO: 3179) NO: 3427) NO: 3675) NO: 3923) 367_F07 DSYGMH WVANINYNGGYTG ARSANWHDTALD ISYVNWY LLIYAATSRA QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2684) NO: 2932) NO: 3180) NO: 3428) NO: 3676) NO: 3924) 367_F11 SSYSMN WVAGINYNSGYTG ARSANWHDTHLD SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2685) NO: 2933) NO: 3181) NO: 3429) NO: 3677) NO: 3925) 367_G05 SDYGMN WVANINYNGGYTS ARSANWHDTALD VSYLNWY LVIYAATSLA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2686) NO: 2934) NO: 3182) NO: 3430) NO: 3678) NO: 3926) 367_G06 SSYGMN WVSGINYNSGYKS ARSANWHDTHLD LTYVNWY LLIYATTSLH QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2687) NO: 2935) NO: 3183) NO: 3431) NO: 3679) NO: 3927) 367_G10 DDYGMN WVSGINYNGGYTS ARSANWHDTALD ISYVNWY LLIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2688) NO: 2936) NO: 3184) NO: 3432) NO: 3680) NO: 3928) 367_H06 SSYGMN WVSNINYNGGYTG ARSANWHDTHLD ITYLNWY LLIYAATSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2689) NO: 2937) NO: 3185) NO: 3433) NO: 3681) NO: 3929) 367_H11 SSYGMN WVAINYNGGYKG ARSANWHDTALD ISYVNWY LVIYAATSRA QQSYNSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2690) NO: 2938) NO: 3186) NO: 3434) NO: 3682) NO: 3930) 368_A01 SSYGMN WVSNINYNGGYTS ARSANWHDTALD ISYLNWY LLIYAATSRH QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2691) NO: 2939) NO: 3187) NO: 3435) NO: 3683) NO: 3931) 368_A05 SSYSMN WVAGINYNSGYTG ARSANWHDTALD VSYLNWY LVIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2692) NO: 2940) NO: 3188) NO: 3436) NO: 3684) NO: 3932) 368_A07 SSYSMN WVAGINYNSGYTS ARSANWHDTHLD LTYLNWY LVIYATTSRA QQSNELPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2693) NO: 2941) NO: 3189) NO: 3437) NO: 3685) NO: 3933) 368_A09 DSYSMN WVSGINYNGGYTS ARSANWHDTHLD LSYVNWY LLIYAVTSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2694) NO: 2942) NO: 3190) NO: 3438) NO: 3686) NO: 3934) 368_B01 SSYGMN WVSGINYNSGYKS ARSANWHDTALD SSYLNWY LLIYAATSRA QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2695) NO: 2943) NO: 3191) NO: 3439) NO: 3687) NO: 3935) 368_B06 DSYGMH WVSGINYNSGYTS ARSANWHDTALD ISYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2696) NO: 2944) NO: 3192) NO: 3440) NO: 3688) NO: 3936) 368_B07 SDYSMN WVSNINYNGGYKS ARSANWHDTALD VSYLNWY LLIYAATSLA QQSYSSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2697) NO: 2945) NO: 3193) NO: 3441) NO: 3689) NO: 3937) 368_C05 DSYGMN WVSGINYNSGYTS ARSANWHDTALD LSYLNWY LVIYAATSRA QQSDSNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2698) NO: 2946) NO: 3194) NO: 3442) NO: 3690) NO: 3938) 368_D01 SSYGMH WVANINYNGGYTS ARSANWHDTALD LSYLNWY LVIYAATSRA QQSDSTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2699) NO: 2947) NO: 3195) NO: 3443) NO: 3691) NO: 3939) 368_D04 SSYGMN WVSGINYNGGYKS ARSANWHDTALD STYVNWY LVIYAVTSRH QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2700) NO: 2948) NO: 3196) NO: 3444) NO: 3692) NO: 3940) 368_D05 SSYSMN WVSGINYNGGYTS ARSANWHDTALD LTYLNWY LVIYAATSRA QQSDDPSL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2701) NO: 2949) NO: 3197) NO: 3445) NO: 3693) NO: 3941) 368_D11 SSYGMN WVSNINYNGGYKS ARSANWHDTALD LTYLNWY LVIYAATSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2702) NO: 2950) NO: 3198) NO: 3446) NO: 3694) NO: 3942) 368_E01 SSYSMN WVASINYNSGYTG ARSANWHDTHLD LSYLNWY LVIYAVTSRH QQSYSLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2703) NO: 2951) NO: 3199) NO: 3447) NO: 3695) NO: 3943) 368_E02 DSYSMN WVAGINYNSGYTS ARSANWHDTHLD LTYLNWY LLIYAATSRA QQSYSSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2704) NO: 2952) NO: 3200) NO: 3448) NO: 3696) NO: 3944) 368_E04 SSYSMN WVANINYNSGYTG ARSANWHDTALD LSYVNWY LLIYAATSRH QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2705) NO: 2953) NO: 3201) NO: 3449) NO: 3697) NO: 3945) 368_E06 SDYGMH WVSGINYNGGYTG ARSANWHDTALD LSYLNWY LVIYGATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2706) NO: 2954) NO: 3202) NO: 3450) NO: 3698) NO: 3946) 368_E07 SSYGMN WVAGINYNGGYTS AKSANWHDTALD LSYLNWY LLIYAVTSRA QQSYENPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2707) NO: 2955) NO: 3203) NO: 3451) NO: 3699) NO: 3947) 368_F03 DSYSMN WVAGINYNSGYTG AKSANWHDTALD ISYLNWY LVIYAATSRH QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2708) NO: 2956) NO: 3204) NO: 3452) NO: 3700) NO: 3948) 368_F11 SDYGMN WVSGINYNGGYTS ARSANWHDTHLD VWYVNWY LVIYAATSRA QQSYNNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2709) NO: 2957) NO: 3205) NO: 3453) NO: 3701) NO: 3949) 368_G01 SDYGMH WVASINYNSGYTS ARSANWHDTALD LTYLNWY LVIYAATSRA QQSYNLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2710) NO: 2959) NO: 3206) NO: 3454) NO: 3702) NO: 3950) 368_G12 SSYGMN WVASINYNSGYTG ARSANWHDTALD SSYVNWY LVIYAVTSRA QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2711) NO: 2959) NO: 3207) NO: 3455) NO: 3703) NO: 3951) 368_H04 SSYSMN WVAGINYNSGYKG AKSANWHDTHLD VSYVNWY LLIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2712) NO: 2960) NO: 3208) NO: 3456) NO: 3704) NO: 3952) 369_A02 SSYSMN WVAGINYNSGYTG ARSANWHDTHLD LSYVNWY LLIYAATSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2713) NO: 2961) NO: 3209) NO: 3457) NO: 3705) NO: 3953) 369_A03 SSYGMN WVSNINYNGGYTG ARSANWHDTALD LTYLNWY LLIYAVTSRH QQGYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2714) NO: 2962) NO: 3210) NO: 3458) NO: 3706) NO: 3954) 369_B01 SSYSMN WVSGINYNGGYTS ARSANWHDTALD LSYLNWY LLIYAVTSRA QQSYENPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2715) NO: 2963) NO: 3211) NO: 3459) NO: 3707) NO: 3955) 369_B01 DSYSMN WVSNINYNGGYKS ARSANWHDTALD LTYLNWY LVIYAATSRA QQSYELPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2716) NO: 2964) NO: 3212) NO: 3460) NO: 3708) NO: 3956) 369_C03 SSYGMN WVSNINYNGGYKS ARSANWHDTALD LTYLNWY LVIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2717) NO: 2965) NO: 3213) NO: 3461) NO: 3709) NO: 3957) 369_C04 SSYSMN WVSNINYNGGYTG ARSANWHDTALD LTYVNWY LLIYTTTSLH QQSYNNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2718) NO: 2966) NO: 3214) NO: 3462) NO: 3710) NO: 3958) 369_D01 SDYGMN WVASINYNGGYTG ARSANWHDTALD LTYLNWY LLIYAATSRA QQSYSNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2719) NO: 2967) NO: 3215) NO: 3463) NO: 3711) NO: 3959) 369_D02 SDYSMN WVSNINYNSGYTG ARSANWHDTALD LSYLNWY LVIYAVTSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2720) NO: 2968) NO: 3216) NO: 3464) NO: 3712) NO: 3960) 369_D04 DSYGMN WVSGINYNGGYTS ARSANWHDTALD LSYVNWY LVIYAATSRA QQSYNLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2721) NO: 2969) NO: 3217) NO: 3465) NO: 3713) NO: 3961) 369_D12 DSYSMN WVAGINYNSGYTS ARSANWHDTALD LSYLNWY LLIYAATSLA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2722) NO: 2970) NO: 3218) NO: 3466) NO: 3714) NO: 3962) 369_E02 DSYGMN WVSNINYNGGYTG ARSANWHDTALD VSYVNWY LLIYATTSRH QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2723) NO: 2971) NO: 3219) NO: 3467) NO: 3715) NO: 3963) 369_E11 SSYGMN WVSNINYNGGYTS ARSANWHDTALD ISYLNWY LLIYAATSLA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2724) NO: 2972) NO: 3220) NO: 3468) NO: 3716) NO: 3964) 369_E12 SSYGMH WVASINYNSGYTS ARSANWHDTALD ISYLNWY LLIYAATSRA QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2725) NO: 2973) NO: 3221) NO: 3469) NO: 3717) NO: 3965) 369_F01 SSYGMN WVSGINYNGGYKS ARSANWHDTALD LTYVNWY LLIYAATSRA QQSYELPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2726) NO: 2974) NO: 3222) NO: 3470) NO: 3718) NO: 3966) 369_F02 SSYGMN WVASINYNSGYKS ARSANWHDTALD VSYLNWY LVIYAATSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2727) NO: 2975) NO: 3223) NO: 3471) NO: 3719) NO: 3967) 369_F03 SSYGMN WVSGINYNSGYTS ARSANWHDTALD VSYVNWY LVIYAATSLA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2728) NO: 2976) NO: 3224) NO: 3472) NO: 3720) NO: 3968) 369_F06 DDYSMN WVAGINYNGGYKG ARSANWHDTALD VSYVNWY LVIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2729) NO: 2977) NO: 3225) NO: 3473) NO: 3721) NO: 3969) 369_F10 DSYGMN WVSNINYNSGYKS ARSANWHDTALD VTYLNWY LLIYAVTSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2730) NO: 2978) NO: 3226) NO: 3474) NO: 3722) NO: 3970) 369_F11 DSYGMN WVSNINYNSGYKS ARSANWHDTALD ISYLNWY LLIYAATSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2731) NO: 2979) NO: 3227) NO: 3475) NO: 3723) NO: 3971) 369_G01 SSYSMN WVSNINYNSGYKS ARSANWHDTALD LSYVNWY LLIYAATSRA QQSYSSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2732) NO: 2980) NO: 3228) NO: 3476) NO: 3724) NO: 3972) 369_G04 DSYSMN WVSGINYNGGYTS ARSANWHDTALD LTYVNWY LLIYATTSRH QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2733) NO: 2981) NO: 3229) NO: 3477) NO: 3725) NO: 3973) 369_G06 DSYGMN WVAGINYNGGYTS ARSANWHDTALD LYSVNWY LVIYAATSRA QQSYENPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2734) NO: 2982) NO: 3230) NO: 3478) NO: 3726) NO: 3974) 369_G11 SSYSMN WVANINYNSGYKG ARSANWHDTALD LTYLNWY LLIYAATSLA QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2735) NO: 2983) NO: 3231) NO: 3479) NO: 3727) NO: 3975) 369_G12 SSYSMN WVANINYNGGYTG ARSANWHDTALD LTYVNWY LVIYAATSRH QQSDNTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2736) NO: 2984) NO: 3232) NO: 3480) NO: 3728) NO: 3976) 369_H05 SSYGMN WVANINYNGGYTG ARSANWHDTALD VSYVNWY LLIYAATSRA QQSYSNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2737) NO: 2985) NO: 3233) NO: 3481) NO: 3729) NO: 3977) 369_H06 SSYGMN WVANINYNGGYKS ARSANWHDTALD VSYVNWY LLIYAATSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2738) NO: 2986) NO: 3234) NO: 3482) NO: 3730) NO: 3978) 369_H09 DDYSMN WVSGINYNGGYTS ARSANWHDTALD LSYVNWY LLIYAVTSLA QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2739) NO: 2987) NO: 3235) NO: 3483) NO: 3731) NO: 3979) 370_A01 SSYSMN WVSGINYNSGYKS ARSANWHDTALD STYLNWY LVIYAATSRA QQSYNLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2740) NO: 2988) NO: 3236) NO: 3484) NO: 3732) NO: 3980) 370_A03 SSYSMN WVSNINYNGGYTS ARSANWHDTALD LSYLNWY LLIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2741) NO: 2989) NO: 3237) NO: 3485) NO: 3733) NO: 3981) 370_A04 DSYSMN WVSGINYNGGYTS ARSANWHDTALD ITYLNWY LLIYAATSRA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2742) NO: 2990) NO: 3238) NO: 3486) NO: 3734) NO: 3982) 370_A12 SSYGMN WVAGINYNGGYTS ARSANWHDTALD LTYLNWY LLIYAATSLA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2743) NO: 2991) NO: 3239) NO: 3487) NO: 3735) NO: 3983) 370_C01 DSYSMN WVSGINYNSGYTG ARSANWHDTALD LTYLNWY LVIYAATSLA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2744) NO: 2992) NO: 3240) NO: 3488) NO: 3736) NO: 3984) 370_C03 SSYGMN WVAGINYNGGYKG ARSANWHDTALD LTYLNWY LLIYYVTNRQ QQSYSSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2745) NO: 2993) NO: 3241) NO: 3489) NO: 3737) NO: 3985) 370_C05 SSYSMN WVAGINYNSGYTG ARSANWHDTALD LSYVNWY LVIYAATSRA QQSYNSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2746) NO: 2994) NO: 3242) NO: 3490) NO: 3738) NO: 3986) 370_C08 SSYGMN WVAGINYNGGYKG ARSANWHDTALD SNYLNWY LLIYAVTSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2747) NO: 2995) NO: 3243) NO: 3491) NO: 3739) NO: 3987) 370_C09 DSYGMN WVSGINYNGGYTS ARSANWHDTALD ISYLNWY LVIYAATSLA QQSYSTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2748) NO: 2996) NO: 3244) NO: 3492) NO: 3740) NO: 3988) 370_D04 DSYSMN WVANINYNSGYKG ARSANWHDTALD LTYLNWY LVIYAATSRA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2749) NO: 2997) NO: 3245) NO: 3493) NO: 3741) NO: 3989) 370_D11 DSYSMN WVSGINYNGGYTG ARSANWHDTALD VSYLNWY LLIYAASTRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2750) NO: 2998) NO: 3246) NO: 3494) NO: 3742) NO: 3990) 370_E03 SSYGMN WVSSINYNGGYKG ARSANWHDTALD LTYLNWY LVIYYASNRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2751) NO: 2999) NO: 3247) NO: 3495) NO: 3743) NO: 3991) 370_E06 SSYGMN WVSGINYNSGYKS ARSANWHDTALD LSYLNWY LVIYATTSLA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2752) NO: 3000) NO: 3248) NO: 3496) NO: 3744) NO: 3992) 370_E09 DDSSMH WVSNINYNGGYTG AKSANWHDTALD LSYVNWY LVIYAATSRA QQSYELPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2753) NO: 3001) NO: 3249) NO: 3497) NO: 3745) NO: 3993) 370_F05 SSYGMN WVSGINYNSGYTS ARSANWHDTALD VSYVNWY LVIYAATSRA QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2754) NO: 3002) NO: 3250) NO: 3498) NO: 3746) NO: 3994) 370_F07 DSYSMN WVSNINYNGGYKG ARSANWHDTALD LSYLNWY LLIYAATSRA QQSYNLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2755) NO: 3003) NO: 3251) NO: 3499) NO: 3747) NO: 3995) 370_F10 SSYSMN WVAGINYNGGYTS ARSANWHDTALD VSYLNWY LVIYAATSRA QQSYNSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2756) NO: 3004) NO: 3252) NO: 3500) NO: 3748) NO: 3996) 370_G02 SDYSMN WVANINYNGGYKG ARSANWHDTALD VSYLNWY LLIYAATSRH QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2757) NO: 3005) NO: 3253) NO: 3501) NO: 3749) NO: 3997) 370_G03 SSYSMN WVANINYNGGYTG ARSANWHDTALD LTYVNWY LVIYATTSRA QQSYNNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2758) NO: 3006) NO: 3254) NO: 3502) NO: 3750) NO: 3998) 370_G06 SDYGMH WVSSINYNGGYTS ARSANWHDTALD LSYVNWY LVIYAATSRA QQSDNTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2759) NO: 3007) NO: 3255) NO: 3503) NO: 3751) NO: 3999) 370_G09 SSYGMN WVAGINYNGGYKS ARSANWHDTALD LSYVNWY LVIYAATSRA QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2760) NO: 3008) NO: 3256) NO: 3504) NO: 3752) NO: 4000) 370_G10 SDYGMN WVSGINYNSGYTS ARSANWHDTALD SSYLNWY LLIYVVNNRA QQSYENPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2761) NO: 3009) NO: 3257) NO: 3505) NO: 3753) NO: 4001) 370_G11 SSYSMN WVASINYNSGYTS ARSANWHDTHLD VSYLNWY LVIYAATSRA QQSYSLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2762) NO: 3010) NO: 3258) NO: 3506) NO: 3754) NO: 4002) 370_H01 SSYSMN WVSGINYNSGYKG ARSANWHDTALD ISYLNWY LLIYAVTSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2763) NO: 3011) NO: 3259) NO: 3607) NO: 3755) NO: 4003) 370_H09 SSYGMN WVANINYNGGYTS ARSANWHDTALD VSYVNWY LLIYAATSRA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2764) NO: 3012) NO: 3260) NO: 3508) NO: 3756) NO: 4004) 371_A03 SDYGMN WVANINYNGGYTG ARSANWHDTALD LSYLNWY LVIYATTSRA QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2765) NO: 3013) NO: 3261) NO: 3509) NO: 3757) NO: 4005) 371_A06 SSYGMN WVAGINYNGGYTS ARSANWHDTALD LTYLNWY LVIYAATSRH QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2766) NO: 3014) NO: 3262) NO: 3510) NO: 3758) NO: 4006) 371_A07 SDYSMN WVSNINYNGGYKS ARSANWHDTALD LSYLNWY LVIYATTSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2767) NO: 3015) NO: 3263) NO: 3511) NO: 3759) NO: 4007) 371_A08 SSYGMH WVSSINYNGGYTS ARSANWHDTALD LSYLNWY LVIYAATSRA QQSYELPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2768) NO: 3016) NO: 3264) NO: 3512) NO: 3760) NO: 4008) 371_A12 DSYSMN WVAGINYNSGYTS ARSANWHDTALD LSYVNWTY LVIYAATSLA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2769) NO: 3017) NO: 3265) NO: 3513) NO: 3761) NO: 4009) 371_B06 DSYSMN WVAGINYNGGYKS ARSANWHDTALD LTYVNWY LVIYAATSRH QQSYNLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2770) NO: 3018) NO: 3266) NO: 3514) NO: 3762) NO: 4010) 371_B07 DSYSMN WVAGINYNGGYTS ARSANWHDTALD LTYVNWY LLIYAATSRA QQSYELPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2771) NO: 3019) NO: 3267) NO: 3515) NO: 3763) NO: 4011) 371_C03 SSYSMN WVSNINYNGGYKG ARSANWHDTALD LSYLNWY LVIYATTSRA QQSTSTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2772) NO: 3020) NO: 3268) NO: 3516) NO: 3764) NO: 4012) 371_D06 DDYSMN WVAGINYNGGYTS ARSANWHDTALD ISYVNWY LLIYAATSRA QQSYSTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2773) NO: 3021) NO: 3269) NO: 3517) NO: 3765) NO: 4013) 371_D09 SSYSMN WVSNINYNSGYTG ARSANWHDTALD LTYLNWY LVIYAATSRA QQSYNNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2774) NO: 3022) NO: 3270) NO: 3518) NO: 3766) NO: 4014) 371_F01 SSYSMN WVAGINYNGGYTG ARSANWHDTALD LTYVNWY LVIYAATSLA QQSYNNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2775) NO: 3023) NO: 3271) NO: 3519) NO: 3767) NO: 4015) 371_F04 DSYSMN WVAGINYNSGYKG ARSANWHDTALD LSYLNWY LLIYAATSRH QQSYNNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2776) NO: 3024) NO: 3272) NO: 3520) NO: 3768) NO: 4016) 371_F06 DSYSMN WVANINYNGGYTS ARSANWHDTALD VSYLNWY LVIYAATSRH QQSYNSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2777) NO: 3025) NO: 3273) NO: 3521) NO: 3769) NO: 4017) 371_F08 DDSYMN WVSGINYNGGYTG ARSANWHDTALD VSYVNWY LVIYAATSRH QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2778) NO: 3026) NO: 3274) NO: 3522) NO: 3770) NO: 4018) 371_G05 DSYSMN WVSGINYNSGYTG ARSANWHDTALD SSYLNWY LLIYAVTSRA QQSYSSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2779) NO: 3027) NO: 3275) NO: 3523) NO: 3771) NO: 4019) 371_G10 SSYSMN WVSGINYNGGYKS ARSANWHDTALD SSYVNWY LLIYAATSRH QQDDDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2780) NO: 3028) NO: 3276) NO: 3524) NO: 3772) NO: 4020) 371_H09 DSYSMN WVSNINYNGGYTS ARSANWHDTALD LTYVNWY LVIYAATSLA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2781) NO: 3029) NO: 3277) NO: 3525) NO: 3773) NO: 4021) 372_A04 DSYSMN WVSGINYNSGYTS ARSANWHDTALD LTYLNWY LVIYAATSRA QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2782) NO: 3030) NO: 3278) NO: 3526) NO: 3774) NO: 4022) 372_B04 DSYGMN WVANINYNGGYTS ARSANWHDTALD LSYVNWY LVIYAATSLA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2783) NO: 3031) NO: 3279) NO: 3527) NO: 3775) NO: 4023) 272_C07 SDYSMN WVSNINYNSGYTS ARSANWHDTHLD LSYLNWY LVIYAATSRH QQSDNTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2784) NO: 3032) NO: 3280) NO: 3528) NO: 3776) NO: 4024) 372_D02 SSYGMN WVAGINYNGGYTG ARSANWHDTALD LTYLNWY LVIYAATSRA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2785) NO: 3033) NO: 3281) NO: 3529) NO: 3777) NO: 4025) 372_F03 SSYGMN WVAGINYNGGYTS ARSANWHDTALD LSYLNWY LVIYAATSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2786) NO: 3034) NO: 3282) NO: 3530) NO: 3778) NO: 4026) 372_F06 SDYGMN WVAGINYNGGYKS ARSANWHDTALD LSYVNWY LLIYAATSLA QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2787) NO: 3035) NO: 3283) NO: 3531) NO: 3779) NO: 4027) 372_F08 SDYSMN WVSNINYNSGYTG ARSANWHDTALD LTYVNWY LVIYAATSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2788) NO: 3036) NO: 3284) NO: 3532) NO: 3780) NO: 4028) 372_F09 DSYSMN WVANINYNSGYKG ARSANWHDTALD LTYLNWY LVIYAATSLA QQSYSSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2789) NO: 3037) NO: 3285) NO: 3533) NO: 3781) NO: 4029) 373_A02 DSYGMN WVSGINYNGGYKG ARSANWHDTALD LSYVNWY LVIYATTSLA QQSYNTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2790 NO: 3038) NO: 3286) NO: 3534) NO: 3782) NO: 4030) 373_A08 DSYGMN WVSNINYNGGYTG ARSANWHDTALD VSYVNWY LLIYAATSLA QQSYSLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2791) NO: 3039) NO: 3287) NO: 3535) NO: 3783) NO: 4031) 373_A10 SSYGMN WVSGINYNSGYTS ARSANWHDTALD LSYLNWY LVIYAATSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2792) NO: 3040) NO: 3288) NO: 3536) NO: 3784) NO: 3032) 373_B04 SSYGMN WVAGINYNSGYKG ARSANWHDTALD LTYLNWY LLIYAATSRA QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2793) NO: 3041) NO: 3289) NO: 3537) NO: 3785) NO: 4033) 373_B06 SDYSMN WVAGINYNGGYTG ARSANWHDTALD LTYVNWY LVIYAATSRH QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2794) NO: 3042) NO: 3290) NO: 3538) NO: 3786) NO: 4034) 373_B10 DSYGMN WVSNINYNGGYTS ARSANWHDTALD LSYLNWY LLIYAATSRA QQSTDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2795) NO: 3043) NO: 3292) NO: 3539) NO: 3787) NO: 4035) 373_B12 DSYGMN WVSSINYNSGYTS ARSANWHDTALD VSYVNWY LLIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2796) NO: 3044) NO: 3292) NO: 3540) NO: 3788) NO: 4036) 373_C02 DDYSMN WVSGINYNSGYKG ARSANWHDTALD LSYVNWY LLIYAATSRA QQSYNTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2797) NO: 3045) NO: 3293) NO: 3541) NO: 3789) NO: 4037) 373_C04 SSYSMN WVANINYNSGYTG ARSANWHTALD ISYVNWY LVIYAVTSRA QQSYNSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2798) NO: 3046) NO: 3294) NO: 3542) NO: 3790) NO: 4038) 373_C06 SSYSMN WVAGINYNGGYTG ARSANWHDTALD VSYVNWY LVIYAATSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2799) NO: 3047) NO: 3295) NO: 3543) NO: 3791) NO: 4039) 373_C08 SSYSMN WVANINYNGGYTS ARSANWHDTALD ISYLNWY LLIYAASSLQ QQSYNNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2800) NO: 3048) NO: 3296) NO: 3544) NO: 3792) NO: 4040) 373_C11 SSYSMN WVSGINYNSGYTG ARSANWHDTALD LTYVNWY LVIYAVTSRA QSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2801) NO: 3049) NO: 3297) NO: 3545) NO: 3793) NO: 4041) 373_D01 DSYSMN WVSGINYNSGYKS ARSANWHDTHLD LSYVNWY LVIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2802) NO: 3050) NO: 3298) NO: 3546) NO: 3794) NO: 4042) 373_D04 DSYSMN WVSGINYNSGYKG ARSANWHDTALD LSYLNWY LLIYAATSRH QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2803) NO: 3051) NO: 3299) NO: 3547) NO: 3795) NO: 4043) 373_D05 SSYSMN WVSGINYNSGYKG ARSANWHDTALD LSYLNWY LVIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2804) NO: 3052) NO: 3300) NO: 3548) NO: 3796) NO: 4044) 373_D08 DDYSMN WVSGINYNGGYKS ARSANWHDTALD LSYVNWY LLIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2805) NO: 3053) NO: 3301) NO: 3549) NO: 3797) NO: 4045) 373_D10 DSYSMN WVSNINYNSGYKG ARSANWHDTALD LSYVNWY LLIYAATSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2806) NO: 3054) NO: 3302) NO: 3550) NO: 3798) NO: 4046) 373_E01 SSYGMN WVSGINYNGGYKG ARSANWHDTALD VYSVNWY LLIYAATSRH QQSYNNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2807) NO: 3055) NO: 3303) NO: 3551) NO: 3799) NO: 4047) 373_E05 DSYGMN WVSNINYNGGYTS ARSANWHDTALD LSYVNWY LLIYAVTSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2808) NO: 3056) NO: 3304) NO: 3552) NO: 3800) NO: 4048) 373_E07 SSYGMN WVANINYNGGYTS ARSANWHDTALD LTYVNWY LLIYAATSLA QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2809) NO: 3057) NO: 3305) NO: 3553) NO: 3801) NO: 4049) 373_E12 SSYSMN WVANINYNGGYTG ARSANWHDTALD LSYVNWY LVIYAATSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 3810) NO: 3058) NO: 3306) NO: 3554) NO: 3802) NO: 4050) 373_G10 SDYGMN WVSNINYNGGYKS ARSANWHDTALD VSYVNWY LLIYAATSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2811) NO: 3059) NO: 3307) NO: 3555) NO: 3803) NO: 4051) 373_G12 SSYSMN WVSNINYNGGYTS ARSANWHDTALD LSYLNWY LLIYATTSLA QQSYNSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2812) NO: 3060) NO: 3308) NO: 3556) NO: 3804) NO: 4052) 373_H01 DSYSMN WVANINYNGGYTG ARSANWHDTALD LSYLNWY LVIYAATSRA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2813) NO: 3061) NO: 3309) NO: 3557) NO: 3805) NO: 4053) 373_H05 SDYSMN WVANINYNGGYKG ARSANWHDTALD LTYVNWY LVIYAATSRA QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2814) NO: 3062) NO: 3310) NO: 3558) NO: 3806) NO: 4054) 374_A07 SSYSMN WVSGINYNSGYKG ARSANWHDTALD LSYVNWY LLIYAVTSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2815) NO: 3063) NO: 3311) NO: 3559) NO: 3807) NO: 4055) 374_B04 SSYSMN WVSNINYNSGYTG ARSANWHDTALD VSYLNWY LLIYAVTSRA QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2816) NO: 3064) NO: 3312) NO: 3560) NO: 3808) NO: 4056) 374_B06 DSYSMN WVAGINYNSGYKG ARSANEHDTHLD LTYVNWY LLIYAATSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2817) NO: 3065) NO: 3313) NO: 3561) NO: 3809) NO: 4057) 374_B12 DSYSMN WVAGINYNGGYTG ARSANWHDTHLD SSYLNWY LVIYAATSRA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2818) NO: 3066) NO: 3314) NO: 3562) NO: 3810) NO: 4058) 374_C03 DSYSMN WVSGINYNSGYTS ARSANWHDTALD LTYLNWY LLIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2819) NO: 3067) NO: 3315) NO: 3563) NO: 3811) NO: 4059) 374_C06 DDYSMN WVSSINYNSGYKG ARSANWHDTALD LTYVNWY LLIYAATSRA QQSYNSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2820) NO: 3068) NO: 3316) NO: 3564) NO: 3812) NO: 4060) 374_D01 DSYSMN WVSGINYNSGYKG ARSANWHDTALD ITYVNWY LLIYAATSLA QQSYSSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2821) NO: 3069) NO: 3317) NO: 3565) NO: 3813) NO: 4061) 374_D08 DSYGMN WVSGINYNSGYTG ARSANWHDTHLD LTYLNWY LLIYAATSRH QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2822) NO: 3070) NO: 3318) NO: 3566) NO: 3814) NO: 4062) 374_E01 SSYGMN WVAGINYNGGYTS ARSANWHDTALD SSYVNWY LLIYAATSRA QQSYSTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2823) NO: 3071) NO: 3319) NO: 3567) NO: 3815) NO: 4063) 374_E02 SSYSMN WVSGINYNGGYTS ARSANWHDTALD LSYLNWY LLIYAATSLA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2824) NO: 3072) NO: 3320) NO: 3568) NO: 3816) NO: 4064) 374_E05 SSYSMN WVAGINYNGGYTS ARSANWHDTALD LSFVNWY LVIYAATSRA QQSYNLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2825) NO: 3073) NO: 3321) NO: 3569) NO: 3817) NO: 4065) 374_E07 SDYSMN WVAGINYNGGYTS ARSANWHDTALD ITYVNWY LVIYAATSRA QQSYNTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2826) NO: 3074) NO: 3322) NO: 3570) NO: 3818) NO: 4066) 374_E08 SSYGMN WVAGINYNGGYKS ARSANEHDTALD LSYLNWY LLIYAATSRH QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2827) NO: 3075) NO: 3323) NO: 3571) NO: 3819) NO: 4067) 374_E11 SSYGMN WVSNINYNGGYTS ARSANWHDTALD VTYLNWY LVIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2828) NO: 3076) NO: 3324) NO: 3572) NO: 3820) NO: 4068) 374_F01 DSYSMN WVSNINYNGGYTG ARSANWHDTALD LSYVNWY LVIYAATSRH QQSYENPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2829) NO: 3077) NO: 3325) NO: 3573) NO: 3821) NO: 4069) 374_F02 DSYSMN WVANINYNSGYTS ARSANWHDTALD VSYLNWY LLIYAASSLQ QQSYELPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2830 NO: 3078) NO: 3326) NO: 3574) NO: 3822) NO: 4070) 374_F04 SSYGMN WVSGINYNSGYKS ARSANWHDTALD LTYVNWY LLIYAATSRA QQSYNSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2831) NO: 3079) NO: 3327) NO: 3575) NO: 3823) NO: 4071) 374_F10 SSYSMN WVSGINYNGGYTS ARSANWHDTALD LSYLNWY LVIYAATSRA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2832) NO: 3080) NO: 3328) NO: 3576) NO: 3824) NO: 4072) 374_F11 DSYSMN WVSNINYNGGYTG ARSANWHDTALD LSYLNWY LLIYAVTSLA QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2933) NO: 3081) NO: 3329) NO: 3577) NO: 3825) NO: 4073) 374_G04 SSYSMN WVAGINYNGGYTG ARSANWHDTALD LTYLNWY LVIYAATSLA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2834) NO: 3082) NO: 3330) NO: 3578) NO: 3826) NO: 4074) 374_G06 SSYGMH WVASINYNGGYTS ARSANWHDTALD LSYLNWY LLIYAVTSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2835) NO: 3083) NO: 3331) NO: 3579) NO: 3827) NO: 4075) 374_G07 SSYSMN WVSGINYNSGYKS ARSANWHDTALD ISYLNWY LLIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2836) NO: 3084) NO: 3332) NO: 3580) NO: 3828) NO: 4076) 374_H03 SSYGMN WVSGINYNSGYKS ARSANWHDTALD LSYVNWY LVIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2837 NO: 3085) NO: 3333) NO: 3581) NO: 3829) NO: 4077) 374_H04 DSYSMN WVSGINYNSGYTS ARSANWHDTALD LTYLNWY LLIYAATSRA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2838 NO: 3086) NO: 3334) NO: 3582) NO: 3830) NO: 4078) 374_H06 SSYGMN WVSNINYNGGYTG ARSANWHDTALD VSYVNWY LVIYAATSRA QQSYNLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2839) NO: 3087) NO: 3335) NO: 3583) NO: 3831) NO: 4079) 374_H07 DSYGMN WVANINYNGGYTG ARSANWHDTALD LTYLNWY LLIYAATSRA QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2840) NO: 3088) NO: 3336) NO: 3584) NO: 3832) NO: 4080) 374_H09 SSYSMN WVANINYNSGYKS ARSANWHDTALD LSYLNWY LVIYAVTSLA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2841) NO: 3089) NO: 3337) NO: 3585) NO: 3833) NO: 4081) 375_A05 SSYGMN WVANINYNGGYKG ARSANWHDTALD LSYLNWY LLIYAATSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2842) NO: 3090) NO: 3338) NO: 3586) NO: 3834) NO: 4082) 375_C06 DDYGMH WVASINYNSGYTS ARSANWHDTALD LTYVNWY LVIYATTSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2843) NO: 3091) NO: 3339) NO: 3587) NO: 3835) NO: 4083) 375_D04 DDSSMH WVSNINYNGGYTG AKSANWHDTALD LSYVNWY LVIYAATSRA QQSYELPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2844) NO: 3092) NO: 3340) NO: 3588) NO: 3836) NO: 4084) 375_D05 SSYSMN WVASINYNSGYTS ARSANWHDTHLD VSYLNWY LLIYAATSLH QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2845) NO: 3093) NO: 3341) NO: 3589) NO: 3837) NO: 4085) 375_D07 SSYGMN WVANINYNSGYTG ARSANWHDTALD ITYLNWY LLIYAATSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2846) NO: 3094) NO: 3342) NO: 3590) NO: 3838) NO: 4086) 375_D08 SDYGMN WVSGINYNSGYKG ARSANWHDTALD ITYLNWY LLIYAATSRA QQSYSTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2847) NO: 3095) NO: 3343) NO: 3591) NO: 3839) NO: 4087) 375_D12 DSYGMN WVSSINYNSGYTS ARSANWHDTALD LTYVNWY LVIYAATSRA QQSYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2848) NO: 3096) NO: 3344) NO: 3592) NO: 3840) NO: 4088) 375_E01 SSYSMN WVSGINYNSGYKS ARSANWHDTLAD LTYLNWY LVIYAATSRA QQSDDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2849) NO: 3097) NO: 3345) NO: 3593) NO: 3841) NO: 4089) 375_E07 SDYSMN WVAGINYNSGYKG ARSANWHDTALD VTYLNWY LLIYVVTNRE AASYETPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2850) NO: 3098) NO: 3346) NO: 3594) NO: 3842) NO: 4090) 375_H12 SSYGMN WVAGINYNGGYKG ARSANWHDTALD LTYLNWY LLIYYVTNRQ QQSYSIPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2851) NO: 3099) NO: 3347) NO: 3595) NO: 3843) NO: 4091) 376_A04 DSYSMN WVSNINYNGGYTS ARSANWHDTALD VTYLNWY LVIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2852) NO: 3100) NO: 3348) NO: 3596) NO: 3844) NO: 4092) 376_A10 SDYGMN WVSNINYNSGYKG ARSANWHDTALD LSYLNWY LLIYAATSRA QQSYESPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2853) NO: 3101) NO: 3349) NO: 3597) NO: 3845) NO: 4093) 376_A12 SSYSMN WVANINYNSGYKG ARSANWHDTALD LSYVNWY LVIYAATSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2854) NO: 3102) NO: 3350) NO: 3598) NO: 3846) NO: 4094) 376_B04 DSYGMH WVASINYNGGYTG ARSANWHDTALD VSYVNWY LVIYAATSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2855) NO: 3103) NO: 3351) NO: 3599) NO: 3847) NO: 4095) 376_B05 SSYSMN WVANINYNGGYTG ARSANWHDTALD ISYVNWY LLIYAATSRA QQSYELPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2856) NO: 3104) NO: 3352) NO: 3600) NO: 3848) NO: 4096) 376_B09 DSYSMN WVANINYNSGYKG ARSANWHDTALD LTYVNWY LVIYAATSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2857) NO: 3105) NO: 3353) NO: 3601) NO: 3849) NO: 4097) 376_B11 SSYSMN WVSGINYNGGYTS ARSANWHDTALD LSYVNWY LVIYAATSRA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2858) NO: 3106) NO: 3354) NO: 3602) NO: 3850) NO: 4098) 376_C01 DSYSMN WVAGINYNGGYTS ARSANWHDTALD LTYLNWY LLIYAATSLA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2859) NO: 3107) NO: 3355) NO: 3603) NO: 3851) NO: 4099) 376_C02 DSYGMN WVSGINYNSGYTS ARSANWHDTALD VSYLNWY LVIYAVTSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2860) NO: 3108) NO: 3356) NO: 3604) NO: 3852) NO: 4100) 376_C12 SSYSMN WVAGINYNGGYTG ARSANWHDTALD LTYVNWY LLIYAATSRA QQDYSDPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2861) NO: 3109) NO: 3357) NO: 3605) NO: 3853) NO: 4101) 376_D05 SSYSMN WVSNINYNGGYKG ARSANWHDTALD VSYVNWY LLIYAATSLA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2862) NO: 3110) NO: 3358) NO: 3606) NO: 3854) NO: 4102) 376_D11 SSYGMN WVANINYNGGYTG ARSANWHDTALD LSYLNWY LVIYAATSRA QQSYNNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2863) NO: 3111) NO: 3359) NO: 3607) NO: 3855) NO: 4103) 376_E03 SSYGMN WVANINYNGGYTG ARSANWHDTALD LSYVNWY LVIYAATSLA QQSYDLPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2864) NO: 3112) NO: 3360) NO: 3608) NO: 3856) NO: 4101) 376_E08 SDYGMN WVAGININGGYTS ARSANWHDTALD VSYVNWY LVIYAATSRA QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2865) NO: 3113) NO: 3361) NO: 3609) NO: 3857) NO: 4105) 376_F03 DSYGMN WVANINYNGGYTG ARSANWHDTALD ITYVNWY LVIYATTLSA QQSYSSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2866) NO: 3114) NO: 3362) NO: 3610) NO: 3858) NO: 4106) 376_F04 DSYSMN WVSNINYNSGYTG ARSANWHDTALD SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2867) NO: 3115) NO: 3363) NO: 3611) NO: 3859) NO: 4107) 376_G08 DSYGMN WVANINYNGGYTS ARSANWHDTALD LSYVNWY LVIYAATSRA QQSYDTPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2868) NO: 3116) NO: 3364) NO: 3612) NO: 3860) NO: 4108) 376_G09 DAYSMN WVSGINYNSGYKG ARSANWHDTALD SYYLNWY LLIYAVTSRA QQSYDNPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2869) NO: 3117) NO: 3365) NO: 3613) NO: 3861) NO: 4109) 376_H09 SDYSMN WVANINYNGGYTG ARSANWHDTALD ITYLNWY LVIYYVSNLP QQSYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2870) NO: 3118) NO: 3366) NO: 3614) NO: 3862) NO: 4110) 376_H10 DSYSMN WVSGINYNSGYKS ARSANWHDTALD LTYLNWY LVIYAATSRH QQDYDSPL (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID (SEQ ID NO: 2871) NO: 3119) NO: 3367) NO: 3615) NO: 3863) NO: 4111)

The consensus sequences for each of these CDRs shown in FIG. 3E are as follows:

HCDR1: (SEQ ID NO: 6578) S/DS/DYG/SMN/H HCDR2: (SEQ ID NO: 6579) WVS/AG/N/SINYNG/SGYT/KS/G HCDR3: (SEQ ID NO: 6597) AR/KSANWHDTA/HLD LCDR1: (SEQ ID NO: 6561) L/V/I/SS/TYLNNWY LCDR2: (SEQ ID NO: 6582) LL/VIYA/YA/V/TT/SS/NR/LA/H/Q LCDR3: (SEQ ID NO: 6598) QQSY/DD/E/N/SS/T/L/NPL

TABLE 2F Group IV Antibody Sequences Ab VH sequence VL sequence 365_E02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FSSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCAKSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4281) GTLVTVSS (SEQ ID NO: 4112) 370_G12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDESPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4282) GTLVTVSS (SEQ ID NO: 4113) 368_C01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN FDSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4283) GTLVTVSS (SEQ ID NO: 4114) 376_C06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4284) GTLVTVSS (SEQ ID NO: 4115) 368_D10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYGMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4285) GTLVTVSS (SEQ ID NO: 4116) 365_G12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYGMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSNPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4286) GTLVTVSS (SEQ ID NO: 4117) 367_C03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4287) GTLVTVSS (SEQ ID NO: 4118) 367_H07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4288) GTLVTVSS (SEQ ID NO: 4119) 371_D03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4289) GTLVTVSS (SEQ ID NO: 4120) 369_C10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FSSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDSLPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4290) GTLVTVSS (SEQ ID NO: 4121) 367_F05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYGMNWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4291) GTLVTVSS (SEQ ID NO: 4122) 365_C07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSDYGMNWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4292) GTLVTVSS (SEQ ID NO: 4123) 374_C08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4293) GTLVTVSS (SEQ ID NO: 4124) 376_A06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYYVSNRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4294) GTLVTVSS (SEQ ID NO: 4125) 376_B07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYYVSNRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4295) GTLVTVSS (SEQ ID NO: 4126) 365_F07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4296) GTLVTVSS (SEQ ID NO: 4127) 369_E10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4297) GTLVTVSS (SEQ ID NO: 4128) 373_E03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTALDYWGQ KVEIK (SEQ ID NO: 4298) GTLVTVSS (SEQ ID NO: 4129) 366_B04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4299) GTLVTVSS (SEQ ID NO: 4130) 376_F12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FDDYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4300) GTLVTVSS (SEQ ID NO: 4131) 369_F07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4301) GTLVTVSS (SEQ ID NO: 4132) DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN 368_C06 EVQLLESGGGLVQPGGSLRLSCAASGFT WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG FDSYSMNWVRQAPGKGLEWVAGINYNGG TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT YKSYADSVKGRFTISRDNSKNTLYLQMN KVEIK (SEQ ID NO: 4302) SLRAEDTAVYYCARSATWHDTHLDYWGQ GTLVTVSS (SEQ ID NO: 4133) 376_E12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4303) GTLVTVSS (SEQ ID NO: 4134) 371_H01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN FDSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4304) GTLVTVSS (SEQ ID NO: 4135) 367_E02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN FDSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4305) GTLVTVSS (SEQ ID NO: 4136) 365_F04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVN FSSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4306) GTLVTVSS (SEQ ID NO: 4137) 370_A09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4307) GTLVTVSS (SEQ ID NO: 4138) 365_B03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4308) GTLVTVSS (SEQ ID NO: 4139) 369_A05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4309) GTLVTVSS (SEQ ID NO: 4140) 373_H10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4310) GTLVTVSS (SEQ ID NO: 4141) 367_A09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4311) GTLVTVSS (SEQ ID NO: 4142) 370_F08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FDSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4312) GTLVTVSS (SEQ ID NO: 4143) 376_B01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4313) GTLVTVSS (SEQ ID NO: 4144) 365_D05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4314) GTLVTVSS (SEQ ID NO: 4145) 373_E04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4315) GTLVTVSS (SEQ ID NO: 4146) 368_G05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4316) GTLVTVSS (SEQ ID NO: 4147) 365_A01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSDYGMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYATTSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4317) GTLVTVSS (SEQ ID NO: 4148) 373_H06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FSSYGMHWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4318) GTLVTVSS (SEQ ID NO: 4149) 369_G07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4319) GTLVTVSS (SEQ ID NO: 4150) 373_G05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVAGINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4320) GTLVTVSS (SEQ ID NO: 4151) 372_F07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDDYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4321) GTLVTVSS (SEQ ID NO: 4152) 370_H03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4322) GTLVTVSS (SEQ ID NO: 4153) 366_A03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4323) GTLVTVSS (SEQ ID NO: 4154) 365_A07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FSSYGMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4324) GTLVTVSS (SEQ ID NO: 4155) 376_B06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4325) GTLVTVSS (SEQ ID NO: 4156) 374_C11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4326) GTLVTVSS (SEQ ID NO: 4157) 375_A06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4327) GTLVTVSS (SEQ ID NO: 4158) 365_B09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILRYLN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4328) GTLVTVSS (SEQ ID NO: 4159) 373_E06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILRYLN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4329) GTLVTVSS (SEQ ID NO: 4160) 374_C05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIIRYLN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4330) GTLVTVSS (SEQ ID NO: 4161) 376_C11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4331) GTLVTVSS (SEQ ID NO: 4162) 373_C09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4332) GTLVTVSS (SEQ ID NO: 4163) 368_H01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYATTSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4333) GTLVTVSS (SEQ ID NO: 4164) 373_B03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4334) GTLVTVSS (SEQ ID NO: 4165) 374_C04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4335) GTLVTVSS (SEQ ID NO: 4166) 371_F05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4336) GTLVTVSS (SEQ ID NO: 4167) 369_A10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4337) GTLVTVSS (SEQ ID NO: 4168) 366_A05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4338) GTLVTVSS (SEQ ID NO: 4169) 375_G07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4339) GTLVTVSS (SEQ ID NO: 4170) 374_D02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISTYVN FDSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAVTSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4340) GTLVTVSS (SEQ ID NO: 4171) 365_A10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYGMHWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLVIYAVTSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4341) GTLVTVSS (SEQ ID NO: 4172) 375_A02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN FSSYSMNWVRQAPGKGLEWVAGINYNSG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4342) GTLVTVSS (SEQ ID NO: 4173) 371_G03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVN FSSYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4343) GTLVTVSS (SEQ ID NO: 4174) 370_E07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4344) GTLVTVSS (SEQ ID NO: 4175) 375_B04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4345) GTLVTVSS (SEQ ID NO: 4176) 367_G07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4346) GTLVTVSS (SEQ ID NO: 4177) 366_C02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FSDYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4347) GTLVTVSS (SEQ ID NO: 4178) 375_C12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4348) GTLVTVSS (SEQ ID NO: 4179) 365_F08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDDYGMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4349) GTLVTVSS (SEQ ID NO: 4180) 368_G09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FDSYGMHWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4350) GTLVTVSS (SEQ ID NO: 4181) 368_E11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FDSYGMHWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4351) GTLVTVSS (SEQ ID NO: 4182) 367_F02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FDSYSMNWVRQAPGKGLEWVANINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4352) GTLVTVSS (SEQ ID NO: 4183) 373_B08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4353) GTLVTVSS (SEQ ID NO: 4184) 374_A11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSDYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4354) GTLVTVSS (SEQ ID NO: 4185) 373_B11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4355) GTLVTVSS (SEQ ID NO: 4186) 373_F03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4356) GTLVTVSS (SEQ ID NO: 4187) 372_D04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVANINYNSG WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4357) GTLVTVSS (SEQ ID NO: 4188) 366_C01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FSDYGMNWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLLIYAATSPASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4358) GTLVTVSS (SEQ ID NO: 4189) 367_A01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4359) GTLVTVSS (SEQ ID NO: 4190) 366_H05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDSYGMHWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4360) GTLVTVSS (SEQ ID NO: 4191) 369_B09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYGMHWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4361) GTLVTVSS (SEQ ID NO: 4192) 366_D07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSDYGMHWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4362) GTLVTVSS (SEQ ID NO: 4193) 369_D11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYGMHWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDELPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4363) GTLVTVSS (SEQ ID NO: 4194) 370_B05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYGMNWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4364) GTLVTVSS (SEQ ID NO: 4195) 366_D02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVASINYNGG WYQQKPGKAPKLLIYATTSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4365) GTLVTVSS (SEQ ID NO: 4196) 368_H12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FDSYSMNWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4366) GTLVTVSS (SEQ ID NO: 4197) 368_F12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FDDYSMNWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4367) GTLVTVSS (SEQ ID NO: 4198) 370_A06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FSSYSMNWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4368) GTLVTVSS (SEQ ID NO: 4199) 369_F12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FSSYSMNWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLLIYAVTSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4369) GTLVTVSS (SEQ ID NO: 4200) 366_A09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSDYGMHWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4370) GTLVTVSS (SEQ ID NO: 4201) 368_H07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMHWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4371) GTLVTVSS (SEQ ID NO: 4202) 370_C04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYGMNWVRQAPGKGLEWVASINYNSG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4372) GTLVTVSS (SEQ ID NO: 4203) 373_E02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVRYLN FDSYGMHWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4373) GTLVTVSS (SEQ ID NO: 4204) 374_E09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FSDYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4374) GTLVTVSS (SEQ ID NO: 4205) 371_C09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4375) GTLVTVSS (SEQ ID NO: 4206) 369_B12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYATTSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4376) GTLVTVSS (SEQ ID NO: 4207) 369_B02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4377) GTLVTVSS (SEQ ID NO: 4208) 365_C09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSDYGMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4378) GTLVTVSS (SEQ ID NO: 4209) 374_B09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVRYLN FSSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4379) GTLVTVSS (SEQ ID NO: 4210) 374_D12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FDSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4380) GTLVTVSS (SEQ ID NO: 4211) 374_C02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4381) GTLVTVSS (SEQ ID NO: 4212) 374_H08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4382) GTLVTVSS (SEQ ID NO: 4213) 369_D06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4383) GTLVTVSS (SEQ ID NO: 4214) 366_B06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYAAPSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYXTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4384) GTLVTVSS (SEQ ID NO: 4215) 367_A11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYGMHWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLVIYATTSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4385) GTLVTVSS (SEQ ID NO: 4216) 369_F04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FSSYGMNWVRQAPGKGLEWVSGINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4386) GTLVTVSS (SEQ ID NO: 4217) 369_A01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4387) GTLVTVSS (SEQ ID NO: 4218) 373_H12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSDYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4388) GTLVTVSS (SEQ ID NO: 4219) 376_C07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4389) GTLVTVSS (SEQ ID NO: 4220) 366_E02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4390) GTLVTVSS (SEQ ID NO: 4221) 376_G01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FDDYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4391) GTLVTVSS (SEQ ID NO: 4222) 373_F02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4392) GTLVTVSS (SEQ ID NO: 4223) 376_E09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4393) GTLVTVSS (SEQ ID NO: 4224) 365_H04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSDYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4394) GTLVTVSS (SEQ ID NO: 4225) 369_E04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSDYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4395) GTLVTVSS (SEQ ID NO: 4226) 374_B11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4396) GTLVTVSS (SEQ ID NO: 4227) 376_G11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVN FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4397) GTLVTVSS (SEQ ID NO: 4228) 374_E04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4398) GTLVTVSS (SEQ ID NO: 4229) 373_B08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FDSYGMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4399) GTLVTVSS (SEQ ID NO: 4230) 375_B10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4400) GTLVTVSS (SEQ ID NO: 4231) 365_E08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4401) GTLVTVSS (SEQ ID NO: 4232) 374_G02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4402) GTLVTVSS (SEQ ID NO: 4233) 373_D09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4403) GTLVTVSS (SEQ ID NO: 4234) 365_A04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSDYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4404) GTLVTVSS (SEQ ID NO: 4235) 371_B05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSSYSMNWVRQAPGKGLEWVSGINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDETPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4405) GTLVTVSS (SEQ ID NO: 4236) 376_H08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDSLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4406) GTLVTVSS (SEQ ID NO: 4237) 367_G08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4407) GTLVTVSS (SEQ ID NO: 4238) 372_H03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIITYVN FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4408) GTLVTVSS (SEQ ID NO: 4239) 366_E03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4409) GTLVTVSS (SEQ ID NO: 4240) 371_F12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FDSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSNNLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4410) GTLVTVSS (SEQ ID NO: 4241) 366_C03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4411) GTLVTVSS (SEQ ID NO: 4242) 376_A01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FDSYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4412) GTLVTVSS (SEQ ID NO: 4243) 365_E03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDERPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4413) GTLVTVSS (SEQ ID NO: 4244) 371_B10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FDSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4414) GTLVTVSS (SEQ ID NO: 4245) 369_G09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FDSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4415) GTLVTVSS (SEQ ID NO: 4246) 369_A06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSDYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4416) GTLVTVSS (SEQ ID NO: 4247) 369_C08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FSDYGMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4417) GTLVTVSS (SEQ ID NO: 4248) 373_A07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDNLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4418) GTLVTVSS (SEQ ID NO: 4249) 367_D02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVN FDDYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4419) GTLVTVSS (SEQ ID NO: 4250) 374_C07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN FDSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDELPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4420) GTLVTVSS (SEQ ID NO: 4251) 374_A03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4421) GTLVTVSS (SEQ ID NO: 4252) 365_A02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4422) GTLVTVSS (SEQ ID NO: 4253) 365_D06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4423) GTLVTVSS (SEQ ID NO: 4254) 366_C07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVSNINYNGG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4424) GTLVTVSS (SEQ ID NO: 4255) 367_F12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN FDDYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4425) GTLVTVSS (SEQ ID NO: 4256) 369_E09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4426) GTLVTVSS (SEQ ID NO: 4257) 365_G02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FSDYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLVIYAVTSLHSGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4427) GTLVTVSS (SEQ ID NO: 4258) 373_D02 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSSYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4428) GTLVTVSS (SEQ ID NO: 4259) 374_E03 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4429) GTLVTVSS (SEQ ID NO: 4260) 374_D11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN FDSYGMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4430) GTLVTVSS (SEQ ID NO: 4261) 370_D07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSSYGMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4431) GTLVTVSS (SEQ ID NO: 4262) 374_A08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FDSYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4432) GTLVTVSS (SEQ ID NO: 4263) 374_G01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDSYSMNWVRQAPGKGLEWVSNINYNSG WYQQKPGKAPKLLIYATTSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4433) GTLVTVSS (SEQ ID NO: 4264) 374_G12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FDDYGMNWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4434) GTLVTVSS (SEQ ID NO: 4265) 375_G10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FSSYGMNWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4435) GTLVTVSS (SEQ ID NO: 4266) 369_H11 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FSDYGMNWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4436) GTLVTVSS (SEQ ID NO: 4267) 375_G12 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FDSYGMHWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4437) GTLVTVSS (SEQ ID NO: 4268) 366_F06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISTYLN FSDYGMNWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4438) GTLVTVSS (SEQ ID NO: 4269) 368_G07 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSSYSMHWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4439) GTLVTVSS (SEQ ID NO: 4270) 367_H04 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN FSSYSMNWVRQAPGKGLEWVSSINYNGG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSDNNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4440) GTLVTVSS (SEQ ID NO: 4271) 374_E06 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN FDSYSMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4441) GTLVTVSS (SEQ ID NO: 4272) 370_A10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN FSDYSMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4442) GTLVTVSS (SEQ ID NO: 4273) 368_H10 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FSSYSMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLVIYAVTSLASGVPSRFSGSGSG YKGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4443) GTLVTVSS (SEQ ID NO: 4274) 368_G08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN FDDYGMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4444) GTLVTVSS (SEQ ID NO: 4275) 365_H09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN FSSYGMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YKSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4445) GTLVTVSS (SEQ ID NO: 4276) 370_A08 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN FDSYSMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4446) GTLVTVSS (SEQ ID NO: 4277) 368_B05 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN FDSYSMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4447) GTLVTVSS (SEQ ID NO: 4278) 375_F01 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN FSSYSMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG YTGYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4448) GTLVTVSS (SEQ ID NO: 4279) 374_F09 EVQLLESGGGLVQPGGSLRLSCAASGFT DIQMTQSPSSLSASVGDRVTITCRASQSISSYVN FSSYGMNWVRQAPGKGLEWVSSINYNSG WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG YTSYADSVKGRFTISRDNSKNTLYLQMN TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT SLRAEDTAVYYCARSATWHDTHLDYWGQ KVEIK (SEQ ID NO: 4449) GTLVTVSS (SEQ ID NO: 4280)

Table 3F provides the amino acid sequences of the CDRs of the antibodies shown in Table 2F.

TABLE 3F CDR sequences for Group VI antibodies Ab HCDR1 HCDR2 HCDR3 LCDR1 LCDR2 LCDR3 365_E02 SSYSMN WVANINY AKSATW ISYLNWY LLIYAATSRA QQSYENPL (SEQ NGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5126) NO: 4450) NO: NO: 4957) 5295) 4619) 4788) 370_G12 SSYSMN WVAGINY ARSATW ITYLNWY LLIYAATSLA QQSDESPL (SEQ NGGYKG HDTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5127) NO: 4451) NO: NO: 4958) 5296) 4620) 4789) 368_C01 DSYGMN WVAGINY ARSATWH ITYLNWY LLIYAATSRA QQSYDSPL (SEQ NGGYTG DTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5128) NO: 4452) NO: NO: 4959) 5297) 4621) 4790) 376_C06 SSYGMN WVAGINY ARSATWH LSYLNWY LVIYAATSRA QQSYDSPL (SEQ NGGYTS DTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5129) NO: 4453) NO: NO: 4960) 5298) 4622) 4791) 368_D10 DSYGMN WVAGINY ARSATWH LSYLNWY LVIYAATSRA QQSYDSPL (SEQ NSGYTS DTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5130) NO: 4454) NO: NO: 4961) 5299) 4623) 4792) 365_G12 SSYGMN WVAGINY ARSATWH LSYVNWY LVIYAATSRA QQSYSNPL (SEQ NSGYTS DTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5131) NO: 4455) NO: NO: 4962) 5300) 4624) 4793) 367_C03 SSYSMN WVANINY ARSATW LSYVNWY LVIYATTSRA QQSYENPL (SEQ NGGYTG HDTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5132) NO: 4456) NO: NO: 4963) 5301) 4625) 4794) 367_H07 SSYSMN WVANINY ARSATWH LSYVNWY LVIYATTSRA QQSYENPL (SEQ NGGYTG DTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5133) NO: 4457) NO: NO: 4964) 5302) 4626) 4795) 371_D03 DSYGMN WVANINY ARSATW LTYVNWY LVIYAATSLA QQSYNTPL (SEQ NGGYTS HDTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5134) NO: 4458) NO: NO: 4965) 5303) 4627) 4796) 369_C10 SSYSMN WVANINY ARSATW VTYLNWY LLIYAATSLH QQSDSLPL (SEQ NGGYTS HDTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5135) NO: 4459) NO: NO: 4966) 5304) 4628) 4797) 367_F05 SSYGMN WVASINY ARSATW LSYVNWY LLIYAATSRA QQSYSSPL (SEQ NGGYTG HDTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5136) NO: 4460) NO: NO: 4967) 5305) 4629) 4798) 365_C07 SDYGMN WVASINY ARSATW VSYVNWY LLIYAATSRA QQSYDTPL (SEQ NGGYTS HDTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5137) NO: 4461) NO: NO: 4968) 5306) 4630) 4799) 374_C08 DSYGMN WVSGINY ARSATW LSYVNWY LLIYAVTSRA QQSYDSPL (SEQ NSGYKS HDTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5138) NO: 4462) NO: NO: 4969) 5307) 4631) 4800) 376_A06 DSYSMN WVSGINY ARSATW LSYLNWY LVIYYVSNRA QQSYDNPL (SEQ NSGYTS HDTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5139) NO: 4463) NO: NO: 4970) 5308) 4632) 4801) 376_B07 DSYSMN WVSGINY ARSATW LSYLNWY LVIYYVSNRA QQSYDNPL (SEQ NSGYTS HDTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5140) NO: 4464) NO: NO: 4971) 5309) 4633) 4802) 365_F07 SSYSMN WVSNINY ARSATW LSYVNWY LVIYAATSRA QQSYDLPL (SEQ NGGYKS HDTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5141) NO: 4465) NO: NO: 4972) 5310) 4634) 4803) 369_E10 SSYSMN WVSNINY ARSATW LSYVNWY LVIYAATSRA QQSYDLPL (SEQ NGGYKS HDTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5142) NO: 4466) NO: NO: 4973) 5311) 4635) 4804) 373_E03 DSYGMN WVSNINY ARSATWH LSYVNWY LVIYAATSRA QQSYDLPL (SEQ NGGYTG DTALD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5143) NO: 4467) NO: NO: 4974) 5312) 4636) 4805) 366_B04 DSYSMN WVAGINY ARSATWH LTYVNWY LVIYAATSRH QQSYDTPL (SEQ NGGYKG DTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5144) NO: 4468) NO: NO: 4975) 5313) 4637) 4806) 376_F12 DDYSMN WVAGINY ARSATW ISYVNWY LLIYAASSLQ QQSYSTPL (SEQ NGGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5145) NO: 4469) NO: NO: 4976) 5314) 4638) 4807) 369_F07 DSYSMN WVAGIN ARSATW LSYVNWY LVIYAATSRA QQSYESPL (SEQ YNGGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5146) NO: 4470) NO: NO: 4977) 5315) 4639) 4808) 368_C06 DSYSMN WVAGINY ARSATW SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ NGGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5147) NO: 4471) NO: NO: 4978) 5316) 4640) 4809) 376_E12 SSYSMN WVAGINY ARSATW LSYLNWY LLIYAASSLQ QQSYSTPL (SEQ NGGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5148) NO: 4472) NO: NO: 4979) 5317) 4641) 4810) 371_H01 DSYSMN WVAGINY ARSATW ITYLNWY LLIYAASSLQ QQSYSTPL (SEQ NGGYTG HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5149) NO: 4473) NO: NO: 4980) 5318) 4642) 4811) 367_E02 DSYSMN WVAGINY ARSATW SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ NGGYTG HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5150) NO: 4474) NO: NO: 4981) 5319) 4643) 4812) 365_F04 SSYGMN WVAGINY ARSATW VTYVNWY LLIYAATSRA QQSYDTPL (SEQ NGGYTG HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5151) NO: 4475) NO: NO: 4982) 5320) 4644) 4813) 370_A09 SSYSMN WVAGINY ARSATW LTYLNWY LVIYAATSRA QQSYDTPL (SEQ NGGYTG HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5152) NO: 4476) NO: NO: 4983) 5321) 4645) 4814) 365_B03 SSYSMN WVAGINY ARSATW VSYLNWY LLIYAATSRA QQSYENPL (SEQ NGGYTG HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5153) NO: 4477) NO: NO: 4984) 5322) 4646) 4815) 369_A05 SSYSMN WVAGINY ARSATW LTYVNWY LVIYAATSRA QQSYESPL (SEQ NGGYTG HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5154) NO: 4478) NO: NO: 4985) 5323) 4647) 4816) 373_H10 SSYSMN WVAGINY ARSATW LSYVNWY LLIYAATSRA QQSYSLPL (SEQ NGGYTG HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5155) NO: 4479) NO: NO: 4986) 5324) 4648) 4817) 367_A09 DSYGMN WVAGINY ARSATW LSYVNWY LVIYAATSRH QQSYDTPL (SEQ NGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5156) NO: 4480) NO: NO: 4987) 5325) 4649) 4818) 370_F08 DSYSMN WVAGINY ARSATW ISYVNWY LLIYAATSRH QQSYNLPL (SEQ NGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5157) NO: 4481) NO: NO: 4988) 5326) 4650) 4819) 376_B01 DSYSMN WVAGINY ARSATW LTYVNWY LVIYAATSRA QQSYNLPL (SEQ NGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5158) NO: 4482) NO: NO: 4989) 5327) 4651) 4820) 365_D05 DSYSMN WVAGINY ARSATW LTYVNWY LLIYAATSRA QQSYNSPL (SEQ NGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5159) NO: 4483) NO: NO: 4990) 5328) 4652) 4821) 373_E04 DSYSMN WVAGINY ARSATW LTYVNWY LLIYAATSRA QQSYNSPL (SEQ NGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5160) NO: 4484) NO: NO: 4991) 5329) 4653) 4822) 368_G05 DSYSMN WVAGINY ARSATW LTYVNWY LLIYAATSLH QQSYNTPL (SEQ NGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5161) NO: 4485) NO: NO: 4992) 5330) 4654) 4823) 365_A01 SDYGMN WVAGINY ARSATW LTYVNWY LVIYATTSLA QQSYSTPL (SEQ NGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5162) NO: 4486) NO: NO: 4993) 5331) 4655) 4824) 373_H06 SSYGMH WVAGINY ARSATW ISYVNWY LLIYAATSLA QQSYDLPL (SEQ NGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5163) NO: 4487) NO: NO: 4994) 5332) 4656) 4825) 369_G07 SSYSMN WVAGINY ARSATW LTYVNWY LVIYAATSRA QQSYDNPL (SEQ NGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID ID NO: (SEQ ID (SEQ ID NO: NO: 5164) NO: 4488) NO: NO: 4995) 5333) 4657) 4826) 373_G05 SSYSMN WVAGINY ARSATW LSYLNWY LLIYAATSLA QQSYELPL (SEQ ID NGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: 4489) (SEQ ID (SEQ ID NO: 4996) NO: 5165) NO:  NO: NO: 4827) 5334) 4658) 372_F07 DDYSMN WVAGINY ARSATW LTYLNWY LVIYAATSRA QQSYELPL (SEQ ID NSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: 4490) (SEQ ID (SEQ ID NO: 4997) NO: 5166) NO: 5335) NO: NO: 4828) 4659) 370_H03 DSYSMN WVAGINY ARSATW LTYLNWY LLIYAATSLA QQSYDTPL (SEQ ID NSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: 4491) (SEQ ID (SEQ ID NO: 4998) NO: 5167) NO: 5336) NO: NO: 4829) 4660) 366_A03 DSYSMN WVAGINY ARSATW SSYLNWY LLIYAATSLA QQSYSNPL (SEQ ID NSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: 4492) (SEQ ID (SEQ ID NO: 4999) NO: 5168) NO: 5337) NO: NO: 4830) 4661) 365_A07 SSYGMN WVAGINY ARSATW VSYLNWY LLIYAATSRA QQSYNLPL (SEQ ID NSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: 4493) (SEQ ID (SEQ ID NO: 5000) NO: 5169) NO: 5338) NO: NO: 4831) 4662) 376_B06 SSYSMN WVAGINY ARSATW LTYLNWY LLIYAATSRA QQSYDLPL (SEQ ID NSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: 4494) (SEQ ID (SEQ ID NO: 5001) NO: 5170) NO: 5339) NO: NO: 4832) 4663) 374_C11 SSYSMN WVAGINY ARSATW LTYLNWY LLIYAATSRA QQSYESPL (SEQ ID NSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: 4495) (SEQ ID (SEQ ID NO: 5002) NO: 5171) NO: 5340) NO: NO: 4833) 4664) 375_A06 SSYSMN WVAGINY ARSATW LTYVNWY LLIYAASSLQ QQSYSTPL (SEQ ID NSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: 4496) (SEQ ID (SEQ ID NO: 5003) NO: 5172) NO: 5341) NO: NO: 4834) 4665) 365_B09 DSYSMN WVAGINY ARSATW LRYLNWY LLIYAATSLH QQSYDNPL (SEQ ID NSGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: 4497) (SEQ ID (SEQ ID NO: 5004) NO: 5173) NO: 5342) NO: NO: 4835) 4666) 373_E06 DSYSMN WVAGINY ARSATW LRYLNWY LLIYAATSLH QQSYDNPL (SEQ ID NSGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: 4498) (SEQ ID (SEQ ID NO: 5005) NO: 5174) NO: 5343) NO: NO: 4836) 4667) 374_C05 DSYSMN WVAGINY ARSAT IRYLNWY LVIYAATSRA QQSYDNPL (SEQ ID NSGYKS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4499) NO: NO: 5006) 5175) 5344) 4668) 4837) 376_C11 DSYSMN WVAGINY ARSAT LTYLNWY LVIYAATSRA QQSYDNPL (SEQ ID NSGYKS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4500) NO: NO: 5007) 5176) 5345) 4669) 4838) 373_C09 DSYSMN WVAGINY ARSAT LTYLNWY LVIYAATSRA QQSYELPL (SEQ ID NSGYKS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4501) NO: NO: 5008) 5177) 5346) 4670) 4839) 368_H01 SSYSMN WVAGINY ARSAT LSYLNWY LLIYATTSLA QQSYDNPL (SEQ ID NSGYKS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4502) NO: NO: 5009) 5178) 5347) 4671) 4840) 373_B03 SSYSMN WVAGINY ARSAT LTYLNWY LVIYAATSLA QQSYDNPL (SEQ ID NSGYKS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4503) NO: NO: 5010) 5179) 5348) 4672) 4841) 374__C04 SSYSMN WVAGINY ARSAT LTYLNWY LLIYAASSLQ QQSYELPL (SEQ ID NSGYKS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4504) NO: NO: 5011) 5180) 5349) 4673) 4842) 371_F05 SSYSMN WVAGINY ARSAT LSYLNWY LLIYAATSRH QQSYENPL (SEQ ID NSGYKS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4505) NO: NO: 5012) 5181) 5350) 4674) 4843) 369__A10 DSYSMN WVAGINY ARSAT LSYLNWY LLIYAATSRA QQSYELPL (SEQ ID NSGY WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: TG (SEQ ID NO: NO: NO: 4506) (SEQ ID NO: 5013) 5182) 5351) NO: 4844) 4675) 366_A05 SSYSMN WVAGINY ARSAT LTYVNWY LVIYAATSLA QQSYNTPL (SEQ ID NSGY WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: TG (SEQ ID NO: NO: NO: 4507) (SEQ ID NO: 5014) 5183) 5352) NO: 4845) 4676) 375_G07 DSYSMN WVAGINY ARSAT LSYLNWY LVIYAATSLA QQSYDLPL (SEQ ID NSGY WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: TS (SEQ ID NO: NO: NO: 4508) (SEQ ID NO: 5015) 5184) 5353) NO: 4846) 4677) 374_D02 DSYSMN WVAGINY ARSAT STYVNWY LLIYAVTSLA QQSYDSPL (SEQ ID NSGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 5354) 4509) NO: NO: 5016) 5185) 4678) 4847) 365_A10 SSYGMH WVAGINY ARSAT LTYLNWY LVIYAVTSLA QQSYDSPL (SEQ ID NSGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: 5017) NO: NO: 5355) 4510) NO: NO: 5186) 4679) 4848) 375_A02 SSYSMN WVAGINY ARSAT SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID NSGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: 5018) NO: NO: 5356) 4511) NO: NO: 5187) 4680) 4849) 371_G03 SSYGMN WVANINY ARSAT VTYVNWY LVIYAATSLA QQSYNLPL (SEQ ID NGGYKG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: 5019) NO: NO: 5357) 4512) NO: NO: 5188) 4681) 4850) 370_E07 DSYSMN WVANINY ARSAT LTYLNWY LLIYAATSRA QQSYDNPL (SEQ ID NGGYTG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: 5020) NO: NO: 5358) 4513) NO: NO: 5189) 4682) 4851) 375_B04 DSYSMN WVANINY ARSAT LTYLNWY LLIYAATSRA QQSYDNPL (SEQ ID NGGYTG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: 5021) NO: NO: 4514) NO: NO: 5190) 5359) 4683) 4852) 367_G07 DSYSMN WVANINY ARSAT LTYVNWY LLIYAATSRA QQSYDNPL (SEQ ID NGGYTG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: 5022) NO: NO: 5360) 4515) NO: NO: 5191) 4684) 4853) 366_C02 SDYSMN WVANINY ARSAT VSYLNWY LLIYAATSRA QQSYDNPL (SEQ ID NGGYTG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: 5023) NO: NO: 5361) 4516) NO: NO: 5192) 4685) 4854) 375_C12 SSYSMN WVANINY ARSAT LTYLNWY LLIYAATSRA QQSYDLPL (SEQ ID NGGYTG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: 5024) NO: NO: 5362) 4517) NO: NO: 5193) 4686) 4855) 365_F08 DDYGMN WVANINY ARSAT LSYVNWY LLIYAATSRH QQSYSLPL (SEQ ID NGGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: 5025) NO: NO: 5363) 4518) NO: NO: 5194) 4687) 4856) 368_G09 DSYGMH WVANIN ARSAT VSYLN LVIYAATSRA QQSYDTPL (SEQ ID YNGGYTS WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4519) NO: NO: NO: 5195) 5364) 4688) 4857) 5026) 368_E11 DSYGMH WVANIN ARSAT ISYVN LLIYAATSRH QQSYELPL (SEQ ID YNGGYTS WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4520) NO: NO: NO: 5196) 5365) 4689) 4858) 5027) 367_F02 DSYSMN WVANIN ARSAT ISYVN LLIYAATSRH QQSYESPL (SEQ ID YNGGYTS WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4521) NO: NO: NO: 5197) 5366) 4690) 4859) 5028) 373_B08 DSYSMN WVANIN ARSAT LTYLN LVIYAATSLA QQSYENPL (SEQ ID YNSGYKG WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4522) NO: NO: NO: 5198) 5367) 4691) 4860) 5029) 374_A11 SDYSMN WVANIN ARSAT LSYVN LVIYAATSRA QQSYSSPL (SEQ ID YNSGYKG WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4523) NO: NO: NO: 5199) 5368) 4692) 4861) 5030) 373_B11 SSYSMN WVANIN ARSAT LSYLN LLIYAATSRA QQSYDNPL (SEQ ID YNSGYKG WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4524) NO: NO: NO: 5200) 5369) 4693) 4862) 5031) 373_F03 DSYSMN WVANIN ARSAT LTYVN LLIYAATSRH QQSYDSPL (SEQ ID YNSGYTG WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4525) NO: NO: NO: 5201) 5370) 4694) 4863) 5032) 372_D04 SSYSMN WVANIN ARSAT LTYLN LLIYAATSLH QQSYDLPL (SEQ ID YNSGYTG WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4526) NO: NO: NO: 5202) 5371) 4695) 4864) 5033) 366_C01 SDYGMN WVASIN ARSAT VTYLN LLIYAATSPA QQSYELPL (SEQ ID YNGGYTG WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4527) NO: NO: NO: 5203) 5372) 4696) 4865) 5034) 367_A01 SSYSMN WVASIN ARSAT LTYLN LLIYAATSRA QQSYDLPL (SEQ ID YNGGYTG WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4528) NO: NO: NO: 5204) 5373) 4697) 4866) 5035) 366_H05 DSYGMH WVASIN ARSAT LSYVNWY LLIYAATSLA QQSYDLPL (SEQ ID YNGGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4529) NO: NO: 5036) 5205) 5374) 4698) 4867) 369_B09 DSYGMH WVASIN ARSAT LTYLNWY LLIYAATSRA QQSYENPL (SEQ ID YNGGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4530) NO: NO: 5037) 5206) 5375) 4699) 4868) 366_D07 SDYGMH WVASIN ARSAT LTYLNWY LLIYAATSLA QQSYSSPL (SEQ ID YNGGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4531) NO: NO: 5038) 5207) 5376) 4700) 4869) 369_D11 SSYGMH WVASIN ARSAT LTYLNWY LVIYAATSLA QQSDELPL (SEQ ID YNGGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4532) NO: NO: 5039) 5208) 5377) 4701) 4870) 370_B05 SSYGMN WVASIN ARSAT LTYVNWY LVIYAATSRA QQSYENPL (SEQ ID YNGGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4533) NO: NO: 5040) 5209) 5378) 4702) 4871) 366_D02 SSYSMN WVASIN ARSAT LSYVNWY LLIYATTSLA QQSYDLPL (SEQ ID YNGGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4534) NO: NO: 5041) 5210) 5379) 4703) 4872) 368_H12 DSYSMN WVASIN ARSAT VTYLNWY LLIYAATSRA QQSYESPL (SEQ ID YNSGYKG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4535) NO: NO: 5042) 5211) 5380) 4704) 4873) 368_F12 DDYSMN WVASIN ARSAT VTYLNWY LVIYAATSLA QQSYDLPL (SEQ ID YNSGYKS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4536) NO: NO: 5043) 5212) 5381) 4705) 4874) 370_A06 SSYSMN WVASIN ARSAT VTYLNWY LVIYAATSLA QQSYDLPL (SEQ ID YNSGYKS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4537) NO: NO: 5044) 5213) 5382) 4706) 4875) 369_F12 SSYSMN WVASIN ARSAT ISYLNWY LLIYAVTSLA QQSYENPL (SEQ ID YNSGYKS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4538) NO: NO: 5045) 5214) 5383) 4707) 4876) 366_A09 SDYGMH WVAS ARSATW LTYLNW LLIYAATSRH QQSYETPL (SEQ ID INYN HDTHLD Y (SEQ ID (SEQ ID NO: SGYTS (SEQ ID (SEQ ID NO: NO: 4539) (SEQ ID NO: NO: 5215) 5384) NO: 4877) 5046) 4708) 368_H07 SSYCMH WVAS ARSATW LSYLNW LLIYAATSRA QQSYENPL (SEQ ID INYN HDTHLD Y (SEQ ID (SEQ ID NO: SGYTS (SEQ ID (SEQ ID NO: NO: 4540) (SEQ ID NO: NO: 5216) 5385) NO: 4878) 5047) 4709) 370_C04 SSYGMN WVAS ARSATW LSYLNW LLIYAASSLQ QQSYENPL (SEQ ID INYN HDTHLD Y (SEQ ID (SEQ ID NO: SGYTS (SEQ ID (SEQ ID NO: NO: 4541) (SEQ ID NO: NO: 5217) 5386) NO: 4879) 5048) 4710) 373_E02 DSYGMH WVSG ARSATW VRYLNW LLIYAASSLQ QQSYSTPL (SEQ ID INYNG HDTHLD Y (SEQ ID (SEQ ID NO: GYKG (SEQ ID (SEQ ID NO: NO: 4542) (SEQ ID NO: NO: 5218) 5387) NO: 4880) 5049) 4711) 374_E09 SDYSMN WVSG ARSATW VTYLNW LVIYAATSRA QQSYDSPL (SEQ ID INYNG HDTHLD Y (SEQ ID (SEQ ID NO: GYKG (SEQ ID (SEQ ID NO: NO: 4543) (SEQ ID NO: NO: 5219) 5388) NO: 4881) 5050) 4712) 371_C09 DSYSMN WVSG ARSATW LTYVNW LLIYAASSLQ QQSYDNPL (SEQ ID INYNG HDTHLD Y (SEQ ID (SEQ ID NO: GYKS (SEQ ID (SEQ ID NO: NO: 4544) (SEQ ID NO: NO: 5220) 5389) NO: 4882) 5051) 4713) 369_B12 DSYSMN WVS ARSATW LTYVNW LLIYATTSLA QQSYDSPL (SEQ ID GINYN HDTHLD Y (SEQ ID (SEQ ID NO: GGYKS (SEQ ID (SEQ ID NO: NO: 4545) (SEQ ID NO: NO: 5221) 5390) NO: 4883) 5052) 4714) 369_B02 DSYSMN WVSG ARSATW LSYLNW LVIYAATSRA QQSYNLPL (SEQ ID INYN HDTHLD Y (SEQ ID (SEQ ID NO: GGYKS (SEQ ID (SEQ ID NO: NO: 4546) (SEQ ID NO: NO: 5222) 5391) NO: 4884) 5053) 4715) 365_C09 SDYGMN W ARSATW VSYVNW LLIYAATSRA QQSYDTPL (SEQ ID VSGIN HDTHLD Y (SEQ ID (SEQ ID NO: YNGGYKS (SEQ ID (SEQ ID NO: NO: 4547) (SEQ ID NO: NO: 5223) 5392) NO: 4885) 5054) 4716) 374_B09 SSYSMN WVSGIN ARSATW VRYLNW LVIYAATSLA QQSYELPL (SEQ ID YNGGYKS HDTHLD Y (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4548) NO: NO: NO: 5224) 5393) 4717) 4886) 5055) 374_D12 DSYSMN WVSGINY ARSATW VSYVNWY LVIYAATSRA QQSYDLPL (SEQ ID NGGYTG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4549) NO: NO: 5056) 5225) 5394) 4718) 4887) 374_C02 DSYSMN WVSGINY ARSATW LSYLNWY LLIYAATSRH QQSYDSPL (SEQ ID NGGYTG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4550) NO: NO: 5057) 5226) 5395) 4719) 4888) 374_H08 DSYSMN WVSGINY ARSATW LSYLNWY LLIYAATSLH QQSYENPL (SEQ ID NGGYTG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4551) NO: NO: 5058) 5227) 5396) 4720) 4889) 369_D06 DSYSMN WVSGINY ARSATW LTYLNWY LLIYAATSRA QQSYETPL (SEQ ID NGGYTG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4552) NO: NO: 5059) 5228) 5397) 4721) 4890) 366_B06 DSYSMN WVSGINY ARSATW LTYVNWY LVIYAAPSLA QQSYXTPL (SEQ ID NGGYTS (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID HDTHLD NO: NO: NO: 4553) NO: (SEQ ID 5060) 5229) 5398) 4722) NO: 4891) 367_A11 SSYGMH WVSGINY ARSATW LSYVNWY LVIYATTSLA QQSY (SEQ ID NGGYTS HDTHLD (SEQ ID (SEQ ID NSPL NO: (SEQ ID (SEQ ID NO: NO: (SEQ ID 4554) NO: NO: 5061) 5230) NO: 4723) 4892) 5399) 369_F04 SSYGMN WVSGINY ARSATW ISYVNWY LLIYAATSRH QQSYDNPL (SEQ ID NGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4555) NO: NO: 5062) 5231) 5400) 4724) 4893) 369_A01 DSYSMN WVSGINY ARSATW LTYVNWY LVIYAATSLA QQSYELPL (SEQ ID NSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4556) NO: NO: 5063) 5232) 5401) 4725) 4894) 373_H12 SDYSMN WVSGINY ARSATW LTYLNWY LLIYAATSRA QQSY (SEQ ID NSGYKG HDTHLD (SEQ ID (SEQ ID NSPL NO: (SEQ ID (SEQ ID NO: NO: (SEQ ID 4557) NO: NO: 5064) 5233) NO: 4726) 4895) 5402) 376_C07 SSYSMN WVSGINY ARSATW LSYVNWY LLIYAATSRH QQSYDLPL (SEQ ID NSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4558) NO: NO: 5065) 5234) 5403) 4727) 4896) 366_E02 SSYSMN WVSGIN ARSATW SSYLNWY LLIYAASSLQ QQSYNSPL (SEQ ID YNSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4559) NO: NO: 5066) 5235) 5404) 4728) 4897) 376_G01 DDYSMN WVSGIN ARSATW LSYVNWY LVIYAVTSRA QQSYELPL (SEQ ID YNSGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4560) NO: NO: 5067) 5236) 5405) 4729) 4898) 373_F02 DSYSMN WVSGIN ARSATW LTYLNWY LLIYAATSRA QQSYDTPL (SEQ ID YNSGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4561) NO: NO: 5068) 5237) 5406) 4730) 4899) 376_E09 DSYSMN WVSGIN ARSATW LTYLNWY LLIYAATSRH QQSYDTPL (SEQ ID YNSGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4562) NO: NO: 5069) 5238) 5407) 4731) 4900) 365_H04 SDYGMN WVSGIN ARSATW LTYVNWY LVIYAATSRA QQSYESPL (SEQ ID YNSGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4563) NO: NO: 5070) 5239) 5408) 4732) 4901) 369_E04 SDYSMN WVSGIN ARSATW LSYVNWY LVIYAATSRA QQSYSLPL (SEQ ID YNSGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4564) NO: NO: 5071) 5240) 5409) 4733) 4902) 374_B11 SSYSMN WVSGIN ARSATW LTYVNWY LVIYAATSRA QQSYDLPL (SEQ ID YNSGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4565) NO: NO: 5072) 5241) 5410) 4734) 4903) 376_G11 SSYSMN WVSGIN ARSATW VTYVNWY LVIYAATSLA QQSYNLPL (SEQ ID YNSGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4566) NO: NO: 5073) 5242) 5411) 4735) 4904) 374_E04 SSYSMN WVSGIN ARSATW LSYLNWY LLIYAVTSRA QQSYNNPL (SEQ ID YNSGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4567) NO: NO: 5074) 5243) 5412) 4736) 4905) 373_E08 DSYGMN WVSGIN ARSATW VSYVNWY LLIYAVTSRA QQSYESPL (SEQ ID YNSGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4568) NO: NO: 5075) 5244) 5413) 4737) 4906) 375_B10 DSYSMN WVSGIN ARSAT LSYLNWY LLIYAATSRH QQSYDLPL (SEQ ID YNSGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4569) NO: NO: 5076) 5245) 5414) 4738) 4907) 365_E08 DSYSMN WVSGIN ARSAT ISYVNWY LVIYAATSLA QQSYDLPL (SEQ ID YNSGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4570) NO: NO: 5077) 5246) 5415) 4739) 4908) 374_G02 DSYSMN WVSGIN ARSAT LTYLNWY LLIYAASSLQ QQSYDTPL (SEQ ID YNSGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4571) NO: NO: 5078) 5247) 5416) 4740) 4909) 373_D09 DSYSMN WVSGIN ARSAT LTYLNWY LVIYAATSRH QQSYENPL (SEQ ID YNSGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4572) NO: NO: 5079) 5248) 5417) 4741) 4910) 365_A04 SDYSMN WVSGIN ARSAT VSYVNWY LVIYAATSLA QQSYSTPL (SEQ ID YNSGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4573) NO: NO: 5080) 5249) 5418) 4742) 4911) 371_B05 SSYSMN WVSGIN ARSAT LTYLNWY LVIYAATSLA QQSDETPL (SEQ ID YNSGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4574) NO: NO: 5081) 5250) 5419) 4743) 4912) 376_H08 DSYGMN WVSNIN ARSAT LTYLNWY LLIYAATSRH QQSDSLPL (SEQ ID YNGGYKG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4575) NO: NO: 5082) 5251) 5420) 4744) 4913) 367_G08 DSYGMN WVSNIN ARSAT LSYLNWY LLIYAATSRA QQSYENPL (SEQ ID YNGGYKG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4576) NO: NO: 5083) 5252) 5421) 4745) 4914) 372_H03 DSYGMN WVSNIN ARSAT ITYVNWY LLIYAATSLA QQSYNLPL (SEQ ID YNGGYKS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4577) NO: NO: 5084) 5253) 5422) 4746) 4915) 366_E03 DSYGMN WVSNIN ARSAT LTYLNWY LVIYAATSRH QQSYSNPL (SEQ ID YNGGYKS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4578) NO: NO: 5085) 5254) 5423) 4747) 4916) 371_F12 DSYSMN WVSNIN ARSAT ISYLNWY LLIYAATSRA QQSNNLPL (SEQ ID YNGGYKS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4579) NO: NO: 5086) 5255) 5424) 4748) 4917) 366_C03 DSYGMN WVSNIN ARSAT LSYLNWY LVIYAATSRA QQSYSNPL (SEQ ID YNGGYTG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4580) NO: NO: 5087) 5256) 5425) 4749) 4918) 376_A01 DSYGMN WVSNIN ARSAT VSYLNWY LLIYAATSRA QQSYSTPL (SEQ ID YNGGYTG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4581) NO: NO: 5088) 5257) 5426) 4750) 4919) 365_E03 DSYSMN WVSNIN ARSAT LTYVNWY LLIYAATSLH QQSDERPL (SEQ ID YNGGYTG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4582) NO: NO: 5089) 5258) 5427) 4751) 4920) 371_B10 DSYSMN WVSNIN ARSAT VSYVNWY LLIYAATSRA QQSYDLPL (SEQ ID YNGGYTG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4583) NO: NO: 5090) 5259) 5428) 4752) 4921) 369_G09 DSYSMN WVSNIN ARSAT VTYLNWY LLIYAATSRA QQSYDLPL (SEQ ID YNGGYTG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4584) NO: NO: 5091) 5260) 5429) 4753) 4922) 369_A06 SDYGMN WVSNIN ARSAT LSYVNWY LLIYAATSLA QQSYDLPL (SEQ ID YNGGYTG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4585) NO: NO: 5092) 5261) 5430) 4754) 4923) 369_C08 SDYGMN WVSNIN ARSAT LTYLNWY LVIYAATSLA QQSYENPL (SEQ ID YNGGYTG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4586) NO: NO: 5093) 5262) 5431) 4755) 4924) 373_A07 SSYSMN WVSNIN ARSAT LTYVNWY LLIYAATSRA QQSDNLPL (SEQ ID YNGGYTG WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4587) NO: NO: 5094) 5263) 5432) 4756) 4925) 367_D02 DDYSMN WVSNIN ARSAT VTYVNWY LLIYAATSRA QQSYENPL (SEQ ID YNGGYTS WHDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4588) NO: NO: 5095) 5264) 5433) 4757) 4926) 374_C07 DSYSMN WVSNIN ARSATW ISYLNWY LLIYAATSRA QQSDELPL (SEQ ID YNGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4589) NO: NO: 5096) 5265) 5434) 4758) 4927) 374_A03 DSYSMN WVSNIN ARSATW LTYLNWY LLIYAATSRA QQSYDNPL (SEQ ID YNGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4590) NO: NO: 5097) 5266) 5435) 4759) 4928) 365_A02 DSYSMN WVSNIN ARSATW LTYVNWY LLIYAATSRA QQSYNSPL (SEQ ID YNGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4591) NO: NO: 5098) 5267) 5436) 4760) 4929) 365_D06 DSYSMN WVSNIN ARSATW LTYVNWY LLIYAATSRA QQSYSLPL (SEQ ID YNGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4592) NO: NO: 5099) 5268) 5437) 4761) 4930) 366_C07 SSYSMN WVSNIN ARSATW LTYVNWY LLIYAATSRA QQSYNSPL (SEQ ID YNGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4593) NO: NO: 5100) 5269) 5438) 4762) 4931) 367_F12 DDYSMN WVSNIN ARSATW SSYLNWY LLIYAASSLQ QQSYSTPL (SEQ ID YNSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4594) NO: NO: 5101) 5270) 5439) 4763) 4932) 369_E09 DSYSMN WVSNIN ARSATW LSYLNWY LVIYAATSRA QQSYDLPL (SEQ ID YNSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4595) NO: NO: 5102) 5271) 5440) 4764) 4933) 365_G02 SDYSMN WVSNIN ARSATW VTYLNWY LVIYAVTSLH QQSYELPL (SEQ ID YNSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4596) NO: NO: 5103) 5272) 5441) 4765) 4934) 373_D02 SSYSMN WVSNIN ARSATW LSYLNWY LLIYAATSLA QQSYDLPL (SEQ ID YNSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4597) NO: NO: 5104) 5273) 5442) 4766) 4935) 374_E03 SSYSMN WVSNIN ARSATW LTYVNWY LVIYAATSLA QQSYDTPL (SEQ ID YNSGYKG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4598) NO: NO: 5105) 5274) 5443) 4767) 4936) 374_D11 DSYGMN WVSNIN ARSATW LTYLNWY LLIYAATSRA QQSYETPL (SEQ ID YNSGYTG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4599) NO: NO: 5106) 5275) 5444) 4768) 4937) 370_D07 SSYGMN WVSNIN ARSATW LSYVNWY LVIYAATSLA QQSYESPL (SEQ ID YNSGYTG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4600) NO: NO: 5107) 5276) 5445) 4769) 4938) 374_A08 DSYSMN WVSNIN ARSATW VTYLNWY LLIYAATSLA QQSYDLPL (SEQ ID YNSGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4601) NO: NO: 5108) 5277) 5446) 4770) 4939) 374_G01 DSYSMN WVSNIN ARSATW LTYVNWY LLIYATTSRH QQSYNLPL (SEQ ID YNSGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4602) NO: NO: 5109) 5278) 5447) 4771) 4940) 374_G12 DDYGMN WVSSIN ARSATW LTYVNWY LVIYAATSLA QQSYNSPL (SEQ ID YNGGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4603) NO: NO: 5110) 5279) 5448) 4772) 4941) 375_G10 SSYGMN WVSSIN ARSATW VTYLNWY LVIYAATSRH QQSYDTPL (SEQ ID YNGGYKS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4604) NO: NO: 5111) 5280) 5449) 4773) 4942) 369_H11 SDYGMN WVSSIN ARSATW LSYLNWY LLIYAATSRH QQSYDLPL (SEQ ID YNGGYTG HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4605) NO: NO: 5112) 5281) 5450) 4774) 4943) 375_G12 DSYGMH WVSSIN ARSATW VSYVNWY LLIYAATSRH QQSYDTPL (SEQ ID YNGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4606) NO: NO: 5113) 5282) 5451) 4775) 4944) 366_F06 SDYGMN WVSSIN ARSATW STYLNWY LLIYAATSLA QQSYSNPL (SEQ ID YNGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4607) NO: NO: 5114) 5283) 5452) 4776) 4945) 368_G07 SSYSMH WVSSIN ARSATW VSYVNWY LVIYAATSRA QQSYDTPL (SEQ ID YNGGYTS HDTHLD (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID NO: NO: NO: 4608) NO: NO: 5115) 5284) 5453) 4777) 4946) 367_H04 SSYSMN WVSSINY ARSAT LTYVN LLIYAATSRH QQSDNNPL (SEQ ID NGGYTS WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4609) NO: NO: NO: 5285) 5454) 4778) 4947) 5116) 374_E06 DSYSMN WVSSINY ARSAT LSYLN LLIYAATSRA QQSYDLPL (SEQ ID NSGYKG WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4610) NO: NO: NO: 5286) 5455) 4779) 4948) 5117) 370_A10 SDYSMN WVSSINY ARSAT LSYVN LLIYAATSLA QQSYDTPL (SEQ ID NSGYKG WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4611) NO: NO: NO: 5287) 5456) 4780) 4949) 5118) 368_H10 SSYSMN WVSSINY ARSAT VSYVN LVIYAVTSLA QQSYETPL (SEQ ID NSGYKG WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4612) NO: NO: NO: 5288) 5457) 4781) 4950) 5119) 368_G08 DDYGMN WVSSINY ARSAT VSYVN LLIYAATSRH QQSY (SEQ ID NSGYKS WHDTHLD WY (SEQ ID NNPL NO: (SEQ ID (SEQ ID (SEQ ID NO: (SEQ ID 4613) NO: NO: NO: 5289) NO: 4782) 4951) 5120) 5458) 365_H09 SSYGMN WVSSINY ARSAT SSYLN LLIYAASSLQ QQSYSTPL (SEQ ID NSGYKS WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4614) NO: NO: NO: 5290) 5459) 4783) 4952) 5121) 370_A08 DSYSMN WVSSINY ARSAT VTYLN LVIYAATSRA QQSYDLPL (SEQ ID NSGYTG WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4615) NO: NO: NO: 5291) 5460) 4784) 4953) 5122) 368_B05 DSYSMN WVSSINY ARSAT SSYLN LLIYAASSLQ QQSYSTPL (SEQ ID NSGYTG WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4616) NO: NO: NO: 5292) 5461) 4785) 4954) 5123) 375_F01 SSYSMN WVSSINY ARSAT VSYLN LVIYAATSRA QQSYDNPL (SEQ ID NSGYTG WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4617) NO: NO: NO: 5293) 5462) 4786) 4955) 5124) 374_F09 SSYGMN WVSSINY ARSAT SSYVN LLIYAATSRA QQSYSTPL (SEQ ID NSGYTS WHDTHLD WY (SEQ ID (SEQ ID NO: (SEQ ID (SEQ ID (SEQ ID NO: NO: 4618) NO: NO: NO: 5294) 5463) 4787) 4956) 5125)

The consensus sequences for each of these CDRs shown in FIG. 3F are as follows:

HCDR1: (SEQ ID NO: 6584) D/SS/DYS/GMN/H HCDR2: (SEQ ID NO: 6585) WVA/SG/N/SINYNG/SGYT/KS/G HCDR3: (SEQ ID NO: 6586) ARSATWHDTH/ALD LCDR1: (SEQ ID NO: 6588) L/V/I/SS/T/RYL/VNWY LCDR2: (SEQ ID NO: 6590) LL/VIYA/YA/V/TT/SS/NR/LA/H/Q LCDR3: (SEQ ID NO: 6591) QQSY/DD/E/S/NL/N/T/SPL

The present antibody may exhibit high affinity binding to ACVR2A. For example, the antibody may binds to ACVR2 with an affinity of at least about 10⁻⁷ M, at least about 10⁻⁸M, at least about 10⁻⁹ M, at least about 10⁻¹⁰ M, at least about 10⁻¹¹ M, or at least about 10⁻¹² M, or greater than 10⁻¹² M. The present antibody binds to ACVR2A with a substantially lower affinity, e.g., at least 10 fold, 50 fold, 100 fold, 500 fold, 1000 fold, 5000 fold, 10,000 fold, 50,000 fold 100,000, or 500,000 fold lower affinity.

The present antibody may reduce binding of ACVR2A to GDF8 and/or other activins. For example, the antibody may reduce binding of ACVR2A to GDF8 and/or other activins by at least about 5%, at least about 10%, at least about 15%, at least about 20%, at least about 25%, at least about 30%, at least about 40%, at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, or more, compared to the degree of binding between ACVR2A and GDF8 and/or other activins in the absence of the antibody.

In some embodiments, an antibody comprises one or more (e.g., one or two) heavy chain variable regions (VH) and/or one or more (e.g., one or two) light chain variable regions (VL), or subfragments thereof capable of binding an epitope. The VH and VL regions can be further subdivided into regions of hypervariability, termed “complementarity determining regions (CDR)”, interspersed with regions that are more conserved, termed “framework regions (FR)”. The extent of the FR and CDRs has been precisely defined (see, Kabat, et al. (1991) Sequences of Proteins of Immunological Interest, Fifth Edition, U.S. Department of Health and Human Services, NIH Publication No. 91-3242; Chothia et al. (1987) J. Mol. Biol. 196: 901-917). A VH can comprise three CDRs and four FRs arranged from N-terminus to C-terminus in the following order: FR1, CDR1, FR2, CDR2, FR3, CDR3, FR4. Similarly, a VL can comprise three CDRs and four FRs arranged from N-terminus to C-terminus in the following order: FR1, CDR1, FR2, CDR2, FR3, CDR3, FR4.

The VH or VL chain of an antibody can further include all or part of a heavy or light chain constant region, to thereby form a heavy or light immunoglobulin chain, respectively. In one embodiment, the antibody is a tetramer of two heavy and two light chains, wherein the heavy and light chains are interconnected by, for example, disulphide bonds. The heavy chain constant region is comprised of three domains, CH1, CH2 and CH3. The light chain constant region is comprised of one domain, CL. The variable regions of the heavy and light chains comprise binding regions that interact with antigen. The constant regions of the antibodies typically mediate the binding of the antibody to host tissues and factors, including various cells of the immune system and the first component of the complement system. The term “antibody” includes intact immunoglobulins of types IgA, IgG, IgE, IgD, IgM and subtypes thereof. In some embodiments, a subject antibody is an IgG isotype.

As used herein the term “immunoglobulin” refers to a protein consisting of one or more polypeptides substantially encoded by immunoglobulin genes. The recognized human immunoglobulin genes include the kappa, lambda, alpha (IgA1 and IgA2), gamma (IgG1, IgG2, IgG3, IgG4), delta, epsilon and mu constant region genes; and numerous immunoglobulin variable region genes. Full-length immunoglobulin light chains (about 25 kD or 214 amino acids) are encoded by a variable region gene at the N-terminus (about 110 amino acids) and a kappa or lambda constant region at the C-terminus. Full-length immunoglobulin heavy chains (about 50 kD or 446 amino acids) are encoded by a variable region gene at the N-terminus (about 116 amino acids) and one of the other aforementioned constant region genes at the C-terminus, e.g. gamma (encoding about 330 amino acids). In some embodiments, a subject antibody comprises full-length immunoglobulin heavy chain and a full-length immunoglobulin light chain.

In some embodiments, a subject antibody does not comprise a full-length immunoglobulin heavy chain and a full-length immunoglobulin light chain, and instead comprises antigen-binding fragments of a full-length immunoglobulin heavy chain and a full-length immunoglobulin light chain. In some embodiments, the antigen-binding fragments are contained on separate polypeptide chains; in other embodiments, the antigen-binding fragments are contained within a single polypeptide chain. The term “antigen-binding fragment” refers to one or more fragments of a full-length antibody that are capable of specifically binding to ACVR2A as described above. Examples of binding fragments include (i) a Fab fragment (a monovalent fragment consisting of the VL, VH, CL and CH1 domains; (ii) a F(ab′)₂ fragment (a bivalent fragment comprising two Fab fragments linked by a disulfide bridge at the hinge region; (iii) a Fd fragment (consisting of the VH and CH1 domains); (iv) a Fv fragment (consisting of the VH and VL domains of a single arm of an antibody); (v) a dAb fragment (consisting of the VH domain); (vi) an isolated CDR; (vii) a single chain Fv (scFv) (consisting of the VH and VL domains of a single arm of an antibody joined by a synthetic linker using recombinant means such that the VH and VL domains pair to form a monovalent molecule); (viii) diabodies (consisting of two scFvs in which the VH and VL domains are joined such that they do not pair to form a monovalent molecule; the VH of each one of the scFv pairs with the VL domain of the other scFv to form a bivalent molecule); (ix) bi-specific antibodies (consisting of at least two antigen binding regions, each region binding a different epitope). In some embodiments, a subject antibody fragment is a Fab fragment. In some embodiments, a subject antibody fragment is a single-chain antibody (scFv).

In some embodiments, a subject antibody is a recombinant or modified antibody, e.g., a chimeric, humanized, deimmunized or an in vitro generated antibody. The term “recombinant” or “modified” antibody as used herein is intended to include all antibodies that are prepared, expressed, created, or isolated by recombinant means, such as (i) antibodies expressed using a recombinant expression vector transfected into a host cell; (ii) antibodies isolated from a recombinant, combinatorial antibody library; (iii) antibodies isolated from an animal (e.g. a mouse) that is transgenic for human immunoglobulin genes; or (iv) antibodies prepared, expressed, created, or isolated by any other means that involves splicing of human immunoglobulin gene sequences to other DNA sequences. Such recombinant antibodies include humanized, CDR grafted, chimeric, deimmunized, and in vitro generated antibodies; and can optionally include constant regions derived from human germline immunoglobulin sequences.

In some embodiments, a subject antibody comprises, in order from N-terminus to C-terminus: a light chain FR1 region; a CDR1; a light chain FR2 region; a CDR2; a light chain FR3 region; a CDR3; optionally a light chain FR4 region; a linker region; optionally a heavy chain FR1 region; a CDR1; a heavy chain FR2 region; a CDR2; a heavy chain FR3 region; a CDR3; and a heavy chain FR4 region. In some of these embodiments, each of the FR regions is a human FR region. The linker region can be from about 5 amino acids to about 50 amino acids in length, e.g., from about 5 aa to about 10 aa, from about 10 aa to about 15 aa, from about 15 aa to about 20 aa, from about 20 aa to about 25 aa, from about 25 aa to about 30 aa, from about 30 aa to about 35 aa, from about 35 aa to about 40 aa, from about 40 aa to about 45 aa, or from about 45 aa to about 50 aa in length.

Linkers suitable for use a subject antibody include “flexible linkers”. If present, the linker molecules are generally of sufficient length to permit some flexible movement between linked regions. The linker molecules are generally about 6-50 atoms long. The linker molecules may also be, for example, aryl acetylene, ethylene glycol oligomers containing 2-10 monomer units, diamines, diacids, amino acids, or combinations thereof. Other linker molecules which can bind to polypeptides may be used in light of this disclosure.

Suitable linkers can be readily selected and can be of any of a suitable of different lengths, such as from 1 amino acid (e.g., Gly) to 20 amino acids, from 2 amino acids to 15 amino acids, from 3 amino acids to 12 amino acids, including 4 amino acids to 10 amino acids, 5 amino acids to 9 amino acids, 6 amino acids to 8 amino acids, or 7 amino acids to 8 amino acids, and may be 1, 2, 3, 4, 5, 6, or 7 amino acids.

Exemplary flexible linkers include glycine polymers (G)_(n), glycine-serine polymers (including, for example, (GS)_(n), GSGGS_(n) (SEQ ID NO: 6599) and GGGS_(n)(SEQ ID NO: 6600), where n is an integer of at least one), glycine-alanine polymers, alanine-serine polymers, and other flexible linkers known in the art. Glycine and glycine-serine polymers are of interest since both of these amino acids are relatively unstructured, and therefore may serve as a neutral tether between components. Glycine polymers are of particular interest since glycine accesses significantly more phi-psi space than even alanine, and is much less restricted than residues with longer side chains (see Scheraga, Rev. Computational Chem. 11173-142 (1992)). Exemplary flexible linkers include, but are not limited GGSG (SEQ ID NO:6601), GGSGG (SEQ ID NO:6602), GSGSG (SEQ ID NO: 6603), GSGGG (SEQ ID NO:6604), GGGSG (SEQ ID NO: 6605), GSSSG (SEQ ID NO: 6606), and the like. The ordinarily skilled artisan will recognize that design of a peptide conjugated to any elements described above can include linkers that are all or partially flexible, such that the linker can include a flexible linker as well as one or more portions that confer less flexible structure.

In some embodiments, a subject antibody is “humanized” The term “humanized antibody” refers to an antibody comprising at least one chain comprising variable region framework residues substantially from a human antibody chain (referred to as the acceptor immunoglobulin or antibody) and at least one CDR substantially from a mouse antibody, (referred to as the donor immunoglobulin or antibody). See, Queen et al., Proc. Natl. Acad. Sci. USA 86:10029 10033 (1989), U.S. Pat. Nos. 5,530,101, 5,585,089, 5,693,761, WO 90/07861, and U.S. Pat. No. 5,225,539. The constant region(s), if present, can also be substantially or entirely from a human immunoglobulin. In some embodiments, a subject antibody may comprise one or more CDRs and one or more FR regions from a human antibody. Methods of making humanized antibodies are known in the art. See, e.g., U.S. Pat. No. 7,256,273.

The substitution of mouse CDRs into a human variable domain framework can result in retention of their correct spatial orientation where, e.g., the human variable domain framework adopts the same or similar conformation to the mouse variable framework from which the CDRs originated. This can be achieved by obtaining the human variable domains from human antibodies whose framework sequences exhibit a high degree of sequence identity with the murine variable framework domains from which the CDRs were derived. The heavy and light chain variable framework regions can be derived from the same or different human antibody sequences. The human antibody sequences can be the sequences of naturally occurring human antibodies or can be consensus sequences of several human antibodies. See Kettleborough et al., Protein Engineering 4:773 (1991); Kolbinger et al., Protein Engineering 6:971 (1993).

Having identified the complementarity determining regions of the murine donor immunoglobulin and appropriate human acceptor immunoglobulins, the next step is to determine which, if any, residues from these components should be substituted to optimize the properties of the resulting humanized antibody. In general, substitution of human amino acid residues with murine should be minimized, because introduction of murine residues increases the risk of the antibody eliciting a human-anti-mouse-antibody (HAMA) response in humans. Art-recognized methods of determining immune response can be performed to monitor a HAMA response in a particular patient or during clinical trials. Patients administered humanized antibodies can be given an immunogenicity assessment at the beginning and throughout the administration of the therapy. The HAMA response is measured, for example, by detecting antibodies to the humanized therapeutic reagent, in serum samples from the patient using a method known to one in the art, including surface plasmon resonance technology (BIACORE) and/or solid-phase ELISA analysis. In many embodiments, a subject humanized antibody does not substantially elicit a HAMA response in a human subject.

Certain amino acids from the human variable region framework residues are selected for substitution based on their possible influence on CDR conformation and/or binding to antigen. The unnatural juxtaposition of murine CDR regions with human variable framework region can result in unnatural conformational restraints, which, unless corrected by substitution of certain amino acid residues, lead to loss of binding affinity.

The selection of amino acid residues for substitution can be determined, in part, by computer modeling. Computer hardware and software for producing three-dimensional images of immunoglobulin molecules are known in the art. In general, molecular models are produced starting from solved structures for immunoglobulin chains or domains thereof. The chains to be modeled are compared for amino acid sequence similarity with chains or domains of solved three-dimensional structures, and the chains or domains showing the greatest sequence similarity is/are selected as starting points for construction of the molecular model. Chains or domains sharing at least 50% sequence identity are selected for modeling, and preferably those sharing at least 60%, 70%, 80%, 90% sequence identity or more are selected for modeling. The solved starting structures are modified to allow for differences between the actual amino acids in the immunoglobulin chains or domains being modeled, and those in the starting structure. The modified structures are then assembled into a composite immunoglobulin. Finally, the model is refined by energy minimization and by verifying that all atoms are within appropriate distances from one another and that bond lengths and angles are within chemically acceptable limits.

CDR and framework regions are as defined by Kabat, Sequences of Proteins of Immunological Interest (National Institutes of Health, Bethesda, Md., 1987 and 1991). An alternative structural definition has been proposed by Chothia et al., J. Mol. Biol. 196:901 (1987); Nature 342:878 (1989); and J. Mol. Biol. 186:651 (1989) (collectively referred to as “Chothia”). When framework residues, as defined by Kabat, supra, constitute structural loop residues as defined by Chothia, supra, the amino acids present in the mouse antibody may be selected for substitution into the humanized antibody. Residues which are “adjacent to a CDR region” include amino acid residues in positions immediately adjacent to one or more of the CDRs in the primary sequence of the humanized immunoglobulin chain, for example, in positions immediately adjacent to a CDR as defined by Kabat, or a CDR as defined by Chothia (See e.g., Chothia and Lesk JMB 196:901 (1987)). These amino acids are particularly likely to interact with the amino acids in the CDRs and, if chosen from the acceptor, to distort the donor CDRs and reduce affinity. Moreover, the adjacent amino acids may interact directly with the antigen (Amit et al., Science, 233:747 (1986)) and selecting these amino acids from the donor may be desirable to keep all the antigen contacts that provide affinity in the original antibody.

In some embodiments, a subject antibody comprises scFv multimers. For example, in some embodiments, a subject antibody is an scFv dimer (e.g., comprises two tandem scFv (scFv₂)), an scFv trimer (e.g., comprises three tandem scFv (scFv₃)), an scFv tetramer (e.g., comprises four tandem scFv (scFv₄)), or is a multimer of more than four scFv (e.g., in tandem). The scFv monomers can be linked in tandem via linkers of from about 2 amino acids to about 10 amino acids in length, e.g., 2 aa, 3 aa, 4 aa, 5 aa, 6 aa, 7 aa, 8 aa, 9 aa, or 10 aa in length. Suitable linkers include, e.g., (Gly)_(x), where x is an integer from 2 to 10. Other suitable linkers are those discussed above. In some embodiments, each of the scFv monomers in a subject scFV multimer is humanized, as described above.

In some embodiments, a subject antibody comprises a constant region of an immunoglobulin (e.g., an Fc region). The Fc region, if present, can be a human Fc region. If constant regions are present, the antibody can contain both light chain and heavy chain constant regions. Suitable heavy chain constant region include CH1, hinge, CH2, CH3, and CH4 regions. The antibodies described herein include antibodies having all types of constant regions, including IgM, IgG, IgD, IgA and IgE, and any isotype, including IgG1, IgG2, IgG3 and IgG4. An example of a suitable heavy chain Fc region is a human isotype IgG1 Fc. Light chain constant regions can be lambda or kappa. A subject antibody (e.g., a subject humanized antibody) can comprise sequences from more than one class or isotype. Antibodies can be expressed as tetramers containing two light and two heavy chains, as separate heavy chains, light chains, as Fab, Fab′ F(ab′)2, and Fv, or as single chain antibodies in which heavy and light chain variable domains are linked through a spacer.

In some embodiments, a subject antibody comprises a free thiol (—SH) group at the carboxyl terminus, where the free thiol group can be used to attach the antibody to a second polypeptide (e.g., another antibody, including a subject antibody), a scaffold, a carrier, etc.

In some embodiments, a subject antibody comprises one or more non-naturally occurring amino acids. In some embodiments, the non-naturally encoded amino acid comprises a carbonyl group, an acetyl group, an aminooxy group, a hydrazine group, a hydrazide group, a semicarbazide group, an azide group, or an alkyne group. See, e.g., U.S. Pat. No. 7,632,924 for suitable non-naturally occurring amino acids. Inclusion of a non-naturally occurring amino acid can provide for linkage to a polymer, a second polypeptide, a scaffold, etc. For example, a subject antibody linked to a water-soluble polymer can be made by reacting a water-soluble polymer (e.g., PEG) that comprises a carbonyl group to an the subject antibody that comprises a non-naturally encoded amino acid that comprises an aminooxy, hydrazine, hydrazide or semicarbazide group. As another example, a subject antibody linked to a water-soluble polymer can be made by reacting a subject antibody that comprises an alkyne-containing amino acid with a water-soluble polymer (e.g., PEG) that comprises an azide moiety; in some embodiments, the azide or alkyne group is linked to the PEG molecule through an amide linkage. A “non-naturally encoded amino acid” refers to an amino acid that is not one of the 20 common amino acids or pyrolysine or selenocysteine. Other terms that may be used synonymously with the term “non-naturally encoded amino acid” are “non-natural amino acid,” “unnatural amino acid,” “non-naturally-occurring amino acid,” and variously hyphenated and non-hyphenated versions thereof. The term “non-naturally encoded amino acid” also includes, but is not limited to, amino acids that occur by modification (e.g. post-translational modifications) of a naturally encoded amino acid (including but not limited to, the 20 common amino acids or pyrolysine and selenocysteine) but are not themselves naturally incorporated into a growing polypeptide chain by the translation complex. Examples of such non-naturally-occurring amino acids include, but are not limited to, N-acetylglucosaminyl-L-serine, N-acetylglucosaminyl-L-threonine, and O-phosphotyrosine.

In some embodiments, a subject antibody is linked (e.g., covalently linked) to a polymer (e.g., a polymer other than a polypeptide). Suitable polymers include, e.g., biocompatible polymers, and water-soluble biocompatible polymers. Suitable polymers include synthetic polymers and naturally-occurring polymers. Suitable polymers include, e.g., substituted or unsubstituted straight or branched chain polyalkylene, polyalkenylene or polyoxyalkylene polymers or branched or unbranched polysaccharides, e.g. a homo- or hetero-polysaccharide. Suitable polymers include, e.g., ethylene vinyl alcohol copolymer (commonly known by the generic name EVOH or by the trade name EVAL); polybutylmethacrylate; poly(hydroxyvalerate); poly(L-lactic acid); polycaprolactone; poly(lactide-co-glycolide); poly(hydroxybutyrate); poly(hydroxybutyrate-co-valerate); polydioxanone; polyorthoester; polyanhydride; poly(glycolic acid); poly(D,L-lactic acid); poly(glycolic acid-co-trimethylene carbonate); polyphosphoester; polyphosphoester urethane; poly(amino acids); cyanoacrylates; poly(trimethylene carbonate); poly(iminocarbonate); copoly(ether-esters) (e.g., poly(ethylene oxide)-poly(lactic acid) (PEO/PLA) co-polymers); polyalkylene oxalates; polyphosphazenes; biomolecules, such as fibrin, fibrinogen, cellulose, starch, collagen and hyaluronic acid; polyurethanes; silicones; polyesters; polyolefins; polyisobutylene and ethylene-alphaolefin copolymers; acrylic polymers and copolymers; vinyl halide polymers and copolymers, such as polyvinyl chloride; polyvinyl ethers, such as polyvinyl methyl ether; polyvinylidene halides, such as polyvinylidene fluoride and polyvinylidene chloride; polyacrylonitrile; polyvinyl ketones; polyvinyl aromatics, such as polystyrene; polyvinyl esters, such as polyvinyl acetate; copolymers of vinyl monomers with each other and olefins, such as ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, ABS resins, and ethylene-vinyl acetate copolymers; polyamides, such as Nylon 66 and polycaprolactam; alkyd resins; polycarbonates; polyoxymethylenes; polyimides; polyethers; epoxy resins; polyurethanes; rayon; rayon-triacetate; cellulose; cellulose acetate; cellulose butyrate; cellulose acetate butyrate; cellophane; cellulose nitrate; cellulose propionate; cellulose ethers; amorphous Teflon; poly(ethylene glycol); and carboxymethyl cellulose.

Suitable synthetic polymers include unsubstituted and substituted straight or branched chain poly(ethyleneglycol), poly(propyleneglycol) poly(vinylalcohol), and derivatives thereof, e.g., substituted poly(ethyleneglycol) such as methoxypoly(ethyleneglycol), and derivatives thereof. Suitable naturally-occurring polymers include, e.g., albumin, amylose, dextran, glycogen, and derivatives thereof.

Suitable polymers can have an average molecular weight in a range of from 500 Da to 50000 Da, e.g., from 5000 Da to 40000 Da, or from 25000 to 40000 Da. For example, in some embodiments, where a subject antibody comprises a poly(ethylene glycol) (PEG) or methoxypoly(ethyleneglycol) polymer, the PEG or methoxypoly(ethyleneglycol) polymer can have a molecular weight in a range of from about 0.5 kiloDaltons (kDa) to 1 kDa, from about 1 kDa to 5 kDa, from 5 kDa to 10 kDa, from 10 kDa to 25 kDa, from 25 kDa to 40 kDa, or from 40 kDa to 60 kDa.

As noted above, in some embodiments, a subject antibody is covalently linked to a PEG polymer. In some embodiments, a subject scFv multimer is covalently linked to a PEG polymer. See, e.g., Albrecht et al. (2006) J. Immunol. Methods 310:100. Methods and reagents suitable for PEGylation of a protein are well known in the art and may be found in, e.g., U.S. Pat. No. 5,849,860. PEG suitable for conjugation to a protein is generally soluble in water at room temperature, and has the general formula R(O—CH₂—CH₂)_(n)O—R, where R is hydrogen or a protective group such as an alkyl or an alkanol group, and where n is an integer from 1 to 1000. Where R is a protective group, it generally has from 1 to 8 carbons.

The PEG conjugated to the subject antibody can be linear. The PEG conjugated to the subject protein may also be branched. Branched PEG derivatives such as those described in U.S. Pat. No. 5,643,575, “star-PEG's” and multi-armed PEG's such as those described in Shearwater Polymers, Inc. catalog “Polyethylene Glycol Derivatives 1997-1998.” Star PEGs are described in the art including, e.g., in U.S. Pat. No. 6,046,305.

A subject antibody can be glycosylated, e.g., comprise a covalently linked carbohydrate or polysaccharide moiety. Glycosylation of antibodies is typically either N-linked or O-linked. N-linked refers to the attachment of the carbohydrate moiety to the side chain of an asparagine residue. The tripeptide sequences asparagine-X-serine and asparagine-X-threonine, where X is any amino acid except proline, are the recognition sequences for enzymatic attachment of the carbohydrate moiety to the asparagine side chain. Thus, the presence of either of these tripeptide sequences in a polypeptide creates a potential glycosylation site. O-linked glycosylation refers to the attachment of one of the sugars N-acetylgalactosamine, galactose, or xylose to a hydroxyamino acid, most commonly serine or threonine, although 5-hydroxyproline or 5-hydroxylysine may also be used.

Addition of glycosylation sites to an antibody is conveniently accomplished by altering the amino acid sequence such that it contains one or more of the above-described tripeptide sequences (for N-linked glycosylation sites). The alteration may also be made by the addition of, or substitution by, one or more serine or threonine residues to the sequence of the original antibody (for O-linked glycosylation sites). Similarly, removal of glycosylation sites can be accomplished by amino acid alteration within the native glycosylation sites of an antibody.

A subject antibody will in some embodiments comprise a “radiopaque” label, e.g. a label that can be easily visualized using for example x-rays. Radiopaque materials are well known to those of skill in the art. The most common radiopaque materials include iodide, bromide or barium salts. Other radiopaque materials are also known and include, but are not limited to organic bismuth derivatives (see, e.g., U.S. Pat. No. 5,939,045), radiopaque multiurethanes (see U.S. Pat. No. 5,346,981), organobismuth composites (see, e.g., U.S. Pat. No. 5,256,334), radiopaque barium multimer complexes (see, e.g., U.S. Pat. No. 4,866,132), and the like.

A subject antibody can be covalently linked to a second moiety (e.g., a lipid, a polypeptide other than a subject antibody, a synthetic polymer, a carbohydrate, and the like) using for example, glutaraldehyde, a homobifunctional cross-linker, or a heterobifunctional cross-linker. Glutaraldehyde cross-links polypeptides via their amino moieties. Homobifunctional cross-linkers (e.g., a homobifunctional imidoester, a homobifunctional N-hydroxysuccinimidyl (NHS) ester, or a homobifunctional sulfhydryl reactive cross-linker) contain two or more identical reactive moieties and can be used in a one step reaction procedure in which the cross-linker is added to a solution containing a mixture of the polypeptides to be linked. Homobifunctional NHS ester and imido esters cross-link amine containing polypeptides. In a mild alkaline pH, imido esters react only with primary amines to form imidoamides, and overall charge of the cross-linked polypeptides is not affected. Homobifunctional sulfhydryl reactive cross-linkers includes bismaleimidhexane (BMH), 1,5-difluoro-2,4-dinitrobenzene (DFDNB), and 1,4-di-(3′,2′-pyridyldithio) propinoamido butane (DPDPB).

Heterobifunctional cross-linkers have two or more different reactive moieties (e.g., amine reactive moiety and a sulfhydryl-reactive moiety) and are cross-linked with one of the polypeptides via the amine or sulfhydryl reactive moiety, then reacted with the other polypeptide via the non-reacted moiety. Multiple heterobifunctional haloacetyl cross-linkers are available, as are pyridyl disulfide cross-linkers. Carbodiimides are a classic example of heterobifunctional cross-linking reagents for coupling carboxyls to amines, which results in an amide bond.

A subject antibody can be immobilized on a solid support. Suitable supports are well known in the art and comprise, inter alia, commercially available column materials, polystyrene beads, latex beads, magnetic beads, colloid metal particles, glass and/or silicon chips and surfaces, nitrocellulose strips, nylon membranes, sheets, duracytes, wells of reaction trays (e.g., multi-well plates), plastic tubes, etc. A solid support can comprise any of a variety of substances, including, e.g., glass, polystyrene, polyvinyl chloride, polypropylene, polyethylene, polycarbonate, dextran, nylon, amylose, natural and modified celluloses, polyacrylamides, agaroses, and magnetite. Suitable methods for immobilizing a subject antibody onto a solid support are well known and include, but are not limited to ionic, hydrophobic, covalent interactions and the like. Solid supports can be soluble or insoluble, e.g., in aqueous solution. In some embodiments, a suitable solid support is generally insoluble in an aqueous solution.

A subject antibody will in some embodiments comprise a detectable label. Suitable detectable labels include any composition detectable by spectroscopic, photochemical, biochemical, immunochemical, electrical, optical or chemical means. Suitable include, but are not limited to, magnetic beads (e.g. Dynabeads™), fluorescent dyes (e.g., fluorescein isothiocyanate, texas red, rhodamine, a green fluorescent protein, a red fluorescent protein, a yellow fluorescent protein, and the like), radiolabels (e.g., ³H, ¹²⁵I ³⁵S, ¹⁴C, or ³²P), enzymes (e.g., horse radish peroxidase, alkaline phosphatase, luciferase, and others commonly used in an enzyme-linked immunosorbent assay (ELISA)), and colorimetric labels such as colloidal gold or colored glass or plastic (e.g. polystyrene, polypropylene, latex, etc.) beads.

In some embodiments, a subject antibody comprises a contrast agent or a radioisotope, where the contrast agent or radioisotope is one that is suitable for use in imaging, e.g., imaging procedures carried out on humans. Non-limiting examples of labels include radioisotope such as ¹²³¹I (iodine), ¹⁸F (fluorine), ⁹⁹Tc (technetium), ¹¹¹In (indium), and ⁶⁷Ga (gallium), and contrast agent such as gadolinium (Gd), dysprosium, and iron. Radioactive Gd isotopes (¹⁵³Gd) also are available and suitable for imaging procedures in non-human mammals. A subject antibody can be labeled using standard techniques. For example, a subject antibody can be iodinated using chloramine T or 1,3,4,6-tetrachloro-3α,6α-dephenylglycouril. For fluorination, fluorine is added to a subject antibody during the synthesis by a fluoride ion displacement reaction. See, Muller-Gartner, H., TIB Tech., 16:122-130 (1998) and Saji, H., Crit. Rev. Ther. Drug Carrier Syst., 16(2):209-244 (1999) for a review of synthesis of proteins with such radioisotopes. A subject antibody can also be labeled with a contrast agent through standard techniques. For example, a subject antibody can be labeled with Gd by conjugating low molecular Gd chelates such as Gd diethylene triamine pentaacetic acid (GdDTPA) or Gd tetraazacyclododecanetetraacetic (GdDOTA) to the antibody. See, Caravan et al., Chem. Rev. 99:2293-2352 (1999) and Lauffer et al., J. Magn. Reson. Imaging, 3:11-16 (1985). A subject antibody can be labeled with Gd by, for example, conjugating polylysine-Gd chelates to the antibody. See, for example, Curtet et al., Invest. Radiol., 33(10):752-761 (1998). Alternatively, a subject antibody can be labeled with Gd by incubating paramagnetic polymerized liposomes that include Gd chelator lipid with avidin and biotinylated antibody. See, for example, Sipkins et al., Nature Med., 4:623-626 (1998).

Suitable fluorescent proteins that can be linked to a subject antibody include, but are not limited to, a green fluorescent protein from Aequoria victoria or a mutant or derivative thereof e.g., as described in U.S. Pat. Nos. 6,066,476; 6,020,192; 5,985,577; 5,976,796; 5,968,750; 5,968,738; 5,958,713; 5,919,445; 5,874,304; e.g., Enhanced GFP, many such GFP which are available commercially, e.g., from Clontech, Inc.; a red fluorescent protein; a yellow fluorescent protein; any of a variety of fluorescent and colored proteins from Anthozoan species, as described in, e.g., Matz et al. (1999) Nature Biotechnol. 17:969-973; and the like.

A subject antibody will in some embodiments be linked to (e.g., covalently or non-covalently linked) a fusion partner, e.g., a ligand; an epitope tag; a peptide; a protein other than an antibody; and the like. Suitable fusion partners include peptides and polypeptides that confer enhanced stability in vivo (e.g., enhanced serum half-life); provide ease of purification, e.g., (His)_(n), e.g., 6His, and the like; provide for secretion of the fusion protein from a cell; provide an epitope tag, e.g., GST, hemagglutinin (HA; e.g., CYPYDVPDYA; SEQ ID NO:6607), FLAG (e.g., DYKDDDDK; SEQ ID NO:6608), c-myc (e.g., CEQKLISEEDL; SEQ ID NO:6609), and the like; provide a detectable signal, e.g., an enzyme that generates a detectable product (e.g., β-galactosidase, luciferase), or a protein that is itself detectable, e.g., a green fluorescent protein, a red fluorescent protein, a yellow fluorescent protein, etc.; provides for multimerization, e.g., a multimerization domain such as an Fc portion of an immunoglobulin; and the like.

The fusion may also include an affinity domain, including peptide sequences that can interact with a binding partner, e.g., such as one immobilized on a solid support, useful for identification or purification. Consecutive single amino acids, such as histidine, when fused to a protein, can be used for one-step purification of the fusion protein by high affinity binding to a resin column, such as nickel sepharose. Exemplary affinity domains include His5 (HHHHH) (SEQ ID NO:6610), HisX6 (HHHHHH) (SEQ ID NO:6611), C-myc (EQKLISEEDL) (SEQ ID NO:6612), Flag (DYKDDDDK) (SEQ ID NO:6608), StrepTag (WSHPQFEK) (SEQ ID NO:6613), hemagglutinin, e.g., HA Tag (YPYDVPDYA; SEQ ID NO:6614), glutathinone-S-transferase (GST), thioredoxin, cellulose binding domain, RYIRS (SEQ ID NO:6615), Phe-His-His-Thr (SEQ ID NO:6616), chitin binding domain, S-peptide, T7 peptide, SH2 domain, C-end RNA tag, WEAAAREACCRECCARA (SEQ ID NO:6617), metal binding domains, e.g., zinc binding domains or calcium binding domains such as those from calcium-binding proteins, e.g., calmodulin, troponin C, calcineurin B, myosin light chain, recoverin, S-modulin, visinin, VILIP, neurocalcin, hippocalcin, frequenin, caltractin, calpain large-subunit, 5100 proteins, parvalbumin, calbindin D9K, calbindin D28K, and calretinin, inteins, biotin, streptavidin, MyoD, leucine zipper sequences, and maltose binding protein.

A subject antibody will in some embodiments be fused to a polypeptide that binds to an endogenous blood brain barrier (BBB) receptor Linking a subject antibody to a polypeptide that binds to an endogenous BBB receptor facilitates crossing the BBB, e.g., in a subject treatment method (see below) involving administration of a subject antibody to an individual in need thereof. Suitable polypeptides that bind to an endogenous BBB include antibodies, e.g., monoclonal antibodies, or antigen-binding fragments thereof, that specifically bind to an endogenous BBB receptor. Suitable endogenous BBB receptors include, but are not limited to, an insulin receptor, a transferrin receptor, a leptin receptor, a lipoprotein receptor, and an insulin-like growth factor receptor. See, e.g., U.S. Patent Publication No. 2009/0156498.

In some embodiments, a subject antibody comprises a polyamine modification. Polyamine modification of a subject antibody enhances permeability of the modified antibody at the BBB. A subject antibody can be modified with polyamines that are either naturally occurring or synthetic. See, for example, U.S. Pat. No. 5,670,477. Useful naturally occurring polyamines include putrescine, spermidine, spermine, 1,3-deaminopropane, norspermidine, syn-homospermidine, thermine, thermospermine, caldopentamine, homocaldopentamine, and canavalmine. Putrescine, spermidine and spermine are particularly useful. Synthetic polyamines are composed of the empirical formula C_(x)H_(y)N_(z), can be cyclic or acyclic, branched or unbranched, hydrocarbon chains of 3-12 carbon atoms that further include 1-6 NR or N(R)₂ moieties, wherein R is H, (C₁-C₄) alkyl, phenyl, or benzyl. Polyamines can be linked to an antibody using any standard crosslinking method.

In some embodiments, a subject antibody is modified to include a carbohydrate moiety, where the carbohydrate moiety can be covalently linked to the antibody. In some embodiments, a subject antibody is modified to include a lipid moiety, where the lipid moiety can be covalently linked to the antibody. Suitable lipid moieties include, e.g., an N-fatty acyl group such as N-lauroyl, N-oleoyl, etc.; a fatty amine such as dodecyl amine, oleoyl amine, etc.; a C3-C16 long-chain aliphatic lipid; and the like. See, e.g., U.S. Pat. No. 6,638,513). In some embodiments, a subject antibody is incorporated into a liposome.

Methods of Producing a Subject Antibody

The present antibody can be produced by any known method, e.g., conventional synthetic methods for protein synthesis; recombinant DNA methods; etc.

Where a subject antibody is a single chain polypeptide, it can synthesized using standard chemical peptide synthesis techniques. Where a polypeptide is chemically synthesized, the synthesis may proceed via liquid-phase or solid-phase. Solid phase polypeptide synthesis (SPPS), in which the C-terminal amino acid of the sequence is attached to an insoluble support followed by sequential addition of the remaining amino acids in the sequence, is an example of a suitable method for the chemical synthesis of a subject antibody. Various forms of SPPS, such as Fmoc and Boc, are available for synthesizing a subject antibody. Techniques for solid phase synthesis are described by Barany and Merrifield, Solid-Phase Peptide Synthesis; pp. 3-284 in The Peptides: Analysis, Synthesis, Biology. Vol. 2: Special Methods in Peptide Synthesis, Part A., Merrifield, et al. J. Am. Chem. Soc., 85: 2149-2156 (1963); Stewart et al., Solid Phase Peptide Synthesis, 2nd ed. Pierce Chem. Co., Rockford, Ill. (1984); and Ganesan A. 2006 Mini Rev. Med Chem. 6:3-10 and Camarero J A et al. 2005 Protein Pept Lett. 12:723-8. Briefly, small insoluble, porous beads are treated with functional units on which peptide chains are built. After repeated cycling of coupling/deprotection, the free N-terminal amine of a solid-phase attached is coupled to a single N-protected amino acid unit. This unit is then deprotected, revealing a new N-terminal amine to which a further amino acid may be attached. The peptide remains immobilized on the solid-phase and undergoes a filtration process before being cleaved off.

Standard recombinant methods can be used for production of a subject antibody. For example, nucleic acids encoding light and heavy chain variable regions, optionally linked to constant regions, are inserted into expression vectors. The light and heavy chains can be cloned in the same or different expression vectors. The DNA segments encoding immunoglobulin chains are operably linked to control sequences in the expression vector(s) that ensure the expression of immunoglobulin polypeptides. Expression control sequences include, but are not limited to, promoters (e.g., naturally-associated or heterologous promoters), signal sequences, enhancer elements, and transcription termination sequences. The expression control sequences can be eukaryotic promoter systems in vectors capable of transforming or transfecting eukaryotic host cells (e.g., COS or CHO cells). Once the vector has been incorporated into the appropriate host, the host is maintained under conditions suitable for high level expression of the nucleotide sequences, and the collection and purification of the antibodies.

Because of the degeneracy of the code, a variety of nucleic acid sequences can encode each immunoglobulin amino acid sequence. The desired nucleic acid sequences can be produced by de novo solid-phase DNA synthesis or by polymerase chain reaction (PCR) mutagenesis of an earlier prepared variant of the desired polynucleotide. Oligonucleotide-mediated mutagenesis is an example of a suitable method for preparing substitution, deletion and insertion variants of target polypeptide DNA. See Adelman et al., DNA 2:183 (1983). Briefly, the target polypeptide DNA is altered by hybridizing an oligonucleotide encoding the desired mutation to a single-stranded DNA template. After hybridization, a DNA polymerase is used to synthesize an entire second complementary strand of the template that incorporates the oligonucleotide primer, and encodes the selected alteration in the target polypeptide DNA.

Suitable expression vectors are typically replicable in the host organisms either as episomes or as an integral part of the host chromosomal DNA. Commonly, expression vectors contain selection markers (e.g., ampicillin-resistance, hygromycin-resistance, tetracycline resistance, kanamycin resistance or neomycin resistance) to permit detection of those cells transformed with the desired DNA sequences.

Escherichia coli is an example of a prokaryotic host cell that can be used for cloning a subject antibody-encoding polynucleotide. Other microbial hosts suitable for use include bacilli, such as Bacillus subtilis, and other enterobacteriaceae, such as Salmonella, Serratia, and various Pseudomonas species. In these prokaryotic hosts, one can also make expression vectors, which will typically contain expression control sequences compatible with the host cell (e.g., an origin of replication). In addition, any number of a variety of well-known promoters will be present, such as the lactose promoter system, a tryptophan (trp) promoter system, a beta-lactamase promoter system, or a promoter system from phage lambda. The promoters will typically control expression, optionally with an operator sequence, and have ribosome binding site sequences and the like, for initiating and completing transcription and translation.

Other microbes, such as yeast, are also useful for expression. Saccharomyces (e.g., S. cerevisiae) and Pichia are examples of suitable yeast host cells, with suitable vectors having expression control sequences (e.g., promoters), an origin of replication, termination sequences and the like as desired. Typical promoters include 3-phosphoglycerate kinase and other glycolytic enzymes. Inducible yeast promoters include, among others, promoters from alcohol dehydrogenase, isocytochrome C, and enzymes responsible for maltose and galactose utilization.

In addition to microorganisms, mammalian cells (e.g., mammalian cells grown in in vitro cell culture) can also be used to express and produce the polypeptides of the present invention (e.g., polynucleotides encoding immunoglobulins or fragments thereof). See Winnacker, From Genes to Clones, VCH Publishers, N.Y., N.Y. (1987). Suitable mammalian host cells include CHO cell lines, various Cos cell lines, HeLa cells, myeloma cell lines, and transformed B-cells or hybridomas. Expression vectors for these cells can include expression control sequences, such as an origin of replication, a promoter, and an enhancer (Queen et al., Immunol. Rev. 89:49 (1986)), and necessary processing information sites, such as ribosome binding sites, RNA splice sites, polyadenylation sites, and transcriptional terminator sequences. Examples of suitable expression control sequences are promoters derived from immunoglobulin genes, SV40, adenovirus, bovine papilloma virus, cytomegalovirus and the like. See Co et al., J. Immunol. 148:1149 (1992).

Once synthesized (either chemically or recombinantly), the whole antibodies, their dimers, individual light and heavy chains, or other forms of a subject antibody (e.g., scFv, etc.) can be purified according to standard procedures of the art, including ammonium sulfate precipitation, affinity columns, column chromatography, high performance liquid chromatography (HPLC) purification, gel electrophoresis, and the like (see generally Scopes, Protein Purification (Springer-Verlag, N.Y., (1982)). A subject antibody can be substantially pure, e.g., at least about 80% to 85% pure, at least about 85% to 90% pure, at least about 90% to 95% pure, or 98% to 99%, or more, pure, e.g., free from contaminants such as cell debris, macromolecules other than a subject antibody, etc.

Compositions

The present disclosure provides a composition comprising a subject antibody. A subject antibody composition can comprise, in addition to a subject antibody, one or more of: a salt, e.g., NaCl, MgCl₂, KCl, MgSO₄, etc.; a buffering agent, e.g., a Tris buffer, N-(2-Hydroxyethyl)piperazine-N′-(2-ethanesulfonic acid) (HEPES), 2-(N-Morpholino)ethanesulfonic acid (MES), 2-(N-Morpholino)ethanesulfonic acid sodium salt (MES), 3-(N-Morpholino)propanesulfonic acid (MOPS), N-tris[Hydroxymethyl]methyl-3-aminopropanesulfonic acid (TAPS), etc.; a solubilizing agent; a detergent, e.g., a non-ionic detergent such as Tween-20, etc.; a protease inhibitor; glycerol; and the like.

Nucleic Acids

The present disclosure provides nucleic acids comprising nucleotide sequences encoding a subject antibody. A nucleotide sequence encoding a subject antibody can be operably linked to one or more regulatory elements, such as a promoter and enhancer, that allow expression of the nucleotide sequence in the intended target cells (e.g., a cell that is genetically modified to synthesize the encoded antibody).

Suitable promoter and enhancer elements are known in the art. For expression in a bacterial cell, suitable promoters include, but are not limited to, lad, lacZ, T3, T7, gpt, lambda P and trc. For expression in a eukaryotic cell, suitable promoters include, but are not limited to, light and/or heavy chain immunoglobulin gene promoter and enhancer elements; cytomegalovirus immediate early promoter; herpes simplex virus thymidine kinase promoter; early and late SV40 promoters; promoter present in long terminal repeats from a retrovirus; mouse metallothionein-I promoter; and various art-known tissue specific promoters.

In some embodiments, e.g., for expression in a yeast cell, a suitable promoter is a constitutive promoter such as an ADH1 promoter, a PGK1 promoter, an ENO promoter, a PYK1 promoter and the like; or a regulatable promoter such as a GAL1 promoter, a GAL10 promoter, an ADH2 promoter, a PHO5 promoter, a CUP1 promoter, a GAL7 promoter, a MET25 promoter, a MET3 promoter, a CYC1 promoter, a HIS3 promoter, an ADH1 promoter, a PGK promoter, a GAPDH promoter, an ADC1 promoter, a TRP1 promoter, a URA3 promoter, a LEU2 promoter, an ENO promoter, a TP1 promoter, and AOX1 (e.g., for use in Pichia). Selection of the appropriate vector and promoter is well within the level of ordinary skill in the art.

Suitable promoters for use in prokaryotic host cells include, but are not limited to, a bacteriophage T7 RNA polymerase promoter; a trp promoter; a lac operon promoter; a hybrid promoter, e.g., a lac/tac hybrid promoter, a tac/trc hybrid promoter, a trp/lac promoter, a T7/lac promoter; a trc promoter; a tac promoter, and the like; an araBAD promoter; in vivo regulated promoters, such as an ssaG promoter or a related promoter (see, e.g., U.S. Patent Publication No. 20040131637), a pagC promoter (Pulkkinen and Miller, J. Bacteriol., 1991: 173(1): 86-93; Alpuche-Aranda et al., PNAS, 1992; 89(21): 10079-83), a nirB promoter (Harborne et al. (1992) Mol. Micro. 6:2805-2813), and the like (see, e.g., Dunstan et al. (1999) Infect. Immun. 67:5133-5141; McKelvie et al. (2004) Vaccine 22:3243-3255; and Chatfield et al. (1992) Biotechnol. 10:888-892); a sigma70 promoter, e.g., a consensus sigma70 promoter (see, e.g., GenBank Accession Nos. AX798980, AX798961, and AX798183); a stationary phase promoter, e.g., a dps promoter, an spy promoter, and the like; a promoter derived from the pathogenicity island SPI-2 (see, e.g., WO96/17951); an actA promoter (see, e.g., Shetron-Rama et al. (2002) Infect. Immun. 70:1087-1096); an rpsM promoter (see, e.g., Valdivia and Falkow (1996). Mol. Microbiol. 22:367); a tet promoter (see, e.g., Hillen,W. and Wissmann,A. (1989) In Saenger,W. and Heinemann,U. (eds), Topics in Molecular and Structural Biology, Protein—Nucleic Acid Interaction. Macmillan, London, UK, Vol. 10, pp. 143-162); an SP6 promoter (see, e.g., Melton et al. (1984) Nucl. Acids Res. 12:7035); and the like. Suitable strong promoters for use in prokaryotes such as Escherichia coli include, but are not limited to Trc, Tac, T5, T7, and P_(Lambda). Non limiting examples of operators for use in bacterial host cells include a lactose promoter operator (Lad repressor protein changes conformation when contacted with lactose, thereby preventing the Lad repressor protein from binding to the operator), a tryptophan promoter operator (when complexed with tryptophan, TrpR repressor protein has a conformation that binds the operator; in the absence of tryptophan, the TrpR repressor protein has a conformation that does not bind to the operator), and a tac promoter operator (see, for example, deBoer et al. (1983) Proc. Natl. Acad. Sci. U.S.A. 80:21-25).

A nucleotide sequence encoding a subject antibody can be present in an expression vector and/or a cloning vector. Where a subject antibody comprises two separate polypeptides, nucleotide sequences encoding the two polypeptides can be cloned in the same or separate vectors. An expression vector can include a selectable marker, an origin of replication, and other features that provide for replication and/or maintenance of the vector.

Large numbers of suitable vectors and promoters are known to those of skill in the art; many are commercially available for generating a subject recombinant constructs. The following vectors are provided by way of example. Bacterial: pBs, phagescript, PsiX174, pBluescript SK, pBs KS, pNH8a, pNH16a, pNH18a, pNH46a (Stratagene, La Jolla, Calif., USA); pTrc99A, pKK223-3, pKK233-3, pDR540, and pRIT5 (Pharmacia, Uppsala, Sweden). Eukaryotic: pWLneo, pSV2cat, pOG44, PXR1, pSG (Stratagene) pSVK3, pBPV, pMSG and pSVL (Pharmacia).

Expression vectors generally have convenient restriction sites located near the promoter sequence to provide for the insertion of nucleic acid sequences encoding heterologous proteins. A selectable marker operative in the expression host may be present. Suitable expression vectors include, but are not limited to, viral vectors (e.g. viral vectors based on vaccinia virus; poliovirus; adenovirus (see, e.g., Li et al., Invest Opthalmol Vis Sci 35:2543 2549, 1994; Borras et al., Gene Ther 6:515 524, 1999; Li and Davidson, PNAS 92:7700 7704, 1995; Sakamoto et al., H Gene Ther 5:1088 1097, 1999; WO 94/12649, WO 93/03769; WO 93/19191; WO 94/28938; WO 95/11984 and WO 95/00655); adeno-associated virus (see, e.g., Ali et al., Hum Gene Ther 9:81 86, 1998, Flannery et al., PNAS 94:6916 6921, 1997; Bennett et al., Invest Opthalmol Vis Sci 38:2857 2863, 1997; Jomary et al., Gene Ther 4:683 690, 1997, Rolling et al., Hum Gene Ther 10:641 648, 1999; Ali et al., Hum Mol Genet 5:591 594, 1996; Srivastava in WO 93/09239, Samulski et al., J. Vir. (1989) 63:3822-3828; Mendelson et al., Virol. (1988) 166:154-165; and Flotte et al., PNAS (1993) 90:10613-10617); SV40; herpes simplex virus; human immunodeficiency virus (see, e.g., Miyoshi et al., PNAS 94:10319 23, 1997; Takahashi et al., J Virol 73:7812 7816, 1999); a retroviral vector (e.g., Murine Leukemia Virus, spleen necrosis virus, and vectors derived from retroviruses such as Rous Sarcoma Virus, Harvey Sarcoma Virus, avian leukosis virus, human immunodeficiency virus, myeloproliferative sarcoma virus, and mammary tumor virus); and the like.

As noted above, a subject nucleic acid comprises a nucleotide sequence encoding a subject antibody. A subject nucleic acid can comprise a nucleotide sequence encoding heavy- and light-chain CDRs. In some embodiments, a subject nucleic acid comprises a nucleotide sequence encoding heavy- and light-chain CDRs, where the CDR-encoding sequences are interspersed with FR-encoding nucleotide sequences. In some embodiments, the FR-encoding nucleotide sequences are human FR-encoding nucleotide sequences.

In some embodiments, a subject nucleic acid comprises a nucleotide sequence having at least about 75%, at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 98%, at least about 99%, or 100%, nucleotide sequence identity to the nucleotide sequence set forth in herein. In some embodiments, a subject nucleic acid comprises a nucleotide sequence having at least about 75%, at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 98%, at least about 99%, or 100%, nucleotide sequence identity to the nucleotide sequence set forth in herein.

Cells

The present disclosure provides isolated genetically modified host cells (e.g., in vitro cells) that are genetically modified with a subject nucleic acid. In some embodiments, a subject isolated genetically modified host cell can produce a subject antibody.

Suitable host cells include eukaryotic host cells, such as a mammalian cell, an insect host cell, a yeast cell; and prokaryotic cells, such as a bacterial cell. Introduction of a subject nucleic acid into the host cell can be effected, for example by calcium phosphate precipitation, DEAE dextran mediated transfection, liposome-mediated transfection, electroporation, or other known method.

Suitable mammalian cells include primary cells and immortalized cell lines. Suitable mammalian cell lines include human cell lines, non-human primate cell lines, rodent (e.g., mouse, rat) cell lines, and the like. Suitable mammalian cell lines include, but are not limited to, HeLa cells (e.g., American Type Culture Collection (ATCC) No. CCL-2), CHO cells (e.g., ATCC Nos. CRL9618, CCL61, CRL9096), 293 cells (e.g., ATCC No. CRL-1573), Vero cells, NIH 3T3 cells (e.g., ATCC No. CRL-1658), Huh-7 cells, BHK cells (e.g., ATCC No. CCL10), PC12 cells (ATCC No. CRL1721), COS cells, COS-7 cells (ATCC No. CRL1651), RAT1 cells, mouse L cells (ATCC No. CCLI.3), human embryonic kidney (HEK) cells (ATCC No. CRL1573), HLHepG2 cells, and the like.

Suitable yeast cells include, but are not limited to, Pichia pastoris, Pichia finlandica, Pichia trehalophila, Pichia koclamae, Pichia membranaefaciens, Pichia opuntiae, Pichia thermotolerans, Pichia salictaria, Pichia guercuum, Pichia pijperi, Pichia stiptis, Pichia methanolica, Pichia sp., Saccharomyces cerevisiae, Saccharomyces sp., Hansenula polymorpha, Kluyveromyces sp., Kluyveromyces lactis, Candida albicans, Aspergillus nidulans, Aspergillus niger, Aspergillus oryzae, Trichoderma reesei, Chrysosporium lucknowense, Fusarium sp., Fusarium gramineum, Fusarium venenatum, Neurospora crassa, Chlamydomonas reinhardtii, and the like.

Suitable prokaryotic cells include, but are not limited to, any of a variety of laboratory strains of Escherichia coli, Lactobacillus sp., Salmonella sp., Shigella sp., and the like. See, e.g., Carrier et al. (1992) J. Immunol. 148:1176-1181; U.S. Pat. No. 6,447,784; and Sizemore et al. (1995) Science 270:299-302. Examples of Salmonella strains which can be employed in the present invention include, but are not limited to, Salmonella typhi and S. typhimurium. Suitable Shigella strains include, but are not limited to, Shigella flexneri, Shigella sonnei, and Shigella disenteriae. Typically, the laboratory strain is one that is non-pathogenic. Non-limiting examples of other suitable bacteria include, but are not limited to, Bacillus subtilis, Pseudomonas pudita, Pseudomonas aeruginosa, Pseudomonas mevalonii, Rhodobacter sphaeroides, Rhodobacter capsulatus, Rhodospirillum rubrum, Rhodococcus sp., and the like. In some embodiments, the host cell is Escherichia coli.

Compositions

The present disclosure provides compositions, including pharmaceutical compositions, comprising a subject antibody. In general, a formulation comprises an effective amount of a subject antibody. An “effective amount” means a dosage sufficient to produce a desired result, e.g., an increase of muscle mass or amelioration of a symptom of a disease. Generally, the desired result is at least a reduction in a symptom of an ACVR2A-associated conditino, as compared to a control. A subject antibody can be delivered in such a manner as to avoid the blood-brain barrier, as described in more detail below. A subject antibody can be formulated and/or modified to enable the antibody to cross the blood-brain barrier.

Formulations

In the subject methods, a subject antibody can be administered to the host using any convenient means capable of resulting in the desired therapeutic effect or diagnostic effect. Thus, the agent can be incorporated into a variety of formulations for therapeutic administration. More particularly, a subject antibody can be formulated into pharmaceutical compositions by combination with appropriate, pharmaceutically acceptable carriers or diluents, and may be formulated into preparations in solid, semi-solid, liquid or gaseous forms, such as tablets, capsules, powders, granules, ointments, solutions, suppositories, injections, inhalants and aerosols.

In pharmaceutical dosage forms, a subject antibody can be administered in the form of their pharmaceutically acceptable salts, or they may also be used alone or in appropriate association, as well as in combination, with other pharmaceutically active compounds. The following methods and excipients are merely exemplary and are in no way limiting.

For oral preparations, a subject antibody can be used alone or in combination with appropriate additives to make tablets, powders, granules or capsules, for example, with conventional additives, such as lactose, mannitol, corn starch or potato starch; with binders, such as crystalline cellulose, cellulose derivatives, acacia, corn starch or gelatins; with disintegrators, such as corn starch, potato starch or sodium carboxymethylcellulose; with lubricants, such as talc or magnesium stearate; and if desired, with diluents, buffering agents, moistening agents, preservatives and flavoring agents.

A subject antibody can be formulated into preparations for injection by dissolving, suspending or emulsifying them in an aqueous or nonaqueous solvent, such as vegetable or other similar oils, synthetic aliphatic acid glycerides, esters of higher aliphatic acids or propylene glycol; and if desired, with conventional additives such as solubilizers, isotonic agents, suspending agents, emulsifying agents, stabilizers and preservatives.

Pharmaceutical compositions comprising a subject antibody are prepared by mixing the antibody having the desired degree of purity with optional physiologically acceptable carriers, excipients, stabilizers, surfactants, buffers and/or tonicity agents. Acceptable carriers, excipients and/or stabilizers are nontoxic to recipients at the dosages and concentrations employed, and include buffers such as phosphate, citrate, and other organic acids; antioxidants including ascorbic acid, glutathione, cysteine, methionine and citric acid; preservatives (such as ethanol, benzyl alcohol, phenol, m-cresol, p-chlor-m-cresol, methyl or propyl parabens, benzalkonium chloride, or combinations thereof); amino acids such as arginine, glycine, ornithine, lysine, histidine, glutamic acid, aspartic acid, isoleucine, leucine, alanine, phenylalanine, tyrosine, tryptophan, methionine, serine, proline and combinations thereof; monosaccharides, disaccharides and other carbohydrates; low molecular weight (less than about 10 residues) polypeptides; proteins, such as gelatin or serum albumin; chelating agents such as EDTA; sugars such as trehalose, sucrose, lactose, glucose, mannose, maltose, galactose, fructose, sorbose, raffinose, glucosamine, N-methylglucosamine, galactosamine, and neuraminic acid; and/or non-ionic surfactants such as Tween, Brij Pluronics, Triton-X, or polyethylene glycol (PEG).

The pharmaceutical composition may be in a liquid form, a lyophilized form or a liquid form reconstituted from a lyophilized form, wherein the lyophilized preparation is to be reconstituted with a sterile solution prior to administration. The standard procedure for reconstituting a lyophilized composition is to add back a volume of pure water (typically equivalent to the volume removed during lyophilization); however solutions comprising antibacterial agents may be used for the production of pharmaceutical compositions for parenteral administration; see also Chen (1992) Drug Dev Ind Pharm 18, 1311-54.

Exemplary antibody concentrations in a subject pharmaceutical composition may range from about 1 mg/mL to about 200 mg/ml or from about 50 mg/mL to about 200 mg/mL, or from about 150 mg/mL to about 200 mg/mL.

An aqueous formulation of the antibody may be prepared in a pH-buffered solution, e.g., at pH ranging from about 4.0 to about 7.0, or from about 5.0 to about 6.0, or alternatively about 5.5. Examples of buffers that are suitable for a pH within this range include phosphate-, histidine-, citrate-, succinate-, acetate-buffers and other organic acid buffers. The buffer concentration can be from about 1 mM to about 100 mM, or from about 5 mM to about 50 mM, depending, e.g., on the buffer and the desired tonicity of the formulation.

A tonicity agent may be included in the antibody formulation to modulate the tonicity of the formulation. Exemplary tonicity agents include sodium chloride, potassium chloride, glycerin and any component from the group of amino acids, sugars as well as combinations thereof. In some embodiments, the aqueous formulation is isotonic, although hypertonic or hypotonic solutions may be suitable. The term “isotonic” denotes a solution having the same tonicity as some other solution with which it is compared, such as physiological salt solution or serum. Tonicity agents may be used in an amount of about 5 mM to about 350 mM, e.g., in an amount of 100 mM to 350 nM.

A surfactant may also be added to the antibody formulation to reduce aggregation of the formulated antibody and/or minimize the formation of particulates in the formulation and/or reduce adsorption. Exemplary surfactants include polyoxyethylensorbitan fatty acid esters (Tween), polyoxyethylene alkyl ethers (Brij), alkylphenylpolyoxyethylene ethers (Triton-X), polyoxyethylene-polyoxypropylene copolymer (Poloxamer, Pluronic), and sodium dodecyl sulfate (SDS). Examples of suitable polyoxyethylenesorbitan-fatty acid esters are polysorbate 20, (sold under the trademark Tween 20™) and polysorbate 80 (sold under the trademark Tween 80™). Examples of suitable polyethylene-polypropylene copolymers are those sold under the names Pluronic® F68 or Poloxamer 188™. Examples of suitable Polyoxyethylene alkyl ethers are those sold under the trademark Brij™. Exemplary concentrations of surfactant may range from about 0.001% to about 1% w/v.

A lyoprotectant may also be added in order to protect the labile active ingredient (e.g. a protein) against destabilizing conditions during the lyophilization process. For example, known lyoprotectants include sugars (including glucose and sucrose); polyols (including mannitol, sorbitol and glycerol); and amino acids (including alanine, glycine and glutamic acid). Lyoprotectants can be included in an amount of about 10 mM to 500 nM.

In some embodiments, a subject formulation includes a subject antibody, and one or more of the above-identified agents (e.g., a surfactant, a buffer, a stabilizer, a tonicity agent) and is essentially free of one or more preservatives, such as ethanol, benzyl alcohol, phenol, m-cresol, p-chlor-m-cresol, methyl or propyl parabens, benzalkonium chloride, and combinations thereof. In other embodiments, a preservative is included in the formulation, e.g., at concentrations ranging from about 0.001 to about 2% (w/v).

For example, a subject formulation can be a liquid or lyophilized formulation suitable for parenteral administration, and can comprise: about 1 mg/mL to about 200 mg/mL of a subject antibody; about 0.001% to about 1% of at least one surfactant; about 1 mM to about 100 mM of a buffer; optionally about 10 mM to about 500 mM of a stabilizer; and about 5 mM to about 305 mM of a tonicity agent; and has a pH of about 4.0 to about 7.0.

As another example, a subject parenteral formulation is a liquid or lyophilized formulation comprising: about 1 mg/mL to about 200 mg/mL of a subject antibody; 0.04% Tween 20 w/v; 20 mM L-histidine; and 250 mM Sucrose; and has a pH of 5.5.

As another example, a subject parenteral formulation comprises a lyophilized formulation comprising: 1) 15 mg/mL of a subject antibody; 0.04% Tween 20 w/v; 20 mM L-histidine; and 250 mM sucrose; and has a pH of 5.5; or 2) 75 mg/mL of a subject antibody; 0.04% Tween 20 w/v; 20 mM L-histidine; and 250 mM sucrose; and has a pH of 5.5; or 3) 75 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L-histidine; and 250 mM Sucrose; and has a pH of 5.5; or 4) 75 mg/mL of a subject antibody; 0.04% Tween 20 w/v; 20 mM L-histidine; and 250 mM trehalose; and has a pH of 5.5; or 6) 75 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L-histidine; and 250 mM trehalose; and has a pH of 5.5.

As another example, a subject parenteral formulation is a liquid formulation comprising: 1) 7.5 mg/mL of a subject antibody; 0.022% Tween 20 w/v; 120 mM L-histidine; and 250 125 mM sucrose; and has a pH of 5.5; or 2) 37.5 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 10 mM L-histidine; and 125 mM sucrose; and has a pH of 5.5; or 3) 37.5 mg/mL of a subject antibody; 0.01% Tween 20 w/v; 10 mM L-histidine; and 125 mM sucrose; and has a pH of 5.5; or 4) 37.5 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 10 mM L-histidine; 125 mM trehalose; and has a pH of 5.5; or 5) 37.5 mg/mL of a subject antibody; 0.01% Tween 20 w/v; 10 mM L-histidine; and 125 mM trehalose; and has a pH of 5.5; or 6) 5 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L-histidine; and 250 mM trehalose; and has a pH of 5.5; or 7) 75 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L-histidine; and 250 mM mannitol; and has a pH of 5.5; or 8) 75 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L histidine; and 140 mM sodium chloride; and has a pH of 5.5; or 9) 150 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L-histidine; and 250 mM trehalose; and has a pH of 5.5; or 10) 150 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L-histidine; and 250 mM mannitol; and has a pH of 5.5; or 11) 150 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L-histidine; and 140 mM sodium chloride; and has a pH of 5.5; or 12) 10 mg/mL of a subject antibody; 0.01% Tween 20 w/v; 20 mM L-histidine; and 40 mM sodium chloride; and has a pH of 5.5.

A subject antibody can be utilized in aerosol formulation to be administered via inhalation. A subject antibody can be formulated into pressurized acceptable propellants such as dichlorodifluoromethane, propane, nitrogen and the like.

Furthermore, a subject antibody can be made into suppositories by mixing with a variety of bases such as emulsifying bases or water-soluble bases. A subject antibody can be administered rectally via a suppository. The suppository can include vehicles such as cocoa butter, carbowaxes and polyethylene glycols, which melt at body temperature, yet are solidified at room temperature.

Unit dosage forms for oral or rectal administration such as syrups, elixirs, and suspensions may be provided wherein each dosage unit, for example, teaspoonful, tablespoonful, tablet or suppository, contains a predetermined amount of the composition containing one or more inhibitors. Similarly, unit dosage forms for injection or intravenous administration may comprise a subject antibody in a composition as a solution in sterile water, normal saline or another pharmaceutically acceptable carrier.

The term “unit dosage form,” as used herein, refers to physically discrete units suitable as unitary dosages for human and animal subjects, each unit containing a predetermined quantity of compounds of the present invention calculated in an amount sufficient to produce the desired effect in association with a pharmaceutically acceptable diluent, carrier or vehicle. The specifications for a subject antibody may depend on the particular antibody employed and the effect to be achieved, and the pharmacodynamics associated with each antibody in the host.

Other modes of administration will also find use with the subject invention. For instance, a subject antibody can be formulated in suppositories and, in some cases, aerosol and intranasal compositions. For suppositories, the vehicle composition will include traditional binders and carriers such as, polyalkylene glycols, or triglycerides. Such suppositories may be formed from mixtures containing the active ingredient in the range of about 0.5% to about 10% (w/w), e.g., about 1% to about 2%.

Intranasal formulations will usually include vehicles that neither cause irritation to the nasal mucosa nor significantly disturb ciliary function. Diluents such as water, aqueous saline or other known substances can be employed with the subject invention. The nasal formulations may also contain preservatives such as, but not limited to, chlorobutanol and benzalkonium chloride. A surfactant may be present to enhance absorption of the subject proteins by the nasal mucosa.

A subject antibody can be administered as an injectable formulation. Typically, injectable compositions are prepared as liquid solutions or suspensions; solid forms suitable for solution in, or suspension in, liquid vehicles prior to injection may also be prepared. The preparation may also be emulsified or the antibody encapsulated in liposome vehicles.

Suitable excipient vehicles are, for example, water, saline, dextrose, glycerol, ethanol, or the like, and combinations thereof. In addition, if desired, the vehicle may contain minor amounts of auxiliary substances such as wetting or emulsifying agents or pH buffering agents. Actual methods of preparing such dosage forms are known, or will be apparent, to those skilled in the art. See, e.g., Remington's Pharmaceutical Sciences, Mack Publishing Company, Easton, Pa., 17th edition, 1985. The composition or formulation to be administered will, in any event, contain a quantity of a subject antibody adequate to achieve the desired state in the subject being treated.

The pharmaceutically acceptable excipients, such as vehicles, adjuvants, carriers or diluents, are readily available to the public. Moreover, pharmaceutically acceptable auxiliary substances, such as pH adjusting and buffering agents, tonicity adjusting agents, stabilizers, wetting agents and the like, are readily available to the public.

In some embodiments, a subject antibody is formulated in a controlled release formulation. Sustained-release preparations may be prepared using methods well known in the art. Suitable examples of sustained-release preparations include semipermeable matrices of solid hydrophobic polymers containing the antibody in which the matrices are in the form of shaped articles, e.g. films or microcapsules. Examples of sustained-release matrices include polyesters, copolymers of L-glutamic acid and ethyl-L-glutamate, non-degradable ethylene-vinyl acetate, hydrogels, polylactides, degradable lactic acid-glycolic acid copolymers and poly-D-(−)-3-hydroxybutyric acid. Possible loss of biological activity and possible changes in immunogenicity of antibodies comprised in sustained-release preparations may be prevented by using appropriate additives, by controlling moisture content and by developing specific polymer matrix compositions.

Controlled release within the scope of this invention can be taken to mean any one of a number of extended release dosage forms. The following terms may be considered to be substantially equivalent to controlled release, for the purposes of the present invention: continuous release, controlled release, delayed release, depot, gradual release, long-term release, programmed release, prolonged release, proportionate release, protracted release, repository, retard, slow release, spaced release, sustained release, time coat, timed release, delayed action, extended action, layered-time action, long acting, prolonged action, repeated action, slowing acting, sustained action, sustained-action medications, and extended release. Further discussions of these terms may be found in Lesczek Krowczynski, Extended-Release Dosage Forms, 1987 (CRC Press, Inc.).

The various controlled release technologies cover a very broad spectrum of drug dosage forms. Controlled release technologies include, but are not limited to physical systems and chemical systems.

Physical systems include, but are not limited to, reservoir systems with rate-controlling membranes, such as microencapsulation, macroencapsulation, and membrane systems; reservoir systems without rate-controlling membranes, such as hollow fibers, ultra microporous cellulose triacetate, and porous polymeric substrates and foams; monolithic systems, including those systems physically dissolved in non-porous, polymeric, or elastomeric matrices (e.g., nonerodible, erodible, environmental agent ingression, and degradable), and materials physically dispersed in non-porous, polymeric, or elastomeric matrices (e.g., nonerodible, erodible, environmental agent ingression, and degradable); laminated structures, including reservoir layers chemically similar or dissimilar to outer control layers; and other physical methods, such as osmotic pumps, or adsorption onto ion-exchange resins.

Chemical systems include, but are not limited to, chemical erosion of polymer matrices (e.g., heterogeneous, or homogeneous erosion), or biological erosion of a polymer matrix (e.g., heterogeneous, or homogeneous). Additional discussion of categories of systems for controlled release may be found in Agis F. Kydonieus, Controlled Release Technologies: Methods, Theory and Applications, 1980 (CRC Press, Inc.).

There are a number of controlled release drug formulations that are developed for oral administration. These include, but are not limited to, osmotic pressure-controlled gastrointestinal delivery systems; hydrodynamic pressure-controlled gastrointestinal delivery systems; membrane permeation-controlled gastrointestinal delivery systems, which include microporous membrane permeation-controlled gastrointestinal delivery devices; gastric fluid-resistant intestine targeted controlled-release gastrointestinal delivery devices; gel diffusion-controlled gastrointestinal delivery systems; and ion-exchange-controlled gastrointestinal delivery systems, which include cationic and anionic drugs. Additional information regarding controlled release drug delivery systems may be found in Yie W. Chien, Novel Drug Delivery Systems, 1992 (Marcel Dekker, Inc.).

Dosages

A suitable dosage can be determined by an attending physician or other qualified medical personnel, based on various clinical factors. As is well known in the medical arts, dosages for any one patient depend upon many factors, including the patient's size, body surface area, age, the particular compound to be administered, sex of the patient, time, and route of administration, general health, and other drugs being administered concurrently. A subject antibody may be administered in amounts between 1 ng/kg body weight and 20 mg/kg body weight per dose, e.g. between 0.1 mg/kg body weight to 10 mg/kg body weight, e.g. between 0.5 mg/kg body weight to 5 mg/kg body weight; however, doses below or above this exemplary range are envisioned, especially considering the aforementioned factors. If the regimen is a continuous infusion, it can also be in the range of 1 μg to 10 mg per kilogram of body weight per minute.

Those of skill will readily appreciate that dose levels can vary as a function of the specific antibody, the severity of the symptoms and the susceptibility of the subject to side effects. Preferred dosages for a given compound are readily determinable by those of skill in the art by a variety of means.

Routes of Administration

A subject antibody is administered to an individual using any available method and route suitable for drug delivery, including in vivo and ex vivo methods, as well as systemic and localized routes of administration.

Conventional and pharmaceutically acceptable routes of administration include intranasal, intramuscular, intratracheal, subcutaneous, intradermal, topical application, intravenous, intraarterial, rectal, nasal, oral, and other enteral and parenteral routes of administration. Routes of administration may be combined, if desired, or adjusted depending upon the antibody and/or the desired effect. A subject antibody composition can be administered in a single dose or in multiple doses. In some embodiments, a subject antibody composition is administered orally. In some embodiments, a subject antibody composition is administered via an inhalational route. In some embodiments, a subject antibody composition is administered intranasally. In some embodiments, a subject antibody composition is administered locally. In some embodiments, a subject antibody composition is administered intracranially. In some embodiments, a subject antibody composition is administered intravenously.

The agent can be administered to a host using any available conventional methods and routes suitable for delivery of conventional drugs, including systemic or localized routes. In general, routes of administration contemplated by the invention include, but are not necessarily limited to, enteral, parenteral, or inhalational routes.

Parenteral routes of administration other than inhalation administration include, but are not necessarily limited to, topical, transdermal, subcutaneous, intramuscular, intraorbital, intracapsular, intraspinal, intrasternal, and intravenous routes, i.e., any route of administration other than through the alimentary canal. Parenteral administration can be carried to effect systemic or local delivery of a subject antibody. Where systemic delivery is desired, administration typically involves invasive or systemically absorbed topical or mucosal administration of pharmaceutical preparations.

A subject antibody can also be delivered to the subject by enteral administration. Enteral routes of administration include, but are not necessarily limited to, oral and rectal (e.g., using a suppository) delivery.

By treatment is meant at least an amelioration of the symptoms associated with the pathological condition afflicting the host, where amelioration is used in a broad sense to refer to at least a reduction in the magnitude of a parameter, e.g. symptom, associated with the pathological condition being treated, such as muscle atrophy. As such, treatment also includes situations where the pathological condition, or at least symptoms associated therewith, are completely inhibited, e.g. prevented from happening, or stopped, e.g. terminated, such that the host no longer suffers from the pathological condition, or at least the symptoms that characterize the pathological condition.

In some embodiments, a subject antibody is administered by injection and/or delivery, e.g., to a site in a brain artery or directly into brain tissue. A subject antibody can also be administered directly to a target site e.g., by biolistic delivery to the target site.

A variety of hosts (wherein the term “host” is used interchangeably herein with the terms “subject,” “individual,” and “patient”) are treatable according to the subject methods. Generally such hosts are “mammals” or “mammalian,” where these terms are used broadly to describe organisms which are within the class mammalia, including the orders carnivore (e.g., dogs and cats), rodentia (e.g., mice, guinea pigs, and rats), and primates (e.g., humans, chimpanzees, and monkeys). In some embodiments, the hosts will be humans.

Kits with unit doses of a subject antibody, e.g. in oral or injectable doses, are provided. In such kits, in addition to the containers containing the unit doses will be an informational package insert describing the use and attendant benefits of the antibody in treating pathological condition of interest. Preferred compounds and unit doses are those described herein above.

Treatment Methods

The present disclosure provides methods of treating an ACVR2A-associated condition, the methods generally involving administering to an individual in need thereof (e.g., an individual having a ACVR2A-associated condition) an effective amount of a subject antibody, alone (e.g., in monotherapy) or in combination (e.g., in combination therapy) with one or more additional therapeutic agents. In certain embodiments, an ACVR2A-specific antibody can be used for treating or preventing a disease or condition that can be treated by decreasing ACVR2A signaling. In certain embodiments, the present invention provides methods of treating or preventing a disease, disorder, or condition in an individual in need thereof through administering to the individual a therapeutically effective amount of an ACVR2A-specific antibody as described above. These methods are particularly aimed at therapeutic and prophylactic treatments of animals, and more particularly, humans.

Mice genetically deficient in the inhibin-α subunit are deficient in inhibin A and inhibin B, have gonadal tumors that overexpress activins A and B (Matzuk et al., 1992, Nature 360:313-319; Matzuk et al., 1994, Proc Natl Acad Sci USA 91:8817-8821). All such mice develop these tumors and eventually die of a cancer cachexia-like syndrome mediated by high levels of tumor-derived activin acting through ACVR2A (Coerver et al., 1996, Mol Endocrinol 10:534-543). While not wishing to limit the present invention, an antibody that specifically blocks binding of a ligand to ACVR2A may be useful for treating a variety of conditions that are related to muscle atrophy. For example, an ACVR2A-specific antibody may be used to reduce the effects of activin-producing tumors, alleviating activin-mediated cachexia, and prolonging patient survival. In some embodiments, the subject may have a muscle-wasting disorder such as insufficient lean body mass, a decrease in muscle mass or muscle function, cachexia or sarcopenia.

ACVR2A and ACVR2A-ligand complexes play essential roles in tissue growth as well as early developmental processes such as the correct formation of various structures or in one or more post-developmental capacities including sexual development, pituitary hormone production, and creation of bone and cartilage. Thus, ACVR2A-associated conditions include abnormal tissue growth and developmental defects. In addition, ACVR2A-associated conditions include, but are not limited to, disorders of cell growth and differentiation such as inflammation, allergy, autoimmune diseases, infectious diseases, and tumors.

Exemplary ACVR2A-associated conditions include neuromuscular disorders (e.g., muscular dystrophy and muscle atrophy), congestive obstructive pulmonary disease or pulmonary emphysema (and associated muscle wasting), muscle wasting syndrome, sarcopenia, cachexia, adipose tissue disorders (e.g., obesity), type 2 diabetes, and bone degenerative disease (e.g., osteoporosis). Other exemplary ACVR2A-associated conditions include musculodegenerative and neuromuscular disorders, tissue repair (e.g., wound healing), neurodegenerative diseases (e.g., amyotrophic lateral sclerosis), immunologic disorders (e.g., disorders related to abnormal proliferation or function of lymphocytes), and obesity or disorders related to abnormal proliferation of adipocytes.

In certain embodiments, an ACVR2A-specific antibody may be used as part of a treatment for a muscular dystrophy. The term “muscular dystrophy” refers to a group of degenerative muscle diseases characterized by gradual weakening and deterioration of skeletal muscles and sometimes the heart and respiratory muscles. Muscular dystrophies are genetic disorders characterized by progressive muscle wasting and weakness that begin with microscopic changes in the muscle. As muscles degenerate over time, the person's muscle strength declines. Exemplary muscular dystrophies that can be treated with a regimen including the subject ACVR2A-specific antibodies include: Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), Emery-Dreifuss muscular dystrophy (EDMD), limb-girdle muscular dystrophy (LGMD), fascioscapulohumeral muscular dystrophy (FSH or FSHD) (also known as Landouzy-Dejerine), myotonic muscular dystrophy (MMD) (also known as Steinert's Disease), oculopharyngeal muscular dystrophy (OPMD), distal muscular dystrophy (DD), congenital muscular dystrophy (CMD), and scapulohumeral muscular dystrophy (SMD).

Duchenne muscular dystrophy (DMD) was first described by the French neurologist Guillaume Benjamin Amand Duchenne in the 1860s. Becker muscular dystrophy (BMD) is named after the German doctor Peter Emil Becker, who first described this variant of DMD in the 1950s. DMD is one of the most frequent inherited diseases in males, affecting one in 3,500 boys. DMD occurs when the dystrophin gene, located on the short arm of the X chromosome, is broken. Since males only carry one copy of the X chromosome, they only have one copy of the dystrophin gene. Without the dystrophin protein, muscle is easily damaged during cycles of contraction and relaxation. While early in the disease muscle compensates by regeneration, later on muscle progenitor cells cannot keep up with the ongoing damage and healthy muscle is replaced by non-functional fibro-fatty tissue.

In other embodiments, ACVR2A-specific antibodies may also be used to treat or prevent muscular atrophy due to myopathies, examples of which include inflammatory myopathy, metabolic myopathy, and myotonia. Subject ACVR2A-specific antibodies have application in treating congenital myopathies such as myotubular myopathy, nemalene myopathy, and mitochondrial myopathy. The subject ACVR2A-specific antibodies may be used to treat inclusion body myositis, myoglobinurias, rhabdomyolysis, myositis ossificans, polymyositis, or dermatomyositis. In addition, ACVR2A-specific antibodies may treat or prevent muscle atrophy arising from glucocorticoid treatment, sarcopenia, prolonged bed rest, skeletal immobilization, sepsis, or congestive heart failure.

An ACVR2A-specific antibody may provide an effective means to increase muscle mass in other neuromuscular diseases or conditions that are in need of muscle growth. For example, amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease or motor neuron disease) is a chronic, incurable, and unstoppable CNS disorder that attacks the motor neurons, components of the CNS that connect the brain to the skeletal muscles. In ALS, the motor neurons deteriorate and eventually die, and though a person's brain normally remains fully functioning and alert, the command to move cannot reach the muscles, Most people who develop ALS are between 40 and 70 years old. The first motor neurons that weaken are those leading to the arms or legs. Those with ALS may have trouble walking, they may drop things, fall, slur their speech, and laugh or cry uncontrollably. Eventually the muscles in the limbs begin to atrophy from disuse. This muscle weakness will become debilitating and a person will need a wheel chair or become unable to function out of bed. Most ALS patients die from respiratory failure or from complications of ventilator assistance like pneumonia, 3-5 years from disease onset. Other neuromuscular diseases in which ACVR2A-specific antibodies may be useful include paralysis due to spinal cord injury or stroke; denervation due to trauma or degenerative, metabolic, or inflammatory neuropathy; adult motor neuron disease; autoimmune motor neuropathy with multifocal conductor block; and infantile or juvenile spinal muscular atrophy.

Increased muscle mass induced by ACVR2A-specific antibodies might also benefit those suffering from muscle wasting diseases. Gonzalez-Cadavid et al. (1998, Proc. Natl. Acad. Sci. USA 95:14938-43) reported that that GDF8 expression correlates inversely with fat-free mass in humans and that increased expression of the GDF8 gene is associated with weight loss in men with AIDS wasting syndrome. By inhibiting the function of GDF8 in AIDS patients, at least certain symptoms of AIDS may be alleviated, if not completely eliminated, thus significantly improving quality of life in AIDS patients.

The cancer anorexia-cachexia syndrome is among the most debilitating and life-threatening aspects of cancer. Progressive weight loss in cancer anorexia-cachexia syndrome is a common feature of many types of cancer and is responsible not only for a poor quality of life and poor response to chemotherapy, but also a shorter survival time than is found in patients with comparable tumors without weight loss. Associated with anorexia, fat and muscle tissue wasting, psychological distress, and a lower quality of life, cachexia arises from a complex interaction between the cancer and the host. It is one of the most common causes of death among cancer patients and is present in 80% at death. It is a complex example of metabolic chaos effecting protein, carbohydrate, and fat metabolism. Tumors produce both direct and indirect abnormalities, resulting in anorexia and weight loss. Currently, there is no treatment to control or reverse the process. Cancer anorexia-cachexia syndrome affects cytokine production, release of lipid-mobilizing and proteolysis-inducing factors, and alterations in intermediary metabolism. Although anorexia is common, a decreased food intake alone is unable to account for the changes in body composition seen in cancer patients, and increasing nutrient intake is unable to reverse the wasting syndrome. Cachexia is generally suspected in patients with cancer if an involuntary weight loss of greater than five percent of premorbid weight occurs within a six-month period.

Since systemic overexpression of GDF8 in adult mice was found to induce profound muscle and fat loss analogous to that seen in human cachexia syndromes (Zimmers et al., 2002, Science 296:1486-1488), the subject ACVR2A-specific antibodies can be, beneficially used to prevent, treat, or alleviate the symptoms of the cachexia syndrome, where muscle growth is desired. This would include cachexia associated with cancer as well as cachexia associated with rheumatoid arthritis.

Combination Therapy

In some embodiments, a subject treatment method involves administering a subject antibody and one or more additional therapeutic agents. Suitable additional therapeutic agents include, but are not limited to, anabolic steroids, deacetylase inhibitors and selective adrenergic receptor modulators (SARMs).

Subjects Suitable for Treatment

A variety of subjects are suitable for treatment with a subject method. Suitable subjects include any individual, e.g., a human, who has an ACVR2A-associated condition, who has been diagnosed with an ACVR2A-associated condition, who is at risk for developing an ACVR2A-associated condition, who has had an ACVR2A-associated condition and is at risk for recurrence of the an ACVR2A-associated condition, or who is recovering from an ACVR2A-associated condition.

EXAMPLES

The following examples are put forth so as to provide those of ordinary skill in the art with a complete disclosure and description of how to make and use the present invention, and are not intended to limit the scope of what the inventors regard as their invention nor are they intended to represent that the experiments below are all or the only experiments performed. Efforts have been made to ensure accuracy with respect to numbers used (e.g. amounts, temperature, etc.) but some experimental errors and deviations should be accounted for. Unless indicated otherwise, parts are parts by weight, molecular weight is weight average molecular weight, temperature is in degrees Celsius, and pressure is at or near atmospheric. Standard abbreviations may be used, e.g., bp, base pair(s); kb, kilobase(s); pl, picoliter(s); s or sec, second(s); min, minute(s); h or hr, hour(s); aa, amino acid(s); kb, kilobase(s); bp, base pair(s); nt, nucleotide(s); i.m., intramuscular(ly); i.p., intraperitoneal(ly); s.c., subcutaneous(ly); and the like.

Example 1 Phage Display Screening

Phagemid expression of diversified monovalent Fab libraries was accomplished by standard methods. TG-1 cells transformed with expression plasmids were grown to mid log (O.D. 600.about.0.3) in 2-YT media supplemented with 100 mcg/ml ampicillin and 2% glucose repression and then infected with m13K07 helper phage and grown overnight in 2-YT media supplemented with 100 mcg ampicillin, 70 mcg/ml kanamycin, and 200 micromolar IPTG. Phage containing supernatants were precipitated using polyethylene glycol and PBS resuspended phage were used to pan on immobilized ACVR2.

Panning of the libraries was performed by using recombinant soluble extracellular domains of ACVR2 (Peprotech or R&D Systems) immobilized on the wells of a microtiter dish or biotinylated ACVR2 immobilized on streptavidin derivatized magnetic beads (Dynal-Life Technologies).

To identify phage clones that encoded ACVR2-binding monovalent Fabs, a portion of the eluted phage were used to infect E. coli HB2151 allowing expression of periplasmic phage-encoded monovalent Fabs. Individual clones were picked into deep-well plates and grown overnight in 2YT containing ampicillin and 0.2 mM IPTG. Bacteria were lysed in BPERII and the lysates were applied to ACVR2 coated plates. Following washing, binding of antibodies was detected using an HRP-conjugated anti-human kappa and lambda light chain antibody (Bethyl). Daughter plates were also inoculated and grown in 2YT-Amp-glucose for Sanger-based sequencing to determine the antibody heavy and light chain sequences.

Example 2 Initial ELISA Assays

The binding of ACVR2A-specific monoclonal antibodies to human ACVR2A, mouse ACVR2A, biotinylated goat anti-human kappa light chain (positive control) and human Fc (negative control) were determined by ELISA.

The results of this assay are shown in Table 4 below. The values shown are optical densities. The data in this table shows that the antibodies listed I specifically bind to ACVR2A. The sequences of the heavy and light chains of the antibodies listed in Table 4 are shown above in FIGS. 2A-2F.

TABLE 4 Goat anti- Human Mouse Human Human Ab ACVR2A ACVR2A Kappa Fc 365_B04 1.993 2.179 3.121 0.271 365_B10 2.819 2.782 3.212 0.322 365_C03 2.257 2.648 3.499 0.332 365_C06 1.785 2.229 3.447 0.318 365_D04 2.269 2.389 3.517 0.316 365_E04 2.342 2.401 3.54 0.46 365_F11 2.01 2.141 3.502 0.302 365_G07 2.424 2.596 3.467 0.331 365_H08 2.674 2.607 3.589 0.488 366_A02 2.448 2.687 3.583 0.336 366_A04 1.823 1.988 3.397 0.319 366_D01 2.361 2.46 3.484 0.374 366_D03 2.233 2.375 3.475 0.318 366_F10 2.048 2.211 3.518 0.28 366_G06 2.676 2.818 3.407 0.341 367_B09 2.422 2.429 3.365 0.476 367_B11 2.34 2.463 3.598 0.37 367_C09 2.413 2.771 3.445 0.263 367_D11 2.395 2.54 3.39 0.304 367_F06 2.008 2.045 3.345 0.265 367_H01 2.817 2.695 3.654 0.388 368_A02 2.573 2.741 3.691 0.376 368_A06 2.249 2.515 3.282 0.483 368_A12 3.009 2.781 3.693 0.425 368_B03 2.045 2.045 3.377 0.297 368_B08 1.979 2.182 3.208 0.314 368_B10 2.349 2.417 3.024 0.412 368_B11 2.14 2.35 3.607 0.286 368_C09 2.478 2.611 3.461 0.341 368_D09 2.194 2.11 3.461 0.212 368_F02 2.184 2.272 3.653 0.317 368_F10 2.254 2.602 3.522 0.328 369_B03 3.321 3.314 3.521 0.62 369_G10 3.37 3.295 3.491 0.423 369_H03 2.829 3.085 3.469 0.498 370_B01 3.375 3.473 3.752 0.47 370_D06 2.257 2.658 3.483 0.334 370_G04 1.825 2.125 3.513 0.423 370_H08 2.937 3.24 3.647 0.538 371_A04 1.008 1.173 3.532 0.315 371_A09 1.855 1.998 3.617 0.302 371_D07 2.661 2.902 3.59 0.299 371_D12 1.89 1.999 3.435 0.337 371_H02 1.881 2.026 3.623 0.388 372_A09 2.433 2.56 3.498 0.31 372_B11 2.309 2.575 3.73 0.438 372_E02 2.841 2.743 3.581 0.431 373_E11 3.301 3.361 3.172 0.243 373_H02 3.245 3.257 3.239 0.287 374_B02 3.421 3.537 3.024 0.179 374_F03 3.532 3.617 3.233 0.185 375_A04 3.72 3.734 3.101 0.177 375_A11 3.729 3.696 3.047 0.176 375_C10 3.459 3.596 3.333 0.294 375_F12 2.951 3.143 3.17 0.175 375_H01 2.787 3.059 3.104 0.216 376_G02 3.694 3.696 3.546 0.285 365_A05 2.34 2.229 3.454 0.331 365_B08 1.137 1.257 3.037 0.229 365_B12 2.334 2.289 3.427 0.307 365_D03 2.351 2.484 3.526 0.346 365_D08 2.264 2.355 3.614 0.35 365_E06 1.988 2.063 3.295 0.301 365_F10 2.752 2.789 3.655 0.386 365_G06 2.198 2.021 3.343 0.32 365_G08 2.527 2.581 3.498 0.346 366_B09 2.304 2.532 3.386 0.283 366_C05 2.007 2.362 3.405 0.269 366_E07 1.677 1.856 3.144 0.262 366_G02 2.163 2.316 3.565 0.357 366_H01 2.794 2.775 3.715 0.384 367_C06 2.119 2.513 3.496 0.29 367_C12 2.065 2.103 3.576 0.31 367_E08 2.042 2.372 3.426 0.299 367_E10 2.765 2.975 3.481 0.271 367_F08 2.079 2.193 3.539 0.299 367_F10 2.215 2.357 3.425 0.253 367_G03 2.591 2.632 3.595 0.341 367_G11 2.559 2.672 3.557 0.305 367_H08 2.266 2.473 3.544 0.312 368_B04 2.266 2.729 3.292 0.304 368_B12 2.514 2.471 3.486 0.567 368_C04 2.485 2.474 3.67 0.302 368_C07 2.577 2.367 3.309 0.282 368_C12 2.488 2.446 3.617 0.346 368_D03 2.394 2.552 3.494 0.374 368_D06 2.027 2.109 3.407 0.265 368_D07 2.2 2.463 3.262 0.309 368_E05 1.868 2.067 3.369 0.266 368_E08 2.267 2.669 3.5 0.255 368_G11 2.105 2.368 3.502 0.306 368_H03 2.44 2.727 3.558 0.343 369_A04 2.761 2.858 3.505 0.353 369_A12 3.175 3.243 3.721 0.461 369_B07 2.631 2.898 3.386 0.319 369_B08 2.751 2.879 3.29 0.309 369_C06 2.755 3.065 3.175 0.414 369_C09 2.883 3.054 3.412 0.32 369_C11 2.799 2.912 3.484 0.378 369_E03 3.147 3.356 3.373 0.63 370_B06 2.876 3.092 3.371 0.441 370_B07 1.914 2.196 3.482 0.336 370_E12 3.388 3.435 3.658 0.656 370_H05 2.939 3.138 3.612 0.364 371_A05 3.047 3.24 3.605 0.369 371_B02 2 2.279 3.59 0.449 371_B11 3.182 3.261 3.594 0.549 371_C02 2.918 2.877 3.656 0.372 371_D05 2.718 3.112 3.438 0.339 371_F07 2.784 2.893 3.342 0.425 371_G07 2.8 2.988 3.413 0.548 372_D07 2.684 2.993 3.704 0.472 373_B01 3.258 3.584 3.114 0.197 373_D11 3.572 3.546 3.202 0.364 373_G06 3.397 3.525 3.231 0.196 374_A10 3.557 3.587 2.999 0.23 374_A12 3.312 3.256 3.063 0.308 374_B01 3.143 3.369 2.918 0.173 374_B07 3.713 3.705 3.295 0.25 374_H02 3.263 3.257 3.183 0.197 375_C03 3.001 3.243 3.162 0.217 375_C05 3.457 3.584 3.316 0.193 375_D02 3.629 3.558 3.202 0.191 375_G08 3.332 3.432 3.267 0.259 375_H04 3.106 3.159 3.148 0.181 376_D08 3.815 3.711 3.471 0.232 376_F09 3.501 3.588 3.353 0.25 376_H12 3.234 3.082 3.487 0.344 365_C05 2.564 2.808 3.527 0.271 365_E10 1.823 2.053 3.337 0.273 365_E12 3.321 3.276 3.522 0.338 365_F02 2.781 3.049 3.396 0.326 365_F03 2.631 2.99 3.574 0.347 365_G03 2.242 2.543 3.543 0.321 365_G04 2.096 2.48 3.295 0.295 365_G05 2.442 2.539 3.352 0.319 365_G09 2.617 2.933 3.671 0.288 365_H07 2.514 2.745 3.431 0.33 366_A06 1.97 2.254 3.24 0.334 366_A08 1.653 1.734 3.23 0.243 366_B05 2.385 2.461 2.955 0.24 366_B07 1.796 1.915 3.222 0.215 366_E01 2.693 2.717 3.66 0.397 366_E08 1.973 2.002 3.349 0.272 366_F02 2.149 2.108 3.597 0.371 366_G12 2.713 2.828 3.586 0.372 366_H04 2.69 2.829 3.524 0.359 367_A03 2.576 2.451 3.438 0.347 367_A06 2.339 2.566 3.358 0.378 367_A08 2.057 2.091 3.337 0.252 367_A10 1.892 2.163 3.392 0.315 367_A12 2.439 2.416 3.647 0.39 367_B01 2.839 2.907 3.674 0.408 367_B04 2.664 3.099 3.342 0.265 367_B12 3.015 3.028 3.745 0.414 367_C07 2.468 2.516 3.414 0.387 367_C10 2.529 2.61 3.386 0.233 367_D03 2.594 2.451 3.455 0.29 367_D06 2.045 2.353 3.25 0.283 367_D08 2.183 2.373 3.501 0.237 367_D12 2.435 2.689 3.569 0.309 367_E05 2.353 2.639 3.466 0.333 367_F01 2.425 2.757 3.724 0.33 367_G01 1.8 1.944 3.578 0.356 367_G04 2.978 3.042 3.356 0.287 367_H02 1.077 1.199 3.616 0.378 367_H03 2.041 2.2 3.341 0.377 368_A03 2.834 2.833 3.411 0.348 368_A04 2.349 2.352 3.565 0.283 368_B09 2.543 2.808 3.434 0.258 368_C02 1.377 1.488 3.513 0.321 368_C08 2.259 2.432 3.383 0.289 368_E12 1.286 1.554 3.652 0.347 368_F09 2.389 2.449 3.578 0.242 368_H02 2.406 2.544 3.578 0.348 368_H05 1.954 2.197 3.342 0.277 369_A07 3.548 3.564 3.421 0.288 369_B05 2.777 3.057 3.44 0.314 369_C05 2.545 2.718 3.022 0.32 369_D03 3.277 3.554 3.606 0.391 369_D07 3.069 2.914 3.259 0.363 369_D09 3.303 3.051 3.446 0.287 369_E06 3.134 3.109 3.515 0.306 369_F08 0.503 0.589 3.099 0.302 369_G08 3.297 3.492 3.582 0.312 370_A02 2.901 2.907 3.624 0.425 370_B03 3.714 3.567 3.607 0.3 370_B11 2.076 2.449 3.685 0.326 370_B12 2.925 3.077 3.563 0.478 370_D01 3.137 3.17 3.664 0.382 370_D05 2.976 3.125 3.49 0.333 370_F03 1.136 1.25 3.301 0.373 370_H02 3.301 3.39 3.667 0.386 370_H07 3 3.245 3.511 0.403 371_A10 2.812 2.779 3.477 0.338 371_B03 1.634 1.935 3.482 0.367 371_B04 2.465 3.129 2.269 0.295 371_B09 0.825 0.827 2.702 0.292 371_B12 2.555 2.4 3.483 0.378 371_C01 2.001 2.273 3.594 0.402 371_C04 2.049 2.246 3.453 0.314 371_C05 1.24 1.355 3.079 0.269 371_C12 3.099 3.196 3.683 0.544 371_D02 2.939 2.991 3.578 0.385 371_D04 1.023 1.295 3.3 0.276 371_E06 3.003 3.029 3.443 0.33 371_E07 3.091 3.348 3.437 0.337 371_E10 3.062 3.052 3.486 0.341 371_F10 2.339 2.31 3.529 0.299 371_F11 3.039 3.253 3.676 0.331 371_G02 3.118 3.06 3.673 0.514 371_G04 3.625 3.577 3.544 0.325 371_G09 2.745 3.066 3.577 0.315 371_G11 2.84 2.752 3.666 0.399 371_H04 3.258 3.507 3.576 0.35 371_H05 1.202 1.245 3.271 0.321 371_H06 3.027 3.111 3.698 0.346 371_H08 1.662 2.039 3.472 0.309 371_H10 2.189 2.553 3.548 0.358 372_B02 3.172 3.509 3.665 0.371 372_C06 3.206 3.536 3.491 0.489 372_D03 3.042 3.289 3.603 0.319 372_E01 3.341 3.34 3.598 0.409 372_G12 2.409 2.725 3.495 0.439 373_A01 3.177 3.477 2.952 0.177 373_A03 3.647 3.634 3.079 0.189 373_A05 3.45 3.423 3.033 0.172 373_A09 3.66 3.615 3.107 0.248 373_A11 3.763 3.679 3.086 0.184 373_A12 3.59 3.315 3.093 0.179 373_B05 3.586 3.526 3.233 0.184 373_B07 3.661 3.61 3.304 0.208 373_C03 3.69 3.654 3.304 0.171 373_C07 3.569 3.578 3.298 0.206 373_C10 3.653 3.645 3.235 0.318 373_D03 3.745 3.694 3.18 0.18 373_D12 3.398 3.207 3.212 0.224 373_E10 3.722 3.636 3.2 0.188 373_F08 3.76 3.701 3.215 0.202 373_F11 3.354 3.46 3.319 0.204 373_F12 3.245 3.217 3.063 0.158 373_G08 3.651 3.673 3.284 0.172 373_H03 3.268 3.289 3.221 0.172 373_H07 3.253 3.27 3.233 0.199 373_H09 0.93 1.354 3.084 0.166 374_A06 3.775 3.747 2.999 0.173 374_A09 3.583 3.644 2.971 0.231 374_B03 3.687 3.697 3.066 0.166 374_B05 3.681 3.652 3.164 0.168 374_B08 3.6 3.629 3.124 0.188 374_B10 3.711 3.686 3.004 0.17 374_C01 2.685 2.929 3.078 0.167 374_C09 3.431 3.509 3.14 0.154 374_C12 3.667 3.326 3.145 0.308 374_D03 3.3 3.48 3.025 0.216 374_D05 3.434 3.565 3.148 0.171 374_D06 3.776 3.674 3.123 0.172 374_D07 3.71 3.684 3.26 0.176 374_D10 3.562 3.638 3.273 0.329 374_E10 3.736 3.768 3.375 0.165 374_E12 3.613 3.284 3.293 0.177 374_F06 3.723 3.704 3.179 0.201 374_F07 3.467 3.542 3.209 0.176 374_F08 3.671 3.676 3.176 0.211 374_G03 3.791 3.64 3.219 0.193 374_G08 3.706 3.704 3.211 0.206 374_G09 3.656 3.598 3.258 0.223 374_G10 3.681 3.737 3.233 0.173 374_G11 3.651 3.597 3.245 0.179 374_H01 3.084 3.261 3.068 0.251 374_H11 3.275 3.285 3.15 0.169 375_A01 3.281 3.676 2.908 0.196 375_A07 3.575 3.644 3.11 0.188 375_A08 3.676 3.687 3.14 0.205 375_A12 3.657 3.347 3.137 0.174 375_B12 3.654 3.338 3.28 0.223 375_C04 3.677 3.675 3.207 0.221 375_D01 3.298 3.608 3.1 0.182 375_D10 3.258 3.454 3.207 0.228 375_E02 3.582 3.691 3.199 0.496 375_E03 3.568 3.638 3.184 0.181 375_E05 3.669 3.709 3.283 0.296 375_E06 3.846 3.672 3.328 0.188 375_E10 3.689 3.792 3.293 0.187 375_F02 3.605 3.646 3.203 0.205 375_F07 3.675 3.707 3.216 0.172 375_F08 3.502 3.581 3.315 0.201 375_G04 2.909 3.294 3.193 0.161 375_G05 3.712 3.745 3.264 0.21 375_H05 3.355 3.331 3.171 0.167 375_H07 3.304 3.293 3.273 0.346 376_A03 3.613 3.65 3.231 0.328 376_B03 3.678 3.668 3.519 0.253 376_B10 3.595 3.665 3.457 0.232 376_C04 3.63 3.654 3.397 0.219 376_C08 3.612 3.627 3.462 0.246 376_D07 3.381 3.444 3.436 0.318 376_E02 3.298 3.376 3.408 0.222 376_E11 3.682 3.646 3.471 0.268 376_F01 2.769 3.015 3.177 0.199 376_F06 3.525 3.649 3.469 0.284 376_G05 3.745 3.773 3.489 0.252 376_G06 3.424 3.58 3.489 0.267 376_G10 3.545 3.524 3.542 0.321 376_H01 3.113 3.308 3.277 0.607 376_H04 3.309 3.338 3.513 0.34 376_H11 3.293 3.309 3.433 0.325 365_A08 1.584 1.593 3.2 0.256 365_A09 2.449 2.479 3.302 0.339 365_C02 2.155 2.332 3.447 0.362 365_C04 2.262 2.673 3.551 0.305 365_D02 2.539 2.699 3.518 0.486 365_D07 1.831 2.058 3.382 0.302 365_D10 2.393 2.236 3.272 0.641 365_E11 1.741 1.736 3.568 0.301 365_F05 2.141 2.232 3.416 0.376 365_H05 2.102 2.195 3.46 0.361 366_D08 2.166 2.463 3.65 0.312 366_F08 1.862 2.004 3.468 0.316 366_G09 1.855 2.041 3.435 0.291 367_A02 2.231 2.416 3.581 0.305 367_B06 1.817 1.889 3.019 0.378 367_C08 1.119 1.218 3.054 0.278 367_D05 1.26 1.373 3.341 0.265 367_D09 2.147 2.045 3.372 0.381 367_E07 1.935 2.055 3.215 0.221 367_E12 2.695 2.913 3.706 0.453 367_F09 1.795 1.818 3.455 0.289 367_H05 2.439 2.698 3.59 0.51 367_H10 2.577 2.353 3.55 0.326 368_B02 2.075 2.24 3.606 0.337 368_C11 2.027 2.209 3.558 0.275 368_D02 1.925 2.26 3.522 0.321 368_D12 2.254 2.283 3.568 0.329 368_F06 1.599 1.68 3.315 0.249 368_G03 2.726 2.746 3.392 0.312 368_G10 2.064 2.283 3.454 0.356 368_H06 2.351 2.654 3.612 0.311 368_H11 1.954 2.129 3.511 0.355 369_A11 2.643 2.774 3.286 0.366 369_C12 3.43 3.447 3.742 0.418 369_D08 2.942 3.127 3.063 0.241 369_E05 1.405 1.642 1.904 0.282 369_E08 1.028 1.227 1.116 0.272 369_F05 0.796 0.931 3.46 0.331 369_F09 3.227 3.381 3.601 0.5 369_G05 3.036 3.278 3.309 0.384 369_H02 3.088 3.29 3.572 0.408 369_H08 3.159 3.231 3.556 0.389 369_H12 3.463 3.42 3.652 0.414 370_B08 3.131 3.247 3.353 0.302 370_C06 3.141 3.414 3.55 0.303 370_C07 3.351 3.369 3.299 0.316 370_C10 1.3 1.383 3.352 0.332 370_D03 3.135 3.249 3.582 0.57 370_D09 2.924 2.531 3.484 0.287 370_E04 2.572 2.721 3.398 0.292 370_E05 2.585 2.768 3.519 0.427 370_F01 3.004 3.136 3.669 0.407 370_F02 2.682 2.891 3.627 0.376 370_F12 3.551 3.572 3.644 0.457 370_G08 3.212 3.326 3.564 0.364 370_H04 3.484 3.558 3.615 0.596 370_H06 3.22 3.394 3.514 0.358 371_B01 3.26 3.271 3.584 0.464 371_C06 2.486 3.012 3.435 0.308 371_C07 1.391 1.446 3.359 0.287 371_E05 2.989 3.178 3.446 0.59 371_E08 2.114 2.267 2.64 0.251 371_E09 2.078 2.283 3.155 0.306 371_E12 3.09 2.993 3.622 0.398 371_F03 1.19 1.302 1.819 0.252 371_F09 3.369 3.57 3.597 0.602 371_G01 2.014 2.242 1.786 0.375 371_H11 2.89 3.121 3.597 0.363 372_B09 3.108 3.011 3.502 0.308 372_E08 2.559 2.816 3.507 0.369 372_F02 3.006 3.094 3.695 0.411 372_H11 2.616 2.86 3.645 0.392 373_A06 3.636 3.624 3.073 0.193 373_B09 3.6 3.621 3.242 0.172 373_D06 3.633 3.574 3.208 0.192 373_F07 3.613 3.62 3.129 0.172 373_G02 3.59 3.559 3.223 0.226 374_A04 3.654 3.682 2.99 0.275 374_A05 3.604 3.6 2.923 0.159 374_C10 3.567 3.671 3.08 0.174 374_D04 3.629 3.649 3.053 0.179 374_D09 3.609 3.646 3.096 0.171 374_G05 3.658 3.667 3.003 0.158 374_H05 3.315 3.297 3.042 0.257 375_A03 3.615 3.619 3.087 0.203 375_B03 3.678 3.7 3.241 0.209 375_C01 2.962 3.27 3.136 0.191 375_C11 3.589 3.613 3.263 0.199 375_F10 3.691 3.767 3.295 0.21 375_H08 3.308 3.28 3.324 0.204 376_A02 3.716 3.634 3.194 0.22 376_A05 3.648 3.644 3.184 0.256 376_A07 3.7 3.722 3.193 0.221 365_A03 3.4 3.243 3.443 0.342 365_A11 2.039 1.937 3.267 0.299 365_A12 2.674 2.871 3.668 0.422 365_B01 2.386 2.646 3.491 0.445 365_B06 2.246 2.418 3.277 0.281 365_B07 2.112 2.213 3.229 0.269 365_B11 2.844 2.755 3.581 0.305 365_C01 2.869 3.025 3.626 0.376 365_C10 2.451 2.441 3.413 0.397 365_C11 2.656 2.781 3.668 0.296 365_C12 1.924 2.04 3.576 0.332 365_D09 1.523 1.35 3.375 0.302 365_D11 2.342 2.224 3.382 0.299 365_D12 2.567 2.613 3.53 0.34 365_E01 2.906 2.837 3.542 0.363 365_E05 2.181 2.437 3.36 0.379 365_E07 2.383 2.701 3.513 0.302 365_E09 1.906 2.16 3.474 0.322 365_F01 2.51 2.471 3.509 0.341 365_F06 1.953 2.082 3.397 0.329 365_F12 2.913 2.828 3.633 0.411 365_G01 2.483 2.647 3.447 0.39 365_G11 1.745 1.785 3.473 0.278 365_H02 2.732 2.908 3.58 0.407 365_H03 2.322 2.654 3.269 0.366 365_H06 2.244 2.459 3.437 0.367 365_H10 2.677 2.823 3.513 0.349 365_H11 3.239 3.353 3.614 0.375 365_H12 2.968 2.908 3.778 0.451 366_A07 2.417 2.679 3.365 0.309 366_B08 2.148 2.376 3.054 0.403 366_B10 2.328 2.444 3.059 0.424 366_B12 3.244 2.989 3.444 0.311 366_D04 2.079 2.125 3.463 0.338 366_E10 2.354 2.389 3.454 0.271 366_F04 1.726 1.912 3.366 0.281 366_F05 2.191 2.668 3.245 0.279 366_F07 2.386 2.534 3.473 0.353 366_G04 1.851 2.176 3.286 0.31 366_G05 2.212 2.496 3.262 0.28 366_H06 2.289 2.591 3.386 0.285 366_H07 2.526 2.673 3.605 0.285 366_H08 2.593 2.77 3.551 0.417 366_H09 2.095 2.437 3.423 0.328 367_A04 2.142 2.202 3.303 0.267 367_A05 2.218 2.384 3.381 0.269 367_B02 2.288 2.422 3.533 0.302 367_B03 2.479 2.659 3.445 0.318 367_B07 1.419 1.488 3.337 0.236 367_B08 2.128 2.245 3.033 0.37 367_C01 2.617 2.987 3.71 0.348 367_C05 2.215 2.856 3.424 0.255 367_C11 2.329 2.545 3.449 0.45 367_D10 2.699 2.667 3.38 0.251 367_E01 2.546 2.523 3.607 0.351 367_E04 2.406 2.573 3.501 0.284 367_E06 2.022 2.313 3.477 0.271 367_E09 1.664 1.81 3.329 0.249 367_E11 2.395 2.909 3.607 0.244 367_F03 2.1 2.392 3.446 0.301 367_F07 2.126 2.246 3.261 0.242 367_F11 1.714 1.873 3.477 0.267 367_G05 2.41 2.711 3.371 0.283 367_G06 2.641 2.81 3.348 0.28 367_G10 2.115 2.316 3.448 0.286 367_H06 2.695 3.083 3.651 0.313 367_H11 2.371 2.693 3.609 0.323 368_A01 2.994 2.9 3.683 0.396 368_A05 2.708 2.696 3.459 0.285 368_A07 2.11 2.312 3.65 0.261 368_A09 2.51 2.628 3.549 0.277 368_B01 2.607 2.588 3.705 0.365 368_B06 2.059 2.341 3.157 0.393 368_B07 1.909 2.065 3.135 0.344 368_C05 1.818 2.018 3.359 0.246 368_D01 2.751 2.971 3.647 0.319 368_D04 2.461 2.699 3.666 0.338 368_D05 2.857 2.868 3.385 0.282 368_D11 2.796 2.96 3.487 0.297 368_E01 2.566 2.849 3.736 0.392 368_E02 2.5 2.788 3.679 0.424 368_E04 3.08 3.232 3.476 0.32 368_E06 2.328 2.339 3.505 0.325 368_E07 1.067 1.169 3.453 0.251 368_F03 2.352 2.601 3.604 0.323 368_F11 2.578 2.726 3.526 0.338 368_G01 2.646 2.824 3.622 0.431 368_G12 2.457 2.535 3.518 0.341 368_H04 1.063 1.362 3.513 0.319 369_A02 3.147 3.457 3.493 0.383 369_A03 0.451 0.561 3.169 0.347 369_B01 3.358 3.457 3.588 0.487 369_C02 3.6 3.517 3.543 0.369 369_C03 3.371 3.649 3.516 0.323 369_C04 1.639 1.649 2.459 0.248 369_D01 3.127 3.317 3.63 0.595 369_D02 3.287 3.436 3.527 0.407 369_D04 3.054 2.968 3.589 0.435 369_D12 3.041 3.105 3.533 0.425 369_E02 2.144 2.341 3.429 0.365 369_E11 2.889 3.202 3.694 0.343 369_E12 2.464 2.692 3.667 0.452 369_F01 3.278 3.418 3.469 0.554 369_F02 3.071 3.35 3.556 0.478 369_F03 2.575 2.749 3.438 0.389 369_F06 3.109 3.066 3.51 0.353 369_F10 3.048 3.225 3.667 0.361 369_F11 3.196 3.373 3.657 0.37 369_G01 3.567 3.666 3.439 0.403 369_G04 2.365 2.685 3.316 0.385 369_G06 2.98 2.914 3.378 0.474 369_G11 3.028 3.06 2.594 0.331 369_G12 1.768 1.882 2.652 0.353 369_H05 3.249 3.342 3.54 0.457 369_H06 3.235 3.555 3.5 0.347 369_H09 2.364 2.643 3.507 0.365 370_A01 2.859 2.955 3.622 0.637 370_A03 3.544 3.633 3.564 0.424 370_A04 2.566 2.736 3.476 0.377 370_A12 3.062 3.188 3.719 0.674 370_C01 3.285 3.38 3.615 0.403 370_C03 3.592 3.773 3.571 0.35 370_C05 3.208 3.546 3.557 0.346 370_C08 2.73 2.967 3.111 0.381 370_C09 1.974 2.248 3.483 0.292 370_D04 3.59 3.737 3.6 0.371 370_D11 2.721 2.794 3.381 0.34 370_E03 3.636 3.738 3.57 0.361 370_E06 2.903 3.025 3.608 0.375 370_E09 3.45 3.555 3.597 0.338 370_F05 2.758 2.913 3.536 0.406 370_F07 3.451 3.534 3.515 0.384 370_F10 3.145 3.216 3.636 0.441 370_G02 2.982 3.22 3.625 0.388 370_G03 3.103 3.435 3.579 0.421 370_G06 2.191 2.334 3.408 0.356 370_G09 3.006 3.136 3.641 0.393 370_G10 2.985 2.744 3.49 0.315 370_G11 2.975 3.07 3.72 0.529 370_H01 3.31 3.179 3.651 0.436 370_H09 2.948 3.277 3.542 0.348 371_A03 2.843 2.622 3.563 0.354 371_A06 2.65 2.786 3.51 0.337 371_A07 2.875 3.059 3.651 0.336 371_A08 1.061 1.161 2.442 0.304 371_A12 3.168 3.299 3.631 0.483 371_B06 2.692 2.712 3.296 0.356 371_B07 2.779 3.045 3.329 0.308 371_C03 3.013 3.241 3.598 0.311 371_D06 1.477 1.555 3.322 0.295 371_D09 2.889 2.936 2.168 0.268 371_F01 2.41 2.618 3.678 0.41 371_F04 2.946 3.102 3.66 0.345 371_F06 2.414 2.795 3.456 0.289 371_F08 2.196 2.546 3.427 0.301 371_G05 1.249 1.329 3.082 0.313 371_G10 1.646 1.922 3.406 0.439 371_H09 2.962 3.225 3.656 0.32 372_A04 3.204 3.404 3.643 0.339 372_B04 2.611 3.122 3.59 0.333 372_C07 2.409 2.638 3.462 0.279 372_D02 2.657 2.907 3.579 0.433 372_F03 3.192 3.308 3.595 0.438 372_F06 2.259 2.539 3.483 0.38 372_F08 3.382 3.217 3.445 0.335 372_F09 3.166 3.043 3.474 0.268 373_A02 2.803 2.974 2.955 0.159 373_A08 3.301 3.309 3.112 0.195 373_A10 3.544 3.55 3.096 0.175 373_B04 3.605 3.617 3.255 0.176 373_B06 3.441 3.43 3.236 0.221 373_B10 3.655 3.597 3.15 0.174 373_B12 3.122 3.075 3.27 0.172 373_C02 3.452 3.466 3.146 0.17 373_C04 3.356 3.502 3.196 0.157 373_C06 3.545 3.531 3.163 0.163 373_C08 3.048 3.193 3.189 0.16 373_C11 3.49 3.468 3.168 0.171 373_D01 3.235 3.574 3.041 0.174 373_D04 3.678 3.646 3.154 0.168 373_D05 3.683 3.734 3.253 0.179 373_D08 3.656 3.665 3.241 0.182 373_D10 3.61 3.61 3.114 0.189 373_E01 2.347 2.56 2.986 0.16 373_E05 3.545 3.592 3.24 0.176 373_E07 3.483 3.536 3.231 0.294 373_E12 3.627 3.333 3.116 0.17 373_G10 3.538 3.563 3.261 0.2 373_G12 3.472 3.288 3.259 0.174 373_H01 3.104 3.28 3.123 0.198 373_H05 3.286 3.295 3.216 0.201 374_A07 3.624 3.712 3.072 0.206 374_B04 3.67 3.641 3.3 0.222 374_B06 3.482 3.595 3.084 0.157 374_B12 3.489 3.326 3.054 0.257 374_C03 3.583 3.612 3.056 0.208 374_C06 3.715 3.712 3.236 0.18 374_D01 3.244 3.578 2.935 0.198 374_D08 3.503 3.591 3.017 0.201 374_E01 3.238 3.556 3.037 0.235 374_E02 3.235 3.329 3.176 0.527 374_E05 3.561 3.568 3.176 0.244 374_E07 3.632 3.581 3.203 0.3 374_E08 3.496 3.524 3.263 0.251 374_E11 3.607 3.586 3.343 0.186 374_F01 3.291 3.597 3.026 0.165 374_F02 3.565 3.586 3.157 0.169 374_F04 3.576 3.645 3.228 0.163 374_F10 3.211 3.453 3.283 0.524 374_F11 3.657 3.608 3.151 0.191 374_G04 2.096 2.317 3.025 0.161 374_G06 3.256 3.421 3.289 0.25 374_G07 3.631 3.723 3.257 0.214 374_H03 3.265 3.268 3.065 0.162 374_H04 3.277 3.31 3.189 0.167 374_H06 3.297 3.264 3.081 0.166 374_H07 3.241 3.251 2.973 0.163 374_H09 3.249 3.264 3.039 0.158 375_A05 3.721 3.685 3.12 0.202 375_C06 2.646 3.212 3.289 0.2 375_D04 3.691 3.699 3.166 0.182 375_D05 3.465 3.609 3.215 0.202 375_D07 3.563 3.633 3.253 0.176 375_D08 3.287 3.403 3.302 0.234 375_D12 3.24 3.156 3.23 0.193 375_E01 3.159 3.627 3.111 0.164 375_E07 3.683 3.81 3.06 0.158 375_H12 3.256 3.104 3.263 0.188 376_A04 3.587 3.578 3.123 0.245 376_A10 3.676 3.642 3.174 0.279 376_A12 3.696 3.341 3.217 0.22 376_B04 3.409 3.479 3.577 0.293 376_B05 3.646 3.778 3.519 0.242 376_B09 3.777 3.717 3.506 0.227 376_B11 3.69 3.753 3.608 0.261 376_C01 3.264 3.599 3.198 0.324 376_C02 3.445 3.529 3.443 0.222 376_C12 3.698 3.322 3.391 0.438 376_D05 3.599 3.707 3.337 0.215 376_D11 3.698 3.621 3.433 0.267 376_E03 3.788 3.744 3.425 0.234 376_E08 3.64 3.638 3.473 0.332 376_F03 3.289 3.471 3.443 0.261 376_F04 3.066 3.29 3.415 0.222 376_G08 3.695 3.637 3.473 0.22 376_G09 3.678 3.646 3.446 0.23 376_H09 3.318 3.299 3.455 0.281 376_H10 3.28 3.293 3.538 0.318 365_E02 2.446 2.609 3.503 0.357 370_G12 1.337 1.6 3.523 0.418 368_C01 2.607 2.922 3.714 0.41 376_C06 3.487 3.563 3.43 0.29 368_D10 2.245 2.449 3.258 0.245 365_G12 2.742 2.748 3.548 0.556 367_C03 2.301 2.808 3.513 0.275 367_H07 2.719 2.684 3.463 0.297 371_D03 1.54 1.826 3.57 0.333 369_C10 2.48 2.456 3.373 0.32 367_F05 2.269 2.485 3.44 0.386 365_C07 1.943 1.917 3.171 0.311 374_C08 3.295 3.417 3.178 0.178 376_A06 3.694 3.742 3.162 0.262 376_B07 3.732 3.714 3.526 0.234 365_F07 3.122 3.184 3.393 0.331 369_E10 3.36 3.534 3.594 0.412 373_E03 3.465 3.465 3.247 0.194 366_B04 2.805 3.046 3.397 0.331 376_F12 3.131 3.247 3.441 0.323 369_F07 3.431 3.43 3.47 0.335 368_C06 0.738 1.034 3.524 0.255 376_E12 3.61 3.316 3.416 0.306 371_H01 3.027 2.995 3.693 0.471 367_E02 1.871 2.026 3.438 0.37 365_F04 2.26 2.509 3.471 0.403 370_A09 3.461 3.269 3.576 0.361 365_B03 2.645 2.53 3.377 0.444 369_A05 3.285 3.25 3.48 0.588 373_H10 3.243 3.251 3.189 0.2 367_A09 2.178 2.41 3.454 0.259 370_F08 2.339 2.994 3.587 0.495 376_B01 3.278 3.67 3.242 0.308 365_D05 2.578 2.72 3.514 0.357 373_E04 3.556 3.546 3.301 0.251 368_G05 2.175 2.421 3.354 0.245 365_A01 2.765 2.9 3.508 0.528 373_H06 3.004 3.151 3.3 0.2 369_G07 3.322 3.369 2.976 0.32 373_G05 3.612 3.615 3.224 0.273 372_F07 3.248 3.241 3.401 0.296 370_H03 3.426 3.565 3.558 0.381 366_A03 1.152 1.119 3.314 0.303 365_A07 2.244 2.255 3.407 0.284 376_B06 3.697 3.773 3.457 0.222 374_C11 3.641 3.593 3.215 0.471 375_A06 3.653 3.707 3.114 0.298 365_B09 3.264 3.319 3.282 0.272 373_E06 3.706 3.639 3.221 0.187 374_C05 3.698 3.693 3.176 0.175 376_C11 3.704 3.626 3.46 0.23 373_C09 3.64 3.597 3.22 0.17 368_H01 3.027 3.142 3.693 0.374 373_B03 3.638 3.621 3.161 0.18 374_C04 3.741 3.741 3.166 0.201 371_F05 2.89 3.149 3.33 0.297 369_A10 3.375 3.139 3.414 0.348 366_A05 2.624 2.596 3.477 0.284 375_G07 3.633 3.672 3.197 0.178 374_D02 3.06 3.2 2.994 0.204 365_A10 2.185 2.492 3.451 0.293 375_A02 2.977 3.178 3.066 0.186 371_G03 3.121 3.267 3.593 0.359 370_E07 3.442 3.496 3.453 0.379 375_B04 3.693 3.73 3.259 0.19 367_G07 3.019 3.197 3.287 0.295 366_C02 3.033 3.04 3.43 0.341 375_C12 3.662 3.328 3.266 0.197 365_F08 2.246 2.611 3.626 0.437 368_G09 2.438 2.815 3.62 0.281 368_E11 2.573 2.923 3.73 0.341 367_F02 2.375 2.268 3.522 0.315 373_B08 3.698 3.663 3.218 0.17 374_A11 3.645 3.722 2.806 0.15 373_B11 3.719 3.652 3.217 0.178 373_F03 3.652 3.603 3.213 0.179 372_D04 3.401 3.408 3.384 0.419 366_C01 2.307 2.406 3.601 0.382 367_A01 3.182 3.284 3.51 0.391 366_H05 2.445 2.737 3.47 0.418 369_B09 1.624 1.577 2.216 0.253 366_D07 2.413 2.623 3.383 0.418 369_D11 2.988 2.99 3.454 0.35 370_B05 2.839 3.111 3.492 0.593 366_D02 2.274 2.549 3.567 0.349 368_H12 2.636 2.693 3.572 0.381 368_F12 1.689 1.702 3.515 0.349 370_A06 2.594 2.769 3.471 0.331 369_F12 2.732 2.819 3.596 0.434 366_A09 1.787 1.926 3.277 0.266 368_H07 2.707 2.864 3.553 0.421 370_C04 2.319 2.632 3.6 0.334 373_E02 3.612 3.643 2.921 0.158 374_E09 3.671 3.578 3.157 0.162 371_C09 3.369 3.289 3.393 0.308 369_B12 2.666 2.759 3.562 0.4 369_B02 3.4 3.546 3.522 0.456 365_C09 2.052 2.178 3.272 0.266 374_B09 3.621 3.652 3.194 0.172 374_D12 3.55 3.28 3.087 0.235 374_C02 3.676 3.64 3.059 0.167 374_H08 3.307 3.271 3.089 0.199 369_D06 3.438 3.346 3.11 0.324 366_B06 2.474 2.453 3.104 0.415 367_A11 2.344 2.521 3.611 0.3 369_F04 1.949 2.171 3.459 0.369 369_A01 3.6 3.66 3.546 0.456 373_H12 3.061 2.985 3.004 0.162 376_C07 3.697 3.714 3.419 0.265 366_E02 2.257 2.581 3.456 0.37 376_G01 3.341 3.663 3.18 0.227 373_F02 3.623 3.6 3.149 0.175 376_E09 3.741 3.76 3.483 0.246 365_H04 2.471 2.588 3.495 0.371 369_E04 2.883 3.304 3.516 0.387 374_B11 3.692 3.657 3.175 0.17 376_G11 3.646 3.604 3.538 0.285 374_E04 3.74 3.716 3.187 0.169 373_E08 2.966 3.235 3.199 0.165 375_B10 3.651 3.74 3.138 0.17 365_E08 2.591 2.585 3.331 0.298 374_G02 3.515 3.538 3.174 0.175 373_D09 3.463 3.505 3.043 0.16 365_A04 1.487 1.405 3.28 0.25 371_B05 1.051 1.243 1.653 0.246 376_H08 3.305 3.279 3.527 0.274 367_G08 2.686 2.779 3.319 0.33 372_H03 2.322 2.697 3.642 0.437 366_E03 2.551 2.724 3.536 0.384 371_F12 2.474 2.304 3.616 0.413 366_C03 2.414 2.736 3.549 0.274 376_A01 3.243 3.661 2.985 0.239 365_E03 2.559 2.692 3.332 0.314 371_B10 3.313 3.36 3.441 0.387 369_G09 3.36 3.269 3.605 0.395 369_A06 2.891 3.012 3.32 0.394 369_C08 2.32 2.325 2.797 0.241 373_A07 3.525 3.594 3.114 0.177 367_D02 2.464 2.464 3.462 0.321 374_C07 3.651 3.698 3.22 0.225 374_A03 3.58 3.71 3.05 0.178 365_A02 3.028 2.962 3.492 0.374 365_D06 2.953 3.075 3.421 0.319 366_C07 3.016 3.06 3.368 0.301 367_F12 2.38 2.285 3.599 0.355 369_E09 3.627 3.767 3.483 0.278 365_G02 1.984 2.155 3.447 0.325 373_D02 3.729 3.645 3.187 0.18 374_E03 3.716 3.789 3.127 0.176 374_D11 3.639 3.579 2.905 0.162 370_D07 2.806 3.141 3.384 0.309 374_A08 3.589 3.673 2.944 0.16 374_G01 3.344 3.595 2.922 0.161 374_G12 3.195 3.215 3.149 0.214 375_G10 3.481 3.639 3.302 0.175 369_H11 1.445 1.639 2.21 0.382 375_G12 3.356 3.29 3.304 0.199 366_F06 1.874 2.155 3.445 0.394 368_G07 1.788 2.048 3.164 0.29 367_H04 1.623 1.849 3.395 0.289 374_E06 3.844 3.755 3.245 0.191 370_A10 2.581 2.878 3.467 0.434 368_H10 2.281 2.156 3.359 0.281 368_G08 1.603 1.752 3.291 0.329 365_H09 2.384 2.563 3.53 0.365 370_A08 2.406 2.335 3.522 0.319 368_B05 1.732 1.755 3.257 0.281 375_F01 3.16 3.455 2.956 0.166 374_F09 3.533 3.617 3.142 0.157

Example 3 Ligand Competition Assays

The ability of several of the antibodies identified in Example 2 to block Activin A and GDF8 binding to ACVR2A or ACVR2B was assessed by ELISA. Activin A (R&D systems) and GDF8 (R&D systems) were coated on 384-well Immunolon plates in 1× coating buffer (SurModics) at 0.5 μg/mL. Antibodies were serially diluted in a 10-point curve starting at 1 μM in 3-fold steps. ACVR2A and ACVR2B proteins were purchased from R&D Systems and biotinylated using the EZ-Link NHS-PEG4-biotin kit (Thermo Fisher). The antibodies were pre-incubated with biotinylated human ACVR2A-Fc, mouse ACVR2A-Fc, human ACVR2B-Fc, or mouse ACVR2B-Fc at a concentration of 500 ng/mL in 1% BSA in PBST for 1 hour. The mixtures of antibodies and biotinylated receptors were added to the Activin A/GDF8-coated plates for 1 hour. The inhibition of ligand-receptor interaction was detected with streptavidin-HRP (Jackson ImmunoResearch) at a concentration of 10 ng/mL and TMB.

The results of this assay are shown in columns A-D of Table 5 below. The values shown are IC50 values. The data in this table shows that the antibodies can specifically block Activin A and GDF8 binding to ACVR2A.

Example 4 ALK5/ACVR2B DIMERIZATION ASSAY

The ability of several of the antibodies identified in Example 2 to specifically block GDF8-induced dimerization between ACVR2A and ALK5 in U2OS cells was assessed using the DiscoverX receptor dimerization assay. In these assays, two receptors are tagged with ProLink™ (PK) or Enzyme Acceptor (EA). Upon ligand-induced activation, the receptors dimerize forcing the two β-gal components to complement and create an active enzyme. Active β-gal generates a chemiluminescent signal in the presence of substrate. In these assays, approximately 5000 U2OS cells were transferred into each well in total volume of 20 ul, antibody was dispensed into each well in total volume of 5 ul, the treated cells were incubated for 3 hr at 37° C., 5 ul of GDF8 was dispensed into wells in total volume of 5 ul (final conc 100 ng/ml), the cells were incubated for 16 hr at 37° C. and 30 ul of 1× Flash detection reagent was added to each well. The reactions were incubated for 1 hr at room temperature and then read on a plate reader.

The results of this assay are shown in columns E and F of Table 5 below. The values shown are IC50 values. The data in this table shows that the antibodies block GDF8-induced dimerization of ALK5/ACVR2A but not ALK5/ACVR2B.

Example 5 Quantitative ELISA Assays

The binding of several of the antibodies identified in Example 2 to human ACVR2A, mouse ACVR2A, human ACVR2B, and mouse ACVR2B were quantified by ELISA. His-tagged recombinant proteins (Sino Biological, Inc.) were His-tagged Human ACVR2A, Mouse ACVR2A, Human ACVR2B, or Mouse ACVR2B were coated on Immunolon 384-well plates at a concentration of 0.5 μg/mL in 1× coating buffer (SurModics). Antibodies were diluted to 1 μM in PBS buffer containing 1% BSA and diluted 3-fold in a 10-point curve. Detection of the antibody binding to the antigen was performed using biotinylated goat anti-human kappa light chain (Bethyl Laboratories). Detection of the secondary antibody was determined using streptavidin-HRP and TMB reagent. All assays were performed at room temperature. Curve-fitting software was used to determine the EC50 for each antibody (MatLab).

The results of this assay are shown in columns G-L of Table 5 below. The values shown are EC50 values. The data in this table shows that the antibodies specifically bind to ACVR2A, not ACVR2B.

Example 6 Activity on Skeletal Muscle Cells

The ability of several of the antibodies identified in Example 2 to alter SMAD3 activity in muscle cells was tested. Primary human myoblasts (Lonza) cultured in Ham's F-10 supplemented with SkGM-2 Single-Quots (Lonza). Myoblasts were differentiated in DMEM/F-12K (50:50) supplemented with 2% horse serum (Corning) and 1% Penicillin/Streptomycin. After 4 days of differentiation, myotubes were pre-treated with antibodies for 1 hour at a starting concentration of 1 μM and diluted serially 3-fold in a 10-point curve. GDF8 (R&D) was added for 1 hour at 100 ng/mL. Cells were lysed in 30 μL of PBS+0.1% Triton-X+lx Halt Protease/Phosphastase inhibitors (Thermo Fisher). Phospho-SMAD3 (Ser423/425) activity was assessed in primary human myotubes by AlphaLisa (Perkin-Elmer) according to manufacturer's instructions.

The results of this assay are shown in column M of Table 5 below. The data in this table shows that the antibodies reduce GDF8-induced SMAD3 phosphorylation in muscle cells.

Example 7 Smad Reporter 293 Assay

The ability of several of the antibodies identified in Example 2 to specifically inhibit GDF8-induced SMAD activation in HEK293 was tested cells using a smad2/3 luciferase reporter construct. In these experiments, a smad2/3 luciferase reporter (SBI #TR203VA-P) was introduced into HEK293 cells. Endogenous ACVR2A and ACVR2B function was knocked out using custom made CRISPR/CAS9 targeting sequences. Finally, individual reporter lines were generated by reintroduction of ACVR2A or ACVR2B expression vectors. This method involved dispensing 30,000 cells into each well in total volume of 80 ul, dispensing antibody into each well in total volume of 10 ul, incubating the treated cells for 1 hr at 37° C., dispensing GDF8 into wells in total volume of 10 ul (final conc. 100 ng/ml), incubating the stimulated cells for 24 hr at 37° C., adding 100 ul of 1X ONE-Glo detection reagent to each well, incubate the plate for 5 min at room temperature and then reading luminescence using a plate reader.

The results of this assay are shown in column N of Table 5 below. The values shown are IC50 values. The data in this table shows that the antibodies inhibit GDF8-induced SMAD3 phosphorylation in HEK293 cells.

Example 8 Smad Reporter 4E1 Assay

The ability of several of the antibodies identified in Example 2 to specifically inhibit GDF8-induced SMAD activation was tested cells using the following protocol. In this assay, HEK293 cells were infected with a lentiviral SMAD2/3/4 reporter (pGF-SMAD2/3/4-mCMV-EF1-Puro System Biosciences). The lentiviral based reporter expresses both GFP and luciferase under the control of a Smad3-responsive element (CAGA)₁₂. Cells were sorted for their responsiveness to GDF8 based on their GFP expression. Single cell clones were expanded and transcriptional activation was tested by GDF8-induced luciferase activity. Clone 4E1 was unresponsive to GDF8 or Activin A. This clone was further transfected with Human or Mouse ACVR2A or ACVR2B plasmids. The ability of the antibodies to inhibit luciferase induction by GDF8 or Activin A in these cell lines was tested.

The results of this assay are shown in column 0 of Table 5 below. These values are IC50 values. The data in this table shows that the antibodies inhibit GDF8 and Activin A-mediated induction of SMAD2/3/4 in HEK293 cells.

TABLE 5 A B C D E F G H I J K L M Comp ELISA Comp ELISA Comp ELISA Comp ELISA Dimer Dimer ELISA ELISA- ELISA- ELISA ELISA ELISA Phospho- N O Human Human Mouse Mouse ALK5/ ALK5/ Human Human Human Mouse Mouse Mouse SMAD3 SMAD 2/3/4 Clone 4E1 + ACVR2A ACVR2A ACVR2A ACVR2A ACVR2A ACVR2B ACVR2A ACVR2A ACVR2B ACVR2A ACVR2A ACVR2B Human Skeletal Reporter Human ACVR2A, Ab Activin A GDF8 Activin A GDF8 GDF8 GDF8 (10 pt) (8 pt) (10 pt) (10 pt) (8 pt) (10 pt) Muscle GDF8 HEK293 Activin A, 10pt 365_B10 0.0819 0.0009 0.0066 0.0002 0.6247 9999 0.0013 0.001 9999 0.001 0.0009 9999 0.031 0.3643 0.0364 365_E04 0.004 0.0048 365_H08 0.4151 0.0116 0.1949 0.0044 9999 9999 0.1963 0.0089 9999 0.0959 0.0055 9999 9999 9999 366_D01 0.338 0.0292 0.2896 0.0133 6.372 9999 0.0017 9999 0.0011 9999 0.1323 0.4973 0.1006 366_G06 0.0059 0.0041 367_H01 0.0363 0.0035 0.0125 0.0014 6.578 9999 0.0064 0.0009 9999 0.0054 0.0025 9999 0.0248 3.679 0.3607 368_A02 0.008 0.008 368_A12 0.081 0.002 0.0348 0.0007 2.303 9999 0.0016 0.0028 9999 0.0015 0.0024 9999 0.046 0.9454 0.1142 368_B10 0.0077 0.0025 0.0084 0.0032 0.4969 9999 0.0053 0.0043 9999 0.0053 0.0045 9999 0.0469 1.387 0.0632 368_F10 0.1033 0.0069 0.1028 0.004 3.946 9999 0.0039 9999 0.0022 9999 0.2567 0.8681 0.2092 369_B03 0.0164 0.0044 0.0115 0.0033 1.761 9999 0.0051 0.0031 9999 0.006 0.0024 9999 0.0157 0.3055 0.1569 369_H03 0.1782 0.0017 0.0246 0.0001 8.179 9999 0.0073 0.003 9999 0.0052 0.01 9999 0.3262 9999 0.0957 370_B01 0.0036 0.0006 0.0027 0.0004 0.1589 9999 0.0004 0.0011 9999 0.0004 0.001 9999 0.0121 0.0535 0.0154 371_D07 0.0271 0.0032 0.0344 0.0035 1.182 9999 0.0093 0.013 9999 0.0057 0.01 9999 0.1265 4.187 0.2217 372_B11 0.0623 0.0059 0.0718 7.11E−05 2.191 9999 0.0042 9999 0.0032 9999 0.3973 4.276 0.2726 373_E11 0.0208 0.0012 0.021 8.31E−05 0.9392 9999 0.0013 9999 0.0012 9999 0.0229 0.4333 0.1403 373_H02 0.01 0.0036 0.006 0.0032 0.7633 9999 0.0032 0.001 9999 0.003 0.0011 9999 0.0145 0.3413 0.0251 374_B02 0.1374 0.0206 0.0771 0.0112 5.938 9999 0.0653 0.01 9999 0.0378 0.0032 9999 0.1183 9999 0.1766 375_A04 0.0025 0.0015 0.0018 0.0011 0.0481 9999 0.0007 0.0006 9999 0.0007 0.0004 9999 0.0076 0.0551 0.0071 375_A11 0.0167 0.0082 0.0105 0.0047 0.939 9999 0.0047 0.0009 9999 0.003 0.0007 9999 0.0127 0.5299 0.0359 375_H01 0.015 0.015 376_G02 0.0144 0.0051 0.0111 0.0041 0.8281 9999 0.0029 0.0018 9999 0.002 0.002 9999 0.1901 0.3337 0.0836 365_G06 0.0151 0.0034 0.0226 0.0028 0.4743 9999 0.0035 0.0026 9999 0.0031 0.0073 9999 0.0875 0.2124 0.0309 367_F10 0.0186 0.0035 0.0168 0.0026 2.249 9999 0.0019 0.0136 9999 0.0017 0.0119 9999 0.1176 0.4684 0.369 368_B12 0.0074 0.0035 0.0128 0.0033 0.4249 9999 0.0047 0.0053 9999 0.0051 0.006 9999 0.0918 1.746 0.1613 369_A12 0.0205 0.0005 0.0119 0.0002 0.3311 9999 0.001 0.0017 9999 0.0008 0.0014 9999 0.0119 0.0948 0.0311 369_E03 0.0777 0.0006 0.0346 0.0049 0.8456 9999 0.001 0.0059 9999 0.0009 0.0043 5.543 0.0235 1.043 0.1305 370_B06 0.018 0.0007 0.0107 0.0002 0.9481 9999 0.0032 0.0018 9999 0.0023 0.0015 9999 0.0061 0.3843 0.0467 371_B11 0.0268 0.0038 0.0147 0.157 0.3699 9999 0.0011 0.0012 9999 0.001 0.0011 9999 0.015 0.2384 0.0316 371_C02 0.0519 0.0043 0.0577 0.0087 3.394 9999 0.0025 0.0045 9999 0.0021 0.0045 9999 0.0488 1.01 0.0956 373_D11 0.0037 0.0005 0.004 0.0001 0.1968 9999 0.0003 9999 0.0003 9999 0.0081 0.3066 0.0225 373_G06 0.0478 0.0053 0.0325 0.0044 9999 9999 0.0052 0.0009 9999 0.0047 0.0021 9999 0.0231 1.969 0.0383 376_D08 0.0027 0.0007 0.0019 0.0007 0.075 9999 0.0006 9999 0.0005 9999 0.0065 0.0343 0.41 376_F09 0.0094 0.0015 0.0101 0.0016 0.3541 9999 0.0046 0.0046 9999 0.0041 0.0028 9999 0.0855 0.4007 0.0407 365_E12 0.0019 0.0017 365_F02 0.0077 0.0022 0.0078 0.0014 0.2793 9999 0.0006 0.0005 9999 0.0006 0.0005 9999 0.026 0.8487 0.0639 365_G05 0.0073 0.0072 367_A03 0.0136 0.0132 367_C07 0.0298 0.0042 0.03 0.0041 1.082 9999 0.0008 9999 0.0007 9999 0.0716 9999 0.1569 369_A07 0.0056 0.0039 0.0029 0.0013 0.5726 9999 0.001 0.0005 9999 0.0008 0.0006 9999 0.0149 0.1323 0.0155 369_B05 0.0027 0.0018 370_A02 0.0022 0.005 370_H02 0.0254 0.0005 0.0123 1.00E−14 0.9495 9999 0.0009 0.0016 9999 0.0008 0.0012 9999 0.0226 0.6343 0.0355 371_A10 0.0058 0.0056 371_C12 0.043 0.0004 0.024 0.0043 0.3096 9999 0.0006 0.0011 9999 0.0005 0.0007 9999 0.0206 0.5658 0.0187 371_D02 0.0028 0.0017 371_G09 0.0019 0.0019 371_G11 0.0062 0.0004 0.0066 0.0045 7.363 9999 0.0042 0.0039 9999 0.0034 0.0031 9999 0.1361 9999 0.3384 372_B02 0.0099 0.0001 0.0045 0.0004 2.192 9999 0.0019 0.0026 9999 0.0014 0.0017 9999 0.1605 1.675 0.1778 372_D03 0.003 0.0004 0.0013 0.0006 0.7064 9999 0.0011 0.0012 9999 0.0009 0.0009 9999 0.058 0.1379 0.0466 373_A03 0.0053 0.0023 0.0031 0.0021 0.2914 9999 0.001 0.001 9999 0.0008 0.0007 9999 0.0148 0.559 0.009 373_A05 0.0032 0.0022 373_A09 0.0012 0.0009 373_A11 0.0009 0.0006 373_B05 0.0022 0.0021 373_C07 0.0126 0.004 0.0087 0.0011 1.215 9999 0.0028 0.0015 9999 0.0025 0.0014 9999 0.0048 1.208 0.0686 373_F08 0.0022 0.0015 0.0017 0.0004 0.0919 9999 0.0006 0.0007 2.32 0.0004 0.0005 2 0.005 0.3677 0.0315 373_F12 0.0016 0.0009 373_G08 0.0041 0.0012 0.0033 0.001 0.2649 9999 0.0009 0.001 9999 0.0007 0.0009 9999 0.0057 0.3073 0.0711 373_H03 0.0199 0.0074 0.0117 0.0066 2.093 9999 0.003 9999 0.0024 9999 0.0129 0.808 0.1144 374_B03 0.0031 0.0015 0.002 0.0006 0.2057 9999 0.0008 0.0009 9999 0.0008 0.0006 9999 0.027 0.2394 0.0399 374_C01 0.3127 0.0191 0.2885 0.0033 9999 9999 0.022 9999 0.0263 9999 1.115 0.8145 4.942 374_C09 0.0467 0.0088 0.0496 0.0047 1.402 9999 0.011 0 9999 0.007 0.004 9999 0.1888 0.7011 0.2959 374_C12 0.0045 0.0023 0.0038 0.0026 0.2619 9999 0.0016 0.0005 0.4162 0.0012 0.0005 0.397 0.027 0.1579 0.083 374_D05 0.0392 0.0065 0.0258 0.0068 1.646 9999 0.0074 0.0022 9999 0.0066 0.0018 9999 0.0177 1.697 0.0851 374_D10 0.0781 0.0038 0.0653 0.0027 3.186 9999 0.0032 1.021 0.0022 1.053 0.1264 9999 4.658 374_G08 0.0056 0.0025 0.0056 0.0017 0.608 9999 0.0018 0.0009 9999 0.0014 0.0009 9999 0.034 0.542 0.0781 375_A01 0.0012 0.001 375_A07 0.0097 0.0025 0.0221 0.0025 0.4117 9999 0.001 9999 0.001 9999 0.014 0.0154 0.0922 375_A12 0.0047 0.0011 0.0033 0.0003 0.3345 9999 0.0007 9999 0.0005 9999 0.0469 1.051 0.0415 375_D10 0.0023 0.0019 375_E05 0.0009 0.0007 375_E10 0.0036 0.002 0.0023 0.0009 0.2255 9999 0.0007 0.0006 9999 0.0007 0.0006 9999 0.0091 0.2237 0.0215 375_F02 0.0288 0.0034 0.0184 0.006 0.8957 9999 0.0037 9999 0.0028 9999 0.0076 0.6181 0.0247 375_G05 0.0008 0.0005 0.001 0.0004 0.1347 9999 0.0005 0.0007 2.852 0.0004 0.0005 2 0.0052 0.0108 0.0668 375_H05 0.0067 0.0019 0.0043 9.34E−05 0.4237 9999 0.0008 0.0006 9999 0.0007 0.0005 9999 0.0346 0.2948 0.0342 376_A03 0.0022 0.0014 376_B10 0.0021 0.0017 376_C08 0.0243 0.0046 0.0272 0.0046 0.9254 9999 0.0044 9999 0.0048 9999 0.0605 1.353 0.1794 376_F01 0.1328 0.0177 0.1264 0.0177 2.893 9999 0.0076 0.0082 0.0922 0.008 0.003 0.0924 0.5947 9999 0.6449 376_F06 0.0352 0.0032 0.021 0.002 0.5714 9999 0.0034 0.0024 9999 0.0032 0.0017 9999 0.0544 9999 0.1295 375_G05 0.0081 0.0036 0.008 0.0032 0.9329 9999 0.0017 0.0006 9999 0.0014 0.0005 9999 0.0658 0.3712 0.0755 376_G10 0.0031 0.0032 376_H01 0.005 0.0025 0.0044 0.0013 0.5641 9999 0.001 0.0012 0.1094 0.0009 0.001 0.0981 0.0562 0.6002 0.0329 376_H11 0.0008 0.0007 0.0013 0.0007 0.0368 9999 0.0004 0.0005 9999 0.0004 0.0004 9999 0.0042 0.0775 0.0084 367_A02 0.0685 0.0168 0.0757 0.0117 1.404 9999 0.0099 9999 0.0053 9999 0.1591 2.765 0.065 368_G03 0.1025 0.0013 0.0477 0.0003 5.011 9999 0.0033 0.0068 9999 0.0026 0.008 9999 0.299 1.678 0.4619 368_H06 0.0138 0.0023 369_C12 0.0022 0.0007 0.0016 0.0006 0.137 9999 0.0007 0.0008 9999 0.0007 0.0005 9999 0.0094 0.0821 0.0435 369_E08 0.0028 0.0023 369_F09 0.0204 0.0007 0.0196 0.0004 0.793 9999 0.0012 2 0.001 2 0.0325 1.095 0.1356 369_H08 0.0721 0.0014 0.0431 0.0002 1.385 9999 0.0013 0.0034 9999 0.001 0.0025 9999 0.0308 0.7511 0.074 369_H12 0.0154 0.001 0.0112 0.0001 1.812 9999 0.0006 0.0011 9999 0.0005 0.001 9999 0.0303 0.3774 0.0815 370_C06 0.0148 0.0005 0.0083 6.83E−05 0.7631 9999 0.0005 0.0009 9999 0.0005 0.0008 9999 0.0111 4999 0.05 370_C07 0.0219 0.0011 0.0064 0.0006 0.3774 9999 0.0006 0.0006 9999 0.0006 0.0005 9999 0.0044 0.1452 0.0213 370_D03 0.0163 0.0025 0.0103 0.0042 0.8872 9999 0.0023 0.0017 9999 0.0017 0.0015 9999 0.0165 0.4708 0.0649 370_E04 0.0067 0.0023 0.0065 0.0005 0.8152 9999 0.0008 0.0007 9999 0.0008 0.0005 9999 0.0136 0.5966 0.0416 370_F12 0.005 0.0002 0.0025 2.65E−05 0.3859 9999 0.0009 0.0006 9999 0.0007 0.0005 9999 0.0066 0.1268 0.0096 371_B01 0.003 0.0006 0.0024 0.0002 0.1059 9999 0.0005 0.0017 9999 0.0005 0.0018 9999 0.0076 0.0454 0.0091 371_E12 0.0023 0.0043 0.0022 0.0024 0.5962 9999 0.0012 9999 0.0011 9999 0.0374 0.3155 0.1173 371_F09 0.0054 0.0006 0.0047 0.0003 0.2882 9999 0.0006 9999 0.0005 9999 0.0311 0.31 0.0405 371_G01 0.0013 0.0012 371_H11 0.0011 0.0008 372_B09 0.0022 0.0002 0.0007 0.0003 0.6034 9999 0.0006 0.0009 9999 0.0006 0.0008 9999 0.0182 0.4639 0.055 372_D06 0.0085 0.001 0.0083 0.0003 0.3887 9999 0.0004 9999 0.0003 9999 0.0303 0.4069 0.0807 373_F07 0.0091 0.002 0.0056 0.0039 3.811 9999 0.0015 9999 0.0014 9999 0.0069 0.397 0.0413 374_A05 0.0023 0.0002 0.0021 0.0005 0.0998 9999 0.0003 0.0008 9999 0.0003 0.0006 9999 0.0081 0.2057 0.0166 374_C10 0.0137 0.003 0.0064 0.0023 0.4673 9999 0.001 0.0013 9999 0.0007 0.001 9999 0.0582 0.0544 0.3012 374_G05 0.0074 0.002 0.0042 0.0027 0.5471 9999 0.0021 0.0006 9999 0.0017 0.0006 9999 0.0132 0.4163 0.0192 365_A12 0.3112 0.0015 0.1194 5.64E−05 9999 9999 0.0103 0.0084 0.7569 0.0059 0.0071 0.3945 0.9032 5.406 1.133 365_B11 0.003 0.0032 365_E05 0.0435 0.0098 0.0528 0.0071 0.8445 9999 0.0045 9999 0.0042 9999 0.2437 0.367 0.0548 365_E07 0.3702 0.0105 0.1501 0.0122 9999 9999 0.011 0.008 9999 0.0048 0.0101 9999 0.5183 9999 0.9486 366_B12 0.0304 0.0115 0.0185 0.0114 0.8558 9999 0.0012 0.0013 9999 0.0009 0.001 9999 0.0392 0.3748 0.053 367_F03 0.01 0.007 367_H06 0.0744 0.0035 0.0653 0.0034 0.8666 9999 0.0018 9999 0.0012 9999 0.108 0.9681 0.3781 367_H11 0.0389 0.0044 0.0258 0.0035 0.4515 9999 0.0057 0.004 9999 0.003 0.0008 9999 0.0703 1.207 0.118 368_F03 0.4171 0.0005 0.0323 0.0001 9999 9999 0.022 0.1 9999 0.0189 0.1503 9999 0.8118 3.259 3.216 369_D02 0.0031 0.0006 0.0039 2.58E−05 0.2671 9999 0.0004 9999 0.0004 9999 0.0135 0.1746 0.0252 369_F01 0.0147 0.0013 0.0147 0.0002 0.4998 9999 0.0008 9999 0.0007 9999 0.0317 0.5266 0.1112 369_F06 0.0038 0.0032 369_G01 0.0112 0.0008 0.0061 0.0001 0.7538 9999 0.0004 9999 0.0004 9999 0.0116 0.1187 0.0275 369_H06 0.0106 0.0028 0.0082 3.81E−05 9999 9999 0.0005 0.0004 9999 0.0005 0.0002 9999 0.0068 9999 0.0225 370_A01 0.0045 0.0039 370_A12 0.0061 0.0023 0.0136 0.0024 0.1245 9999 0.0009 0.0016 9999 0.0008 0.0015 9999 0.0632 0.031 0.0036 370_C01 0.0017 0.0015 370_C03 0.0007 0.0004 0.0006 0.0004 0.0388 9999 0.0004 0.0003 9999 0.0004 0.0004 9999 0.0029 0.0133 0.0035 370_C05 0.0053 0.0032 0.0036 0.0024 0.927 9999 0.0012 0.0033 9999 0.0011 0.0024 9999 0.0082 0.2655 0.0343 370_C08 0.021 0.0016 370_D04 0.0055 0.0012 0.0038 0.0013 0.1029 9999 0.0005 0.0007 9999 0.0004 0.0006 9999 0.0074 0.0452 0.0153 370_E09 0.0043 0.0009 0.0021 0.0006 0.2656 9999 0.0006 0.0007 9999 0.0005 0.0006 9999 0.0093 0.1226 0.009 370_H01 0.0084 0.0006 0.0056 2.61E−05 2.84 9999 0.0005 0.0004 9999 0.0005 0.0003 9999 0.0093 4999 0.039 371_A06 0.0014 0.0014 371_B07 0.0161 0.0023 0.0155 0.0003 1.236 9999 0.0012 0.0014 1.77 0.0011 0.0012 9999 0.0402 0.4951 0.0734 371_F01 0.005 0.0046 371_F04 0.0023 0.0022 372_A04 0.0031 0.0028 0.0051 0.0022 0.3792 9999 0.0008 9999 0.0007 9999 0.0193 0.0367 0.0423 372_D02 0.0029 0.0027 372_F03 0.0047 0.0005 0.0041 0.0002 0.1903 9999 0.0003 0.0008 9999 0.0004 0.0008 9999 0.0646 0.1972 0.0233 372_F08 0.0031 0.0113 0.0026 0.0113 0.371 9999 0.0009 9999 0.0008 9999 0.023 0.3148 0.0248 372_F09 0.0053 0.0002 0.0113 0.0029 1.012 9999 0.001 0.0009 9999 0.0009 0.0008 9999 0.018 1.8 0.087 373_A10 0.0028 0.002 0.0055 0.0018 0.3578 2.53 0.0006 9999 0.0006 9999 0.0111 0.0965 0.0534 373_B04 0.0186 0.0023 0.0103 0.0031 1.268 9999 0.0026 0.0018 9999 0.0027 0.0013 9999 0.0093 1.028 0.1154 373_C02 0.0302 0.0052 0.0179 0.0022 3.29 9999 0.0053 9999 0.0052 9999 0.0083 1.389 0.1045 373_C06 0.001 0.001 373_D04 0.0019 0.0013 0.0023 0.0012 0.1467 9999 0.0006 9999 0.0005 9999 0.0078 0.137 0.0189 373_D10 0.0069 0.0018 0.0033 0.0004 0.2803 9999 0.0015 0.0008 9999 0.0012 0.0005 9999 0.006 0.0821 0.0176 374_B04 0.0043 0.0018 0.0029 0.0016 0.2473 9999 0.0014 0.0003 9999 0.0015 0.0003 9999 0.0093 0.1014 0.0156 374_B06 0.0614 0.0041 0.0513 0.0001 0.5987 9999 0.0011 0.004 9999 0.0009 0.004 9999 0.0407 0.3649 0.0717 374_C03 0.0016 0.001 0.0026 0.0007 0.1284 9999 0.0005 9999 0.0004 9999 0.0094 0.0468 0.0144 374_C06 0.0105 0.0039 0.0059 0.0032 0.5205 9999 0.0019 0.0008 9999 0.0015 0.0007 9999 0.0138 0.296 0.015 374_D08 0.9536 0.0698 0.6104 0.0621 9999 9999 0.3558 0.01 9999 0.2008 0.01 9999 0.2299 9999 1.286 374_E01 0.0013 0.001 374_E05 0.0074 0.0023 0.0079 0.0019 0.3051 9999 0.0013 0.0016 0.1534 0.0014 0.0011 0.1414 0.0497 0.6496 2.729 365_E02 0.4962 0.0046 0.1616 0.0012 12.07 9999 0.0095 0.008 9999 0.0047 0.0013 9999 0.3412 9999 0.4773 376_C06 0.0349 0.0049 0.0238 0.0053 0.711 9999 0.0042 0.0016 9999 0.0022 0.001 9999 0.0107 0.1983 0.0817 368_D10 0.0119 0.0045 0.0195 0.0033 0.4824 9999 0.0019 9999 0.0014 9999 0.0601 0.2942 0.0389 374_C08 0.182 0.0325 0.194 0.0223 9999 9999 0.0462 9999 0.0285 9999 0.5848 9999 9999 376_A06 0.0011 0.0006 0.0009 0.0004 0.0189 9999 0.0004 0.0004 9999 0.0004 0.0003 9999 0.0043 0.0203 0.0037 365_F07 0.0044 0.0017 0.0037 0.0006 0.136 9999 0.0012 0.0006 9999 0.0013 0.0007 9999 0.011 0.0925 0.0354 376_B01 0.0035 0.0006 0.0039 8.50E−05 0.2036 9999 0.0004 9999 0.0004 9999 0.0086 0.369 0.0283 365_D05 0.0146 0.0025 0.0149 0.0009 0.9169 9999 0.0008 9999 0.0008 9999 0.0209 0.6678 0.1817 369_G07 0.0068 0.001 0.0075 0.0001 9999 9999 0.0007 9999 0.0006 9999 0.012 0.0327 0.1333 373_G05 0.0023 0.0002 0.0021 0.0002 0.1636 9999 0.0003 9999 0.0002 9999 0.0059 0.1546 0.0202 376_B06 0.0016 0.001 0.0014 0.0007 0.0381 9999 0.0005 0.0006 9999 0.0005 0.0004 9999 0.0042 0.0005 0.0164 374_C11 0.0192 0.0015 0.0105 0.0034 0.9402 9999 0.0018 0.3945 0.0015 0.3304 0.0266 0.6324 0.0328 375_A06 0.0032 0.0016 0.0025 0.0013 0.1302 9999 0.0012 0.0005 9999 0.0011 0.0004 9999 0.0318 0.1546 0.014 373_E06 0.0002 0.0002 0.0002 0.0001 0.0082 9999 0.0002 0.0002 9999 0.0002 0.0002 9999 0.0005 0.0089 0.0022 374_C05 0.0009 0.0005 0.0011 0.0004 0.1344 9999 0.0007 0.0005 9999 0.0007 0.0004 9999 0.0124 0.0142 9999 368_H01 0.0017 0.0014 373_B03 0.0006 0.0005 369_A10 0.017 0.0005 0.0077 8.47E−05 5000 9999 0.001 0.0015 9999 0.001 0.0005 9999 0.0076 5000 0.071 366_A05 0.7418 9999 0.0004 0.0006 9999 0.0005 0.0005 9999 0.0244 0.6492 0.0524 375_G07 0.0085 0.0032 0.0053 0.0031 0.7814 9999 0.0022 0.0012 9999 0.0016 0.001 9999 0.0112 0.2215 0.0786 371_G03 0.001 0.001 370_E07 0.0009 0.0005 0.0013 0.0005 0.1001 9999 0.0007 0.0003 9999 0.0008 0.0003 9999 0.0046 0.0764 0.013 367_G07 0.0007 0.0009 0.0011 0.0007 0.1113 9999 0.0011 0.0005 9999 0.0009 0.0004 9999 0.0068 0.0843 0.0124 375_C12 0.0006 0.0003 0.0007 0.0004 0.0414 9999 0.0004 0.0003 0.4421 0.0004 0.0003 0.4194 0.0063 0.0237 0.2784 373_B08 0.003 0.0012 0.002 0.0012 0.3478 9999 0.0015 0.0005 9999 0.0017 0.0004 9999 0.0102 0.1201 0.017 374_A11 0.0038 0.0015 0.0027 0.0015 0.6038 9999 0.0013 0.0004 9999 0.0011 0.0003 9999 0.0086 0.079 0.0188 373_B11 0.0003 0.0002 0.0005 0.0003 0.0185 9999 0.0002 9999 0.0003 9999 0.0008 0.024 0.0036 372_D04 0.0022 0.0008 0.0026 0.0317 0.1255 9999 0.0009 0.0005 9999 0.0009 0.0005 9999 0.0114 0.0938 0.0179 367_A01 0.0021 0.0009 0.0041 0.0011 0.1471 9999 0.0012 0.0009 9999 0.0011 0.0007 9999 0.0065 0.1617 0.0355 373_E02 0.0034 0.0013 0.0021 0.0013 4999 9999 0.0012 0.0006 9999 0.0012 0.0005 9999 0.0049 4999 4999

While the present invention has been described with reference to the specific embodiments thereof, it should be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the true spirit and scope of the invention. In addition, many modifications may be made to adapt a particular situation, material, composition of matter, process, process step or steps, to the objective, spirit and scope of the present invention. All such modifications are intended to be within the scope of the claims appended hereto. 

1. An antibody that specifically binds to ACVR2A, wherein the antibody comprises: (a) a variable domain comprising: i. heavy chain CDR1, CDR2 and CDR3 regions that are identical the heavy chain CDR1, CDR2 and CDR3 regions of an antibody selected from any of Tables 2A-2F; and ii. light chain CDR1, CDR2 and CDR3 regions that are identical the light chain CDR1, CDR2 and CDR3 regions of the antibody selected from any of Tables 2A-2F; or (b) a variant of said variable domain of (a) that is otherwise identical to said antibody variable domain except for up to 15 amino acid substitutions in said CDR regions.
 2. An antibody that specifically binds to ACVR2A, wherein the antibody comprises: a heavy chain variable domain comprising: a heavy chain framework, a CDR1 region, a CDR2 region, and a CDR3 region of sequence AxxAxWHDTxLD (SEQ ID NO: 6618); and a light chain variable domain comprising: a light chain framework, a CDR1 region, a CDR2 region, and a CDR3 region.
 3. The antibody of claim 1, wherein the heavy chain variable domain comprises a CDR3 region of sequence ARSATWHDTxLD (SEQ ID NO: 6549), ARAATWHDTxLD (SEQ ID NO: 6540), ARGANWHDTxLD (SEQ ID NO: 6542), ARGATWHDTxLD (SEQ ID NO: 6544), ARSANWHDTxLD (SEQ ID NO: 6546) or ARSATWHDTxLD (SEQ ID NO: 6548).
 4. The antibody of claim 1, wherein the antibody comprises: a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of D/SS/DYG/SMH/N (SEQ ID NO: 6550), ii. a CDR2 region that has a sequence of WVA/SS/G/NINYNG/SGYT/KS/G (SEQ ID NO: 6619), and iii. a CDR3 region that has a sequence of ARAANWHDTA/HLD (SEQ ID NO: 6620); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of L/V/I/SS/T/RYL/VNWY (SEQ ID NO: 6554), ii. a CDR2 region that has a sequence of LV/LIYA/YNA/V/TT/S/NS/NR/LA/H/Q/P (SEQ ID NO: 6621), and iii. a CDR3 region that has a sequence of QQ/HSY/DD/E/S/NL/N/S/TPL (SEQ ID NO: 6593).
 5. The antibody of claim 1, wherein the antibody comprises: a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of D/SS/DYG/SMH/N (SEQ ID NO: 6550), ii. a CDR2 region that has a sequence of WVA/SS/G/NINYNG/SGYT/KS/G (SEQ ID NO: 6551), and iii. a CDR3 region that has a sequence of ARAATWHDTH/ALD (SEQ ID NO: 6559); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of L/V/I/SS/TYL/VNWY (SEQ ID NO: 6561), ii. a CDR2 region that has a sequence of LL/VIYA/YA/T/VT/S/NS/NR/LA/P/Q (SEQ ID NO: 6563), and iii. a CDR3 region that has a sequence of QQSY/D/ND/E/S/NL/S/T/NPL (SEQ ID NO: 6565).
 6. The antibody of claim 1, wherein the antibody comprises: a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of S/DS/DYS/GMN/H (SEQ ID NO: 6566), ii. a CDR2 region that has a sequence of WVS/AG/S/NINYNG/SGYT/KS/G (SEQ ID NO: 6567), and iii. a CDR3 region that has a sequence of ARGANWHDTA/HLD (SEQ ID NO: 6543); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of L/V/S/IS/TYL/VNWY (SEQ ID NO: 6569), ii. a CDR2 region that has a sequence of LL/VIYAA/V/TT/SSR/LA/H/Q (SEQ ID NO: 6571), and iii. a CDR3 region that has a sequence of QQSY/DD/E/S/NS/T/N/LPL (SEQ ID NO: 6573).
 7. The antibody of claim 1, wherein the antibody comprises: a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of S/DS/DYS/GMN/H (SEQ ID NO: 6574), ii. a CDR2 region that has a sequence of WVA/SG/N/SINYNG/SGYT/KS/G (SEQ ID NO: 6575), and iii. a CDR3 region that has a sequence of ARGATWHDTH/ALD (SEQ ID NO: 6595); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of L/I/V/SS/TYL/VNWY (SEQ ID NO: 6596), ii. a CDR2 region that has a sequence of LL/VIYAA/V/TT/SSR/LA/H/Q (SEQ ID NO: 6571), and iii. a CDR3 region that has a sequence of QQSY/DD/E/S/NT/S/N/LPL (SEQ ID NO: 6577).
 8. The antibody of claim 1, wherein the antibody comprises: a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of S/DS/DYG/SMN/H (SEQ ID NO: 6578), ii. a CDR2 region that has a sequence of WVS/AG/N/SINYNG/SGYT/KS/G (SEQ ID NO: 6579), and iii. a CDR3 region that has a sequence of AR/KSANWHDTA/HLD (SEQ ID NO: 6580); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of L/V/I/SS/TYL/VNWY (SEQ ID NO: 6561), ii. a CDR2 region that has a sequence of LL/VIYA/YAN/TT/SS/NR/LA/H/Q (SEQ ID NO: 6582), and iii. a CDR3 region that has a sequence of QQSY/DD/E/N/SS/T/L/NPL (SEQ ID NO: 6598).
 9. The antibody of claim 1, wherein the antibody comprises: a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of D/SS/DYS/GMN/H (SEQ ID NO: 6584), ii. a CDR2 region that has a sequence of WVA/SG/N/SINYNG/SGYT/KS/G (SEQ ID NO: 6585), and iii. a CDR3 region that has a sequence of ARSATWHDTH/ALD (SEQ ID NO: 6586); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of L/V/I/SS/T/RYL/VNWY (SEQ ID NO: 6588), ii. a CDR2 region that has a sequence of LL/VIYA/YAN/TT/SS/NR/LA/H/Q (SEQ ID NO: 6590), and iii. a CDR3 region that has a sequence of QQSY/DD/E/S/NL/N/T/SPL (SEQ ID NO: 6591).
 10. The antibody of claim 1, wherein the antibody comprises: a heavy chain variable domain comprising an amino acid sequence that is at least 80% identical to the amino acid sequence of the heavy chain variable domain of an antibody selected from any of Tables 2A-2F; and a light chain variable domain comprising an amino acid sequence that is at least 80% identical to the light chain variable domain of the antibody selected from any of Tables 2A-2F.
 11. The antibody of claim 1, wherein the heavy chain variable domain and the light chain variable domain are present in separate polypeptides.
 12. The antibody of claim 1, wherein the heavy chain variable domain and the light chain variable domain are present in a single polypeptide.
 13. The antibody of claim 1, wherein the antibody binds ACVR2A with an affinity in the range of 10⁷ M⁻¹ to 10¹² M⁻¹.
 14. The antibody of claim 1, wherein the antibody comprises a covalently linked non-peptide synthetic polymer.
 15. The antibody of claim 14, wherein the synthetic polymer is poly(ethylene glycol) polymer.
 16. The antibody of claim 1, wherein the antibody comprises a covalently linked lipid or fatty acid moiety.
 17. The antibody of claim 1, wherein the antibody comprises a covalently linked polysaccharide or carbohydrate moiety.
 18. The antibody of claim 1, wherein the antibody is a single chain Fv (scFv) antibody.
 19. The antibody of claim 18, wherein the scFv is multimerized. 20-22. (canceled)
 23. A method of treating a condition in a patient comprising administering to a patient in need thereof an effective amount of the antibody of claim
 1. 24. The method according to claim 23, wherein the condition is associated with muscle atrophy.
 25. The method according to claim 23, wherein the condition is characterized by a decrease in muscle mass or muscle function, or insufficient lean body mass.
 26. The method according to claim 23, wherein the condition is cachexia or sarcopenia. 